ITRM20050418A1 - Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. - Google Patents

Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.

Info

Publication number
ITRM20050418A1
ITRM20050418A1 IT000418A ITRM20050418A ITRM20050418A1 IT RM20050418 A1 ITRM20050418 A1 IT RM20050418A1 IT 000418 A IT000418 A IT 000418A IT RM20050418 A ITRM20050418 A IT RM20050418A IT RM20050418 A1 ITRM20050418 A1 IT RM20050418A1
Authority
IT
Italy
Prior art keywords
butylossiminomethyl
camptotecin
immediate release
oral absorption
therapeutic systems
Prior art date
Application number
IT000418A
Other languages
English (en)
Italian (it)
Inventor
Antonio Longo
Silvia Pace
Massimo Pedrani
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to IT000418A priority Critical patent/ITRM20050418A1/it
Priority to CA2612080A priority patent/CA2612080C/en
Priority to JP2008524462A priority patent/JP5225084B2/ja
Priority to DK06777710.2T priority patent/DK1915153T3/da
Priority to EP06777710.2A priority patent/EP1915153B1/en
Priority to HK09103194.9A priority patent/HK1125293B/xx
Priority to ES06777710T priority patent/ES2407408T3/es
Priority to AU2006278114A priority patent/AU2006278114B2/en
Priority to SI200631573T priority patent/SI1915153T1/sl
Priority to HRP20130364TT priority patent/HRP20130364T1/hr
Priority to PT67777102T priority patent/PT1915153E/pt
Priority to KR1020087003092A priority patent/KR101301548B1/ko
Priority to MX2008001029A priority patent/MX2008001029A/es
Priority to PCT/EP2006/064111 priority patent/WO2007017331A2/en
Priority to PL06777710T priority patent/PL1915153T3/pl
Priority to US11/993,328 priority patent/US20090053307A1/en
Priority to BRPI0614471-3A priority patent/BRPI0614471A2/pt
Priority to CN200680027844.9A priority patent/CN101287466B/zh
Priority to RS20130196A priority patent/RS52777B/sr
Publication of ITRM20050418A1 publication Critical patent/ITRM20050418A1/it
Priority to CY20131100341T priority patent/CY1114311T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT000418A 2005-08-04 2005-08-04 Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. ITRM20050418A1 (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT000418A ITRM20050418A1 (it) 2005-08-04 2005-08-04 Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
HRP20130364TT HRP20130364T1 (hr) 2005-08-04 2006-07-11 TERAPIJSKI SUSTAVI S TRENUTNIM OTPUŠTANJEM, NAMIJENJENI POBOLJŠANOJ ORALNOJ APSORPCIJI 7-[(E)-tert-BUTILOKSIIMINOMETIL] KAMPTOTECINA
PT67777102T PT1915153E (pt) 2005-08-04 2006-07-11 Sistemas terapêuticas de libertação imediata para melhorar a absorção de 7-[(e)-terc- butiloximinometil]camptotecina
DK06777710.2T DK1915153T3 (da) 2005-08-04 2006-07-11 Terapeutiske systemer med omgående frigivelse til forbedret oral absorption af 7-[(E)-tert-butyloxyiminomethyl]camptothecin
