JP2004505604A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004505604A5 JP2004505604A5 JP2001560365A JP2001560365A JP2004505604A5 JP 2004505604 A5 JP2004505604 A5 JP 2004505604A5 JP 2001560365 A JP2001560365 A JP 2001560365A JP 2001560365 A JP2001560365 A JP 2001560365A JP 2004505604 A5 JP2004505604 A5 JP 2004505604A5
- Authority
- JP
- Japan
- Prior art keywords
- electric field
- cells
- cell
- dividing
- division
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 description 184
- 230000005684 electric field Effects 0.000 description 135
- 238000000034 method Methods 0.000 description 47
- 210000001519 tissue Anatomy 0.000 description 44
- 206010028980 Neoplasm Diseases 0.000 description 30
- 239000012528 membrane Substances 0.000 description 25
- 230000006378 damage Effects 0.000 description 23
- 230000008569 process Effects 0.000 description 23
- 210000004881 tumor cell Anatomy 0.000 description 23
- 210000000170 cell membrane Anatomy 0.000 description 13
- 210000005061 intracellular organelle Anatomy 0.000 description 13
- 210000003463 organelle Anatomy 0.000 description 13
- 238000011282 treatment Methods 0.000 description 13
- 230000032823 cell division Effects 0.000 description 12
- 230000012010 growth Effects 0.000 description 9
- 230000001965 increasing effect Effects 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 7
- 238000002512 chemotherapy Methods 0.000 description 6
- 210000000349 chromosome Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000005855 radiation Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000001086 cytosolic effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000003834 intracellular effect Effects 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 230000010076 replication Effects 0.000 description 5
- 201000009030 Carcinoma Diseases 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 210000003722 extracellular fluid Anatomy 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 241000195493 Cryptophyta Species 0.000 description 3
- 206010039491 Sarcoma Diseases 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 210000003850 cellular structure Anatomy 0.000 description 3
- 210000004718 centriole Anatomy 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 230000021953 cytokinesis Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000010291 electrical method Methods 0.000 description 3
- 238000004520 electroporation Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 210000002977 intracellular fluid Anatomy 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000010287 polarization Effects 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 108091060290 Chromatid Proteins 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 208000009956 adenocarcinoma Diseases 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 230000003466 anti-cipated effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000004756 chromatid Anatomy 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 210000000777 hematopoietic system Anatomy 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000031864 metaphase Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000011278 mitosis Effects 0.000 description 2
- 238000011275 oncology therapy Methods 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 235000012771 pancakes Nutrition 0.000 description 2
- 208000037803 restenosis Diseases 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 201000003076 Angiosarcoma Diseases 0.000 description 1
- 206010003571 Astrocytoma Diseases 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 208000005243 Chondrosarcoma Diseases 0.000 description 1
- 201000009047 Chordoma Diseases 0.000 description 1
