JP5128940B2 - 置換イミダゾキノリン、イミダゾピリジン、およびイミダゾナフチリジン - Google Patents
置換イミダゾキノリン、イミダゾピリジン、およびイミダゾナフチリジン Download PDFInfo
- Publication number
- JP5128940B2 JP5128940B2 JP2007516773A JP2007516773A JP5128940B2 JP 5128940 B2 JP5128940 B2 JP 5128940B2 JP 2007516773 A JP2007516773 A JP 2007516773A JP 2007516773 A JP2007516773 A JP 2007516773A JP 5128940 B2 JP5128940 B2 JP 5128940B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- alkylene
- mmol
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[n]1c(c(*)c(*)nc2)c2nc1* Chemical compound C[n]1c(c(*)c(*)nc2)c2nc1* 0.000 description 7
- ARFLRXBQSACJDT-UHFFFAOYSA-N CCNC1(CC1)O Chemical compound CCNC1(CC1)O ARFLRXBQSACJDT-UHFFFAOYSA-N 0.000 description 1
- ZDXQGELFNKIKJO-UHFFFAOYSA-N CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCOCC1)NS(C)(=O)=O Chemical compound CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCOCC1)NS(C)(=O)=O ZDXQGELFNKIKJO-UHFFFAOYSA-N 0.000 description 1
- ZXDZVERSDOMZHA-UHFFFAOYSA-N CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CCC1(CCCCC1)O Chemical compound CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CCC1(CCCCC1)O ZXDZVERSDOMZHA-UHFFFAOYSA-N 0.000 description 1
- CSMBBMUEKKEEDW-UHFFFAOYSA-N CCc1nc2c(N)nc(cccc3)c3c2[n]1CC(CC1)(CCN1S(C)(=O)=O)O Chemical compound CCc1nc2c(N)nc(cccc3)c3c2[n]1CC(CC1)(CCN1S(C)(=O)=O)O CSMBBMUEKKEEDW-UHFFFAOYSA-N 0.000 description 1
- XYVOGZHQWDDMIH-UHFFFAOYSA-N CCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCC1)O Chemical compound CCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCC1)O XYVOGZHQWDDMIH-UHFFFAOYSA-N 0.000 description 1
- CVLOKCLWSBSIQZ-UHFFFAOYSA-N COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCC1)O Chemical compound COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCC1)O CVLOKCLWSBSIQZ-UHFFFAOYSA-N 0.000 description 1
- GOUOTEXHGINABP-UHFFFAOYSA-N COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCCC1)O Chemical compound COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCCC1)O GOUOTEXHGINABP-UHFFFAOYSA-N 0.000 description 1
- VKFXAXZJHBUSAD-UHFFFAOYSA-N Cc1nc2c(N)nc(C)c(C)c2[n]1CC1(CCOCC1)O Chemical compound Cc1nc2c(N)nc(C)c(C)c2[n]1CC1(CCOCC1)O VKFXAXZJHBUSAD-UHFFFAOYSA-N 0.000 description 1
- ZQMLODWLYNGVBU-UHFFFAOYSA-N Cc1nc2cnc(C)c(C)c2[n]1CC1(CCOCC1)O Chemical compound Cc1nc2cnc(C)c(C)c2[n]1CC1(CCOCC1)O ZQMLODWLYNGVBU-UHFFFAOYSA-N 0.000 description 1
- YVJDSNJBFUZDKA-UHFFFAOYSA-N Nc1c2nc(CNC(C3CC3)=O)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 Chemical compound Nc1c2nc(CNC(C3CC3)=O)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 YVJDSNJBFUZDKA-UHFFFAOYSA-N 0.000 description 1
- YMKWTWVPHJHFNS-UHFFFAOYSA-N Nc1c2nc(CO)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 Chemical compound Nc1c2nc(CO)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 YMKWTWVPHJHFNS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58127404P | 2004-06-18 | 2004-06-18 | |
| US60/581,274 | 2004-06-18 | ||
| PCT/US2005/021445 WO2006028545A2 (en) | 2004-06-18 | 2005-06-17 | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008503484A JP2008503484A (ja) | 2008-02-07 |
| JP2008503484A5 JP2008503484A5 (https=) | 2008-08-07 |
| JP5128940B2 true JP5128940B2 (ja) | 2013-01-23 |
Family
ID=36036778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007516773A Expired - Fee Related JP5128940B2 (ja) | 2004-06-18 | 2005-06-17 | 置換イミダゾキノリン、イミダゾピリジン、およびイミダゾナフチリジン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7884207B2 (https=) |
| EP (1) | EP1765348B1 (https=) |
| JP (1) | JP5128940B2 (https=) |
| AU (1) | AU2005283085B2 (https=) |
| CA (1) | CA2571360C (https=) |
| WO (1) | WO2006028545A2 (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04012199A (es) | 2002-06-07 | 2005-02-25 | 3M Innovative Properties Co | Imidazopiridinas sustituidas con eter. |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| MXPA06002199A (es) * | 2003-08-27 | 2006-05-22 | 3M Innovative Properties Co | Imidazoquinolinas sustituidas con grupos ariloxi o arilalquilenoxi. |
