JP5127723B2 - 新規な硫酸水素塩 - Google Patents

新規な硫酸水素塩 Download PDF

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JP5127723B2
JP5127723B2 JP2008547679A JP2008547679A JP5127723B2 JP 5127723 B2 JP5127723 B2 JP 5127723B2 JP 2008547679 A JP2008547679 A JP 2008547679A JP 2008547679 A JP2008547679 A JP 2008547679A JP 5127723 B2 JP5127723 B2 JP 5127723B2
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fluoro
bromo
phenylamino
chloro
methyl
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JP2009521487A (ja
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スクワイアー、クリストファー、ジョン
デマッテイ、ジョン
ロバーツ、ロナルド、ジョン
− スン ツァン、ツン
− シン、ゴークン シャルマ
ペルベズ、モハメド
フォード、ジェイムズ、ゲア
ストレイ、リチャード、アンソニー
ディキンソン、ポール、アルフレッド
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アレイ バイオファーマ、インコーポレイテッド
アストラゼネカ エービー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
JP2008547679A 2005-12-21 2006-12-12 新規な硫酸水素塩 Active JP5127723B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75278105P 2005-12-21 2005-12-21
US60/752,781 2005-12-21
PCT/US2006/061895 WO2007076245A2 (en) 2005-12-21 2006-12-12 Novel hydrogen sulfate salt

Publications (2)

Publication Number Publication Date
JP2009521487A JP2009521487A (ja) 2009-06-04
JP5127723B2 true JP5127723B2 (ja) 2013-01-23

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ID=38218759

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JP2008547679A Active JP5127723B2 (ja) 2005-12-21 2006-12-12 新規な硫酸水素塩

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US (4) US20100016393A1 (hr)
EP (1) EP1968948B1 (hr)
JP (1) JP5127723B2 (hr)
KR (1) KR101361460B1 (hr)
CN (2) CN101360718B (hr)
AR (1) AR058696A1 (hr)
AU (1) AU2006330759B2 (hr)
BR (1) BRPI0620091A2 (hr)
CA (1) CA2634149C (hr)
CY (1) CY1114303T1 (hr)
DK (1) DK1968948T3 (hr)
EC (1) ECSP088597A (hr)
ES (1) ES2421746T3 (hr)
FR (1) FR21C1051I2 (hr)
HK (1) HK1124043A1 (hr)
HR (1) HRP20130663T1 (hr)
HU (1) HUS2100046I1 (hr)
IL (1) IL192224A (hr)
LT (1) LTC1968948I2 (hr)
MX (1) MX2008008298A (hr)
MY (1) MY157733A (hr)
NL (1) NL301139I2 (hr)
NZ (1) NZ569792A (hr)
PL (1) PL1968948T3 (hr)
PT (1) PT1968948E (hr)
RS (1) RS52843B (hr)
SI (1) SI1968948T1 (hr)
TW (1) TWI405756B (hr)
UA (1) UA93531C2 (hr)
WO (1) WO2007076245A2 (hr)
ZA (1) ZA200805705B (hr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220405506A1 (en) * 2021-06-22 2022-12-22 Intrinsic Innovation Llc Systems and methods for a vision guided end effector

