JP5117384B2 - 点眼剤の形態における眼用生理学的サプリメントまたは医薬の調製のためのｌ−カルニチンまたはアルカノイルｌ−カルニチンの使用 - Google Patents
点眼剤の形態における眼用生理学的サプリメントまたは医薬の調製のためのｌ−カルニチンまたはアルカノイルｌ−カルニチンの使用 Download PDFInfo
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- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004382 visual function Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05014337 | 2005-07-01 | ||
| EP05014337.9 | 2005-07-01 | ||
| PCT/EP2006/062919 WO2007003481A1 (en) | 2005-07-01 | 2006-06-06 | Use of l-carnitine or of alkanoyl l-carnitines for the preparation of a physiological supplement or medicament for ophthalmic use in the form of eye-drops |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500369A JP2009500369A (ja) | 2009-01-08 |
| JP2009500369A5 JP2009500369A5 (ko) | 2009-07-23 |
| JP5117384B2 true JP5117384B2 (ja) | 2013-01-16 |
Family
ID=36930661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519890A Expired - Fee Related JP5117384B2 (ja) | 2005-07-01 | 2006-06-06 | 点眼剤の形態における眼用生理学的サプリメントまたは医薬の調製のためのｌ−カルニチンまたはアルカノイルｌ−カルニチンの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7655698B2 (ko) |
| EP (1) | EP1906949B1 (ko) |
| JP (1) | JP5117384B2 (ko) |
| KR (1) | KR101401353B1 (ko) |
| CN (1) | CN101242825B (ko) |
| AU (1) | AU2006265248B2 (ko) |
| BR (1) | BRPI0612596A2 (ko) |
| CA (1) | CA2611909C (ko) |
| HK (1) | HK1118721A1 (ko) |
| MX (1) | MX2007016047A (ko) |
| TW (1) | TWI404526B (ko) |
| WO (1) | WO2007003481A1 (ko) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2611909C (en) * | 2005-07-01 | 2014-01-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition for treatment of corneal disease |
| JP5384362B2 (ja) * | 2006-12-11 | 2014-01-08 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 角膜疾患を処置するための点眼剤の形態の医薬の調製におけるｌ−カルニチンの使用 |
| EP2101725A1 (en) * | 2006-12-14 | 2009-09-23 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Use of l-carnitine or of alkanoyl l-carnitines for the preparation of a physiological supplement or medicament for ophthalmic use in the form of eye drops |
| BRPI0720434A2 (pt) * | 2006-12-22 | 2014-01-07 | Sigma Tau Ind Farmaceuti | Gel útil para liberação de fármacos oftálmicos |
| WO2009006130A2 (en) * | 2007-06-28 | 2009-01-08 | Bausch & Lomb Incorporated | Salt free hyaluronate ophthalmic solution |
| TWI474817B (zh) * | 2008-07-04 | 2015-03-01 | Sigma Tau Ind Farmaceuti | 用於預防或治療調節性眼疲勞之化合物類 |
| WO2010085568A1 (en) * | 2009-01-21 | 2010-07-29 | The Research Foundation Of State University Of New York | Methods of diagnosing and treating severe dry eye syndrome |
| US20110015154A1 (en) * | 2009-07-20 | 2011-01-20 | Kellermann Gottfried H | Supporting acetylcholine function |
| US20110098265A1 (en) * | 2009-10-28 | 2011-04-28 | Neuroscience, Inc. | Methods for reducing cravings and impulses associated with addictive and compulsive behaviors |
| EP2363126A1 (en) * | 2010-03-04 | 2011-09-07 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Composition comprising as active ingredient L-carnitine in combination with hydroxykynurenine-O-beta-DL-glucoside, for the prevention and/or treatment of pathologies of the eye due to ultraviolet radiation |
| US10085960B2 (en) | 2012-03-30 | 2018-10-02 | Brien Holden Vision Institute | Methods and compositions for reducing ocular discomfort |
| US10238673B2 (en) * | 2013-03-13 | 2019-03-26 | Genetic Disease Investigators, LLC | Methods and compositions for treatment of dry eye and correction of organ dysfunctions |
| EP2783695A1 (en) * | 2013-03-28 | 2014-10-01 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Physiological supplement or medicament for ophthalmic use containing L-carnitine or alkanoyl L-carnitines in combination with eledoisin |
| US9173915B1 (en) | 2014-10-10 | 2015-11-03 | Peter F. Kador | Antioxidant eye drops |
| CN110559261A (zh) * | 2018-06-06 | 2019-12-13 | 常州药物研究所有限公司 | 含有纳米交联透明质酸的脂质体微乳及其制备方法和应用 |
| CN110604811B (zh) * | 2018-06-14 | 2023-01-31 | 陕西慧康生物科技有限责任公司 | 含有重组人溶菌酶和重组人表皮生长因子的人工泪液 |
| CN110604812B (zh) * | 2018-06-14 | 2023-01-31 | 陕西慧康生物科技有限责任公司 | 一种含有重组人溶菌酶的人工泪液 |
| WO2021221741A1 (en) * | 2020-04-28 | 2021-11-04 | Lonza Consumer Health Inc. | Nutritional composition comprising carnitine and method for treating or preventing an infection in a mammal |
