JP5240398B2 - アルキルアミン誘導体 - Google Patents

アルキルアミン誘導体

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Publication number
JP5240398B2
JP5240398B2 JP2012503276A JP2012503276A JP5240398B2 JP 5240398 B2 JP5240398 B2 JP 5240398B2 JP 2012503276 A JP2012503276 A JP 2012503276A JP 2012503276 A JP2012503276 A JP 2012503276A JP 5240398 B2 JP5240398 B2 JP 5240398B2
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substituted
unsubstituted
amino
alkyl
acid
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JPWO2011108690A1 (ja
Inventor
正之 杉木
亨 岡松
徹雄 矢野
真也 谷口
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/202—Aliphatic compounds
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    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/204—Aromatic compounds
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
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    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
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JP2012503276A 2010-03-04 2011-03-04 アルキルアミン誘導体 Active JP5240398B2 (ja)

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JP2010048310 2010-03-04
JP2010048310 2010-03-04
PCT/JP2011/055033 WO2011108690A1 (ja) 2010-03-04 2011-03-04 アルキルアミン誘導体
JP2012503276A JP5240398B2 (ja) 2010-03-04 2011-03-04 アルキルアミン誘導体

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JPWO2011108690A1 JPWO2011108690A1 (ja) 2013-06-27
JP5240398B2 true JP5240398B2 (ja) 2013-07-17

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011108724A1 (ja) 2010-03-04 2011-09-09 味の素株式会社 糖尿病又は肥満症の予防又は治療剤
CA2791174C (en) 2010-03-04 2015-11-17 Ajinomoto Co., Inc. Alkylamine derivative
EP2551262A4 (en) 2010-03-24 2014-01-15 Ajinomoto Kk GLUTAMATE DERIVATIVES OR SALTS THEREOF
JPWO2011126099A1 (ja) 2010-04-02 2013-07-11 味の素株式会社 糖尿病又は肥満症の予防又は治療剤
WO2015030106A1 (ja) * 2013-09-02 2015-03-05 国立大学法人京都大学 Ｇｇｔ阻害作用を有する化合物及びｇｇｔファミリー酵素阻害剤
EP3305760A4 (en) * 2015-06-01 2019-01-23 Ajinomoto Co., Inc. PROCESS FOR THE PREPARATION OF AN ALKYLAMINE DERIVATIVE AND PRODUCTION INTERMEDIATE OF AN ALKYLAMINE DERIVATIVE
EP3730134B8 (en) 2017-12-20 2025-09-03 EA Pharma Co., Ltd. Medicinal composition for preventing or treating secondary hyperparathyroidism under maintenance dialysis
KR20210146280A (ko) 2019-04-03 2021-12-03 이에이 파마 가부시키가이샤 안정성이 양호한 의약 조성물

