CA2612080C - Immediate-release therapeutic systems for improved oral absorption of 7-[(e)-t-butyloxyiminomethyl] camptothecin - Google Patents
Immediate-release therapeutic systems for improved oral absorption of 7-[(e)-t-butyloxyiminomethyl] camptothecin Download PDFInfo
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- CA2612080C CA2612080C CA2612080A CA2612080A CA2612080C CA 2612080 C CA2612080 C CA 2612080C CA 2612080 A CA2612080 A CA 2612080A CA 2612080 A CA2612080 A CA 2612080A CA 2612080 C CA2612080 C CA 2612080C
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
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- 230000036470 plasma concentration Effects 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229950009213 rubitecan Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- SLBXZQMMERXQAL-UHFFFAOYSA-M sodium;1-dodecoxy-4-hydroxy-1,4-dioxobutane-2-sulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O SLBXZQMMERXQAL-UHFFFAOYSA-M 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM2005A000418 | 2005-08-04 | ||
| IT000418A ITRM20050418A1 (it) | 2005-08-04 | 2005-08-04 | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
| PCT/EP2006/064111 WO2007017331A2 (en) | 2005-08-04 | 2006-07-11 | Immediate release therapeutic systems for improved oral absorption of 7- [ (e) -tert-butyloxyiminomethyl] camptothecin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2612080A1 CA2612080A1 (en) | 2007-02-15 |
| CA2612080C true CA2612080C (en) | 2013-09-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2612080A Expired - Fee Related CA2612080C (en) | 2005-08-04 | 2006-07-11 | Immediate-release therapeutic systems for improved oral absorption of 7-[(e)-t-butyloxyiminomethyl] camptothecin |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20090053307A1 (enExample) |
| EP (1) | EP1915153B1 (enExample) |
| JP (1) | JP5225084B2 (enExample) |
| KR (1) | KR101301548B1 (enExample) |
| CN (1) | CN101287466B (enExample) |
| AU (1) | AU2006278114B2 (enExample) |
| BR (1) | BRPI0614471A2 (enExample) |
| CA (1) | CA2612080C (enExample) |
| CY (1) | CY1114311T1 (enExample) |
| DK (1) | DK1915153T3 (enExample) |
| ES (1) | ES2407408T3 (enExample) |
| HR (1) | HRP20130364T1 (enExample) |
| IT (1) | ITRM20050418A1 (enExample) |
| MX (1) | MX2008001029A (enExample) |
| PL (1) | PL1915153T3 (enExample) |
| PT (1) | PT1915153E (enExample) |
| RS (1) | RS52777B (enExample) |
| SI (1) | SI1915153T1 (enExample) |
| WO (1) | WO2007017331A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2519193C2 (ru) | 2008-09-12 | 2014-06-10 | Критикал Фармасьютикалс Лимитед | Усовершенствование всасывания терапевтических средств через слизистые оболочки или кожу |
| USD618617S1 (en) | 2008-12-30 | 2010-06-29 | Multiway Industries (Hk) Ltd. | Three way electrical plug |
| US7892036B2 (en) * | 2008-12-30 | 2011-02-22 | Multiway Industries (Hk) Ltd. | Electrical wall tap assembly |
| USD618175S1 (en) | 2009-10-15 | 2010-06-22 | Multiway Industries (Hk) Ltd. | Three-outlet surge-protected adaptor |
| USD616823S1 (en) | 2009-10-15 | 2010-06-01 | Multiway Industries (Hk) Ltd. | Single-outlet surge-protected adaptor |
| EP2510924B1 (en) * | 2009-12-08 | 2014-10-08 | IL Hwa Co., Ltd | SOLID DISPERSIONS CONTAINING 20-O-ß-D-GLUCOPYRANOSYL-20(S)-PROTOPANAXADIOL |
| USD651977S1 (en) | 2011-01-10 | 2012-01-10 | Multiway Industries (Hk) Ltd. | Multiple outlet electrical connector |
| CN108066311B (zh) * | 2017-12-26 | 2020-09-08 | 兆科（广州）肿瘤药物有限公司 | 一种吉马替康胶囊及其制备方法 |
| USD958079S1 (en) | 2019-08-30 | 2022-07-19 | Multiway Industries (Hk) Ltd. | 3-way electrical tap |
