JP5129133B2 - 安定なｎａｄ／ｎａｄｈ誘導体 - Google Patents
安定なｎａｄ／ｎａｄｈ誘導体 Download PDFInfo
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- JP5129133B2 JP5129133B2 JP2008523257A JP2008523257A JP5129133B2 JP 5129133 B2 JP5129133 B2 JP 5129133B2 JP 2008523257 A JP2008523257 A JP 2008523257A JP 2008523257 A JP2008523257 A JP 2008523257A JP 5129133 B2 JP5129133 B2 JP 5129133B2
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- dehydrogenase
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- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical class C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 title description 25
- 102000004190 Enzymes Human genes 0.000 claims description 57
- 108090000790 Enzymes Proteins 0.000 claims description 57
- 239000005515 coenzyme Substances 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 34
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 30
- 238000012360 testing method Methods 0.000 claims description 30
- 239000012491 analyte Substances 0.000 claims description 29
- 238000001514 detection method Methods 0.000 claims description 28
- 238000005259 measurement Methods 0.000 claims description 27
- 239000003153 chemical reaction reagent Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- -1 alkyl compound Chemical class 0.000 claims description 16
- 229910052760 oxygen Inorganic materials 0.000 claims description 16
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 13
- 239000008103 glucose Substances 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 229910052801 chlorine Inorganic materials 0.000 claims description 11
- 239000000758 substrate Substances 0.000 claims description 11
- 229910052717 sulfur Inorganic materials 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 238000006911 enzymatic reaction Methods 0.000 claims description 7
- 229930024421 Adenine Natural products 0.000 claims description 6
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 6
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 6
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 102000004420 Creatine Kinase Human genes 0.000 claims description 6
- 108010042126 Creatine kinase Proteins 0.000 claims description 6
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 6
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- 229960000643 adenine Drugs 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 108030000198 L-amino-acid dehydrogenases Proteins 0.000 claims description 5
- 125000002837 carbocyclic group Chemical group 0.000 claims description 5
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- 102000004008 5'-Nucleotidase Human genes 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 101710088194 Dehydrogenase Proteins 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 235000001014 amino acid Nutrition 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- 108010043671 prostatic acid phosphatase Proteins 0.000 claims description 4
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims description 3
- 108010050201 2-hydroxybutyrate dehydrogenase Proteins 0.000 claims description 3
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 claims description 3
- 108010024636 Glutathione Proteins 0.000 claims description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- 108010009384 L-Iditol 2-Dehydrogenase Proteins 0.000 claims description 3
- 102100026974 Sorbitol dehydrogenase Human genes 0.000 claims description 3
- 235000010323 ascorbic acid Nutrition 0.000 claims description 3
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- 239000011668 ascorbic acid Substances 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 235000012000 cholesterol Nutrition 0.000 claims description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 3
- 235000018417 cysteine Nutrition 0.000 claims description 3
- 229960002433 cysteine Drugs 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 235000001727 glucose Nutrition 0.000 claims description 3
- 229960003180 glutathione Drugs 0.000 claims description 3
- 235000003969 glutathione Nutrition 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 229960001860 salicylate Drugs 0.000 claims description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 3
- 108700040097 Glycerol dehydrogenases Proteins 0.000 claims description 2
