JP5099951B2 - 副作用が減少されたヘモグロビン組成物 - Google Patents
副作用が減少されたヘモグロビン組成物 Download PDFInfo
- Publication number
- JP5099951B2 JP5099951B2 JP2001537359A JP2001537359A JP5099951B2 JP 5099951 B2 JP5099951 B2 JP 5099951B2 JP 2001537359 A JP2001537359 A JP 2001537359A JP 2001537359 A JP2001537359 A JP 2001537359A JP 5099951 B2 JP5099951 B2 JP 5099951B2
- Authority
- JP
- Japan
- Prior art keywords
- hemoglobin
- mammal
- globin
- blood
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16528999P | 1999-11-12 | 1999-11-12 | |
| US60/165,289 | 1999-11-12 | ||
| PCT/US2000/030857 WO2001034648A1 (en) | 1999-11-12 | 2000-11-10 | Reduced side-effect hemoglobin compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011030290A Division JP2011098985A (ja) | 1999-11-12 | 2011-02-15 | 副作用が減少されたヘモグロビン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003515533A JP2003515533A (ja) | 2003-05-07 |
| JP2003515533A5 JP2003515533A5 (enExample) | 2007-12-27 |
| JP5099951B2 true JP5099951B2 (ja) | 2012-12-19 |
Family
ID=22598286
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001537359A Expired - Fee Related JP5099951B2 (ja) | 1999-11-12 | 2000-11-10 | 副作用が減少されたヘモグロビン組成物 |
| JP2011030290A Pending JP2011098985A (ja) | 1999-11-12 | 2011-02-15 | 副作用が減少されたヘモグロビン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011030290A Pending JP2011098985A (ja) | 1999-11-12 | 2011-02-15 | 副作用が減少されたヘモグロビン組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6670323B1 (enExample) |
| EP (2) | EP2292657A1 (enExample) |
| JP (2) | JP5099951B2 (enExample) |
| AU (1) | AU784195B2 (enExample) |
| CA (1) | CA2391226A1 (enExample) |
| NO (1) | NO20022229L (enExample) |
| WO (1) | WO2001034648A1 (enExample) |
| ZA (1) | ZA200203817B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670323B1 (en) * | 1999-11-12 | 2003-12-30 | Baxter International, Inc. | Reduced side-effect hemoglobin compositions |
| DE10224750A1 (de) | 2002-06-04 | 2003-12-24 | Fresenius Medical Care De Gmbh | Vorrichtung zur Behandlung einer medizinischen Flüssigkeit |
| US7092752B2 (en) * | 2002-07-27 | 2006-08-15 | Sheng-Xing Ma | Skin acupoint/meridian nitric oxide collection kit and method thereof |
| US9138707B2 (en) * | 2002-12-10 | 2015-09-22 | Sy Kimball | Portable, nitric oxide generator |
| EP1449535B1 (en) * | 2003-02-18 | 2006-05-03 | Clinique La Prairie Research SA | Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components |
| ES2347805T3 (es) * | 2004-08-31 | 2010-11-04 | Sangart, Inc. | Metodos para aumentar la estabilidad hemodinamica usando composiciones que transportan oxigeno. |
| US7976866B2 (en) * | 2004-12-06 | 2011-07-12 | Opremcak E Mitchel | Bandage and method for vital bleaching of skin |
| US7935074B2 (en) | 2005-02-28 | 2011-05-03 | Fresenius Medical Care Holdings, Inc. | Cassette system for peritoneal dialysis machine |
| US8071546B2 (en) * | 2005-06-10 | 2011-12-06 | La Jolla Bioengineering Institute | Uses of pegylated albumin |
| US8741832B2 (en) * | 2005-06-10 | 2014-06-03 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated albumin and uses thereof |
| US8197231B2 (en) | 2005-07-13 | 2012-06-12 | Purity Solutions Llc | Diaphragm pump and related methods |
| US9649467B2 (en) | 2008-01-31 | 2017-05-16 | Syk Technologies, Llc | Nitric oxide reactor and distributor apparatus and method |
| US8720436B2 (en) * | 2008-01-31 | 2014-05-13 | Genosys, Inc. | Nitric oxide gel apparatus and method |
| US8434475B2 (en) | 2008-01-31 | 2013-05-07 | Genosys, Inc. | Nitric oxide reactor and distributor apparatus and method |
| US20090247619A1 (en) * | 2008-03-06 | 2009-10-01 | University Of Kentucky | Cannabinoid-Containing Compositions and Methods for Their Use |
| US8501090B2 (en) * | 2008-03-24 | 2013-08-06 | Christian S. Minton | Anti-microbial gas apparatus and method |
| US8192401B2 (en) | 2009-03-20 | 2012-06-05 | Fresenius Medical Care Holdings, Inc. | Medical fluid pump systems and related components and methods |
| EP2453946B1 (en) | 2009-07-15 | 2013-02-13 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems |
| US8720913B2 (en) | 2009-08-11 | 2014-05-13 | Fresenius Medical Care Holdings, Inc. | Portable peritoneal dialysis carts and related systems |
