JP5117384B2 - 点眼剤の形態における眼用生理学的サプリメントまたは医薬の調製のためのl−カルニチンまたはアルカノイルl−カルニチンの使用 - Google Patents
点眼剤の形態における眼用生理学的サプリメントまたは医薬の調製のためのl−カルニチンまたはアルカノイルl−カルニチンの使用 Download PDFInfo
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- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004382 visual function Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Description
- 上皮: これは外来物質、例えば、埃または水が眼、および角膜のその他の層に透過するのを阻止するために主に機能し、酸素および涙に含まれるその他の必要な細胞栄養素を吸収する滑らかな表面を提供する。この層は、約5細胞の深さであり、数千の小さい神経終末で満たされており、そのため角膜はこすられたりひっかかれたりした場合に疼痛に対して非常に感受性となる。
- 角膜実質: これは上皮の後ろに位置し、角膜実質は角膜の約 90 パーセントを構成する。それは主に水、角膜に強度、弾性および形状を与える層状のタンパク質繊維;そしてそれを備える細胞からなる。タンパク質繊維の特有の形状、編成および位置は、角膜の光を伝導する透明性を生み出すのに必須である。
-内皮: この細胞単層は角膜実質と眼房水との間に位置する。角膜実質は水を吸収する傾向があるため、内皮の主な働きは角膜実質の過剰の水をくみ出すことである。このポンプ作用がなければ、角膜実質は水により膨潤し、濁り、最終的には不透明になってしまう。
ここで、
L-カルニチンは好ましくは0.3-3%の用量で存在し、もっとも好ましくは1%の用量で存在する;
-タウリンは好ましくは0.1-4% の用量で存在し、もっとも好ましくは 0.5%の用量で存在する;
-ヒアルロン酸ナトリウムは好ましくは0.05-1.5%の用量で存在し、もっとも好ましくは 0.2%の用量で存在する;
-ビタミン Eは好ましくは0.05-1.0% の用量で存在し、もっとも好ましくは 0,2%の用量で存在する;
-マンガンは好ましくは0.01-0.1 mg/L の用量で存在し、もっとも好ましくは0.051 mg/Lの用量で存在する;
-亜鉛は好ましくは0.5-1.5 mg/L の用量で存在し、もっとも好ましくは 1.02 mg/Lの用量で存在する;
-ナトリウムは好ましくは5-5000 mg/Lの用量で存在し、もっとも好ましくは 30 mg/Lの用量で存在する;
-カリウムは好ましくは 1-1000 mg/Lの用量で存在し、もっとも好ましくは 9 mg/Lの用量で存在する。
実施例 1
眼球乾燥症候群を患う43名の患者を含めた臨床試験を行った。
この臨床試験において集めた患者サンプルは16名の患者からなり、8名の男性および8名の女性であり、21〜32歳であり (平均年齢: 25 ± 4.2 歳)、6 ジオプター以下の近視により両眼に屈折矯正レーザー手術 (PRK)を受けたものであった。
表 4
- L-カルニチン 1%;
-タウリン 0.5%;
- ヒアルロン酸ナトリウム 0.2%;
-ビタミン E 0,2%;
-マンガン 0.051 mg/L;
- 亜鉛 1.02 mg/L;
-ナトリウム 30 mg/L;
-カリウム 9 mg/L;
-ナトリウムメルチオラート(mertiolate) 0.02 mg/mL;
-鉱質除去水;
-体積5 mL/バイアル。
Claims (9)
- 角膜疾患の治療のための、点眼剤の形態における眼用生理学的サプリメントまたは医薬であって、
- 0.3-3.0%の範囲の L-カルニチン;
- 0.1-4.0%の範囲のタウリン;
- 0.05-1.5%の範囲のヒアルロン酸ナトリウム;
- 0.05-1.0%の範囲のビタミン E;
- 0.01-0.1 mg/Lの範囲のマンガン;
- 0.5-1.5 mg/Lの範囲の亜鉛;
- 5-5,000 mg/Lの範囲のナトリウム; および
- 1-1,000 mg/Lの範囲のカリウム
を含む、生理学的サプリメントまたは医薬。 - 1以上の眼科上許容される賦形剤もしくは希釈剤またはこれらの混合物をさらに含んでいてもよい、請求項1の生理学的サプリメントまたは医薬。
- 角膜疾患が、脱上皮疾患; 眼球乾燥症候群; 感染性角膜炎; 酸またはアルカリ腐蝕性損傷;角膜剥離および/または傷害;角膜実質の退行性疾患;屈折矯正レーザー手術による角膜実質損傷; ジストロフィー疾患および角膜表面の透明性の障害からなる群から選択される、請求項1の生理学的サプリメントまたは医薬。
- 角膜剥離および/または傷害が機械的作用またはコンタクトレンズに起因する請求項3の生理学的サプリメントまたは医薬。
- 角膜実質の退行性疾患が慢性または急性円錐角膜である請求項3の生理学的サプリメントまたは医薬。
- 該角膜表面の透明性の障害が、感染性角膜炎、角膜を構成する様々な成分の構造の傷害および損傷;遺伝性または退行性疾患に起因する請求項3の生理学的サプリメントまたは医薬。
- 角膜炎が、ウイルス、細菌または真菌薬に起因し; 角膜の構造の傷害および損傷が機械的、術後またはレーザー屈折矯正手術後型に起因し;遺伝性または退行性疾患が慢性または急性円錐角膜である、請求項6の生理学的サプリメントまたは医薬。
- 術後またはレーザー屈折矯正手術後損傷が混濁である、請求項7の生理学的サプリメントまたは医薬。
- 抗酸化剤; ビタミン C; ルリジサ油; 上皮形成および抗-血管新生剤; 無機物質; 細胞のモル浸透圧濃度の調節物質; 抗生物質; 抗ウイルスおよび抗真菌薬をさらに含む、請求項1の生理学的サプリメントまたは医薬。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05014337 | 2005-07-01 | ||
EP05014337.9 | 2005-07-01 | ||
PCT/EP2006/062919 WO2007003481A1 (en) | 2005-07-01 | 2006-06-06 | Use of l-carnitine or of alkanoyl l-carnitines for the preparation of a physiological supplement or medicament for ophthalmic use in the form of eye-drops |
Publications (3)
Publication Number | Publication Date |
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JP2009500369A JP2009500369A (ja) | 2009-01-08 |
JP2009500369A5 JP2009500369A5 (ja) | 2009-07-23 |
JP5117384B2 true JP5117384B2 (ja) | 2013-01-16 |
Family
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JP2008519890A Expired - Fee Related JP5117384B2 (ja) | 2005-07-01 | 2006-06-06 | 点眼剤の形態における眼用生理学的サプリメントまたは医薬の調製のためのl−カルニチンまたはアルカノイルl−カルニチンの使用 |
Country Status (12)
Country | Link |
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US (2) | US7655698B2 (ja) |
EP (1) | EP1906949B1 (ja) |
JP (1) | JP5117384B2 (ja) |
KR (1) | KR101401353B1 (ja) |
CN (1) | CN101242825B (ja) |
AU (1) | AU2006265248B2 (ja) |
BR (1) | BRPI0612596A2 (ja) |
CA (1) | CA2611909C (ja) |
HK (1) | HK1118721A1 (ja) |
MX (1) | MX2007016047A (ja) |
TW (1) | TWI404526B (ja) |