- 208000006332 Choriocarcinoma Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000009798 Craniopharyngioma Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 208000002927 Hamartoma Diseases 0.000 description 1
- 208000001258 Hemangiosarcoma Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 208000018142 Leiomyosarcoma Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000000172 Medulloblastoma Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 206010029098 Neoplasm skin Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000007452 Plasmacytoma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 201000010208 Seminoma Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000014070 Vestibular schwannoma Diseases 0.000 description 1
- 208000004064 acoustic neuroma Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000006990 cholangiocarcinoma Diseases 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 208000002445 cystadenocarcinoma Diseases 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000008556 epithelial cell proliferation Effects 0.000 description 1
- 208000010932 epithelial neoplasm Diseases 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003313 haploid nucleated cell Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 208000011379 keloid formation Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 206010024627 liposarcoma Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000012804 lymphangiosarcoma Diseases 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 206010027191 meningioma Diseases 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 208000001611 myxosarcoma Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 210000004560 pineal gland Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000031877 prophase Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 208000018964 sebaceous gland cancer Diseases 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 201000008759 sweat gland cancer Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18329500P | 2000-02-17 | 2000-02-17 | |
| US60/183,295 | 2000-02-17 | ||
| PCT/IB2001/000202 WO2001060994A1 (en) | 2000-02-17 | 2001-02-16 | Method and apparatus for destroying dividing cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004505604A JP2004505604A (ja) | 2004-02-26 |
| JP2004505604A5 true JP2004505604A5 (enExample) | 2011-08-04 |
| JP5280600B2 JP5280600B2 (ja) | 2013-09-04 |
Family
ID=22672230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001560365A Expired - Lifetime JP5280600B2 (ja) | 2000-02-17 | 2001-02-16 | 分裂中の細胞を破壊するための方法および装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7333852B2 (enExample) |
| EP (2) | EP2335776A1 (enExample) |
| JP (1) | JP5280600B2 (enExample) |
| CN (1) | CN1416466A (enExample) |
| AU (1) | AU3399801A (enExample) |
| CA (1) | CA2400526C (enExample) |
| WO (1) | WO2001060994A1 (enExample) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| EP2335776A1 (en) | 2000-02-17 | 2011-06-22 | Yoram Palti | Method and apparatus for destroying dividing cells |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US8447395B2 (en) | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| US7599745B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Treating a tumor or the like with an electric field |
| US7136699B2 (en) * | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US6868289B2 (en) * | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| ES2344215T3 (es) | 2004-12-07 | 2010-08-20 | Standen Ltd. | Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo. |
| JP5559460B2 (ja) * | 2004-12-27 | 2014-07-23 | スタンデン・リミテッド | 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法 |
| US20070021803A1 (en) | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| CA2624624C (en) * | 2005-10-03 | 2016-07-19 | Novocure Limited | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| JP5457183B2 (ja) * | 2006-09-14 | 2014-04-02 | ラジュール・テクノロジーズ・エルエルシイ | 癌細胞を破壊する装置及び方法 |
