CY1114311T1 - Θεραπευτικα συστηματα αμεσης απελευθερωσης για βελτιωμενη απο του στοματος απορροφηση 7-[(ε)-τριτ-βουτυλοξυιμινομεθυλο]καμπτοθεκινης - Google Patents

Θεραπευτικα συστηματα αμεσης απελευθερωσης για βελτιωμενη απο του στοματος απορροφηση 7-[(ε)-τριτ-βουτυλοξυιμινομεθυλο]καμπτοθεκινης

Info

Publication number
CY1114311T1
CY1114311T1 CY20131100341T CY131100341T CY1114311T1 CY 1114311 T1 CY1114311 T1 CY 1114311T1 CY 20131100341 T CY20131100341 T CY 20131100341T CY 131100341 T CY131100341 T CY 131100341T CY 1114311 T1 CY1114311 T1 CY 1114311T1
Authority
CY
Cyprus
Prior art keywords
immediate release
oral absorption
butyloxyminomethyl
trit
therapeutic systems
Prior art date
Application number
CY20131100341T
Other languages
English (en)
Inventor
Antonio Longo
Silvia Pace
Massimo Pedrani
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of CY1114311T1 publication Critical patent/CY1114311T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Abstract

Περιγράφεται εδώ μία φαρμακευτική σύνθεση, η οποία περιλαμβάνει καμπτοθεκίνη ως δραστικό συστατικό. Περιγράφονται ιδιαίτερα θεραπευτικά συστήματα άμεσης απελευθέρωσης για τη βελτιωμένη από του στόματος απορρόφηση 7-[(Ε)-τριτ-βουτυλοξυιμινομεθυλο] καμπτοθεκίνης, τα οποία περιλαμβάνουν μία μήτρα, η οποία αποτελείται από υγρές αμφίφιλες ουσίες ή διαθέτουν ένα σημείο τήξης χαμηλότερο από 60°C, εις τα οποία το δραστικό συστατικό είναι τουλάχιστον εν μέρει διαλυμένο και/ή διασπαρμένο και/ή ενσωματωμένο.
CY20131100341T 2005-08-04 2013-04-25 Θεραπευτικα συστηματα αμεσης απελευθερωσης για βελτιωμενη απο του στοματος απορροφηση 7-[(ε)-τριτ-βουτυλοξυιμινομεθυλο]καμπτοθεκινης CY1114311T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000418A ITRM20050418A1 (it) 2005-08-04 2005-08-04 Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
EP06777710.2A EP1915153B1 (en) 2005-08-04 2006-07-11 Immediate release therapeutic systems for improved oral absorption of 7-[(e)-tert-butyloxyiminomethyl]camtothecin

Publications (1)

Publication Number Publication Date
CY1114311T1 true CY1114311T1 (el) 2016-08-31

Family

ID=37727667

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100341T CY1114311T1 (el) 2005-08-04 2013-04-25 Θεραπευτικα συστηματα αμεσης απελευθερωσης για βελτιωμενη απο του στοματος απορροφηση 7-[(ε)-τριτ-βουτυλοξυιμινομεθυλο]καμπτοθεκινης

Country Status (20)

Country Link
US (1) US20090053307A1 (el)
EP (1) EP1915153B1 (el)
JP (1) JP5225084B2 (el)
KR (1) KR101301548B1 (el)
CN (1) CN101287466B (el)
AU (1) AU2006278114B2 (el)
BR (1) BRPI0614471A2 (el)
CA (1) CA2612080C (el)
CY (1) CY1114311T1 (el)
DK (1) DK1915153T3 (el)
ES (1) ES2407408T3 (el)
HK (1) HK1125293A1 (el)
HR (1) HRP20130364T1 (el)
IT (1) ITRM20050418A1 (el)
MX (1) MX2008001029A (el)
PL (1) PL1915153T3 (el)
PT (1) PT1915153E (el)
RS (1) RS52777B (el)
SI (1) SI1915153T1 (el)
WO (1) WO2007017331A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ591261A (en) 2008-09-12 2012-12-21 Critical Pharmaceuticals Ltd Improvements in the absorption of therapeutic agents across mucosal membranes or the skin
US7892036B2 (en) * 2008-12-30 2011-02-22 Multiway Industries (Hk) Ltd. Electrical wall tap assembly
USD618617S1 (en) 2008-12-30 2010-06-29 Multiway Industries (Hk) Ltd. Three way electrical plug
USD618175S1 (en) 2009-10-15 2010-06-22 Multiway Industries (Hk) Ltd. Three-outlet surge-protected adaptor
USD616823S1 (en) 2009-10-15 2010-06-01 Multiway Industries (Hk) Ltd. Single-outlet surge-protected adaptor
CN102740841A (zh) * 2009-12-08 2012-10-17 株式会社一和 含有20-O-β-D-吡喃葡糖基-20(S)-原人参二醇的固体分散体
USD651977S1 (en) 2011-01-10 2012-01-10 Multiway Industries (Hk) Ltd. Multiple outlet electrical connector
CN108066311B (zh) * 2017-12-26 2020-09-08 兆科（广州）肿瘤药物有限公司 一种吉马替康胶囊及其制备方法
USD955993S1 (en) 2019-08-30 2022-06-28 Multiway Industries (Hk) Ltd. 3-way electrical tap
USD958079S1 (en) 2019-08-30 2022-07-19 Multiway Industries (Hk) Ltd. 3-way electrical tap
CN111529497A (zh) * 2020-02-11 2020-08-14 兆科（广州）肿瘤药物有限公司 一种吉马替康药物固体分散组合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
WO1999006024A1 (en) * 1997-07-29 1999-02-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
AR013261A1 (es) * 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
DK1044977T3 (da) * 1999-03-09 2002-07-08 Sigma Tau Ind Farmaceuti Camptothecinderivater med antitumoraktivitet
AU5273200A (en) * 1999-05-24 2000-12-12 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
KR20070010133A (ko) * 2004-03-26 2007-01-22 노파르티스 아게 고정 투여 요법으로 증식성 질병의 치료를 위한 캄프토테신유도체의 용도
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
BRPI0515832A (pt) * 2004-12-21 2008-08-05 Sigma Tau Ind Farmaceuti processo estereosseletivo e formas cristalinas de uma camptotecina

