JP5253737B2 - Ｄ３アゴニスト性治療薬としての（ｓ）−２−ｎ−プロピルアミノ−５−ヒドロキシテトラリン - Google Patents
Ｄ３アゴニスト性治療薬としての（ｓ）−２−ｎ−プロピルアミノ−５−ヒドロキシテトラリン Download PDFInfo
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- JP5253737B2 JP5253737B2 JP2006544295A JP2006544295A JP5253737B2 JP 5253737 B2 JP5253737 B2 JP 5253737B2 JP 2006544295 A JP2006544295 A JP 2006544295A JP 2006544295 A JP2006544295 A JP 2006544295A JP 5253737 B2 JP5253737 B2 JP 5253737B2
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- Prior art keywords
- hydroxytetralin
- propylamino
- acid
- prodrug
- disease
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Neurosurgery (AREA)
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- Neurology (AREA)
- Addiction (AREA)
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- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
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- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359528A DE10359528A1 (de) | 2003-12-18 | 2003-12-18 | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
| DE10359528.7 | 2003-12-18 | ||
| PCT/EP2004/014143 WO2005058296A1 (de) | 2003-12-18 | 2004-12-13 | (s)-2-n-propylamino-5-hydroxytetralin als d3-agonistisches therapeutikum |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007514674A JP2007514674A (ja) | 2007-06-07 |
| JP2007514674A5 JP2007514674A5 (https=) | 2008-02-14 |
| JP5253737B2 true JP5253737B2 (ja) | 2013-07-31 |
Family
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Family Applications (1)
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| JP2006544295A Expired - Fee Related JP5253737B2 (ja) | 2003-12-18 | 2004-12-13 | Ｄ３アゴニスト性治療薬としての（ｓ）−２−ｎ−プロピルアミノ−５−ヒドロキシテトラリン |
Country Status (21)
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| US (2) | US8609641B2 (https=) |
| EP (1) | EP1694318B1 (https=) |
| JP (1) | JP5253737B2 (https=) |
| KR (1) | KR101083568B1 (https=) |
| CN (1) | CN1929829B (https=) |
| AT (1) | ATE356621T1 (https=) |
| AU (1) | AU2004298341B2 (https=) |
| BR (1) | BRPI0417739A (https=) |
| CA (1) | CA2547820C (https=) |
| CY (1) | CY1106589T1 (https=) |
| DE (2) | DE10359528A1 (https=) |
| DK (1) | DK1694318T3 (https=) |
| ES (1) | ES2282923T3 (https=) |
| HR (1) | HRP20070175T3 (https=) |
| IS (1) | IS2533B (https=) |
| MX (1) | MXPA06006696A (https=) |
| PL (1) | PL1694318T3 (https=) |
| PT (1) | PT1694318E (https=) |
| RS (1) | RS50536B (https=) |
| SI (1) | SI1694318T1 (https=) |
| WO (1) | WO2005058296A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19814084B4 (de) | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| DE10041479A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
| US20040048779A1 (en) * | 2002-05-06 | 2004-03-11 | Erwin Schollmayer | Use of rotigotine for treating the restless leg syndrome |
| DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
| US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| US8211462B2 (en) | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
| ATE295726T1 (de) | 2002-12-02 | 2005-06-15 | Sanol Arznei Schwarz Gmbh | Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese |
| DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
| DE10359528A1 (de) | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
| EP1547592A1 (en) | 2003-12-23 | 2005-06-29 | Schwarz Pharma Ag | Intranasal formulation of rotigotine |
| DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
| US20050197385A1 (en) * | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
| DE102004014841B4 (de) * | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
| TWI392670B (zh) | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途 |
| EP1987815A1 (en) * | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders |
| SI2215072T1 (sl) | 2007-11-28 | 2015-10-30 | Ucb Pharma Gmbh | Polimorfna oblika rotigotina |
| US8604242B2 (en) * | 2008-10-13 | 2013-12-10 | Interquim, S.A. | Process for the preparation of optically active (S)-(−)-2-(N-propylamino)-5-methoxytetraline and (S)-(−)-2-(N-propylamino)-5-hydroxytetraline compounds |
| EP2281559A1 (en) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis |
| JP5738875B2 (ja) | 2009-10-16 | 2015-06-24 | エピオメド セラピューティクス， インク． | 催吐治療 |
| US9925150B2 (en) | 2009-12-22 | 2018-03-27 | Lts Lohmann Therapie-Systeme Ag | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