| JP2010534056A (ja) * | 2007-02-16 | 2010-11-04 | イオジェニックス・プロプライエタリー・リミテッド | 水生生物の培養を改善するための方法 |
| WO2009044289A1 (en) * | 2007-03-06 | 2009-04-09 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| CN101820947A (zh) * | 2007-08-14 | 2010-09-01 | 诺沃库勒有限公司 | 用电场治疗寄生物 |
| WO2009036472A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Prostate cancer ablation |
| WO2009036459A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-tine probe and treatment by activation of opposing tines |
| WO2009036457A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-layer electrode ablation probe and related methods |
| US20100100093A1 (en) * | 2008-09-16 | 2010-04-22 | Lazure Technologies, Llc. | System and method for controlled tissue heating for destruction of cancerous cells |
| US8728139B2 (en) | 2009-04-16 | 2014-05-20 | Lazure Technologies, Llc | System and method for energy delivery to a tissue using an electrode array |
| US9526911B1 (en) | 2010-04-27 | 2016-12-27 | Lazure Scientific, Inc. | Immune mediated cancer cell destruction, systems and methods |
| US9233257B1 (en) | 2010-11-22 | 2016-01-12 | Jacob Zabara | Electromagnetic radiation treatment |
| US8684901B1 (en) | 2010-11-22 | 2014-04-01 | Jacob Zabara | Electromagnetic radiation treatment for cancer and pathological genetic regulations |
| AU2012364909B2 (en) | 2011-02-15 | 2016-11-24 | Hemosonics, Llc | Characterization of blood hemostasis and oxygen transport parameters |
| US9789328B2 (en) * | 2012-10-26 | 2017-10-17 | Robert E. Sandstrom | Tumor treatment with free radical lifetimes enhanced by persistent low strength magnetic field |
| US9757582B2 (en) * | 2012-10-26 | 2017-09-12 | Robert E. Sandstrom | Tumor treatment with free radical lifetimes enhanced by persistant low strength magnetic field |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US20190117963A1 (en) | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9833617B2 (en) | 2014-07-25 | 2017-12-05 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| US20180001075A1 (en) | 2016-06-30 | 2018-01-04 | Novocure Limited | Arrays for Longitudinal Delivery of TTFields to a Body |
| WO2018134733A1 (en) | 2017-01-19 | 2018-07-26 | Moshe Giladi | System for viewing cell cultures under a microscope whilst applying ttfields |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| CO2018001283A1 (es) | 2018-02-07 | 2019-08-09 | Panacea Quantum Leap Tech Llc | Método de estimulación de tejidos con campos eléctricos y magnéticos por barrido en frecuencia |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| EP3773726B1 (en) | 2018-04-09 | 2024-06-05 | Novocure GmbH | Treating tumors with ttfields and an aurora kinase inhibitor |
| EP3775956B1 (en) | 2018-04-10 | 2022-03-23 | Novocure GmbH | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| ES3047748T3 (en) | 2018-07-03 | 2025-12-04 | Univ Leland Stanford Junior | Using alternating electric fields to increase cell membrane permeability |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| KR102794415B1 (ko) | 2018-07-10 | 2025-04-09 | 노보큐어 게엠베하 | 교류 전기장을 사용한 바이러스 감염 억제 |
| MX2020013431A (es) | 2018-07-18 | 2021-05-27 | Novocure Gmbh | Uso de densidad de perdida de potencia y mediciones relacionadas para cuantificar la dosis de campos de tratamiento de tumores (ttfield). |
| EP3878389B1 (en) | 2018-08-23 | 2025-08-06 | Novocure GmbH | Using alternating electric fields to increase permeability of the blood brain barrier |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| WO2020049482A1 (en) | 2018-09-07 | 2020-03-12 | Yaniv Alon | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP3984590B1 (en) | 2018-10-15 | 2022-12-07 | Novocure GmbH | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