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PT3000810T (pt) 2002-03-13 2017-10-25 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
TWI405756B (zh) 2005-12-21 2013-08-21 Array Biopharma Inc 新穎硫酸氫鹽
EP2231281A2 (en) * 2007-12-12 2010-09-29 AstraZeneca AB Combination comprising a mek inhibitor and an aurora kinase inhibitor
SA109300195B1 (ar) * 2008-03-28 2013-04-20 Astrazeneca Ab تركيبة صيدلانية جديدة مضادة للسرطان
WO2011095807A1 (en) 2010-02-07 2011-08-11 Astrazeneca Ab Combinations of mek and hh inhibitors
WO2012145503A1 (en) * 2011-04-21 2012-10-26 Novartis Ag Pharmaceutical combinations
CA2856297C (en) 2011-11-23 2023-10-17 Medimmune, Llc Binding molecules specific for her3 and uses thereof
WO2013109142A1 (en) 2012-01-16 2013-07-25 Stichting Het Nederlands Kanker Instituut Combined pdk and mapk/erk pathway inhibition in neoplasia
PT3702351T (pt) 2012-10-19 2024-01-17 Array Biopharma Inc Formulação contendo um inibidor de mek
RU2656597C2 (ru) 2013-03-06 2018-06-06 Астразенека Аб Хиназолиновые ингибиторы активирующих мутированных форм рецептора эпидермального фактора роста
WO2015041534A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk in combination with raf/erk/mek
US9629851B2 (en) 2013-09-20 2017-04-25 Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis ROCK in combination with MAPK pathway
US20170027940A1 (en) 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (en) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions for cancer treatment
CN105566327A (zh) * 2014-10-09 2016-05-11 江苏恒瑞医药股份有限公司 一种jak激酶抑制剂的硫酸氢盐的i型结晶及其制备方法
EP3355923B1 (en) 2015-10-01 2022-02-23 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Histone deacetylase inhibitors for use in the treatment of drug resistant melanoma
AU2016336133B2 (en) * 2015-10-06 2021-02-25 Redhill Biopharma Ltd. Combination therapies for treating cancer
WO2017099591A1 (en) 2015-12-07 2017-06-15 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Treatment of inhibitor resistant braf-mutant cancers
WO2017204626A1 (en) 2016-05-24 2017-11-30 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Combination therapy - combined map2k4/map3k1 and mek/erk inhibition
US20230192625A1 (en) * 2017-11-14 2023-06-22 Shenzhen Targetrx, Inc. Substituted benzimidazole compound and composition comprising same
RS64236B1 (sr) * 2018-10-31 2023-06-30 Servier Lab Nova so bcl-2 inhibitora, kristalni oblik iste, postupak za njenu pripremu i farmaceutske kompozicije koje je sadrže
WO2023238000A1 (en) * 2022-06-06 2023-12-14 Glenmark Life Sciences Limited Process for preparation of selumetinib and salts thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220405506A1 (en) * 2021-06-22 2022-12-22 Intrinsic Innovation Llc Systems and methods for a vision guided end effector

Also Published As

Publication number Publication date
CA2634149A1 (en) 2007-07-05
KR20080080200A (ko) 2008-09-02
ES2421746T3 (es) 2013-09-05
MX2008008298A (es) 2008-09-24
TW200800915A (en) 2008-01-01
PL1968948T3 (pl) 2013-10-31
PT1968948E (pt) 2013-07-25
MY157733A (en) 2016-07-15
US9562017B2 (en) 2017-02-07
IL192224A (en) 2014-08-31
CN101360718A (zh) 2009-02-04
CN102329270A (zh) 2012-01-25
JP2009521487A (ja) 2009-06-04
US20120253049A1 (en) 2012-10-04
NL301139I1 (hr) 2021-11-03
ZA200805705B (en) 2012-09-26
LTPA2021530I1 (hr) 2021-12-27
US9156795B2 (en) 2015-10-13
CA2634149C (en) 2013-08-13
FR21C1051I1 (fr) 2021-12-24
US20160024018A1 (en) 2016-01-28
TWI405756B (zh) 2013-08-21
CN101360718B (zh) 2012-01-11
SI1968948T1 (sl) 2013-08-30
NZ569792A (en) 2011-01-28
HK1124043A1 (en) 2009-07-03
ECSP088597A (es) 2008-08-29
BRPI0620091A2 (pt) 2011-11-01
HUS2100046I1 (hu) 2021-11-29
HRP20130663T1 (en) 2013-08-31
EP1968948B1 (en) 2013-05-22
AU2006330759B2 (en) 2012-12-06
FR21C1051I2 (fr) 2023-02-17
WO2007076245A2 (en) 2007-07-05
DK1968948T3 (da) 2013-08-26
RS52843B (en) 2013-12-31
EP1968948A4 (en) 2010-12-15
WO2007076245A3 (en) 2008-01-24
KR101361460B1 (ko) 2014-02-10
US20140221443A1 (en) 2014-08-07
US20100016393A1 (en) 2010-01-21
AU2006330759A1 (en) 2007-07-05
NL301139I2 (nl) 2022-02-22
CY1114303T1 (el) 2016-08-31
LTC1968948I2 (hr) 2023-07-10
EP1968948A2 (en) 2008-09-17
AR058696A1 (es) 2008-02-20
UA93531C2 (en) 2011-02-25
IL192224A0 (en) 2009-02-11

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