Also Published As

Publication number Publication date
US20090053307A1 (en) 2009-02-26
ITRM20050418A1 (it) 2007-02-05
DK1915153T3 (da) 2013-06-24
CN101287466A (zh) 2008-10-15
MX2008001029A (es) 2008-03-14
AU2006278114B2 (en) 2011-06-23
AU2006278114A1 (en) 2007-02-15
KR101301548B1 (ko) 2013-09-06
BRPI0614471A2 (pt) 2011-03-29
SI1915153T1 (sl) 2013-06-28
PT1915153E (pt) 2013-06-05
EP1915153B1 (en) 2013-04-10
HK1125293A1 (en) 2009-08-07
CA2612080A1 (en) 2007-02-15
KR20080031945A (ko) 2008-04-11
JP5225084B2 (ja) 2013-07-03
EP1915153A2 (en) 2008-04-30
HRP20130364T1 (hr) 2013-05-31
CA2612080C (en) 2013-09-03
PL1915153T3 (pl) 2013-09-30
ES2407408T3 (es) 2013-06-12
RS52777B (en) 2013-10-31
JP2009503013A (ja) 2009-01-29
CN101287466B (zh) 2014-11-05
WO2007017331A2 (en) 2007-02-15
WO2007017331A3 (en) 2007-09-27

Similar Documents

Publication Publication Date Title
CY1114311T1 (el) Θεραπευτικα συστηματα αμεσης απελευθερωσης για βελτιωμενη απο του στοματος απορροφηση 7-[(ε)-τριτ-βουτυλοξυιμινομεθυλο]καμπτοθεκινης
CL2007001918A1 (es) Compuestos derivados heteroarilos sustituidos; metodo para la preparacion de los compuestos; composicion farmaceutica; y uso para el tratamiento del dolor, depresion, enfermedad de alzheimer e hipertension entre otras.
CY1115891T1 (el) Φαρμακευτικες συνθεσεις για την αντιμετωπιση των διαταραχων του εσω ωτος
ECSP067062A (es) Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
BRPI0516830A (pt) composições de droga de liberação sustentada convenientemente implantáveis
CY1111977T1 (el) Παραγωγα πιπεριδιν-4-υλ-πυριδαζιν-3-υλαμινης ως ταχεως διασπομενοι ανταγωνιστες υποδοχεα ντοπαμινης 2
ATE413162T1 (de) Pharmazeutische zusammensetzungen zur sicheren verabreichung von bei der behandlung von drogenabhängigkeit verwendeten arzneimitteln
CY1115289T1 (el) Μεθοδοι αγωγης εναντι ασθενειας που σχετιζεται με φλεγμονη
DK1748756T3 (da) Præparater som omfatter drospirenon der er molekylært dispergeret
PA8592301A1 (es) Nuevos derivados de fluoroglicosidos heterociclicos, medicamentos que contienen estos compuestos, y el uso de los mismos
CR8831A (es) Compuestos y metodos para el tratamiento de dislipidemia
CY1105362T1 (el) Παραγωγα σουλφοναμιδιου, η παρασκευη τους και η εφαρμογη αυτων ως φαρμακα
CL2007002733A1 (es) Compuestos derivados de 2-aril-6-fenil-imidazo[1,2-a]piridinas; procedimiento de obtencion de los compuestos; composicion farmaceutica; y uso para el tratamiento y prevencion de enfermedades neurodegenerativas, osteoporosis y cancer.
AR023423A1 (es) Derivados de adamantano, procedimientos para su preparacion, composicion farmaceutica, procedimiento para la preparacion de la composicion farmaceutica, yuso de dichos derivados para la manufactura de medicamentos
CL2007001917A1 (es) Compuestos derivados de azaindol espirociclicos; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento del dolor, condiciones de panico, depresion, mal de alzheimer, migrana, entre otras.
PA8720801A1 (es) Nuevas combinaciones terapeuticas para el tratamiento de la depresion
CY1112376T1 (el) Παραγωγα 2,3,4,9-τετραϋδρο-1η-καρβαζολης ως ανταγωνιστες του υποδοχεα crth2
DOP2006000231A (es) Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
CY1111389T1 (el) Φαρμακευτικες ενωσεις που περιεχουν ιματινιμπη και ενα επιβραδυντικο εκλυσης
ATE478840T1 (de) 3-aminoazetidinderivate enthaltende pharmazeutische zusammensetzungen, diese derivate und deren herstellung
DE602005027707D1 (de) Isoindolin-verbindungen und deren verwendungen
CY1110332T1 (el) Παραγωγα βενζιμιδαζολης, συνθεσεις που τα περιεχουν, παρασκευη αυτων και χρηση τους
BRPI0508540B8 (pt) composto, composição farmacêutica, e, uso de um composto
CL2007002578A1 (es) Compuestos derivados de n-(1-ftalazin-1-il-piperidin-4-il)-amidas; composicion farmaceutica; y uso para el tratamiento y prevencion de trastornos de la fertilidad, osteoporosis y cancer.
DE60313359D1 (de) Fenofibratsäure enthaltende pharmazeutische zusammensetzung und deren physiologisch verträgliche salze und derivate