| JP7148722B2 (ja) | 2018-10-25 | 2022-10-05 | ゼーヴ・ボンゾン | 被験者の脊椎構造体に対する交番電界(例えばTTField)の送達 |
| EP3880299B1 (en) | 2018-11-13 | 2025-09-24 | The Methodist Hospital | Device for oncomagnetic treatment |
| IL280843B2 (en) | 2018-11-19 | 2025-10-01 | Novocure Gmbh | Arrays for providing fields treat growth with selectively addressable sub-elements |
| SG11202101810SA (en) | 2018-11-29 | 2021-03-30 | Novocure Gmbh | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
| EP3961565A1 (en) | 2019-01-08 | 2022-03-02 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| IL284284B2 (en) | 2019-02-26 | 2026-03-01 | Novocure Gmbh | Frequency determination for tumor-treating field therapy is based on the electrical characteristic of targeted cancer cells. |
| EP3954314B1 (en) | 2019-02-27 | 2025-01-08 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| CN113613651B (zh) | 2019-03-29 | 2025-08-12 | 诺沃库勒有限责任公司 | 用PTGER3抑制剂恢复TTField抗性癌细胞中对TTField的敏感性的方法 |
| US11291837B2 (en) | 2019-04-17 | 2022-04-05 | Novocure Gmbh | Uploading data from an isolated system without compromising isolation |
| EP4480526A3 (en) | 2019-04-22 | 2025-03-12 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| CN113766949B (zh) | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| US11691006B2 (en) | 2019-04-22 | 2023-07-04 | Boston Scientific Scimed, Inc. | Electrical stimulation devices for cancer treatment |
| EP3958960B1 (en) | 2019-04-23 | 2025-06-18 | Boston Scientific Scimed, Inc. | Electrical stimulation with thermal treatment or thermal monitoring |
| US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| JP2022529374A (ja) | 2019-04-23 | 2022-06-21 | ボストン サイエンティフィック サイムド,インコーポレイテッド | がん治療のための電気刺激用電極 |
| US11654279B2 (en) | 2019-07-31 | 2023-05-23 | Novocure Gmbh | Applying tumor treating fields (TTFields) via electrodes embedded into skull implants |
| WO2021024170A1 (en) | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| US11890467B2 (en) | 2019-08-30 | 2024-02-06 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the neck |
| JP7453355B2 (ja) | 2019-09-30 | 2024-03-19 | テーデーカー エレクトロニクス アーゲー | 多結晶セラミック固体、該固体による誘電体電極、該電極を備える装置及び製造方法 |
| US11534601B2 (en) | 2019-11-08 | 2022-12-27 | Novocure Gmbh | Perforated hydrogel configurations and methods of production and use thereof |
| WO2021111186A1 (en) | 2019-12-02 | 2021-06-10 | Novocure Gmbh | Methods and apparatuses for optimizing transducer array placement |
| ES2950234T3 (es) | 2019-12-31 | 2023-10-06 | Novocure Gmbh | Matrices para administrar campos de tratamiento de tumores (camposTT) con elementos de electrodos y sensores de temperatura accesibles individualmente |
| EP4075442A1 (en) | 2019-12-31 | 2022-10-19 | Novocure GmbH | Methods, systems, and apparatuses for fast approximation of electric field distribution |
| EP4091665B1 (en) | 2019-12-31 | 2024-10-30 | Novocure GmbH | High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels |
| WO2021136965A2 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Methods, systems, and apparatuses for image segmentation |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| US11458298B2 (en) | 2020-01-22 | 2022-10-04 | Novocure Gmbh | Assemblies containing two conductive gel compositions and methods of production and use thereof |
| CN115515674A (zh) | 2020-02-24 | 2022-12-23 | 波士顿科学国际有限公司 | 用于治疗胰腺癌的系统和方法 |
| US20210299440A1 (en) | 2020-03-30 | 2021-09-30 | Novocure Gmbh | Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases |
| BR112022021484A2 (pt) | 2020-04-24 | 2022-12-13 | Novocure Gmbh | Uso de campos elétricos alternados para aumentar a permeabilidade da barreira hematoencefálica |
| WO2021223684A1 (zh) * | 2020-05-02 | 2021-11-11 | 电冷科学有限公司 | 一种避免活性非消融电极附近组织损伤的装置 |
| TWI889816B (zh) | 2020-05-06 | 2025-07-11 | 瑞士商諾沃庫勒有限責任公司 | 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 |