| US8685467B2 (en) | 2010-08-03 | 2014-04-01 | J. W. Randolph Miller | Nitric oxide generation, dilution, and topical application apparatus and method |
| US8609815B2 (en) * | 2010-09-02 | 2013-12-17 | Sangart, Inc. | Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant |
| DE102010053973A1 (de) | 2010-12-09 | 2012-06-14 | Fresenius Medical Care Deutschland Gmbh | Medizinisches Gerät mit einer Heizung |
| US9694125B2 (en) | 2010-12-20 | 2017-07-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9624915B2 (en) | 2011-03-09 | 2017-04-18 | Fresenius Medical Care Holdings, Inc. | Medical fluid delivery sets and related systems and methods |
| CN103648540B (zh) | 2011-04-21 | 2016-06-01 | 弗雷塞尼斯医疗保健控股公司 | 医疗流体泵送系统及相关装置和方法 |
| ES2432075T3 (es) | 2011-07-23 | 2013-11-29 | Sastomed Gmbh | Espray para heridas |
| BR112014007029A2 (pt) | 2011-09-23 | 2017-04-11 | Bluebird Bio Inc | métodos aperfeiçoados de terapia gênica |
| MX359398B (es) | 2011-09-30 | 2018-09-27 | Bluebird Bio Inc | Compuestos para transduccion viral mejorada. |
| US9186449B2 (en) | 2011-11-01 | 2015-11-17 | Fresenius Medical Care Holdings, Inc. | Dialysis machine support assemblies and related systems and methods |
| IN2014MN02089A (enExample) * | 2012-03-20 | 2015-09-11 | Einstein Coll Med | |
| US20130261412A1 (en) * | 2012-03-28 | 2013-10-03 | II Robert Lawrence Reed | System and method for managing fluid levels in patients based upon creatinine clearance |
| US9610392B2 (en) | 2012-06-08 | 2017-04-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9500188B2 (en) | 2012-06-11 | 2016-11-22 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| JP2014062050A (ja) * | 2012-09-19 | 2014-04-10 | Fujifilm Corp | 多価官能マレイミド系重合性化合物、これを含む硬化組成物およびインク組成物 |
| US9561323B2 (en) | 2013-03-14 | 2017-02-07 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassette leak detection methods and devices |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| US10117985B2 (en) | 2013-08-21 | 2018-11-06 | Fresenius Medical Care Holdings, Inc. | Determining a volume of medical fluid pumped into or out of a medical fluid cassette |
| TWI666319B (zh) | 2014-08-12 | 2019-07-21 | 美商巴克斯歐塔公司 | 在分泌furin之哺乳動物表現系統中生產經完全加工且具功能性之因子X |
| EP4400101A1 (en) | 2016-01-27 | 2024-07-17 | SYK Technologies, LLC | Nitric oxide topical application apparatus and methods |
| EP3413896B1 (en) | 2016-02-12 | 2021-03-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| CA3014078A1 (en) | 2016-02-12 | 2017-08-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| JP7387597B2 (ja) | 2017-07-18 | 2023-11-28 | ヴァーテック・バイオ・インコーポレイテッド | ヘモグロビンを含む代用血液及び作製方法 |
| GB201721503D0 (en) * | 2017-12-20 | 2018-01-31 | Univ Essex | Modified globin proteins |
| US10752672B1 (en) * | 2019-02-01 | 2020-08-25 | Cheer Global Limited | Recombinant hemoglobins and methods of preparation and use thereof |
| JP7593609B2 (ja) * | 2020-02-28 | 2024-12-03 | 学校法人 中央大学 | ヘモグロビン微粒子及び人工酸素運搬体 |
| US12459820B2 (en) | 2020-06-11 | 2025-11-04 | J. W. Randolph Miller | Stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy |
| WO2022184005A1 (en) | 2021-03-01 | 2022-09-09 | Billion King International Limited | Thiosuccinyl-crosslinked hemoglobin conjugates and methods of use and preparation thereof |
| EP4402242A4 (en) * | 2021-09-17 | 2025-08-06 | Univ Yale | METHODS, SYSTEMS AND COMPOSITIONS FOR RESTORING AND PRESERVING INTACT ORGANS IN A MAMMAL |
| CN115317595A (zh) * | 2021-09-27 | 2022-11-11 | 中国人民解放军军事科学院军事医学研究院 | 一种聚乙二醇化牛血红蛋白氧载体及其制备方法与应用 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3525272A (en) | 1967-10-20 | 1970-08-25 | Westinghouse Air Brake Co | Multiposition control handle having detent means |
| DE2449885C3 (de) | 1974-10-21 | 1980-04-30 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat |
| US4061736A (en) | 1975-02-02 | 1977-12-06 | Alza Corporation | Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin |
| US4001200A (en) | 1975-02-27 | 1977-01-04 | Alza Corporation | Novel polymerized, cross-linked, stromal-free hemoglobin |
| US4001401A (en) | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
| US4053590A (en) | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
