JP5168712B2 - ナテグリニド含有製剤 - Google Patents
ナテグリニド含有製剤 Download PDFInfo
- Publication number
- JP5168712B2 JP5168712B2 JP2006511837A JP2006511837A JP5168712B2 JP 5168712 B2 JP5168712 B2 JP 5168712B2 JP 2006511837 A JP2006511837 A JP 2006511837A JP 2006511837 A JP2006511837 A JP 2006511837A JP 5168712 B2 JP5168712 B2 JP 5168712B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- pharmaceutical composition
- nateglinide
- acid
- sweetener
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 title claims description 33
- 229960000698 nateglinide Drugs 0.000 title claims description 33
- 238000002360 preparation method Methods 0.000 title description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 51
- 239000008194 pharmaceutical composition Substances 0.000 claims description 33
- 235000003599 food sweetener Nutrition 0.000 claims description 22
- 239000003765 sweetening agent Substances 0.000 claims description 22
- 150000007522 mineralic acids Chemical class 0.000 claims description 17
- 150000007524 organic acids Chemical class 0.000 claims description 17
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims description 13
- 229960004106 citric acid Drugs 0.000 claims description 13
- 235000015165 citric acid Nutrition 0.000 claims description 13
- 239000000796 flavoring agent Substances 0.000 claims description 13
- 235000019634 flavors Nutrition 0.000 claims description 13
- 239000006191 orally-disintegrating tablet Substances 0.000 claims description 13
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 10
- 235000019800 disodium phosphate Nutrition 0.000 claims description 10
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 10
- 239000003205 fragrance Substances 0.000 claims description 10
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 6
- 229960004543 anhydrous citric acid Drugs 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- 244000246386 Mentha pulegium Species 0.000 claims description 5
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 5
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 239000011668 ascorbic acid Substances 0.000 claims description 5
- 235000010323 ascorbic acid Nutrition 0.000 claims description 5
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 5
- 229950008138 carmellose Drugs 0.000 claims description 5
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 5
- 239000007884 disintegrant Substances 0.000 claims description 5
- 235000001050 hortel pimenta Nutrition 0.000 claims description 5
- 235000011090 malic acid Nutrition 0.000 claims description 5
- 239000001630 malic acid Substances 0.000 claims description 5
- 235000002906 tartaric acid Nutrition 0.000 claims description 5
- 239000011975 tartaric acid Substances 0.000 claims description 5
- 125000001755 (-)-menthol group Chemical group 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 239000001530 fumaric acid Substances 0.000 claims description 4
- 235000011087 fumaric acid Nutrition 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 229960000913 crospovidone Drugs 0.000 claims description 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 2
- 229960005069 calcium Drugs 0.000 claims description 2
- 235000001465 calcium Nutrition 0.000 claims description 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 2
- 229940032147 starch Drugs 0.000 claims description 2
- 229920002261 Corn starch Polymers 0.000 claims 3
- 239000008120 corn starch Substances 0.000 claims 3
- 239000004386 Erythritol Substances 0.000 claims 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 2
- 229940009714 erythritol Drugs 0.000 claims 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 2
- 235000019414 erythritol Nutrition 0.000 claims 2
- 229940083542 sodium Drugs 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- 235000019658 bitter taste Nutrition 0.000 description 19
- 238000011156 evaluation Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 9
- 239000003826 tablet Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical group OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 7
- 238000005469 granulation Methods 0.000 description 7
- 230000003179 granulation Effects 0.000 description 7
- 229940085605 saccharin sodium Drugs 0.000 description 7
- 239000000654 additive Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000011812 mixed powder Substances 0.000 description 5
- 230000001603 reducing effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 108010011485 Aspartame Proteins 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 4
- 239000000605 aspartame Substances 0.000 description 4
- 229960003438 aspartame Drugs 0.000 description 4
- 235000010357 aspartame Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000019640 taste Nutrition 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- -1 sodium and potassium Chemical class 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 150000001342 alkaline earth metals Chemical class 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229940088679 drug related substance Drugs 0.000 description 2
