JP5086991B2 - プロスタグランジンe2(pge2)の生産に関連する障害の処置のための3−アミノカルバゾールのベンゾイル誘導体の使用 - Google Patents

プロスタグランジンe2(pge2)の生産に関連する障害の処置のための3−アミノカルバゾールのベンゾイル誘導体の使用 Download PDF

Info

Publication number
JP5086991B2
JP5086991B2 JP2008511591A JP2008511591A JP5086991B2 JP 5086991 B2 JP5086991 B2 JP 5086991B2 JP 2008511591 A JP2008511591 A JP 2008511591A JP 2008511591 A JP2008511591 A JP 2008511591A JP 5086991 B2 JP5086991 B2 JP 5086991B2
Authority
JP
Japan
Prior art keywords
production
aminocarbazole
group
pge
prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008511591A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008540591A (ja
JP2008540591A5 (enExample
Inventor
ポレンツァーニ ロレンツォ
マンガーノ ジョルジーナ
コレッタ イザベラ
アレッサンドラ アリシ マリア
カッツォーラ ニコラ
フルロッティ グイド
マウゲリ カテリーナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco ACRAF SpA filed Critical Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Publication of JP2008540591A publication Critical patent/JP2008540591A/ja
Publication of JP2008540591A5 publication Critical patent/JP2008540591A5/ja
Application granted granted Critical
Publication of JP5086991B2 publication Critical patent/JP5086991B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP2008511591A 2005-05-19 2006-05-03 プロスタグランジンe2(pge2)の生産に関連する障害の処置のための3−アミノカルバゾールのベンゾイル誘導体の使用 Expired - Fee Related JP5086991B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2005A000909 2005-05-19
IT000909A ITMI20050909A1 (it) 2005-05-19 2005-05-19 Uso di un benzoil derivato dal 3-ammino-carbazolo per la produzione di un farmaco per il trattamento di un disturbo associato alla produzione di prostaglandina e2-pge2-
PCT/EP2006/004348 WO2006122680A1 (en) 2005-05-19 2006-05-03 Use of a benzoyl derivative of 3-aminocarbazole for the treatment of a disorder associated with the production of prostaglandin e2 (pge2)

Publications (3)

Publication Number Publication Date
JP2008540591A JP2008540591A (ja) 2008-11-20
JP2008540591A5 JP2008540591A5 (enExample) 2009-05-14
JP5086991B2 true JP5086991B2 (ja) 2012-11-28

Family

ID=35219704

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008511591A Expired - Fee Related JP5086991B2 (ja) 2005-05-19 2006-05-03 プロスタグランジンe2(pge2)の生産に関連する障害の処置のための3−アミノカルバゾールのベンゾイル誘導体の使用

Country Status (23)

Country Link
US (1) US8686021B2 (enExample)
EP (1) EP1881826B1 (enExample)
JP (1) JP5086991B2 (enExample)
KR (1) KR101312579B1 (enExample)
CN (1) CN101166528B (enExample)
AR (1) AR054126A1 (enExample)
AT (1) ATE473739T1 (enExample)
AU (1) AU2006246688B2 (enExample)
BR (1) BRPI0609718A2 (enExample)
CA (1) CA2604562C (enExample)
DE (1) DE602006015457D1 (enExample)
DK (1) DK1881826T3 (enExample)
EA (1) EA012724B1 (enExample)
ES (1) ES2347174T3 (enExample)
GE (1) GEP20094738B (enExample)
IL (1) IL186072A (enExample)
IT (1) ITMI20050909A1 (enExample)
MX (1) MX2007013491A (enExample)
PL (1) PL1881826T3 (enExample)
PT (1) PT1881826E (enExample)
SI (1) SI1881826T1 (enExample)
UA (1) UA94044C2 (enExample)
WO (1) WO2006122680A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20051523A1 (it) 2005-08-03 2007-02-04 Acraf Composto del 3-ammino-carbazolo composizione farmaceutica che lo contiene e metodo per prepararlo
EP2119705A1 (en) 2008-05-14 2009-11-18 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. 3-Aminocarbozole compound, pharmaceutical composition containing it and preparation method therefor
US8880004B2 (en) 2009-05-14 2014-11-04 Qualcomm Incorporated System and method for resolving conflicts between air interfaces in a wireless communication system

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002241368A (ja) * 1997-02-18 2002-08-28 Shionogi & Co Ltd 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物
US6399631B1 (en) 1999-07-23 2002-06-04 Pfizer Inc. Carbazole neuropeptide Y5 antagonists
AU6000900A (en) 1999-07-23 2001-02-13 Astrazeneca Uk Limited Carbazole derivatives and their use as neuropeptide y5 receptor ligands
JP2003507424A (ja) * 1999-08-26 2003-02-25 ブリストル−マイヤーズ スクイブ カンパニー Npyアンタゴニスト:スピロイソキノリノン誘導体
DE10125961A1 (de) 2001-05-29 2002-12-12 Boehringer Ingelheim Int Carbazolderivate und deren Verwendung zur Herstellung einer Arzneimittelzusammensetzung zur Behandlung von im Zusammenhang mit NPY stehenden Leiden
CA2403307A1 (en) * 2001-10-23 2003-04-23 Neurogen Corporation Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives
KR20030042344A (ko) * 2001-11-22 2003-05-28 한국생명공학연구원 에레모필란계 화합물 또는 곰취추출물을 유효성분으로함유하는 염증질환 치료제, 면역질환 치료제, 및 암 치료제
ES2193875B2 (es) * 2002-04-09 2005-03-01 Laboratorios Del Dr. Esteve, S.A. Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos.
KR100402714B1 (ko) * 2002-12-23 2003-11-13 한국생명공학연구원 디테르펜계 화합물을 염증질환, 면역질환 및 암 치료제로사용하는 신규한 용도

