JP5113526B2 - レプチン拮抗薬 - Google Patents
レプチン拮抗薬 Download PDFInfo
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- JP5113526B2 JP5113526B2 JP2007542513A JP2007542513A JP5113526B2 JP 5113526 B2 JP5113526 B2 JP 5113526B2 JP 2007542513 A JP2007542513 A JP 2007542513A JP 2007542513 A JP2007542513 A JP 2007542513A JP 5113526 B2 JP5113526 B2 JP 5113526B2
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- Prior art keywords
- leptin
- seq
- human
- polypeptide
- antagonist
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- Endocrinology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/996,607 | 2004-11-26 | ||
| US10/996,607 US7307142B2 (en) | 2004-11-26 | 2004-11-26 | Leptin antagonists |
| PCT/IL2005/001250 WO2006056987A2 (en) | 2004-11-26 | 2005-11-24 | Leptin antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521795A JP2008521795A (ja) | 2008-06-26 |
| JP2008521795A5 JP2008521795A5 (https=) | 2009-02-05 |
| JP5113526B2 true JP5113526B2 (ja) | 2013-01-09 |
Family
ID=36204374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542513A Expired - Fee Related JP5113526B2 (ja) | 2004-11-26 | 2005-11-24 | レプチン拮抗薬 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7307142B2 (https=) |
| EP (1) | EP1814986B1 (https=) |
| JP (1) | JP5113526B2 (https=) |
| CN (1) | CN101189335B (https=) |
| AT (1) | ATE498683T1 (https=) |
| DE (1) | DE602005026432D1 (https=) |
| ES (1) | ES2363011T3 (https=) |
| WO (1) | WO2006056987A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8716220B2 (en) * | 2005-09-07 | 2014-05-06 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta |
| US8227408B2 (en) * | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
| US8642543B2 (en) * | 2005-09-07 | 2014-02-04 | Neurotez, Inc. | Methods for treating progressive cognitive disorders related to neurofibrillary tangles |
| US8778890B2 (en) | 2009-03-31 | 2014-07-15 | Temple University—Of the Commonwealth System of Higher Education | Leptin antagonist and methods of use |
| AU2011243965A1 (en) | 2010-04-22 | 2012-12-06 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | High affinity leptins and leptin antagonists |
| WO2014024189A1 (en) * | 2012-08-06 | 2014-02-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Pegylated high affinity leptins with increased biological activity |
| IT1423968B1 (https=) * | 2014-04-28 | 2016-08-26 | ||
| US11123461B2 (en) | 2015-02-26 | 2021-09-21 | Remodeless Cv Ltd | Treatment of ischemia and reperfusion using leptin antagonist |
| US10926006B2 (en) | 2015-02-26 | 2021-02-23 | Remodeless Cv Ltd | Drug eluting stent |
| EP3261582B1 (en) | 2015-02-26 | 2021-01-06 | Remodeless CV Ltd. | Methods and compositions relating to leptin antagonists |
| CN104829707B (zh) * | 2015-05-06 | 2017-12-19 | 广东省生物资源应用研究所 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
| CN104829708B (zh) * | 2015-05-06 | 2017-11-28 | 广东省生物资源应用研究所 | 一条d螺旋区突变的瘦素活性肽及其编码基因和应用 |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| US10550192B2 (en) * | 2016-11-08 | 2020-02-04 | Regeneron Pharmaceuticals, Inc. | Antigen-binding proteins that antagonize leptin receptor |
| DK3773713T3 (da) | 2018-04-06 | 2025-08-18 | Regeneron Pharma | Leptinreceptoragonistantistof til anvendelse i forøgelse af knoglemasse hos et individ, der lider af metabolisk dysfunktion eller hypoleptinæmI |
| KR20210104744A (ko) | 2018-12-18 | 2021-08-25 | 리제너론 파마슈티칼스 인코포레이티드 | 렙틴 수용체, gdf8 및 액티빈 a에 대한 길항제를 사용하여 체중 및 제지방 근육량을 향상시키기 위한 조성물 및 방법 |
| WO2024050285A2 (en) * | 2022-08-31 | 2024-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Leptin analogs for treating obesity and weight management |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| WO1997020933A2 (en) * | 1995-12-06 | 1997-06-12 | Schering Corporation | MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS |
| US20020160935A1 (en) | 2000-03-24 | 2002-10-31 | Smithkline Beecham Plc | Use of leptin antagonists for the treatment of diabetes |
| CZ90999A3 (cs) | 1996-09-20 | 1999-06-16 | Hoechst Aktiengesellschaft | Farmaceutický přípravek obsahující antagonistu leptinu vhodný pro léčení inzulínové rezistence u diabetes mellitus II. typu |
| HUP0402071A2 (hu) | 2001-02-06 | 2005-01-28 | Merck Patent Gmbh. | Csökkentett immunogenitású, módosított leptin |
-
2004
- 2004-11-26 US US10/996,607 patent/US7307142B2/en not_active Expired - Fee Related
-
2005
- 2005-11-24 EP EP05809259A patent/EP1814986B1/en not_active Expired - Lifetime
- 2005-11-24 WO PCT/IL2005/001250 patent/WO2006056987A2/en not_active Ceased
- 2005-11-24 AT AT05809259T patent/ATE498683T1/de not_active IP Right Cessation
- 2005-11-24 JP JP2007542513A patent/JP5113526B2/ja not_active Expired - Fee Related
- 2005-11-24 CN CN2005800471206A patent/CN101189335B/zh not_active Expired - Fee Related
- 2005-11-24 DE DE602005026432T patent/DE602005026432D1/de not_active Expired - Lifetime
- 2005-11-24 ES ES05809259T patent/ES2363011T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005026432D1 (de) | 2011-03-31 |
| US7307142B2 (en) | 2007-12-11 |
| EP1814986A2 (en) | 2007-08-08 |
| US20060154859A1 (en) | 2006-07-13 |
| JP2008521795A (ja) | 2008-06-26 |
| WO2006056987A2 (en) | 2006-06-01 |
| CN101189335B (zh) | 2012-01-11 |
| WO2006056987A3 (en) | 2006-08-24 |
| EP1814986B1 (en) | 2011-02-16 |
| ES2363011T3 (es) | 2011-07-18 |
| CN101189335A (zh) | 2008-05-28 |
| ATE498683T1 (de) | 2011-03-15 |
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