| US4473496A (en) | 1981-09-14 | 1984-09-25 | The United States Of America As Represented By The Secretary Of The Army | Intramolecularly crosslinked hemoglobin |
| DE3144705C2 (de) | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
| US4529719A (en) | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| US4600531A (en) | 1984-06-27 | 1986-07-15 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
| US4598064A (en) | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
| US4584130A (en) | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
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| US4868119A (en) | 1986-12-11 | 1989-09-19 | Genetics Institute, Inc. | Hematopoietic growth factors |
| US4826811A (en) | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5032676A (en) | 1986-10-14 | 1991-07-16 | Immunex Corporation | Nonglycosylated analogs of human colony stimulating factors |
| DE3636590A1 (de) | 1986-10-28 | 1988-05-26 | Braun Melsungen Ag | Blutersatzmittel |
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| OA09736A (en) | 1987-02-18 | 1993-11-30 | Schering Biotech Corp | "Human interleukin-3 and muteins thereof". |
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| JP2562840B2 (ja) | 1988-08-01 | 1996-12-11 | 富士通株式会社 | 電界効果トランジスタ |
| IL87707A (en) | 1988-09-08 | 1994-06-24 | Technion Inst For Research And | Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof |
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| US5665869A (en) | 1993-11-15 | 1997-09-09 | Somatogen, Inc. | Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin |
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| US5631219A (en) | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
| US5585484A (en) | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| US5733869A (en) * | 1995-10-06 | 1998-03-31 | Baxter International, Inc. | Therapeutic administration of hemoglobin in cardiac arrest |
| AU4661797A (en) | 1996-10-21 | 1998-05-15 | Baxter International Inc. | Therapeutic use of hemoglobin to treat head injury |
| WO1998050430A2 (en) | 1997-05-02 | 1998-11-12 | Somatogen, Inc. | Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging |
| US6670323B1 (en) * | 1999-11-12 | 2003-12-30 | Baxter International, Inc. | Reduced side-effect hemoglobin compositions |
| EP2340681B1 (en) | 2008-09-25 | 2014-11-12 | Nokia Corporation | Synchronization for device-to-device communication |
| US9005548B2 (en) | 2009-02-25 | 2015-04-14 | California Institute Of Technology | Methods for fabricating high aspect ratio probes and deforming high aspect ratio nanopillars and micropillars |
| JP5963422B2 (ja) | 2010-12-17 | 2016-08-03 | キヤノン株式会社 | 撮像装置、表示装置、コンピュータプログラムおよび立体像表示システム |
-
2000
- 2000-11-10 US US09/709,914 patent/US6670323B1/en not_active Expired - Fee Related
- 2000-11-10 JP JP2001537359A patent/JP5099951B2/ja not_active Expired - Fee Related
- 2000-11-10 EP EP10075434A patent/EP2292657A1/en not_active Withdrawn
- 2000-11-10 EP EP00980318A patent/EP1233986A4/en not_active Withdrawn
- 2000-11-10 WO PCT/US2000/030857 patent/WO2001034648A1/en not_active Ceased
- 2000-11-10 CA CA002391226A patent/CA2391226A1/en not_active Abandoned
- 2000-11-10 AU AU17597/01A patent/AU784195B2/en not_active Ceased
-
2002
- 2002-05-10 NO NO20022229A patent/NO20022229L/no not_active Application Discontinuation
- 2002-05-14 ZA ZA200203817A patent/ZA200203817B/xx unknown
-
2003
- 2003-12-29 US US10/747,580 patent/US7211560B2/en not_active Expired - Fee Related
-
2011
- 2011-02-15 JP JP2011030290A patent/JP2011098985A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20040259769A1 (en) | 2004-12-23 |
| NO20022229L (no) | 2002-07-11 |
| AU784195B2 (en) | 2006-02-16 |
| US6670323B1 (en) | 2003-12-30 |
| JP2003515533A (ja) | 2003-05-07 |
| US7211560B2 (en) | 2007-05-01 |
| CA2391226A1 (en) | 2001-05-17 |
| WO2001034648A1 (en) | 2001-05-17 |
| EP1233986A1 (en) | 2002-08-28 |
| EP1233986A4 (en) | 2003-01-02 |
| EP2292657A1 (en) | 2011-03-09 |
| ZA200203817B (en) | 2003-02-28 |
| JP2011098985A (ja) | 2011-05-19 |
| AU1759701A (en) | 2001-06-06 |
| NO20022229D0 (no) | 2002-05-10 |
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