JP5225084B2 - ７−［（ｅ）−ｔ−ブチルオキシミノメチル］カンプトテシンの改良された経口吸収のための即効型治療システム - Google Patents
７−［（ｅ）−ｔ−ブチルオキシミノメチル］カンプトテシンの改良された経口吸収のための即効型治療システム Download PDFInfo
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- JP5225084B2 JP5225084B2 JP2008524462A JP2008524462A JP5225084B2 JP 5225084 B2 JP5225084 B2 JP 5225084B2 JP 2008524462 A JP2008524462 A JP 2008524462A JP 2008524462 A JP2008524462 A JP 2008524462A JP 5225084 B2 JP5225084 B2 JP 5225084B2
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- 231100000086 high toxicity Toxicity 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 125000000879 imine group Chemical group 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
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- 230000036470 plasma concentration Effects 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
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- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| ITRM2005A000418 | 2005-08-04 | ||
| IT000418A ITRM20050418A1 (it) | 2005-08-04 | 2005-08-04 | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
| PCT/EP2006/064111 WO2007017331A2 (en) | 2005-08-04 | 2006-07-11 | Immediate release therapeutic systems for improved oral absorption of 7- [ (e) -tert-butyloxyiminomethyl] camptothecin |
Publications (3)
| Publication Number | Publication Date |
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| JP2009503013A JP2009503013A (ja) | 2009-01-29 |
| JP2009503013A5 JP2009503013A5 (enExample) | 2010-09-09 |
| JP5225084B2 true JP5225084B2 (ja) | 2013-07-03 |
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| EP (1) | EP1915153B1 (enExample) |
| JP (1) | JP5225084B2 (enExample) |
| KR (1) | KR101301548B1 (enExample) |
| CN (1) | CN101287466B (enExample) |
| AU (1) | AU2006278114B2 (enExample) |
| BR (1) | BRPI0614471A2 (enExample) |
| CA (1) | CA2612080C (enExample) |
| CY (1) | CY1114311T1 (enExample) |
| DK (1) | DK1915153T3 (enExample) |
| ES (1) | ES2407408T3 (enExample) |
| HR (1) | HRP20130364T1 (enExample) |
| IT (1) | ITRM20050418A1 (enExample) |
| MX (1) | MX2008001029A (enExample) |
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| PT (1) | PT1915153E (enExample) |
| RS (1) | RS52777B (enExample) |
| SI (1) | SI1915153T1 (enExample) |
| WO (1) | WO2007017331A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2519193C2 (ru) | 2008-09-12 | 2014-06-10 | Критикал Фармасьютикалс Лимитед | Усовершенствование всасывания терапевтических средств через слизистые оболочки или кожу |
| USD618617S1 (en) | 2008-12-30 | 2010-06-29 | Multiway Industries (Hk) Ltd. | Three way electrical plug |
| US7892036B2 (en) * | 2008-12-30 | 2011-02-22 | Multiway Industries (Hk) Ltd. | Electrical wall tap assembly |
| USD618175S1 (en) | 2009-10-15 | 2010-06-22 | Multiway Industries (Hk) Ltd. | Three-outlet surge-protected adaptor |
| USD616823S1 (en) | 2009-10-15 | 2010-06-01 | Multiway Industries (Hk) Ltd. | Single-outlet surge-protected adaptor |
| EP2510924B1 (en) * | 2009-12-08 | 2014-10-08 | IL Hwa Co., Ltd | SOLID DISPERSIONS CONTAINING 20-O-ß-D-GLUCOPYRANOSYL-20(S)-PROTOPANAXADIOL |
| USD651977S1 (en) | 2011-01-10 | 2012-01-10 | Multiway Industries (Hk) Ltd. | Multiple outlet electrical connector |