| USD955993S1 (en) | 2019-08-30 | 2022-06-28 | Multiway Industries (Hk) Ltd. | 3-way electrical tap |
| CN111529497A (zh) * | 2020-02-11 | 2020-08-14 | 兆科（广州）肿瘤药物有限公司 | 一种吉马替康药物固体分散组合物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| NZ502569A (en) * | 1997-07-29 | 2002-05-31 | Upjohn Co | Self-emulsifying formulation for lipophilic compounds comprising a mixture of diglyceride and monoglyceride in a ratio of 9:1 to 6:4 |
| AR013261A1 (es) * | 1997-08-01 | 2000-12-13 | Smithkline Beecham Corp | Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina |
| US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| PT1044977E (pt) * | 1999-03-09 | 2002-09-30 | Sigma Tau Ind Farmaceuti | Derivados de camptotecina com actividade antitumoral |
| AU5273200A (en) * | 1999-05-24 | 2000-12-12 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| CN101480395A (zh) * | 2004-03-26 | 2009-07-15 | 诺瓦提斯公司 | 喜树碱衍生物以固定给药方案治疗增生性疾病的用途 |
| GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| PL1828196T3 (pl) * | 2004-12-21 | 2013-02-28 | Sigma Tau Ind Farmaceuti | Stereoselektywny sposób wytwarzania i krystaliczne formy kamptotecyny |
-
2005
- 2005-08-04 IT IT000418A patent/ITRM20050418A1/it unknown
-
2006
- 2006-07-11 JP JP2008524462A patent/JP5225084B2/ja not_active Expired - Fee Related
- 2006-07-11 SI SI200631573T patent/SI1915153T1/sl unknown
- 2006-07-11 RS RS20130196A patent/RS52777B/sr unknown
- 2006-07-11 PT PT67777102T patent/PT1915153E/pt unknown
- 2006-07-11 BR BRPI0614471-3A patent/BRPI0614471A2/pt not_active Application Discontinuation
- 2006-07-11 CN CN200680027844.9A patent/CN101287466B/zh active Active
- 2006-07-11 WO PCT/EP2006/064111 patent/WO2007017331A2/en not_active Ceased
- 2006-07-11 MX MX2008001029A patent/MX2008001029A/es active IP Right Grant
- 2006-07-11 DK DK06777710.2T patent/DK1915153T3/da active
- 2006-07-11 CA CA2612080A patent/CA2612080C/en not_active Expired - Fee Related
- 2006-07-11 US US11/993,328 patent/US20090053307A1/en not_active Abandoned
- 2006-07-11 EP EP06777710.2A patent/EP1915153B1/en active Active
- 2006-07-11 AU AU2006278114A patent/AU2006278114B2/en not_active Ceased
- 2006-07-11 HR HRP20130364TT patent/HRP20130364T1/hr unknown
- 2006-07-11 PL PL06777710T patent/PL1915153T3/pl unknown
- 2006-07-11 ES ES06777710T patent/ES2407408T3/es active Active
- 2006-07-11 KR KR1020087003092A patent/KR101301548B1/ko not_active Expired - Fee Related
-
2013
- 2013-04-25 CY CY20131100341T patent/CY1114311T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007017331A3 (en) | 2007-09-27 |
| BRPI0614471A2 (pt) | 2011-03-29 |
| MX2008001029A (es) | 2008-03-14 |
| ES2407408T3 (es) | 2013-06-12 |
| HRP20130364T1 (hr) | 2013-05-31 |
| CA2612080A1 (en) | 2007-02-15 |
| AU2006278114B2 (en) | 2011-06-23 |
| US20090053307A1 (en) | 2009-02-26 |
| PL1915153T3 (pl) | 2013-09-30 |
| CN101287466A (zh) | 2008-10-15 |
| EP1915153A2 (en) | 2008-04-30 |
| KR20080031945A (ko) | 2008-04-11 |
| PT1915153E (pt) | 2013-06-05 |
| ITRM20050418A1 (it) | 2007-02-05 |
| JP5225084B2 (ja) | 2013-07-03 |
| WO2007017331A2 (en) | 2007-02-15 |
| KR101301548B1 (ko) | 2013-09-06 |
| HK1125293A1 (en) | 2009-08-07 |
| CN101287466B (zh) | 2014-11-05 |
| DK1915153T3 (da) | 2013-06-24 |
| JP2009503013A (ja) | 2009-01-29 |
| AU2006278114A1 (en) | 2007-02-15 |
| CY1114311T1 (el) | 2016-08-31 |
| EP1915153B1 (en) | 2013-04-10 |
| SI1915153T1 (sl) | 2013-06-28 |
| RS52777B (sr) | 2013-10-31 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20220301 |
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| MKLA | Lapsed |
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