| ES2729824T3 (es) * | 2011-04-08 | 2019-11-06 | Laurus Labs Ltd | Formas sólidas de compuestos antirretrovirales, procedimiento para la preparación y composición farmacéutica de los mismos |
| EP2559435A1 (en) | 2011-08-19 | 2013-02-20 | UCB Pharma GmbH | Rotigotine in the treatment of hemispatial neglect, stroke and deficits following stroke |
| CN102634064B (zh) * | 2012-04-10 | 2013-09-11 | 宁波长阳科技有限公司 | 一种含磷阻燃剂、阻燃聚酯薄膜及其制备方法 |
| US9956201B2 (en) | 2014-07-21 | 2018-05-01 | Spriaso Llc | Compositions comprising bioreversible derivatives of hydroxy N-substituted-2-aminotetralins, and related dosage forms |
| WO2021206741A1 (en) * | 2020-04-09 | 2021-10-14 | Delahoussaye Kevin | Modulating neurotransmitter concentration |
| DE102021213721A1 (de) * | 2021-12-02 | 2023-06-07 | Continental Reifen Deutschland Gmbh | Verbindung, Kautschukmischung enthaltend die Verbindung, Fahrzeugreifen, der die Kautschukmischung in wenigstens einem Bauteil aufweist, Verfahren zur Herstellung der Verbindung sowie Verwendung der Verbindung als Alterungsschutzmittel und/oder Antioxidationsmittel und/oder Farbstoff |
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| DE3062971D1 (en) | 1979-09-14 | 1983-06-09 | Sandoz Ag | Derivatives of tetraline, their preparation and medicaments containing these compounds |
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| US5177112A (en) | 1983-01-03 | 1993-01-05 | Whitby Research, Inc. | Substituted 2-aminotetralins |
| FR2563731B1 (fr) * | 1984-05-07 | 1989-03-24 | Nelson Res & Dev | Composition therapeutique contenant de la 2-(n-phenylethyl-n-propylamino)-5-hydroxytetraline pour traiter la maladie de parkinson, pour stimuler selectivement les recepteurs de dopamine d-2 et procede de production d'une composition pharmaceutique utile au traitement de la maladie de parkinson |
| FR2679451B1 (fr) | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | Comprime multiparticulaire a delitement rapide. |
| US5464632C1 (en) | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| WO1993023035A2 (en) | 1992-05-18 | 1993-11-25 | Smithkline Beecham Plc | Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and parkinson's disease |
| SE9301732D0 (sv) | 1993-05-18 | 1993-05-18 | Haakan Wilhelm Wikstroem | New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins |
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| IT1292155B1 (it) | 1997-06-13 | 1999-01-25 | Zambon Spa | Derivati naftotiazolonici attivi sul recettore dopaminergico d 3 |
| DE19814084B4 (de) | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
| FR2785538B1 (fr) | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
| HK1049156B (en) * | 1999-11-23 | 2004-12-10 | Ucb Manufacturing Ireland Limited | Improved process for preparing nitrogen-substituted aminotetralins |
| DE10041479A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| US20030027793A1 (en) | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
| US20030026830A1 (en) | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
| PT1256339E (pt) | 2001-05-08 | 2004-02-27 | Lohmann Therapie Syst Lts | Sistema terapeutico transdermico para doenca de parkinson que induz niveis plasmaticos altos de rotigotina |
| EP1256340B1 (en) | 2001-05-08 | 2003-08-13 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of Parkinson's disease |
| FR2829028B1 (fr) | 2001-08-29 | 2004-12-17 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et d'un produit qui active la neurotransmission dopaminergique dans le cerveau, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de |
| HU227543B1 (en) | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| HUP0103986A2 (hu) | 2001-09-28 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
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| US20040048779A1 (en) | 2002-05-06 | 2004-03-11 | Erwin Schollmayer | Use of rotigotine for treating the restless leg syndrome |
| DE10220230A1 (de) | 2002-05-06 | 2003-11-27 | Sanol Arznei Schwarz Gmbh | Verwendung von Rotigotine zur Behandlung des Restless Leg Syndroms |
| US20060216336A1 (en) | 2002-05-07 | 2006-09-28 | Hans-Michael Wolff | Transdermal therapeutic system for Parkinson's Disease |
| US8211462B2 (en) | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
| DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| US8246980B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