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53111793A (en) * 1977-01-12 1978-09-29 Coulter Electronics Colorimetric method for measuring activity of gammaaglutamyltranspeptidase enzyme in receiving medium solution and btologtcal fluids
JPS54125668A (en) * 1978-03-08 1979-09-29 Ciba Geigy Ag Novel ureaa and amideecompound and manufacture
JPS57142977A (en) * 1981-02-27 1982-09-03 Otsuka Pharmaceut Co Ltd Tetrazole derivative
JPS6233152A (ja) * 1985-08-02 1987-02-13 カセラ・アクチエンゲゼルシヤフト ２，５ジメチルピロ−ル誘導体、その製造法及びその使用法
JPH04182467A (ja) * 1990-11-15 1992-06-30 Ube Ind Ltd ジアリールメトキシピペリジン誘導体
JPH06172287A (ja) * 1992-07-09 1994-06-21 Nippon Zoki Pharmaceut Co Ltd アミノカルボン酸誘導体及び該化合物を含有する医薬組成物
JPH11147872A (ja) * 1997-08-18 1999-06-02 F Hoffmann La Roche Ag Ｃｃｒ−３受容体アンタゴニスト
WO2007055388A2 (en) * 2005-11-09 2007-05-18 Ajinomoto Co., Inc. Calcium receptor activator
WO2009097113A2 (en) * 2008-01-28 2009-08-06 New York University Oxazole and thiazole compounds as b-catenin modulators and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2114158A1 (de) 1971-03-24 1972-09-28 Bayer Ag Reaktivfarbstoffe
JPS5637224B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-08-04 1981-08-29
AT331994B (de) 1972-12-05 1976-09-10 Boehringer Mannheim Gmbh Verfahren zur bestimmung von delta-glutamyltranspeptidase
JPS5434007A (en) 1977-08-23 1979-03-13 Olympus Optical Co Ltd Revolving electric machine
US4147802A (en) * 1978-03-17 1979-04-03 Stanley Drug Products, Inc. Method of treating bacterial infections
IT1261255B (it) 1993-09-09 1996-05-09 Rotta Research Lab Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
DE4413265A1 (de) * 1994-04-16 1995-10-19 Basf Ag Hydroxyphenylharnstoffe
US5628195A (en) 1995-03-01 1997-05-13 Apd Cryogenics, Inc. Vibrationally isolated thermal system for a cryogenically cooled device
JP2001505585A (ja) * 1996-12-16 2001-04-24 藤沢薬品工業株式会社 新規アミド化合物およびそれらの一酸化窒素シンターゼ阻害剤としての用途
FR2800735B1 (fr) * 1999-11-09 2002-02-01 Centre Nat Rech Scient Nouvelles aralkyle-1,2-diamines possedant une activite calcimimetique et leur mode de preparation
PT1757582E (pt) * 2004-05-28 2016-03-04 Mitsubishi Tanabe Pharma Corp Arilalquilaminas e processo para a sua produção
PT1882684E (pt) 2005-05-19 2015-02-10 Astellas Pharma Inc Derivado de pirrolidina ou um seu sal
ES2351094T3 (es) * 2005-11-09 2011-01-31 Ajinomoto Co., Inc. Procedimiento de cribado para los agentes que confieren el kokumi.
JP4553052B2 (ja) * 2005-11-09 2010-09-29 味の素株式会社 コク味付与剤
US8153658B2 (en) * 2006-11-16 2012-04-10 Astellas Pharma, Inc. Piperidine derivative or salt thereof
EP2156846B1 (en) 2007-05-08 2014-08-13 Ajinomoto Co., Inc. Prophylactic or therapeutic agent for diarrhea
EP2269646A4 (en) 2008-02-25 2011-06-29 Ajinomoto Kk PROPHYLACTIC OR THERAPEUTIC ACTIVE AGAINST DIABETES OR ADIPOSITAS
WO2009119554A1 (ja) 2008-03-24 2009-10-01 味の素株式会社 消化管の重炭酸分泌促進剤
EP2286836A4 (en) 2008-04-17 2011-10-12 Ajinomoto Kk IMMUNOSTIMULATING AGENT
CA2726610C (en) * 2008-06-05 2015-05-05 Asahi Kasei Pharma Corporation Sulfonamide compounds and use thereof
KR101700152B1 (ko) 2008-10-03 2017-01-26 이에이 파마 가부시키가이샤 ＣａＳＲ 효능제
EP2435404A1 (en) 2009-05-27 2012-04-04 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
JP2012528084A (ja) 2009-05-27 2012-11-12 レオ ファーマ アクティーゼルスカブ 新規のカルシウム感知受容体調節化合物およびその医薬用途
WO2010136036A2 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Calcium-sensing receptor-active compounds
DK3192520T3 (da) 2009-07-29 2019-05-27 Kai Pharmaceuticals Inc Terapeutiske midler til reducering af niveauerne af parathyreoideahormon
AU2010339303B2 (en) * 2009-12-28 2013-06-20 Ajinomoto Co., Inc. Lanthionine derivative
WO2011108724A1 (ja) 2010-03-04 2011-09-09 味の素株式会社 糖尿病又は肥満症の予防又は治療剤
CA2791174C (en) * 2010-03-04 2015-11-17 Ajinomoto Co., Inc. Alkylamine derivative
EP2551262A4 (en) 2010-03-24 2014-01-15 Ajinomoto Kk GLUTAMATE DERIVATIVES OR SALTS THEREOF
JPWO2011126099A1 (ja) * 2010-04-02 2013-07-11 味の素株式会社 糖尿病又は肥満症の予防又は治療剤

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53111793A (en) * 1977-01-12 1978-09-29 Coulter Electronics Colorimetric method for measuring activity of gammaaglutamyltranspeptidase enzyme in receiving medium solution and btologtcal fluids
JPS54125668A (en) * 1978-03-08 1979-09-29 Ciba Geigy Ag Novel ureaa and amideecompound and manufacture
JPS57142977A (en) * 1981-02-27 1982-09-03 Otsuka Pharmaceut Co Ltd Tetrazole derivative
JPS6233152A (ja) * 1985-08-02 1987-02-13 カセラ・アクチエンゲゼルシヤフト ２，５ジメチルピロ−ル誘導体、その製造法及びその使用法
JPH04182467A (ja) * 1990-11-15 1992-06-30 Ube Ind Ltd ジアリールメトキシピペリジン誘導体
JPH06172287A (ja) * 1992-07-09 1994-06-21 Nippon Zoki Pharmaceut Co Ltd アミノカルボン酸誘導体及び該化合物を含有する医薬組成物
JPH11147872A (ja) * 1997-08-18 1999-06-02 F Hoffmann La Roche Ag Ｃｃｒ−３受容体アンタゴニスト
WO2007055388A2 (en) * 2005-11-09 2007-05-18 Ajinomoto Co., Inc. Calcium receptor activator
WO2009097113A2 (en) * 2008-01-28 2009-08-06 New York University Oxazole and thiazole compounds as b-catenin modulators and uses thereof

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EP2546231A4 (en) 2014-04-30
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US20130237702A1 (en) 2013-09-12
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CA2791174C (en) 2015-11-17
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US9561216B2 (en) 2017-02-07
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BR112012021657A2 (pt) 2016-09-27
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ES2712048T3 (es) 2019-05-09
CA2791174A1 (en) 2011-09-09
EP2546231A1 (en) 2013-01-16
KR101493717B1 (ko) 2015-02-16
CN102781910A (zh) 2012-11-14
WO2011108690A1 (ja) 2011-09-09
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US9253997B2 (en) 2016-02-09
PL2546231T3 (pl) 2019-05-31
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CN103951615A (zh) 2014-07-30
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