| EP4168108A4 (en) | 2020-06-19 | 2024-07-17 | The Methodist Hospital dba Houston Methodist Hospital | METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| US12594421B2 (en) * | 2020-08-03 | 2026-04-07 | Novocure Gmbh | Compositions and methods for increasing cancer cell sensitivity to alternating electric fields |
| CN114075508A (zh) * | 2020-08-14 | 2022-02-22 | 上海必修福企业管理有限公司 | 电场发生装置及其在影响细胞的分裂周期中的用途和方法 |
| JP7777118B2 (ja) | 2020-09-25 | 2025-11-27 | ノボキュア ゲーエムベーハー | 過熱することなく電流を最大化するために腫瘍治療電場(TTField)における個々の電極要素における金属化範囲を変化させること |
| DE102020133165B9 (de) | 2020-12-11 | 2024-06-06 | Tdk Electronics Ag | Keramikelektrode, Baugruppe mit der Keramikelektrode, Anordnung mit der Keramikelektrode und Verfahren zur Herstellung einer Keramikelektrode |
| US11883652B2 (en) | 2020-12-21 | 2024-01-30 | Novocure Gmbh | Optimization of composite electrode |
| EP4240470A1 (en) | 2021-02-17 | 2023-09-13 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas |
| US12440680B2 (en) | 2021-03-12 | 2025-10-14 | Novocure Gmbh | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| EP4277693B1 (en) | 2021-03-12 | 2024-11-13 | Novocure Gmbh | Methods of production of an electrode array |
| EP4271466A2 (en) | 2021-03-18 | 2023-11-08 | Novocure Gmbh | Constructing a 3d phantom with liquid hydrogel |
| EP4284489B1 (en) | 2021-03-31 | 2025-07-16 | Novocure Gmbh | Impedance tomography using electrodes of a tumor treating fields (ttfields) system |
| KR20240027008A (ko) | 2021-06-30 | 2024-02-29 | 노보큐어 게엠베하 | 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용 |
| US20230024216A1 (en) | 2021-07-21 | 2023-01-26 | Novocure Gmbh | Conductive pad generating tumor treating field and methods of production and use thereof |
| US11877838B2 (en) * | 2021-08-14 | 2024-01-23 | Nano Hesgarsazan Salamat Arya | Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields |
| EP4376939A1 (en) | 2021-09-14 | 2024-06-05 | Novocure GmbH | Temperature independent method and system for applying ttfields |
| JP2024533808A (ja) | 2021-09-30 | 2024-09-12 | ノボキュア ゲーエムベーハー | 毛包と相互作用する腫瘍治療電場を印加するための方法およびシステム |
| WO2023095111A1 (en) | 2021-11-29 | 2023-06-01 | Novocure Gmbh | Methods of reducing ciliogenesis with alternating electric fields |
| WO2023105391A1 (en) | 2021-12-07 | 2023-06-15 | Novocure Gmbh | Compact dc system for delivering a square wave ac signal |
| US12434051B2 (en) | 2021-12-10 | 2025-10-07 | Novocure Gmbh | Compression garment assembly for applying TTFields and methods of production and use thereof |
| US20230173265A1 (en) | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
| EP4649993A3 (en) | 2021-12-10 | 2025-12-31 | Novocure GmbH | COMPRESSION GARMENT SET FOR APPLYING TT FIELDS |
| US12599765B2 (en) | 2021-12-14 | 2026-04-14 | Novocure Gmbh | Shifting of transducer array to reduce skin irritation |
| WO2023126842A1 (en) | 2021-12-29 | 2023-07-06 | Novocure Gmbh | Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes |
| EP4456971A1 (en) | 2021-12-30 | 2024-11-06 | Novocure GmbH | Selecting values of parameters for treatment using tumor treating fields (ttfields) |
| US12478779B2 (en) | 2022-03-29 | 2025-11-25 | Novocure Gmbh | Electrode array having a semi-liquid conductive gel |
| US12478793B2 (en) | 2022-03-30 | 2025-11-25 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| EP4460361B1 (en) | 2022-03-30 | 2025-03-19 | Novocure GmbH | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| CN119173302A (zh) | 2022-04-01 | 2024-12-20 | 得克萨斯大学体系董事会 | 用于应用与个性化超分割立体定向适应性放射疗法相组合的肿瘤治疗电场的方法和仪器 |
| WO2023242741A1 (en) | 2022-06-13 | 2023-12-21 | Novocure Gmbh | Systems and methods for increasing intestinal absorption of therapeutic agents |
| JP2025520608A (ja) | 2022-06-20 | 2025-07-03 | ノボキュア ゲーエムベーハー | 癌を治療するための組成物、システム、および方法、腫瘍治療場およびvegf阻害剤 |