| WO2023069036A1 (en) * | 2021-10-18 | 2023-04-27 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | An ophthalmic formulation for treatment and prevention of cataract and production method thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1263606A (en) * | 1985-05-29 | 1989-12-05 | Jeffrey P. Gilbard | Non-toxic opthalmic preparations |
| GB8710780D0 (en) * | 1987-05-07 | 1987-06-10 | Scras | Opthalmological application of eicosapentaenoic acid |
| IT1235153B (it) * | 1988-11-15 | 1992-06-22 | Sigma Tau Ind Farmaceuti | Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento |
| EP0546728A3 (en) * | 1991-12-13 | 1993-09-08 | Alcon Laboratories Inc | Physiological tear compositions and methods for their preparation |
| WO1995005803A1 (en) * | 1993-08-20 | 1995-03-02 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| EP0778021A4 (en) * | 1994-09-14 | 1998-06-03 | Taisho Pharmaceutical Co Ltd | DROPS TO CARE FOR THE CORNEA |
| JPH08133968A (ja) * | 1994-09-14 | 1996-05-28 | Taisho Pharmaceut Co Ltd | 角膜障害修復用点眼液 |
| AU730307B2 (en) * | 1995-11-14 | 2001-03-01 | Xoma Corporation | Bactericidal permeability increasing protein (BPI) for treating conditions associated with corneal injury |
| KR980008239A (ko) * | 1996-07-26 | 1998-04-30 | 김충환 | 사이클로스포린-함유 약학적 조성물 |
| US5817630A (en) * | 1997-03-18 | 1998-10-06 | Austin Nutriceutical Corporation | Glutathione antioxidant eye drops |
| AU1295200A (en) * | 1998-11-13 | 2000-06-05 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| ES2206363T3 (es) * | 2000-04-07 | 2004-05-16 | Laboratoire Medidom S.A. | Formulaciones oftalmicas a base de ciclosporina, de acido hialuronico y de polisorbato. |
| RU2165749C1 (ru) * | 2000-07-06 | 2001-04-27 | Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" | Способ восстановления эндотелия роговицы |
| AU2002252338B2 (en) * | 2001-03-15 | 2007-09-13 | Rhode Island Hospital, A Lifespan Partner | Taurine compounds |
| AU2003259145A1 (en) * | 2002-07-17 | 2004-02-02 | Spencer P. Thornton | Treatment for dry eye syndrome |
| US7465463B2 (en) * | 2002-09-04 | 2008-12-16 | Polyheal, Ltd. | Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues |
| EP1611883A1 (en) * | 2003-03-26 | 2006-01-04 | Menicon Co., Ltd. | Composition for ophthalmic use |
| US8569367B2 (en) * | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| CA2611909C (en) * | 2005-07-01 | 2014-01-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition for treatment of corneal disease |
-
2006
- 2006-06-06 CA CA2611909A patent/CA2611909C/en not_active Expired - Fee Related
- 2006-06-06 MX MX2007016047A patent/MX2007016047A/es active IP Right Grant
- 2006-06-06 KR KR1020087002706A patent/KR101401353B1/ko not_active IP Right Cessation
- 2006-06-06 WO PCT/EP2006/062919 patent/WO2007003481A1/en active Application Filing
- 2006-06-06 BR BRPI0612596-4A patent/BRPI0612596A2/pt not_active IP Right Cessation
- 2006-06-06 CN CN2006800297134A patent/CN101242825B/zh not_active Expired - Fee Related
- 2006-06-06 JP JP2008519890A patent/JP5117384B2/ja not_active Expired - Fee Related
- 2006-06-06 EP EP06763523.5A patent/EP1906949B1/en active Active
- 2006-06-06 AU AU2006265248A patent/AU2006265248B2/en not_active Ceased
- 2006-06-20 TW TW095122061A patent/TWI404526B/zh not_active IP Right Cessation
- 2006-12-14 US US11/570,662 patent/US7655698B2/en not_active Expired - Fee Related
-
2008
- 2008-09-29 HK HK08110830.5A patent/HK1118721A1/xx not_active IP Right Cessation
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2009
- 2009-12-18 US US12/641,687 patent/US8377988B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007003481A1 (en) | 2007-01-11 |
| EP1906949B1 (en) | 2015-02-11 |
| US20100093858A1 (en) | 2010-04-15 |
| US7655698B2 (en) | 2010-02-02 |
| US8377988B2 (en) | 2013-02-19 |
| JP2009500369A (ja) | 2009-01-08 |
| BRPI0612596A2 (pt) | 2010-11-23 |
| TW200744574A (en) | 2007-12-16 |
| KR20080030077A (ko) | 2008-04-03 |
| KR101401353B1 (ko) | 2014-05-29 |
| AU2006265248A1 (en) | 2007-01-11 |
| CN101242825A (zh) | 2008-08-13 |
| CA2611909A1 (en) | 2007-01-11 |
| US20070265338A1 (en) | 2007-11-15 |
| HK1118721A1 (en) | 2009-02-20 |
| CN101242825B (zh) | 2011-03-30 |
| EP1906949A1 (en) | 2008-04-09 |
| MX2007016047A (es) | 2008-03-10 |
| TWI404526B (zh) | 2013-08-11 |
| AU2006265248B2 (en) | 2011-12-15 |
| CA2611909C (en) | 2014-01-07 |
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