| CN108066311B (zh) * | 2017-12-26 | 2020-09-08 | 兆科（广州）肿瘤药物有限公司 | 一种吉马替康胶囊及其制备方法 |
| USD958079S1 (en) | 2019-08-30 | 2022-07-19 | Multiway Industries (Hk) Ltd. | 3-way electrical tap |
| USD955993S1 (en) | 2019-08-30 | 2022-06-28 | Multiway Industries (Hk) Ltd. | 3-way electrical tap |
| CN111529497A (zh) * | 2020-02-11 | 2020-08-14 | 兆科（广州）肿瘤药物有限公司 | 一种吉马替康药物固体分散组合物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| NZ502569A (en) * | 1997-07-29 | 2002-05-31 | Upjohn Co | Self-emulsifying formulation for lipophilic compounds comprising a mixture of diglyceride and monoglyceride in a ratio of 9:1 to 6:4 |
| AR013261A1 (es) * | 1997-08-01 | 2000-12-13 | Smithkline Beecham Corp | Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina |
| US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| PT1044977E (pt) * | 1999-03-09 | 2002-09-30 | Sigma Tau Ind Farmaceuti | Derivados de camptotecina com actividade antitumoral |
| AU5273200A (en) * | 1999-05-24 | 2000-12-12 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| CN101480395A (zh) * | 2004-03-26 | 2009-07-15 | 诺瓦提斯公司 | 喜树碱衍生物以固定给药方案治疗增生性疾病的用途 |
| GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| PL1828196T3 (pl) * | 2004-12-21 | 2013-02-28 | Sigma Tau Ind Farmaceuti | Stereoselektywny sposób wytwarzania i krystaliczne formy kamptotecyny |
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- 2006-07-11 SI SI200631573T patent/SI1915153T1/sl unknown
- 2006-07-11 RS RS20130196A patent/RS52777B/sr unknown
- 2006-07-11 PT PT67777102T patent/PT1915153E/pt unknown
- 2006-07-11 BR BRPI0614471-3A patent/BRPI0614471A2/pt not_active Application Discontinuation
- 2006-07-11 CN CN200680027844.9A patent/CN101287466B/zh active Active
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- 2006-07-11 CA CA2612080A patent/CA2612080C/en not_active Expired - Fee Related
- 2006-07-11 US US11/993,328 patent/US20090053307A1/en not_active Abandoned
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- 2006-07-11 HR HRP20130364TT patent/HRP20130364T1/hr unknown
- 2006-07-11 PL PL06777710T patent/PL1915153T3/pl unknown
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2013
- 2013-04-25 CY CY20131100341T patent/CY1114311T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007017331A3 (en) | 2007-09-27 |
| BRPI0614471A2 (pt) | 2011-03-29 |
| MX2008001029A (es) | 2008-03-14 |
| ES2407408T3 (es) | 2013-06-12 |
| HRP20130364T1 (hr) | 2013-05-31 |
| CA2612080A1 (en) | 2007-02-15 |
| AU2006278114B2 (en) | 2011-06-23 |
| US20090053307A1 (en) | 2009-02-26 |
| PL1915153T3 (pl) | 2013-09-30 |
| CN101287466A (zh) | 2008-10-15 |
| EP1915153A2 (en) | 2008-04-30 |
| KR20080031945A (ko) | 2008-04-11 |
| PT1915153E (pt) | 2013-06-05 |
| ITRM20050418A1 (it) | 2007-02-05 |
| WO2007017331A2 (en) | 2007-02-15 |
| KR101301548B1 (ko) | 2013-09-06 |
| CA2612080C (en) | 2013-09-03 |
| HK1125293A1 (en) | 2009-08-07 |
| CN101287466B (zh) | 2014-11-05 |
| DK1915153T3 (da) | 2013-06-24 |
| JP2009503013A (ja) | 2009-01-29 |
| AU2006278114A1 (en) | 2007-02-15 |
| CY1114311T1 (el) | 2016-08-31 |
| EP1915153B1 (en) | 2013-04-10 |
| SI1915153T1 (sl) | 2013-06-28 |
| RS52777B (sr) | 2013-10-31 |
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