| JP2025520663A (ja) | 2022-06-21 | 2025-07-03 | ノボキュア ゲーエムベーハー | 交流電場とcrispr-casシステムを用いた症状および疾患の治療システムおよび方法 |
| WO2024052877A1 (en) | 2022-09-08 | 2024-03-14 | Novocure Gmbh | Constructing a 3d phantom with a matrix material having conductive particles dispersed therein |
| EP4554661A1 (en) | 2022-09-27 | 2025-05-21 | Novocure GmbH | Ingestible implantable device to measure internal ttfield intensity |
| CA3180284A1 (en) | 2022-09-29 | 2024-03-29 | Novocure Gmbh | Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment |
| US20240108908A1 (en) | 2022-09-29 | 2024-04-04 | Novocure Gmbh | System and method for maintaining ttfields during battery changes |
| JP2025534245A (ja) | 2022-09-30 | 2025-10-15 | ノボキュア ゲーエムベーハー | 交流電場および樹状細胞を用いたがん治療のための組成物、システムおよび方法 |
| US20240108699A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for reducing electrosensation and/or skin irritation |
| JP2025532048A (ja) | 2022-09-30 | 2025-09-29 | ノボキュア ゲーエムベーハー | 交流電場およびアポトーシスがん細胞ワクチンを用いたがん治療のための組成物、システムおよび方法 |
| CN119968220A (zh) | 2022-09-30 | 2025-05-09 | 诺沃库勒有限责任公司 | 用于TTField施加系统的单导线温度测量解决方案及其生产和使用方法 |
| CN115845254B (zh) * | 2022-11-23 | 2024-02-02 | 湖南安泰康成生物科技有限公司 | 小细胞肺癌治疗系统以及交变电场发生装置 |
| CN120417961A (zh) | 2022-11-30 | 2025-08-01 | 诺沃库勒有限责任公司 | 具有替代阵列材料的换能器阵列 |
| WO2024127192A1 (en) | 2022-12-13 | 2024-06-20 | Novocure Gmbh | Wireless transducer arrays applying tumor treating fields and systems and methods of use thereof |
| IL320470A (en) | 2022-12-28 | 2025-06-01 | Novocure Gmbh | Compositions, systems and methods for treating cancer using tumor-treating fields and anti-VEGFR-2 antibodies |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| US20240366954A1 (en) | 2023-03-30 | 2024-11-07 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields and killer cells |
| CN120936371A (zh) | 2023-03-30 | 2025-11-11 | 诺沃库勒有限责任公司 | 用于使用肿瘤治疗电场和嵌合抗原受体(car)免疫细胞治疗癌症的组合物、系统和方法 |
| WO2024201412A1 (en) | 2023-03-31 | 2024-10-03 | Novocure Gmbh | Microneedles to overcome contact resistance |
| WO2024257051A1 (en) | 2023-06-15 | 2024-12-19 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and thioredoxin/glutathione inhibitors |
| CN121969367A (zh) | 2023-09-21 | 2026-05-01 | 诺沃库勒有限责任公司 | 使用肿瘤治疗电场结合免疫检查点抑制剂及mhc i类激活剂治疗癌症的组合物、系统和方法 |
| TW202529847A (zh) | 2023-09-28 | 2025-08-01 | 瑞士商諾沃庫勒有限責任公司 | 具有子陣列的換能器陣列及其製造和使用方法 |
| CN121925295A (zh) | 2023-09-29 | 2026-04-24 | 诺沃库勒有限责任公司 | 使用振幅和频率的交错变化来改善用交变电场进行治疗期间的电感觉 |
| WO2025068918A1 (en) | 2023-09-29 | 2025-04-03 | Novocure Gmbh | Apparatus and method of reapplying transducer arrays to a patient |
| WO2025068877A1 (en) | 2023-09-29 | 2025-04-03 | Novocure Gmbh | Low frequency rf ablation system |
| WO2025088586A1 (en) | 2023-10-27 | 2025-05-01 | Brown University | Compositions, systems, and methods for treating cancer using tumor treating fields with inhibitors of mif, mica, and/or micb |
| WO2025186743A1 (en) | 2024-03-05 | 2025-09-12 | Novocure Gmbh | Combinations for treating cancer in standard of care and/or profibrotic chemotherapeutic agent-naive patients using tumor treating fields and chemotherapeutic agents |
| WO2025191539A1 (en) | 2024-03-15 | 2025-09-18 | Novocure Gmbh | Reduced impedance transducer array for applying alternating electric fields and methods of production and use thereof |
| US20250367138A1 (en) | 2024-05-31 | 2025-12-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and methylglyoxal |
| WO2026003783A1 (en) | 2024-06-27 | 2026-01-02 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and nf-κb inhibitors |
| WO2026033423A1 (en) | 2024-08-05 | 2026-02-12 | Novocure Gmbh | Flexible layer for use in a tumor treating fields transducer |
| US20260034376A1 (en) | 2024-08-05 | 2026-02-05 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer and foam layer |