| CA2537763A1 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for cd5+ b cell lymphoma |
| TW200526656A (en) | 2003-10-03 | 2005-08-16 | 3M Innovative Properties Co | Pyrazolopyridines and analogs thereof |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| CA2540541C (en) | 2003-10-03 | 2012-03-27 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| WO2005051317A2 (en) | 2003-11-25 | 2005-06-09 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| US8541438B2 (en) * | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| US7915281B2 (en) | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
| ATE555786T1 (de) | 2004-09-02 | 2012-05-15 | 3M Innovative Properties Co | 1-alkoxy 1h-imidazo-ringsysteme und verfahren |
| AU2005326708C1 (en) | 2004-12-30 | 2012-08-30 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| JP5543068B2 (ja) | 2004-12-30 | 2014-07-09 | スリーエム イノベイティブ プロパティズ カンパニー | キラル縮合[1,2]イミダゾ[4,5−c]環状化合物 |
| WO2006084251A2 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
| AU2006338521A1 (en) | 2005-02-09 | 2007-10-11 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted thiazolo(4,5-c) ring compounds and methods |
| ES2475728T3 (es) * | 2005-02-09 | 2014-07-11 | 3M Innovative Properties Company | Tiazoloquinolinas y tiazolonaftiridinas sustituidas con alcoxi |
| CA2597446A1 (en) * | 2005-02-11 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Substituted imidazoquinolines and imidazonaphthyridines |
| CA2597587A1 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods |
| CA2598695A1 (en) * | 2005-02-23 | 2006-09-21 | Coley Pharmaceutical Group, Inc. | Hydroxyalkyl substituted imidazoquinolines |
| US8343993B2 (en) | 2005-02-23 | 2013-01-01 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazonaphthyridines |
| WO2006091647A2 (en) * | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Method of preferentially inducing the biosynthesis of interferon |
| CA2598656A1 (en) * | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Hydroxyalkyl substituted imidazoquinoline compounds and methods |
| JP2008535832A (ja) | 2005-04-01 | 2008-09-04 | コーリー ファーマシューティカル グループ,インコーポレイテッド | ピラゾロピリジン−1,4−ジアミン、およびそのアナログ |
| JP2008538550A (ja) * | 2005-04-01 | 2008-10-30 | コーリー ファーマシューティカル グループ,インコーポレイテッド | ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての1−置換ピラゾロ(3,4−c)環状化合物 |
| EA200800782A1 (ru) * | 2005-09-09 | 2008-08-29 | Коли Фармасьютикал Груп, Инк. | ПРОИЗВОДНЫЕ АМИДА И КАРБАМАТА N-{2-[4-АМИНО-2-(ЭТОКСИМЕТИЛ)-1Н-ИМИДАЗОЛО[4,5-c]ХИНОЛИН-1-IL]-1,1-ДИМЕТИЛЭТИЛ}МЕТАНСУЛЬФОНАМИДА И СПОСОБЫ |
| ZA200803029B (en) | 2005-09-09 | 2009-02-25 | Coley Pharm Group Inc | Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods |
| KR20080083270A (ko) | 2005-11-04 | 2008-09-17 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 하이드록시 및 알콕시 치환된 1에이치 이미다조퀴놀린 및방법 |
| EP1988896A4 (en) | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | CONJUGATES TO MODIFY IMMUNE REACTIONS |
| WO2007106854A2 (en) * | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| US7906506B2 (en) | 2006-07-12 | 2011-03-15 | 3M Innovative Properties Company | Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods |
| WO2008030511A2 (en) * | 2006-09-06 | 2008-03-13 | Coley Pharmaceuticial Group, Inc. | Substituted 3,4,6,7-tetrahydro-5h, 1,2a,4a,8-tetraazacyclopenta[cd]phenalenes |
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| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| WO2009125809A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | ピペリジン誘導体 |
| WO2009125808A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | アミノシクロヘキシル誘導体 |
| US8232409B2 (en) | 2008-10-15 | 2012-07-31 | Janssen Pharmaceutica N.V. | Heterocyclic benzimidazoles as TRPM8 modulators |
| EP2523957A1 (en) * | 2010-01-12 | 2012-11-21 | F. Hoffmann-La Roche AG | Tricyclic heterocyclic compounds, compositions and methods of use thereof |
| EP2397482A1 (en) | 2010-06-15 | 2011-12-21 | Almirall, S.A. | Heteroaryl imidazolone derivatives as jak inhibitors |