WO (1) | WO2007003481A1 (ja) |
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CA2611909C (en) * | 2005-07-01 | 2014-01-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition for treatment of corneal disease |
JP5384362B2 (ja) * | 2006-12-11 | 2014-01-08 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 角膜疾患を処置するための点眼剤の形態の医薬の調製におけるl−カルニチンの使用 |
EP2101725A1 (en) * | 2006-12-14 | 2009-09-23 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Use of l-carnitine or of alkanoyl l-carnitines for the preparation of a physiological supplement or medicament for ophthalmic use in the form of eye drops |
BRPI0720434A2 (pt) * | 2006-12-22 | 2014-01-07 | Sigma Tau Ind Farmaceuti | Gel útil para liberação de fármacos oftálmicos |
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WO2010085568A1 (en) * | 2009-01-21 | 2010-07-29 | The Research Foundation Of State University Of New York | Methods of diagnosing and treating severe dry eye syndrome |
US20110015154A1 (en) * | 2009-07-20 | 2011-01-20 | Kellermann Gottfried H | Supporting acetylcholine function |
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US10085960B2 (en) | 2012-03-30 | 2018-10-02 | Brien Holden Vision Institute | Methods and compositions for reducing ocular discomfort |
US10238673B2 (en) * | 2013-03-13 | 2019-03-26 | Genetic Disease Investigators, LLC | Methods and compositions for treatment of dry eye and correction of organ dysfunctions |
EP2783695A1 (en) * | 2013-03-28 | 2014-10-01 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Physiological supplement or medicament for ophthalmic use containing L-carnitine or alkanoyl L-carnitines in combination with eledoisin |
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CN110559261A (zh) * | 2018-06-06 | 2019-12-13 | 常州药物研究所有限公司 | 含有纳米交联透明质酸的脂质体微乳及其制备方法和应用 |
CN110604811B (zh) * | 2018-06-14 | 2023-01-31 | 陕西慧康生物科技有限责任公司 | 含有重组人溶菌酶和重组人表皮生长因子的人工泪液 |
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WO2023069036A1 (en) * | 2021-10-18 | 2023-04-27 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | An ophthalmic formulation for treatment and prevention of cataract and production method thereof |
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-
2006
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- 2006-06-06 MX MX2007016047A patent/MX2007016047A/es active IP Right Grant
- 2006-06-06 KR KR1020087002706A patent/KR101401353B1/ko not_active IP Right Cessation
- 2006-06-06 WO PCT/EP2006/062919 patent/WO2007003481A1/en active Application Filing
- 2006-06-06 BR BRPI0612596-4A patent/BRPI0612596A2/pt not_active IP Right Cessation
- 2006-06-06 CN CN2006800297134A patent/CN101242825B/zh not_active Expired - Fee Related
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- 2006-06-06 EP EP06763523.5A patent/EP1906949B1/en active Active
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- 2006-06-20 TW TW095122061A patent/TWI404526B/zh not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
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WO2007003481A1 (en) | 2007-01-11 |
EP1906949B1 (en) | 2015-02-11 |
US20100093858A1 (en) | 2010-04-15 |
US7655698B2 (en) | 2010-02-02 |
US8377988B2 (en) | 2013-02-19 |
JP2009500369A (ja) | 2009-01-08 |
BRPI0612596A2 (pt) | 2010-11-23 |
TW200744574A (en) | 2007-12-16 |
KR20080030077A (ko) | 2008-04-03 |
KR101401353B1 (ko) | 2014-05-29 |
AU2006265248A1 (en) | 2007-01-11 |
CN101242825A (zh) | 2008-08-13 |
CA2611909A1 (en) | 2007-01-11 |
US20070265338A1 (en) | 2007-11-15 |
HK1118721A1 (en) | 2009-02-20 |
CN101242825B (zh) | 2011-03-30 |
EP1906949A1 (en) | 2008-04-09 |
MX2007016047A (es) | 2008-03-10 |
TWI404526B (zh) | 2013-08-11 |
AU2006265248B2 (en) | 2011-12-15 |
CA2611909C (en) | 2014-01-07 |
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