| US20260083819A1 (en) | 2024-09-20 | 2026-03-26 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and interferon gamma |
| WO2026069010A1 (en) | 2024-09-25 | 2026-04-02 | Novocure Gmbh | Compositions and systems for treating cancer using tumor treating fields (ttfields) and ace inhibitors |
| WO2026069112A1 (en) | 2024-09-26 | 2026-04-02 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields, chemotherapeutic agents, and anti-fibrotic agents |
| US20260091226A1 (en) | 2024-09-30 | 2026-04-02 | Novocure Gmbh | Transducer array generating tumor treating field and methods of production and use thereof |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR446660A (fr) | 1911-09-02 | 1912-12-12 | Gottlieb Schuettel | Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux |
| BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
| US3991770A (en) | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
| US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4121592A (en) * | 1975-08-04 | 1978-10-24 | Critical Systems, Inc. | Apparatus for heating tissue |
| DE2907013A1 (de) | 1978-02-24 | 1979-08-30 | American Med Syst | Verfahren und vorrichtung zum beguenstigen der heilung von verletzten knochenknorpeln und geweben im gesichtsbereich |
| DE2813068A1 (de) * | 1978-03-25 | 1979-10-04 | Philips Patentverwaltung | Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen |
| GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
| US4472506A (en) | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
| US4467809A (en) * | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
| US4622952A (en) | 1983-01-13 | 1986-11-18 | Gordon Robert T | Cancer treatment method |
| CA1244889A (en) * | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
| DE3323415C2 (de) | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen |
| SE455920B (sv) | 1986-01-29 | 1988-08-22 | Hans Wiksell | Anordning for hypertermibehandling av tumorer |
| US4923814A (en) | 1986-05-09 | 1990-05-08 | Electropore, Inc. | High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor |
| CN86103803B (zh) | 1986-06-05 | 1987-11-18 | 北京信息工程学院 | 静电场治疗装置 |
| US4822470A (en) * | 1987-10-09 | 1989-04-18 | Baylor College Of Medicine | Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses |
| US4936303A (en) * | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
| JPH0629196B2 (ja) | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
| US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
| US5158071A (en) * | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
| GB8904998D0 (en) | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
| US5099756A (en) * | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
| US5441746A (en) * | 1989-12-22 | 1995-08-15 | Molecular Bioquest, Inc. | Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production |
| US5236410A (en) * | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| WO1992007621A1 (en) * | 1990-11-05 | 1992-05-14 | Bsd Medical Corporation | Urethral inserted applicator for prostate hyperthermia |
| CA2109084C (en) | 1991-05-03 | 2004-02-24 | University Technologies International, Inc. | Biofilm reduction method |
| US5441532A (en) * | 1991-06-26 | 1995-08-15 | Massachusetts Institute Of Technology | Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators |
| US5697909A (en) * | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | Methods and apparatus for surgical cutting |
| US5468223A (en) * | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| US5458597A (en) * | 1993-11-08 | 1995-10-17 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
| IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5704355A (en) * | 1994-07-01 | 1998-01-06 | Bridges; Jack E. | Non-invasive system for breast cancer detection |
