JP5230407B2 - キノリン−カルボキサミド化合物の結晶形態物 - Google Patents

キノリン−カルボキサミド化合物の結晶形態物 Download PDF

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JP5230407B2
JP5230407B2 JP2008505559A JP2008505559A JP5230407B2 JP 5230407 B2 JP5230407 B2 JP 5230407B2 JP 2008505559 A JP2008505559 A JP 2008505559A JP 2008505559 A JP2008505559 A JP 2008505559A JP 5230407 B2 JP5230407 B2 JP 5230407B2
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salt form
crystalline salt
crystalline
oxo
isopropyl
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JP2008535848A5 (OSRAM
JP2008535848A (ja
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ポール アール． ファザリー，
エス． ディレック ターナー，
アダム ゴールドブルーム，
ロバート チャオ，
ダニエル ジェノブ，
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セラヴァンス， インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008505559A 2005-04-06 2006-04-05 キノリン−カルボキサミド化合物の結晶形態物 Active JP5230407B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66878005P 2005-04-06 2005-04-06
US60/668,780 2005-04-06
PCT/US2006/012978 WO2006108127A2 (en) 2005-04-06 2006-04-05 Crystalline form of a quinolinone-carboxamide compound

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012113464A Division JP2012153725A (ja) 2005-04-06 2012-05-17 キノリン−カルボキサミド化合物の結晶形態物

Publications (3)

Publication Number Publication Date
JP2008535848A JP2008535848A (ja) 2008-09-04
JP2008535848A5 JP2008535848A5 (OSRAM) 2009-05-07
JP5230407B2 true JP5230407B2 (ja) 2013-07-10

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ID=37074104

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JP2008505559A Active JP5230407B2 (ja) 2005-04-06 2006-04-05 キノリン−カルボキサミド化合物の結晶形態物
JP2012113464A Withdrawn JP2012153725A (ja) 2005-04-06 2012-05-17 キノリン−カルボキサミド化合物の結晶形態物

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JP2012113464A Withdrawn JP2012153725A (ja) 2005-04-06 2012-05-17 キノリン−カルボキサミド化合物の結晶形態物

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Country Link
US (4) US7728004B2 (OSRAM)
EP (1) EP1874766B1 (OSRAM)
JP (2) JP5230407B2 (OSRAM)
KR (1) KR101322873B1 (OSRAM)
CN (1) CN101151264B (OSRAM)
AR (2) AR053208A1 (OSRAM)
AT (1) ATE479682T1 (OSRAM)
AU (1) AU2006232129B2 (OSRAM)
BR (1) BRPI0610657A2 (OSRAM)
CA (1) CA2603654C (OSRAM)
CY (1) CY1111275T1 (OSRAM)
DE (1) DE602006016586D1 (OSRAM)
DK (1) DK1874766T3 (OSRAM)
EA (1) EA012115B1 (OSRAM)
ES (1) ES2350495T3 (OSRAM)
HR (1) HRP20100629T1 (OSRAM)
IL (1) IL186023A (OSRAM)
MA (1) MA29403B1 (OSRAM)
MX (1) MX2007012438A (OSRAM)
MY (1) MY151075A (OSRAM)
NO (1) NO339699B1 (OSRAM)
NZ (1) NZ561900A (OSRAM)
PE (1) PE20061310A1 (OSRAM)
PL (1) PL1874766T3 (OSRAM)
PT (1) PT1874766E (OSRAM)
SI (1) SI1874766T1 (OSRAM)
TW (1) TWI377206B (OSRAM)
WO (1) WO2006108127A2 (OSRAM)
ZA (1) ZA200708071B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7063671B2 (en) * 2002-06-21 2006-06-20 Boston Scientific Scimed, Inc. Electronically activated capture device
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
ATE441646T1 (de) * 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
ATE431824T1 (de) 2004-11-05 2009-06-15 Theravance Inc Chinolinon-carboxamid-verbindungen
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
CN102775396B (zh) 2005-11-08 2014-10-08 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的杂环调控剂
US20080287486A1 (en) * 2007-05-17 2008-11-20 Theravance, Inc. Prokinetic agent for bowel preparation
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
NZ614151A (en) * 2007-12-07 2015-04-24 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
HUE038141T2 (hu) * 2009-04-13 2018-10-29 Theravance Biopharma R&D Ip Llc 5-HT4 receptor agonisták és acetilkolinészteráz inhibitorok kombinációi kognitív rendellenességek kezelésére
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
ES2527849T3 (es) 2010-02-02 2015-01-30 Novartis Ag Derivados de ciclohexilamida como antagonistas del receptor de CRF
ES3017582T3 (en) 2010-04-07 2025-05-13 Vertex Pharma Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
CN105848657B (zh) 2013-11-12 2020-05-22 沃泰克斯药物股份有限公司 制备用于治疗cftr介导的疾病的药物组合物的方法
SI3661518T1 (sl) * 2017-07-31 2025-01-31 Alfasigma S.P.A. Načini zdravljenja simptomov gastropareze z zdravilom velusetrag
US10570127B1 (en) 2018-11-05 2020-02-25 Renexxion, Llc Material and methods for the treatment of gastro-intestinal disorders
JP2025533507A (ja) 2022-09-20 2025-10-07 アルファシグマ ソシエタ ペル アチオニ 慢性偽性腸閉塞症（ｃｉｐｏ）の治療に使用するためのベルセトラグ