| US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| ATE295726T1 (de) | 2002-12-02 | 2005-06-15 | Sanol Arznei Schwarz Gmbh | Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese |
| DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| DE10334187A1 (de) | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
| DE10334188B4 (de) | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
| DE10359528A1 (de) | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
| EP1547592A1 (en) | 2003-12-23 | 2005-06-29 | Schwarz Pharma Ag | Intranasal formulation of rotigotine |
| DE10361258A1 (de) | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
| US20050197385A1 (en) | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
| DE102004014841B4 (de) | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
| US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
| TWI392670B (zh) | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途 |
| EP1987815A1 (en) | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders |
| SI2215072T1 (sl) | 2007-11-28 | 2015-10-30 | Ucb Pharma Gmbh | Polimorfna oblika rotigotina |
| EP2281559A1 (en) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis |
| US9925150B2 (en) | 2009-12-22 | 2018-03-27 | Lts Lohmann Therapie-Systeme Ag | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
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2003
- 2003-12-18 DE DE10359528A patent/DE10359528A1/de not_active Ceased
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2004
- 2004-12-13 WO PCT/EP2004/014143 patent/WO2005058296A1/de not_active Ceased
- 2004-12-13 ES ES04803781T patent/ES2282923T3/es not_active Expired - Lifetime
- 2004-12-13 PL PL04803781T patent/PL1694318T3/pl unknown
- 2004-12-13 AU AU2004298341A patent/AU2004298341B2/en not_active Ceased
- 2004-12-13 RS RSP-2007/0117A patent/RS50536B/sr unknown
- 2004-12-13 HR HR20070175T patent/HRP20070175T3/xx unknown
- 2004-12-13 BR BRPI0417739-8A patent/BRPI0417739A/pt not_active Application Discontinuation
- 2004-12-13 DE DE502004003249T patent/DE502004003249D1/de not_active Expired - Lifetime
- 2004-12-13 US US10/587,637 patent/US8609641B2/en not_active Expired - Fee Related
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- 2004-12-13 SI SI200430278T patent/SI1694318T1/sl unknown
- 2004-12-13 AT AT04803781T patent/ATE356621T1/de active
- 2004-12-13 MX MXPA06006696A patent/MXPA06006696A/es active IP Right Grant
- 2004-12-13 EP EP04803781A patent/EP1694318B1/de not_active Expired - Lifetime
- 2004-12-13 PT PT04803781T patent/PT1694318E/pt unknown
- 2004-12-13 DK DK04803781T patent/DK1694318T3/da active
- 2004-12-13 JP JP2006544295A patent/JP5253737B2/ja not_active Expired - Fee Related
- 2004-12-13 CA CA2547820A patent/CA2547820C/en not_active Expired - Fee Related
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2006
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- 2006-06-12 IS IS8505A patent/IS2533B/is unknown
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2007
- 2007-05-14 CY CY20071100652T patent/CY1106589T1/el unknown
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2013
- 2013-10-25 US US14/063,821 patent/US9108900B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IS2533B (is) | 2009-07-15 |
| AU2004298341B2 (en) | 2011-03-10 |
| KR20060126500A (ko) | 2006-12-07 |
| CA2547820C (en) | 2013-02-19 |
| IS8505A (is) | 2006-06-12 |
| DE10359528A1 (de) | 2005-07-28 |
| ES2282923T3 (es) | 2007-10-16 |
| MXPA06006696A (es) | 2006-08-31 |
| AU2004298341A1 (en) | 2005-06-30 |
| US9108900B2 (en) | 2015-08-18 |
| EP1694318A1 (de) | 2006-08-30 |
| PT1694318E (pt) | 2007-05-31 |
| RS50536B (sr) | 2010-05-07 |
| CN1929829A (zh) | 2007-03-14 |
| BRPI0417739A (pt) | 2007-04-03 |
| PL1694318T3 (pl) | 2007-07-31 |
| HRP20070175T3 (hr) | 2007-06-30 |
| KR101083568B1 (ko) | 2011-11-14 |
| EP1694318B1 (de) | 2007-03-14 |
| SI1694318T1 (sl) | 2007-08-31 |
| DK1694318T3 (da) | 2007-06-25 |
| ATE356621T1 (de) | 2007-04-15 |
| US20070197480A1 (en) | 2007-08-23 |
| CN1929829B (zh) | 2010-12-15 |
| DE502004003249D1 (en) | 2007-04-26 |
| CY1106589T1 (el) | 2012-01-25 |
| CA2547820A1 (en) | 2005-06-30 |
| JP2007514674A (ja) | 2007-06-07 |
| US20140051768A1 (en) | 2014-02-20 |
| WO2005058296A1 (de) | 2005-06-30 |
| HK1094421A1 (en) | 2007-03-30 |
| US8609641B2 (en) | 2013-12-17 |
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