EP06777710.2A EP1915153B1 (en) 2005-08-04 2006-07-11 Immediate release therapeutic systems for improved oral absorption of 7-[(e)-tert-butyloxyiminomethyl]camtothecin
HK09103194.9A HK1125293B (en) 2005-08-04 2006-07-11 Immediate release therapeutic systems for improved oral absorption of 7-[(e)-tertbutyloxyiminoxmethyl] camptothecin
ES06777710T ES2407408T3 (es) 2005-08-04 2006-07-11 Sistemas terapéuticos de liberación inmediata para mejorar la absorción oral de 7-[(E)-terc-butiloxiiminometil]camptotecina
AU2006278114A AU2006278114B2 (en) 2005-08-04 2006-07-11 Immediate release therapeutic systems for improved oral absorption of 7- [ (E) -tert-butyloxyiminomethyl] camptothecin
SI200631573T SI1915153T1 (sl) 2005-08-04 2006-07-11 Terapevtski sistemi s takojšnjim sproščanjem za izboljšano oralno absorpcijo 7-((E)-terc.-butiloksiiminometil)kamptotecina
CA2612080A CA2612080C (en) 2005-08-04 2006-07-11 Immediate-release therapeutic systems for improved oral absorption of 7-[(e)-t-butyloxyiminomethyl] camptothecin
JP2008524462A JP5225084B2 (ja) 2005-08-04 2006-07-11 ７−［（ｅ）−ｔ−ブチルオキシミノメチル］カンプトテシンの改良された経口吸収のための即効型治療システム
KR1020087003092A KR101301548B1 (ko) 2005-08-04 2006-07-11 ７-〔（ｅ）-ｔ-부틸옥시미노메틸〕 캄토테신의 향상된경구 흡수를 위한 즉시­방출 치료 시스템
MX2008001029A MX2008001029A (es) 2005-08-04 2006-07-11 Sistemas terapeuticos de liberacion inmediata para absorcion oral mejorada de 7-[(e)-t-butiloximinometil]camptotecina.
PCT/EP2006/064111 WO2007017331A2 (en) 2005-08-04 2006-07-11 Immediate release therapeutic systems for improved oral absorption of 7- [ (e) -tert-butyloxyiminomethyl] camptothecin
PL06777710T PL1915153T3 (pl) 2005-08-04 2006-07-11 Systemy terapeutyczne o natychmiastowym uwalnianiu do ulepszonej doustnej absorpcji 7-[(E)-tertbutyloksyiminometylo]kamtotecyny
US11/993,328 US20090053307A1 (en) 2005-08-04 2006-07-11 Immediate-release therapeutic systems for improved oral absorption of 7-[(e)]-t-buty-loxyminomethyl] camptothecin
BRPI0614471-3A BRPI0614471A2 (pt) 2005-08-04 2006-07-11 sistemas terapêuticos com liberação imediata para absorção oral aperfeiçoada de 7-[(e)-t-butilóximinometil] camptotecina
CN200680027844.9A CN101287466B (zh) 2005-08-04 2006-07-11 用于改善7-[(e)-叔丁氧亚氨基甲基]喜树碱经口吸收的即释治疗系统
RS20130196A RS52777B (sr) 2005-08-04 2006-07-11 Terapijski sistem sa trenutnim otpuštanjem za poboljšanu oralnu apsorpciju 7-[(e)-tert-butiloksiiminometil] kamptotecina
CY20131100341T CY1114311T1 (el) 2005-08-04 2013-04-25 Θεραπευτικα συστηματα αμεσης απελευθερωσης για βελτιωμενη απο του στοματος απορροφηση 7-[(ε)-τριτ-βουτυλοξυιμινομεθυλο]καμπτοθεκινης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000418A ITRM20050418A1 (it) 2005-08-04 2005-08-04 Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.