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims description 2
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 2
- 150000001721 carbon Chemical group 0.000 claims description 2
- 239000011535 reaction buffer Substances 0.000 claims description 2
- PEHVGBZKEYRQSX-UHFFFAOYSA-N 7-deaza-adenine Chemical compound NC1=NC=NC2=C1C=CN2 PEHVGBZKEYRQSX-UHFFFAOYSA-N 0.000 claims 8
- LHCPRYRLDOSKHK-UHFFFAOYSA-N 7-deaza-8-aza-adenine Chemical compound NC1=NC=NC2=C1C=NN2 LHCPRYRLDOSKHK-UHFFFAOYSA-N 0.000 claims 4
- 108020005199 Dehydrogenases Proteins 0.000 claims 3
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 2
- HRYKDUPGBWLLHO-UHFFFAOYSA-N 8-azaadenine Chemical compound NC1=NC=NC2=NNN=C12 HRYKDUPGBWLLHO-UHFFFAOYSA-N 0.000 claims 2
- 238000006356 dehydrogenation reaction Methods 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 74
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 54
- 229950006238 nadide Drugs 0.000 description 52
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 47
- 229940088598 enzyme Drugs 0.000 description 46
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- 239000000203 mixture Substances 0.000 description 29
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 20
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
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- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 10
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- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 7
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| US7553615B2 (en) * | 2005-07-28 | 2009-06-30 | Roche Diagnostics Operations, Inc. | Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH |
| EP2022859A1 (de) * | 2007-08-01 | 2009-02-11 | Roche Diagnostics GmbH | Verfahren und Vorrichtung zur Bestimmung der Konzentration eines Analyten mittels Fluoreszenzmessung |
| CN101497638B (zh) * | 2008-01-30 | 2012-09-26 | 中国科学院大连化学物理研究所 | 一种nad+类似物及其合成和应用 |
| EP2093284A1 (de) * | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| WO2010094632A1 (de) | 2009-02-19 | 2010-08-26 | F. Hoffmann-La Roche Ag | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
| EP2226008A1 (de) | 2009-02-19 | 2010-09-08 | Roche Diagnostics GmbH | Verfahren zur Herstellung eines analytischen Magazins |
| EP2226007A1 (de) | 2009-02-19 | 2010-09-08 | Roche Diagnostics GmbH | Testelementmagazin mit abgedeckten Testfeldern |
| EP2398388B1 (de) * | 2009-02-19 | 2020-04-08 | Roche Diabetes Care GmbH | Platzsparende magazinierung analytischer hilfsmittel |
| EP2398909B1 (de) | 2009-02-19 | 2015-07-22 | F. Hoffmann-La Roche AG | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
| CN102471272B (zh) * | 2009-07-27 | 2014-09-10 | 霍夫曼-拉罗奇有限公司 | 制备n-取代吡啶鎓化合物的方法和物质 |
| WO2011012269A2 (en) | 2009-07-27 | 2011-02-03 | Roche Diagnostics Gmbh | Method and substances for preparation of n-substituted pyridinium compounds |
| JP5540096B2 (ja) * | 2009-07-27 | 2014-07-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | カルバ−ｎａｄの酵素合成 |
| EP2292751A1 (de) | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| EP2287605A1 (de) * | 2009-08-20 | 2011-02-23 | Roche Diagnostics GmbH | Vereinfachte Magazinierung integrierter Systeme |
| EP2333544A1 (de) | 2009-12-11 | 2011-06-15 | F. Hoffmann-La Roche AG | Sterilisierbare Chemie für Testelemente |
| MX2012006706A (es) | 2009-12-16 | 2012-07-03 | Hoffmann La Roche | Deteccion de la descomposicion de las enzimas en un elemento de prueba mediante la liberacion controlada de analito protegido. |
| KR101252351B1 (ko) * | 2010-05-24 | 2013-04-08 | 동국대학교 산학협력단 | 전기효소적 합성 반응을 위한 ｎａｄ(ｐ) 유도체의 전기화학적 환원 방법 |
| CN102453067B (zh) * | 2010-10-29 | 2015-08-05 | 中国科学院大连化学物理研究所 | 一种nad+类似物的制备方法及其应用 |
| CN103347858B (zh) | 2011-01-26 | 2016-09-14 | 霍夫曼-拉罗奇有限公司 | 制备n-取代的吡啶鎓化合物的方法和物质 |
| EP2977004B1 (de) | 2011-04-12 | 2019-10-02 | Roche Diabetes Care GmbH | Analytisches hilfsmittel |
| US9752990B2 (en) | 2013-09-30 | 2017-09-05 | Honeywell International Inc. | Low-powered system for driving a fuel control mechanism |
| CN102863495A (zh) * | 2011-07-06 | 2013-01-09 | 上海执诚生物科技股份有限公司 | 一种含有nad+或nadh的稳定的组合物 |
| JP2014530208A (ja) | 2011-09-28 | 2014-11-17 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | アゾメディエーター |
| JP6128808B2 (ja) * | 2011-11-15 | 2017-05-17 | 栄研化学株式会社 | 酵素活性の検出、測定方法およびこれを利用したキット |