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3122671B2 (ja) 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
CA2097815C (en) 1990-12-28 2001-04-17 Fumio Suzuki Quinoline derivative
EP0670319A4 (en) 1992-11-20 1996-01-17 Thaisho Pharmaceutical Co Ltd HETEROCYCLIC COMPOUNDS.
JP3829879B2 (ja) 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
US7105195B2 (en) * 2003-07-25 2006-09-12 General Mills, Inc. Reduced trans fat product
WO2005049608A1 (en) 2003-11-24 2005-06-02 Pfizer Japan, Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
US7728006B2 (en) 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ATE441646T1 (de) 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
ATE431824T1 (de) 2004-11-05 2009-06-15 Theravance Inc Chinolinon-carboxamid-verbindungen
JP2008530225A (ja) 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
WO2006094063A1 (en) 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound

Also Published As

Publication number Publication date
NO20075574L (no) 2007-11-02
KR101322873B1 (ko) 2013-10-30
HRP20100629T1 (hr) 2010-12-31
PT1874766E (pt) 2010-11-30
BRPI0610657A2 (pt) 2010-07-13
CN101151264A (zh) 2008-03-26
EA200702161A1 (ru) 2008-04-28
EP1874766A2 (en) 2008-01-09
IL186023A (en) 2011-09-27
PL1874766T3 (pl) 2011-02-28
EA012115B1 (ru) 2009-08-28
MA29403B1 (fr) 2008-04-01
EP1874766B1 (en) 2010-09-01
AR110019A2 (es) 2019-02-13
JP2012153725A (ja) 2012-08-16
IL186023A0 (en) 2008-01-20
TW200643020A (en) 2006-12-16
CA2603654A1 (en) 2006-10-12
ATE479682T1 (de) 2010-09-15
AU2006232129A1 (en) 2006-10-12
WO2006108127A3 (en) 2007-01-04
DE602006016586D1 (de) 2010-10-14
PE20061310A1 (es) 2007-01-23
US7728004B2 (en) 2010-06-01
US20160095849A1 (en) 2016-04-07
HK1110866A1 (en) 2008-07-25
US20100197728A1 (en) 2010-08-05
CA2603654C (en) 2014-05-27
US20140256769A1 (en) 2014-09-11
US9126994B2 (en) 2015-09-08
NZ561900A (en) 2010-12-24
NO339699B1 (no) 2017-01-23
US8658671B2 (en) 2014-02-25
US9402840B2 (en) 2016-08-02
AR053208A1 (es) 2007-04-25
WO2006108127A2 (en) 2006-10-12
TWI377206B (en) 2012-11-21
CN101151264B (zh) 2011-07-06
ZA200708071B (en) 2008-10-29
AU2006232129B2 (en) 2012-07-12
US20060229332A1 (en) 2006-10-12
CY1111275T1 (el) 2015-08-05
KR20070116988A (ko) 2007-12-11
DK1874766T3 (da) 2010-12-06
JP2008535848A (ja) 2008-09-04
SI1874766T1 (sl) 2010-12-31
ES2350495T3 (es) 2011-01-24
MY151075A (en) 2014-03-31
MX2007012438A (es) 2007-12-05

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