Publications (1)

Publication Number Publication Date
ITRM20050418A1 true ITRM20050418A1 (it) 2007-02-05

Family

ID=37727667

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000418A ITRM20050418A1 (it) 2005-08-04 2005-08-04 Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.

Country Status (19)

Country Link
US (1) US20090053307A1 (enExample)
EP (1) EP1915153B1 (enExample)
JP (1) JP5225084B2 (enExample)
KR (1) KR101301548B1 (enExample)
CN (1) CN101287466B (enExample)
AU (1) AU2006278114B2 (enExample)
BR (1) BRPI0614471A2 (enExample)
CA (1) CA2612080C (enExample)
CY (1) CY1114311T1 (enExample)
DK (1) DK1915153T3 (enExample)
ES (1) ES2407408T3 (enExample)
HR (1) HRP20130364T1 (enExample)
IT (1) ITRM20050418A1 (enExample)
MX (1) MX2008001029A (enExample)
PL (1) PL1915153T3 (enExample)
PT (1) PT1915153E (enExample)
RS (1) RS52777B (enExample)
SI (1) SI1915153T1 (enExample)
WO (1) WO2007017331A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011002688A (es) 2008-09-12 2011-04-12 Critical Pharmaceuticals Ltd Mejoramientos en la absorcion de agentes terapeuticos a traves de las membranas mucosas o la piel.
USD618617S1 (en) 2008-12-30 2010-06-29 Multiway Industries (Hk) Ltd. Three way electrical plug
US7892036B2 (en) * 2008-12-30 2011-02-22 Multiway Industries (Hk) Ltd. Electrical wall tap assembly
USD618175S1 (en) 2009-10-15 2010-06-22 Multiway Industries (Hk) Ltd. Three-outlet surge-protected adaptor
USD616823S1 (en) 2009-10-15 2010-06-01 Multiway Industries (Hk) Ltd. Single-outlet surge-protected adaptor
WO2011071194A1 (ko) * 2009-12-08 2011-06-16 주식회사 일화 20-O-β-D-글루코피라노실-20(S)-프로토파낙사디올을 포함하는 고체분산체
USD651977S1 (en) 2011-01-10 2012-01-10 Multiway Industries (Hk) Ltd. Multiple outlet electrical connector
CN108066311B (zh) * 2017-12-26 2020-09-08 兆科（广州）肿瘤药物有限公司 一种吉马替康胶囊及其制备方法
USD958079S1 (en) 2019-08-30 2022-07-19 Multiway Industries (Hk) Ltd. 3-way electrical tap
USD955993S1 (en) 2019-08-30 2022-06-28 Multiway Industries (Hk) Ltd. 3-way electrical tap
CN111529497A (zh) * 2020-02-11 2020-08-14 兆科（广州）肿瘤药物有限公司 一种吉马替康药物固体分散组合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
SI0999826T1 (en) * 1997-07-29 2004-12-31 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
AR013261A1 (es) * 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
DK1044977T3 (da) * 1999-03-09 2002-07-08 Sigma Tau Ind Farmaceuti Camptothecinderivater med antitumoraktivitet
KR20070058028A (ko) * 1999-05-24 2007-06-07 소너스파머슈티칼즈인코포레이티드 난용성 약물용 에멀젼 부형제
WO2005092302A2 (en) * 2004-03-26 2005-10-06 Novartis Ag Use of camptothecin derivates for the treatment of proliferative diseases in a fixed dosing regimen
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
ES2395930T3 (es) * 2004-12-21 2013-02-18 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Procedimiento estereoselectivo y formas cristalinas de una camptotecina

Also Published As

Publication number Publication date
KR20080031945A (ko) 2008-04-11
CN101287466B (zh) 2014-11-05
PT1915153E (pt) 2013-06-05
WO2007017331A2 (en) 2007-02-15
HRP20130364T1 (hr) 2013-05-31
AU2006278114A1 (en) 2007-02-15
SI1915153T1 (sl) 2013-06-28
AU2006278114B2 (en) 2011-06-23
BRPI0614471A2 (pt) 2011-03-29
MX2008001029A (es) 2008-03-14
HK1125293A1 (en) 2009-08-07
EP1915153B1 (en) 2013-04-10
ES2407408T3 (es) 2013-06-12
PL1915153T3 (pl) 2013-09-30
RS52777B (sr) 2013-10-31
JP2009503013A (ja) 2009-01-29
EP1915153A2 (en) 2008-04-30
CA2612080C (en) 2013-09-03
WO2007017331A3 (en) 2007-09-27
CN101287466A (zh) 2008-10-15
KR101301548B1 (ko) 2013-09-06
CY1114311T1 (el) 2016-08-31
JP5225084B2 (ja) 2013-07-03
CA2612080A1 (en) 2007-02-15
US20090053307A1 (en) 2009-02-26
DK1915153T3 (da) 2013-06-24

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