| EP2620507A1 (en) | 2012-01-25 | 2013-07-31 | Roche Diagnostics GmbH | Method for the evaluation of the quality of a test element |
| EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
| CN104246482B (zh) | 2012-04-19 | 2017-04-12 | 霍夫曼-拉罗奇有限公司 | 用于测定血液中的分析物浓度的方法和设备 |
| US8920628B2 (en) | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Systems and methods for multiple analyte analysis |
| US8921061B2 (en) * | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Reagent materials and associated test elements |
| HUE034313T2 (en) | 2012-12-20 | 2018-02-28 | Hoffmann La Roche | Procedures for evaluating medical measurement curves |
| CA2884919C (en) | 2012-12-20 | 2021-05-04 | F. Hoffmann-La Roche Ag | Method for analyzing a sample of a body fluid |
| EP2770064A1 (de) | 2013-02-22 | 2014-08-27 | F. Hoffmann-La Roche AG | Hocheffiziente Herstellung von Blutglucose-Teststreifen |
| EP2781919A1 (en) | 2013-03-19 | 2014-09-24 | Roche Diagniostics GmbH | Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid |
| EP2994536B1 (en) | 2013-05-08 | 2017-06-14 | Roche Diabetes Care GmbH | Stabilization of enzymes by nicotinic acid |
| CN105247069A (zh) * | 2013-06-04 | 2016-01-13 | 豪夫迈·罗氏有限公司 | 用于fret的新化合物及与其相关的方法 |
| EP2811299A1 (en) | 2013-06-07 | 2014-12-10 | Roche Diagniostics GmbH | Test element for detecting at least one analyte in a body fluid |
| WO2015063025A1 (en) | 2013-10-29 | 2015-05-07 | F. Hoffmann-La Roche Ag | Nano-enzyme containers for test elements |
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| US20170233787A1 (en) * | 2014-08-05 | 2017-08-17 | Becton, Dickinson And Company | Methods and compositions for analyzing glucose-6-phosphate dehydrogenase activity in blood samples |
| EP3757096B1 (en) | 2014-08-22 | 2025-03-12 | Roche Diagnostics GmbH | Redoxindicators for a use in cell viability testing |
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| EP3394252B1 (en) | 2015-12-21 | 2020-04-29 | F. Hoffmann-La Roche AG | Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same |
| CN108473966A (zh) | 2016-02-09 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 来自类球红细菌的突变体3-羟基丁酸脱氢酶及其相关方法和用途 |
| EP4481375A3 (en) | 2016-10-05 | 2025-04-02 | F. Hoffmann-La Roche AG | Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same |
| EP3339431A1 (en) | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
| CN107966555A (zh) * | 2017-11-23 | 2018-04-27 | 中山市创艺生化工程有限公司 | 一种用于稳定保存nad或其衍生物的存储液 |
| EP3759231B1 (en) | 2018-02-28 | 2023-10-18 | F. Hoffmann-La Roche AG | Biocompatibility coating for continuous analyte measurement |
| CN111217744A (zh) * | 2018-11-26 | 2020-06-02 | 中国科学院大连化学物理研究所 | 一种d-氨基酸基nad+类似物及其合成和应用 |
| WO2022132963A1 (en) | 2020-12-15 | 2022-06-23 | Abbott Diabetes Care Inc. | Nad(p) depot for nad(p)-dependent enzyme-based sensors |
| WO2025245355A1 (en) | 2024-05-24 | 2025-11-27 | Abbott Diabetes Care Inc. | Dispensed area and drop solid content tunability |
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| JPS53107486A (en) * | 1977-02-28 | 1978-09-19 | Wako Pure Chem Ind Ltd | Stabilized nadh aqueous solution |
| JPS61274636A (ja) | 1985-05-30 | 1986-12-04 | 西南自動車工業株式会社 | 活魚水槽 |
| US5801006A (en) * | 1997-02-04 | 1998-09-01 | Specialty Assays, Inc. | Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites |
| JP4260245B2 (ja) * | 1998-06-25 | 2009-04-30 | 株式会社三菱化学ヤトロン | 還元型ニコチンアミドアデニンジヌクレオチド類の分解を防止する方法及び分解防止用試薬 |
| US6380380B1 (en) | 1999-01-04 | 2002-04-30 | Specialty Assays, Inc. | Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates |
| WO2001094370A1 (en) | 2000-06-07 | 2001-12-13 | Wako Pure Chemical Industries, Ltd. | Coenzyme derivatives and enzymes appropriate therefor |
| US8846132B2 (en) | 2002-05-16 | 2014-09-30 | Roche Diagnostics Operations, Inc. | Method for producing polymer layers |
| DE10221845A1 (de) | 2002-05-16 | 2003-11-27 | Roche Diagnostics Gmbh | Verfahren und Reagenzsystem mit nicht-regenerierbarem Enzym-Coenzym-Komplex |
| DE102005035461A1 (de) * | 2005-07-28 | 2007-02-15 | Roche Diagnostics Gmbh | Stabile NAD/NADH-Derivate |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012224638A (ja) * | 2005-07-28 | 2012-11-15 | F Hoffmann-La Roche Ag | 安定なｎａｄ／ｎａｄｈ誘導体 |
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