Also Published As

Publication number Publication date
CN101166528A (zh) 2008-04-23
EP1881826A1 (en) 2008-01-30
IL186072A0 (en) 2008-08-07
CA2604562C (en) 2013-09-17
ITMI20050909A1 (it) 2006-11-20
IL186072A (en) 2012-05-31
ES2347174T3 (es) 2010-10-26
PT1881826E (pt) 2010-08-05
CN101166528B (zh) 2011-06-15
AU2006246688A1 (en) 2006-11-23
UA94044C2 (ru) 2011-04-11
JP2008540591A (ja) 2008-11-20
KR101312579B1 (ko) 2013-09-30
KR20080018898A (ko) 2008-02-28
SI1881826T1 (sl) 2010-10-29
WO2006122680A1 (en) 2006-11-23
GEP20094738B (en) 2009-07-27
MX2007013491A (es) 2008-01-24
PL1881826T3 (pl) 2010-12-31
CA2604562A1 (en) 2006-11-23
AR054126A1 (es) 2007-06-06
US20080287518A1 (en) 2008-11-20
BRPI0609718A2 (pt) 2011-10-18
EP1881826B1 (en) 2010-07-14
EA012724B1 (ru) 2009-12-30
DE602006015457D1 (de) 2010-08-26
HK1119571A1 (en) 2009-03-13
ATE473739T1 (de) 2010-07-15
EA200702534A1 (ru) 2008-04-28
AU2006246688B2 (en) 2011-09-22
US8686021B2 (en) 2014-04-01
DK1881826T3 (da) 2010-11-01

Similar Documents

Publication Publication Date Title
JP5922116B2 (ja) 複数のプロスタグランジン受容体で作用する全般的な抗炎症反応をもたらす化合物
CN103249408A (zh) 利用多不饱和长链酮类的类风湿性关节炎治疗
JP2017114861A (ja) モノアミン神経伝達物質によって影響を受ける病態の処置における(+)−1−(3,4−ジクロロフェニル)−3−アザビシクロ[3.1.0]ヘキサンの調製および使用
KR20060096145A (ko) 티헬퍼세포-2에서 발현되는 유사수용체 유도성 물질의길항제 화합물의 치료용도
KR101333753B1 (ko) 세포 손상 및 염증 질환의 치료 또는 예방용 약학 조성물
KR101278620B1 (ko) 3-아미노카바졸 화합물, 이를 함유하는 약학적 조성물 및이의 제조 방법
La Corte et al. Prophylaxis and treatment of NSAID-induced gastroduodenal disorders
JP5086991B2 (ja) プロスタグランジンe2(pge2)の生産に関連する障害の処置のための3−アミノカルバゾールのベンゾイル誘導体の使用
US4694018A (en) Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives
WO2006016689A1 (ja) Ep4アゴニストを含有してなる下部尿路系疾患の予防および/または治療剤
KR101189751B1 (ko) 세포 손상 및 염증 질환의 치료 또는 예방용 약학 조성물
FI107609B (fi) Menetelmä terapeuttisesti käyttökelpoisten 3-(1-substituoituja pyratsoyyli)-2-oksi-indolijohdannaisten valmistamiseksi
JPH0633258B2 (ja) 2―グアニジノ―4―アリールチアゾール化合物
WO2004089411A1 (ja) 脊柱管狭窄症治療剤
Romeiro et al. Synthesis, pharmacological evaluation and docking studies of new sulindac analogues
HK1119571B (en) Use of a benzoyl derivative of 3-aminocarbazole in manufacture of a medicament in the treatment of a disorder associated with the production of prostaglandin e2 (pge2)
JPH06509110A (ja) 胃及び十二指腸障害を治療する方法及び組成物並びに新規なpge↓2誘導体
TWI325317B (en) Appetite-stimulating agents and remedies for anorexia
MODEL PHARMACEUTICAL SCIENCES
Pepper NONSTEROIDAL ANTIINFLAMMATORY DRUGS: New Perspectives on a Familiar Drug Class
RU2643669C1 (ru) 3-[3-(морфолин-4-ил)пропил]-2-[(2,2,3-триметилциклопент-3-ен-1-ил)метил]-1,3-тиазолидин-4-он, обладающий противоязвенной и противовоспалительной активностью
TW379220B (en) Pyrazolidine derivative, radical scavenger, brain--infarction depressant, and brain-edma depressant
Chetty Raju et al. Cyclooxygenase inhibitors
TW200530219A (en) Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds
TW201306838A (zh) 菸鹼酸模擬物及其使用方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090323

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090323

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120424

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120723

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120828

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120907

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150914

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees