JP5163868B2 - 貼付剤 - Google Patents
貼付剤 Download PDFInfo
- Publication number
- JP5163868B2 JP5163868B2 JP2007338726A JP2007338726A JP5163868B2 JP 5163868 B2 JP5163868 B2 JP 5163868B2 JP 2007338726 A JP2007338726 A JP 2007338726A JP 2007338726 A JP2007338726 A JP 2007338726A JP 5163868 B2 JP5163868 B2 JP 5163868B2
- Authority
- JP
- Japan
- Prior art keywords
- sensitive adhesive
- meth
- ester
- pressure
- primer layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000010410 layer Substances 0.000 claims description 71
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 41
- 229920001577 copolymer Polymers 0.000 claims description 34
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 34
- 229920005749 polyurethane resin Polymers 0.000 claims description 34
- 150000002148 esters Chemical class 0.000 claims description 18
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 125000001033 ether group Chemical group 0.000 claims description 2
- -1 hydroxyl compound Chemical class 0.000 description 42
- 238000000576 coating method Methods 0.000 description 27
- 239000011248 coating agent Substances 0.000 description 25
- 239000000203 mixture Substances 0.000 description 19
- 239000000178 monomer Substances 0.000 description 19
- 238000001035 drying Methods 0.000 description 18
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- 125000004432 carbon atom Chemical group C* 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 239000004014 plasticizer Substances 0.000 description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 238000004132 cross linking Methods 0.000 description 9
- 239000003431 cross linking reagent Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 150000002430 hydrocarbons Chemical group 0.000 description 9
- 239000000853 adhesive Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 8
- 230000035699 permeability Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 230000000996 additive effect Effects 0.000 description 7
- 239000012790 adhesive layer Substances 0.000 description 7
- 150000001298 alcohols Chemical class 0.000 description 7
- 238000004873 anchoring Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 230000037303 wrinkles Effects 0.000 description 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 5
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- 229940114077 acrylic acid Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
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- 239000011505 plaster Substances 0.000 description 5
- 229920006267 polyester film Polymers 0.000 description 5
- 239000003505 polymerization initiator Substances 0.000 description 5
- 229920005862 polyol Polymers 0.000 description 5
- 150000003077 polyols Chemical class 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
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- 238000003892 spreading Methods 0.000 description 5
- 230000007480 spreading Effects 0.000 description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 4
- WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000008602 contraction Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000012948 isocyanate Substances 0.000 description 4
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 4
- 229920005906 polyester polyol Polymers 0.000 description 4
- 239000005056 polyisocyanate Substances 0.000 description 4
- 229920001228 polyisocyanate Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229940083542 sodium Drugs 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 206010040844 Skin exfoliation Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000007720 emulsion polymerization reaction Methods 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 150000002513 isocyanates Chemical class 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000010734 process oil Substances 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- ZXHZWRZAWJVPIC-UHFFFAOYSA-N 1,2-diisocyanatonaphthalene Chemical compound C1=CC=CC2=C(N=C=O)C(N=C=O)=CC=C21 ZXHZWRZAWJVPIC-UHFFFAOYSA-N 0.000 description 2
- FKKAGFLIPSSCHT-UHFFFAOYSA-N 1-dodecoxydodecane;sulfuric acid Chemical class OS(O)(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC FKKAGFLIPSSCHT-UHFFFAOYSA-N 0.000 description 2
- RNFJDJUURJAICM-UHFFFAOYSA-N 2,2,4,4,6,6-hexaphenoxy-1,3,5-triaza-2$l^{5},4$l^{5},6$l^{5}-triphosphacyclohexa-1,3,5-triene Chemical compound N=1P(OC=2C=CC=CC=2)(OC=2C=CC=CC=2)=NP(OC=2C=CC=CC=2)(OC=2C=CC=CC=2)=NP=1(OC=1C=CC=CC=1)OC1=CC=CC=C1 RNFJDJUURJAICM-UHFFFAOYSA-N 0.000 description 2
- KANZWHBYRHQMKZ-UHFFFAOYSA-N 2-ethenylpyrazine Chemical compound C=CC1=CN=CC=N1 KANZWHBYRHQMKZ-UHFFFAOYSA-N 0.000 description 2
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 2
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 235000002566 Capsicum Nutrition 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 2
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 2
- 229920006243 acrylic copolymer Polymers 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 239000002216 antistatic agent Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- 229960002504 capsaicin Drugs 0.000 description 2
- 235000017663 capsaicin Nutrition 0.000 description 2
- 239000001390 capsicum minimum Substances 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
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- 239000003086 colorant Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- 229940031578 diisopropyl adipate Drugs 0.000 description 2
- 229940031569 diisopropyl sebacate Drugs 0.000 description 2
- 150000002009 diols Chemical class 0.000 description 2
- 238000003618 dip coating Methods 0.000 description 2
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 2
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
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- 239000003063 flame retardant Substances 0.000 description 2
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- 235000011187 glycerol Nutrition 0.000 description 2