- 238000007908 dry granulation Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- OELFLUMRDSZNSF-OFLPRAFFSA-N (2R)-2-[[oxo-(4-propan-2-ylcyclohexyl)methyl]amino]-3-phenylpropanoic acid Chemical compound C1CC(C(C)C)CCC1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-OFLPRAFFSA-N 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 235000016795 Cola Nutrition 0.000 description 1
- 235000011824 Cola pachycarpa Nutrition 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 101100120289 Drosophila melanogaster Flo1 gene Proteins 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 244000290333 Vanilla fragrans Species 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 235000019987 cider Nutrition 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006511837A JP5168712B2 (ja) | 2004-04-01 | 2005-04-01 | ナテグリニド含有製剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004108925 | 2004-04-01 | ||
| JP2004108925 | 2004-04-01 | ||
| JP2006511837A JP5168712B2 (ja) | 2004-04-01 | 2005-04-01 | ナテグリニド含有製剤 |
| PCT/JP2005/006459 WO2005094812A1 (ja) | 2004-04-01 | 2005-04-01 | ナテグリニド含有製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2005094812A1 JPWO2005094812A1 (ja) | 2008-02-14 |
| JP5168712B2 true JP5168712B2 (ja) | 2013-03-27 |
Family
ID=35063493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006511837A Expired - Fee Related JP5168712B2 (ja) | 2004-04-01 | 2005-04-01 | ナテグリニド含有製剤 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP5168712B2 (ko) |
| KR (2) | KR20120064735A (ko) |
| WO (1) | WO2005094812A1 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100882156B1 (ko) | 2003-08-08 | 2009-02-06 | 아지노모토 가부시키가이샤 | 나테글리니드 함유 제제 |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| US20080107787A1 (en) * | 2006-11-02 | 2008-05-08 | The Coca-Cola Company | Anti-Diabetic Composition with High-Potency Sweetener |
| ES2660962T3 (es) | 2008-07-28 | 2018-03-26 | Takeda Pharmaceutical Company Limited | Composición farmacéutica fotoestabilizada |
| CN105362240B (zh) | 2011-04-28 | 2019-04-30 | 田边三菱制药株式会社 | 口腔内速崩片 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022105A1 (fr) * | 1996-11-15 | 1998-05-28 | Ajinomoto Co., Inc. | Preparation en comprimes |
| WO2001047557A1 (fr) * | 1999-12-28 | 2001-07-05 | Ajinomoto Co., Inc. | Preparations orales pour diabetes |
| WO2002034254A1 (fr) * | 2000-10-24 | 2002-05-02 | Ajinomoto Co.,Inc. | Preparations contenant du nateglinide |
| WO2002040010A1 (fr) * | 2000-10-24 | 2002-05-23 | Ajinomoto Co.,Inc. | Preparations de medicament contenant du nateglinide |
| JP2002179558A (ja) * | 2000-10-06 | 2002-06-26 | Takeda Chem Ind Ltd | 固形製剤 |
| JP2003509457A (ja) * | 1999-09-17 | 2003-03-11 | ノバルティス アクチエンゲゼルシャフト | 代謝障害、とりわけ糖尿病、または糖尿病関連疾患もしくは病状の処置方法 |
| JP2003518496A (ja) * | 1999-12-23 | 2003-06-10 | ノバルティス アクチエンゲゼルシャフト | グルコース代謝障害を処置するための血糖降下薬の使用 |
| JP2006514660A (ja) * | 2003-01-28 | 2006-05-11 | レーム ゲゼルシャフト ミツト ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 直接崩壊し、かつ作用物質を放出する経口薬剤形を製造するための方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10298062A (ja) * | 1997-04-24 | 1998-11-10 | Pfizer Pharmaceut Co Ltd | 口腔内速溶型錠剤 |
| AU9187598A (en) * | 1997-09-30 | 1999-04-23 | Daiichi Pharmaceutical Co., Ltd. | Oral preparation |
| JP4300652B2 (ja) * | 1998-09-21 | 2009-07-22 | 大正製薬株式会社 | 経口用固形製剤 |
| JP2000290199A (ja) * | 1999-03-31 | 2000-10-17 | Taisho Pharmaceut Co Ltd | 経口用医薬組成物 |
| JP2001069961A (ja) * | 1999-09-02 | 2001-03-21 | Fuji Chem Ind Co Ltd | 苦味マスキング用組成物 |
| JP2002154966A (ja) * | 2000-11-22 | 2002-05-28 | Taisho Pharmaceut Co Ltd | アセチルサリチル酸アルミニウム含有組成物 |
| JP5062871B2 (ja) * | 2003-05-13 | 2012-10-31 | 東和薬品株式会社 | 苦味を低減した口腔内崩壊錠剤 |
| JP4519444B2 (ja) * | 2003-10-31 | 2010-08-04 | ライオン株式会社 | 口腔内崩壊錠 |
| JP4444626B2 (ja) * | 2003-10-31 | 2010-03-31 | ライオン株式会社 | 口腔内崩壊錠 |
-
2005
- 2005-04-01 WO PCT/JP2005/006459 patent/WO2005094812A1/ja active Application Filing
- 2005-04-01 KR KR1020127014297A patent/KR20120064735A/ko not_active Application Discontinuation
- 2005-04-01 JP JP2006511837A patent/JP5168712B2/ja not_active Expired - Fee Related
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2006
- 2006-09-29 KR KR1020067020510A patent/KR101175120B1/ko not_active IP Right Cessation
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022105A1 (fr) * | 1996-11-15 | 1998-05-28 | Ajinomoto Co., Inc. | Preparation en comprimes |
| JP2003509457A (ja) * | 1999-09-17 | 2003-03-11 | ノバルティス アクチエンゲゼルシャフト | 代謝障害、とりわけ糖尿病、または糖尿病関連疾患もしくは病状の処置方法 |
| JP2003518496A (ja) * | 1999-12-23 | 2003-06-10 | ノバルティス アクチエンゲゼルシャフト | グルコース代謝障害を処置するための血糖降下薬の使用 |
| WO2001047557A1 (fr) * | 1999-12-28 | 2001-07-05 | Ajinomoto Co., Inc. | Preparations orales pour diabetes |
| JP2002179558A (ja) * | 2000-10-06 | 2002-06-26 | Takeda Chem Ind Ltd | 固形製剤 |
| WO2002034254A1 (fr) * | 2000-10-24 | 2002-05-02 | Ajinomoto Co.,Inc. | Preparations contenant du nateglinide |
| WO2002040010A1 (fr) * | 2000-10-24 | 2002-05-23 | Ajinomoto Co.,Inc. | Preparations de medicament contenant du nateglinide |
| JP2006514660A (ja) * | 2003-01-28 | 2006-05-11 | レーム ゲゼルシャフト ミツト ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 直接崩壊し、かつ作用物質を放出する経口薬剤形を製造するための方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120064735A (ko) | 2012-06-19 |
| KR20060134144A (ko) | 2006-12-27 |
| WO2005094812A1 (ja) | 2005-10-13 |
| KR101175120B1 (ko) | 2012-08-21 |
| JPWO2005094812A1 (ja) | 2008-02-14 |
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