| ES2617451T3 (es) | 2010-08-17 | 2017-06-19 | 3M Innovative Properties Company | Composiciones lipidadas de compuestos modificadores de la respuesta inmunitaria, formulaciones, y métodos |
| WO2012167088A1 (en) | 2011-06-03 | 2012-12-06 | 3M Innovative Properties Company | Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom |
| EP3153180A1 (en) | 2011-06-03 | 2017-04-12 | 3M Innovative Properties Company | Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| PT2941233T (pt) | 2013-01-07 | 2020-11-13 | Univ Pennsylvania | Composições e métodos para tratar linfoma cutâneo de células t |
| WO2014139080A1 (en) * | 2013-03-12 | 2014-09-18 | Boehringer Ingelheim International Trading (Shanghai) Co., Ltd. | Novel process for the manufacture of 3-oxo-tetrahydrofuran |
| EP4105208A1 (en) | 2013-07-31 | 2022-12-21 | Novartis AG | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions |
| US9920052B2 (en) | 2013-12-09 | 2018-03-20 | Ucb Biopharma Sprl | Imidazopyridine derivatives as modulators of TNF activity |
| CN108026092B (zh) | 2015-08-31 | 2021-01-26 | 3M创新有限公司 | 胍取代的咪唑并[4,5-c]环化合物 |
| WO2017040234A1 (en) | 2015-08-31 | 2017-03-09 | 3M Innovative Properties Company | IMIDAZO[4,5-c] RING COMPOUNDS CONTAINING SUBSTITUTED GUANIDINE GROUPS |
| EP3356371A4 (en) * | 2015-09-29 | 2020-06-24 | The University of Chicago | POLYMER CONJUGATE VACCINE |
| WO2017059280A1 (en) | 2015-10-02 | 2017-04-06 | The University Of North Carolina At Chapel Hill | Novel pan-tam inhibitors and mer/axl dual inhibitors |
| KR102726248B1 (ko) | 2016-07-07 | 2024-11-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
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| EP3589631B1 (en) | 2017-03-01 | 2021-07-21 | 3M Innovative Properties Company | Imidazo[4,5-c]ring compounds containing guanidine substituted benzamide groups |
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| JP7251893B2 (ja) | 2018-02-28 | 2023-04-04 | スリーエム イノベイティブ プロパティズ カンパニー | N-1分枝基を有する置換イミダゾ[4,5-c]キノリン化合物 |
| JP2021516045A (ja) | 2018-02-28 | 2021-07-01 | ファイザー・インク | Il−15バリアントおよびその使用 |
| SI3797121T1 (sl) | 2018-05-23 | 2024-09-30 | Pfizer Inc. | Protitelesa, specifična za CD3, in njihova uporaba |
| MX2020012607A (es) | 2018-05-23 | 2021-01-29 | Pfizer | Anticuerpos especificos para gucy2c y sus usos. |
| CN112218864B (zh) * | 2018-05-24 | 2023-09-08 | 3M创新有限公司 | N-1支链环烷基取代的咪唑并[4,5-c]喹啉化合物、组合物和方法 |
| WO2020128893A1 (en) | 2018-12-21 | 2020-06-25 | Pfizer Inc. | Combination treatments of cancer comprising a tlr agonist |
| AU2020241686A1 (en) | 2019-03-15 | 2021-11-04 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting HER2 |
| WO2020198583A1 (en) | 2019-03-27 | 2020-10-01 | Insilico Medicine Ip Limited | Bicyclic jak inhibitors and uses thereof |
| US11458163B2 (en) | 2019-04-17 | 2022-10-04 | University Of Kansas | Platinum(IV) conjugates and methods of use |
| CN115151253B (zh) * | 2019-09-23 | 2025-04-15 | 南京征祥医药有限公司 | 磷酸二酯酶抑制剂及用途 |
| JP7369297B2 (ja) | 2019-12-17 | 2023-10-25 | ファイザー・インク | Cd47、pd-l1に特異的な抗体、およびその使用 |
| TW202216779A (zh) | 2020-07-17 | 2022-05-01 | 美商輝瑞股份有限公司 | 治療性抗體類和彼等之用途 |
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2005
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- 2005-06-17 EP EP05814989.9A patent/EP1765348B1/en not_active Expired - Lifetime
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Also Published As
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|---|---|
| EP1765348B1 (en) | 2016-08-03 |
| CA2571360C (en) | 2014-11-25 |
| AU2005283085B2 (en) | 2012-06-21 |
| US7884207B2 (en) | 2011-02-08 |
| CA2571360A1 (en) | 2006-03-16 |
| US20070287724A1 (en) | 2007-12-13 |
| WO2006028545A2 (en) | 2006-03-16 |
| WO2006028545A3 (en) | 2007-08-23 |
| JP2008503484A (ja) | 2008-02-07 |
| EP1765348A2 (en) | 2007-03-28 |
| EP1765348A4 (en) | 2010-05-26 |
| AU2005283085A1 (en) | 2006-03-16 |
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