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 2
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- 230000001771 impaired effect Effects 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 2
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- 239000011259 mixed solution Substances 0.000 description 2
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 2
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 2
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- 150000001451 organic peroxides Chemical class 0.000 description 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 2
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- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 2
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- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 2
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 2
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
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- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- PMDHMYFSRFZGIO-UHFFFAOYSA-N 1,4,7-trioxacyclotridecane-8,13-dione Chemical compound O=C1CCCCC(=O)OCCOCCO1 PMDHMYFSRFZGIO-UHFFFAOYSA-N 0.000 description 1
- KBKGPMDADJLBEM-UHFFFAOYSA-N 1-(4-pentylphenyl)ethanone Chemical compound CCCCCC1=CC=C(C(C)=O)C=C1 KBKGPMDADJLBEM-UHFFFAOYSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- DCRYNQTXGUTACA-UHFFFAOYSA-N 1-ethenylpiperazine Chemical compound C=CN1CCNCC1 DCRYNQTXGUTACA-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Description
[1].エステル系ポリウレタン樹脂フィルムである支持体の片面に、プライマー層及び(メタ)アクリル酸アルキルエステルを構成単位として有する(共)重合体を含む粘着剤層を順に積層してなり、上記プライマー層がエーテル系ポリウレタン樹脂フィルムであることを特徴とする貼付剤、
[2].上記(メタ)アクリル酸アルキルエステルを構成単位として有する(共)重合体が、架橋された(共)重合体であることを特徴とする[1]記載の貼付剤を提供する。
本発明の支持体はエステル系ポリウレタン樹脂フィルムからなる。エステル系ポリウレタン樹脂は、イソシアネート基を有する硬化剤(ポリイソシアネート)と高分子末端に水酸基を有するポリエステルポリオールとからなり、水酸基とイソシアネート基との反応によりウレタン結合を形成し硬化させることによって得ることができる。エステル系ポリウレタン樹脂は、1種単独で又は2種以上を適宜組み合わせて用いることができる。
50%伸長回復率(%)=100−(B−A)×100/(A×0.5)
(但し、上記式中、Aは試料の初期の長さ(100mm)、Bは引っ張り試験後の試料の長さ(mm)を示す。)
本発明のプライマー層はエーテル系ポリウレタン樹脂フィルムからなる。エーテル系ポリウレタン樹脂フィルムは、イソシアネート基を有する硬化剤(ポリイソシアネート)と高分子末端に水酸基を有するポリエーテルポリオールとからなり、水酸基とイソシアネート基との反応によりウレタン結合を形成し硬化させることによって得ることができる。
本発明の粘着剤層は、(メタ)アクリル酸アルキルエステルを構成単位として有する(共)重合体を含む。以下、粘着剤層を構成しているものを「粘着剤組成物(膏体)」と表す。(メタ)アクリル酸アルキルエステルとしては、具体的には、アルキル基がブチル、ペンチル、ヘキシル、ヘプチル、オクチル、ノニル、デシル、ウンデシル、ドデシル、トリデシル等の炭素数4〜13の直鎖状アルキル基や、2−エチルヘキシル等の分岐状アルキル基等のものが挙げられ、これらは1種単独で又は2種以上を適宜組み合わせて用いることができる。中でも、アクリル酸、メタクリル酸、アクリル酸エチル、アクリル酸n−ブチル、アクリル酸オクチル、アクリル酸2−エチルヘキシル、アクリル酸2−ヒドロキシエチル、メタアクリル酸2−エチルヘキシル、メタクリル酸メチル、メタクリル酸ドデシルが好ましい。なお、本発明において、(メタ)アクリル酸はアクリル酸及び/又はメタクリル酸をいう。
で表される脂肪酸エステルを好適に使用することができる。
上記支持体の片面に、プライマー層及び粘着剤層を順に積層してなり、支持体、プライマー層及び粘着剤層を備えた貼付剤が形成される。支持体に積層されたプライマー層への、粘着剤層の積層は、例えば、(i)粘着剤層用塗工液を調製し、(ii)この粘着剤溶液をライナーに塗工し、乾燥させ、ライナーの片面に粘着剤層を積層する。(iii)支持体に積層されたプライマー層表面に、ライナーの片面に設けられた粘着剤層を積層する。
(メタ)アクリル酸アルキルエステルを構成単位として有する(共)重合体と、他任意成分とを混合後、固形分として30〜80質量%、好ましくは40〜60質量%となるよう溶剤で調整し、粘着剤層用塗工液を得る。この溶剤としては、水、メタノール、エタノール、アセトン、酢酸エチル、トルエン、その他有機溶剤も使用できるが、好ましくは水、エタノール、酢酸エチルがよい。