| US6447499B2 (en) * | 1995-07-28 | 2002-09-10 | James R. Gray | Use of a polarized field to modify the efficacy of a bioactive agent |
| US5606971A (en) * | 1995-11-13 | 1997-03-04 | Artann Corporation, A Nj Corp. | Method and device for shear wave elasticity imaging |
| US5718246A (en) | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| US5869326A (en) * | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| WO1999011771A1 (en) | 1997-09-04 | 1999-03-11 | Science Research Laboratory, Inc. | Cell separation using electric fields |
| US6027488A (en) | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US5976092A (en) | 1998-06-15 | 1999-11-02 | Chinn; Douglas O. | Combination stereotactic surgical guide and ultrasonic probe |
| US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| WO2000053113A1 (en) * | 1999-03-09 | 2000-09-14 | Thermage, Inc. | Apparatus and method for treatment of tissue |
| US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
| US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| EP2335776A1 (en) | 2000-02-17 | 2011-06-22 | Yoram Palti | Method and apparatus for destroying dividing cells |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7599745B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Treating a tumor or the like with an electric field |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6994706B2 (en) * | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| DE102004028156A1 (de) | 2004-06-09 | 2006-01-05 | Kalbe, Jochen, Dr. | Kombination von Radiowellen mit pharmakologisch aktiven Substanzen |
| ES2344215T3 (es) | 2004-12-07 | 2010-08-20 | Standen Ltd. | Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo. |
| JP5559460B2 (ja) | 2004-12-27 | 2014-07-23 | スタンデン・リミテッド | 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法 |
| DK1899001T3 (en) | 2005-06-08 | 2017-12-04 | Novocure Ltd | DEVICE FOR CANCER TREATMENT WITH ELECTRIC FIELDS MADE FOR DESIRED LOCATIONS IN A BODY |
| CA2624624C (en) | 2005-10-03 | 2016-07-19 | Novocure Limited | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| WO2009044289A1 (en) | 2007-03-06 | 2009-04-09 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| CN101820947A (zh) | 2007-08-14 | 2010-09-01 | 诺沃库勒有限公司 | 用电场治疗寄生物 |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
-
2001
- 2001-02-16 EP EP10012031A patent/EP2335776A1/en not_active Ceased
- 2001-02-16 JP JP2001560365A patent/JP5280600B2/ja not_active Expired - Lifetime
- 2001-02-16 US US10/204,334 patent/US7333852B2/en not_active Ceased
- 2001-02-16 CN CN01806416A patent/CN1416466A/zh active Pending
- 2001-02-16 US US12/199,498 patent/USRE43618E1/en not_active Expired - Lifetime
- 2001-02-16 WO PCT/IB2001/000202 patent/WO2001060994A1/en not_active Ceased
- 2001-02-16 CA CA2400526A patent/CA2400526C/en not_active Expired - Lifetime
- 2001-02-16 AU AU33998/01A patent/AU3399801A/en not_active Abandoned
- 2001-02-16 EP EP01906036A patent/EP1259596A4/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5280600B2 (ja) | 分裂中の細胞を破壊するための方法および装置 | |
| US7016725B2 (en) | Method and apparatus for destroying dividing cells | |
| US10994133B2 (en) | Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms | |
| EP2183024B1 (en) | Treating parasites with electric fields | |
| JP4750784B2 (ja) | 異なる周波数の電界による腫瘍等の治療 | |
| US7519420B2 (en) | Apparatus for selectively destroying dividing cells | |
| CA2697012C (en) | Treating bacteria with electric fields | |
| US7146210B2 (en) | Apparatus and method for optimizing tumor treatment efficiency by electric fields | |
| CN101124011B (zh) | 利用电场从不同方向治疗肿瘤等 | |
| US20230149708A1 (en) | Tumor treating fields (ttf) for cancer treatment | |
| HK1139089A (en) | Treating parasites with electric fields | |
| HK1139089B (en) | Treating parasites with electric fields |