この粘着剤溶液をライナーに塗工する。上記粘着剤層用塗工液の溶剤が水の場合、例えば、架橋剤とキレート剤を水に溶解させた後、好ましくは水酸化ナトリウム、水酸化カリウム又はアンモニア水で、pHをアルカリ側へ、好ましくはpH8以上、より好ましくはpH9〜12に調整する。これに、アクリル系(共)重合体と、その他任意成分を混合し、全体が均一になるまで十分に撹拌した後、塗工を行う。溶剤が酢酸エチルの場合は、上記(共)重合体と、好適には架橋剤と、その他成分とを、酢酸エチル中で混合し、全体が均一になるまで十分に撹拌した後、塗工を行う。
乾燥して粘着剤層を形成した後、支持体に積層されたプライマー層表面に、ライナーの片面に設けられた粘着剤層を積層し、支持体、プライマー層、粘着剤層、ライナーの順で積層された貼付剤を得、適当な大きさに裁断して用いることができる。
(i)共重合体のエマルジョンと、薬物を溶解させた可塑剤とを混合し、混合液1を得た。別途、水20部(架橋剤1質量部に対し)に、架橋剤と架橋調整剤を混合溶解し、必要に応じてpH調整剤でpHを10に調整し、混合液2を得た。混合液1に、混合液2を混合し、全体が均一になるまで十分に撹拌し、粘着剤層用塗工液を調製した。
(ii)乾燥後の膏体量が、1.0g/10×7cmとなるように、ライナー(ポリエステルフィルム(75μm))にコンマコーターにより塗工し、乾燥させた。乾燥は、90℃の乾燥機中で15分間行った。
(iii)表中の支持体の片面に、表に示すプライマー層形成に用いるプライマー層用塗工液を塗工し、乾燥することによって、プライマー層を積層した。支持体に積層されたプライマー層表面に、ライナーの片面に設けられた粘着剤層を積層させ、適当な大きさに裁断し、貼付剤を得た。表中には、乾燥後の粘着剤組成を示す。
(i)共重合体のエマルジョンと、薬物を溶解させた可塑剤と、架橋剤を混合し、全体が均一になるまで十分に撹拌し、粘着剤層用塗工液を調製した。
(ii)乾燥後の膏体量が、1.0g/10×7cmとなるように、ライナー(ポリエステルフィルム(75μm))にコンマコーターにより塗工し、乾燥させた。乾燥は、90℃の乾燥機中で15分間行った。
(iii)表中の支持体の片面に、表に示すプライマー層形成に用いるプライマー層用塗工液を塗工し、乾燥することによって、プライマー層を積層した。支持体に積層されたプライマー層表面に、ライナーの片面に設けられた粘着剤層を積層させ、適当な大きさに裁断し、各例の貼付剤を得た。表中には、乾燥後の粘着剤層組成を示す。
<フィルムのしわ評価>
5:しわがない
4:ややしわがある
3:かなりしわがある
2:少ししわがある
1:非常にしわがある
貼付剤を皮膚(性別;男、年齢20〜40才、人数10名)に3時間貼付し、剥離した時の全膏体量(粘着剤組成物の全量)に対する、皮膚に残存した膏体量の割合(質量%)を求めた。これを支持体と粘着剤との投錨性の指標とした。
[共重合体]
共重合体(1):メタクリル酸・アクリル酸n−ブチルコポリマー(商品名「RODERM」ロームアンドハース社製)
共重合体(2):アクリル酸2−エチルヘキシル(10部),メタアクリル酸2−エチルヘキシル(80部),メタクリル酸ドデシル(10部)、重合開始剤として過酸化ラウロイル使用
共重合体(3):アクリル酸エチル(3部)、メタアクリル酸エチル(7部),メタアクリル酸2−エチルヘキシル(90部)、重合開始剤として過酸化ラウロイル使用
[プライマー層]
プライマー層用塗工液
エーテル系ポリウレタン樹脂フィルム:
サカタインクス社製「サピリア」(エーテル系ウレタン樹脂13〜20%、添加剤(4〜8%)、溶剤(炭化水素系、アルコール系、酢酸エステル類等)50〜77%)
塩化ビニル−エステル系ポリウレタン樹脂フィルム:
サカタインクス社製「XGL−010」(エステル系ウレタン樹脂9〜15%、添加剤(1〜5%)、溶剤(炭化水素系、アルコール系、ケトン類等)54〜89%)
エステル系ポリウレタン樹脂フィルム:
サカタインクス社製「ラミオール マークIII」(エステル系ポリウレタン樹脂10〜15%、添加剤(1〜2%)、溶剤(炭化水素系、アルコール系、ケトン類等)39〜84%)
[支持体]
エステル系ポリウレタン樹脂フィルム(1):
セーレン(株)製、厚み10μm、表面マット加工
エステル系ポリウレタン樹脂フィルム(2):
東レ(株)製、厚み15μm、表面マット加工
エステル系ポリウレタン樹脂フィルム(3):
シーダム(株)製、厚み30μm、表面マット加工
エーテル系ポリウレタン樹脂フィルム:
東レ(株)製、厚み15μm、表面マット加工
Claims (2)
- エステル系ポリウレタン樹脂フィルムである支持体の片面に、プライマー層及び(メタ)アクリル酸アルキルエステルを構成単位として有する(共)重合体を含む粘着剤層を順に積層してなり、上記プライマー層がエーテル系ポリウレタン樹脂フィルムであることを特徴とする貼付剤。
- 上記(メタ)アクリル酸アルキルエステルを構成単位として有する(共)重合体が、架橋された(共)重合体であることを特徴とする請求項1記載の貼付剤。
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JP6045892B2 (ja) * | 2012-11-30 | 2016-12-14 | 東洋化学株式会社 | 曲げ変形を受ける対象物に被覆して用いる被覆材用複合フィルム |
EP2975066B1 (en) | 2013-03-14 | 2018-08-22 | Kaneka Corporation | Polymer production method |
WO2016129596A1 (ja) | 2015-02-13 | 2016-08-18 | 株式会社カネカ | 粒子状重合体の製造方法 |
JP6731219B2 (ja) | 2015-05-28 | 2020-07-29 | スリーエム イノベイティブ プロパティズ カンパニー | 粘着シート |
JP6573483B2 (ja) * | 2015-05-28 | 2019-09-11 | スリーエム イノベイティブ プロパティズ カンパニー | 粘着シート |
JP7066508B2 (ja) * | 2018-05-02 | 2022-05-13 | 株式会社ニトムズ | ポリウレタン積層シートおよび粘着シート |
JP7369552B2 (ja) * | 2018-06-29 | 2023-10-26 | ニチバン株式会社 | 医療用貼付材 |
JP7203624B2 (ja) * | 2019-02-06 | 2023-01-13 | バンドー化学株式会社 | 光学透明粘着シート、積層シート及び貼り合わせ構造物 |
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