JP5086267B2 - 臭化チオトロピウムの新規な形態およびそれを製造する方法 - Google Patents

臭化チオトロピウムの新規な形態およびそれを製造する方法 Download PDF

Info

Publication number
JP5086267B2
JP5086267B2 JP2008538130A JP2008538130A JP5086267B2 JP 5086267 B2 JP5086267 B2 JP 5086267B2 JP 2008538130 A JP2008538130 A JP 2008538130A JP 2008538130 A JP2008538130 A JP 2008538130A JP 5086267 B2 JP5086267 B2 JP 5086267B2
Authority
JP
Japan
Prior art keywords
tiotropium bromide
tiotropium
bromide
hours
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2008538130A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009513675A (ja
Inventor
ディウルゲロフ，ニコラ
スカルピッタ，フランチェスカ
ポンティロリ，アレッサンドロ
コバチネ−メゼイ，アドリエンヌ
アロンヒメ，ジュディス
イェゴロブ，アレクサンドル
Original Assignee
シコール インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38115166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5086267(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by シコール インコーポレイティド filed Critical シコール インコーポレイティド
Publication of JP2009513675A publication Critical patent/JP2009513675A/ja
Application granted granted Critical
Publication of JP5086267B2 publication Critical patent/JP5086267B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2008538130A 2005-12-19 2006-12-19 臭化チオトロピウムの新規な形態およびそれを製造する方法 Active JP5086267B2 (ja)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US75267205P 2005-12-19 2005-12-19
US60/752,672 2005-12-19
US75453005P 2005-12-27 2005-12-27
US60/754,530 2005-12-27
US76143706P 2006-01-23 2006-01-23
US60/761,437 2006-01-23
US77405106P 2006-02-15 2006-02-15
US60/774,051 2006-02-15
US78031006P 2006-03-07 2006-03-07
US60/780,310 2006-03-07
US83218906P 2006-07-20 2006-07-20
US60/832,189 2006-07-20
US85122306P 2006-10-12 2006-10-12
US60/851,223 2006-10-12
US85274006P 2006-10-18 2006-10-18
US60/852,740 2006-10-18
PCT/US2006/048734 WO2007075858A2 (en) 2005-12-19 2006-12-19 Novel forms of tiotropium bromide and processes for preparation thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2012037796A Division JP5567610B2 (ja) 2005-12-19 2012-02-23 臭化チオトロピウムの新規な形態およびそれを製造する方法
JP2012127232A Division JP2012176975A (ja) 2005-12-19 2012-06-04 臭化チオトロピウムの新規な形態およびそれを製造する方法

Publications (2)

Publication Number Publication Date
JP2009513675A JP2009513675A (ja) 2009-04-02
JP5086267B2 true JP5086267B2 (ja) 2012-11-28

Family

ID=38115166

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008538130A Active JP5086267B2 (ja) 2005-12-19 2006-12-19 臭化チオトロピウムの新規な形態およびそれを製造する方法
JP2012037796A Active JP5567610B2 (ja) 2005-12-19 2012-02-23 臭化チオトロピウムの新規な形態およびそれを製造する方法
JP2012127232A Pending JP2012176975A (ja) 2005-12-19 2012-06-04 臭化チオトロピウムの新規な形態およびそれを製造する方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012037796A Active JP5567610B2 (ja) 2005-12-19 2012-02-23 臭化チオトロピウムの新規な形態およびそれを製造する方法
JP2012127232A Pending JP2012176975A (ja) 2005-12-19 2012-06-04 臭化チオトロピウムの新規な形態およびそれを製造する方法

Country Status (17)

Country Link
US (4) US8163913B2 (cg-RX-API-DMAC7.html)
EP (2) EP1869035B2 (cg-RX-API-DMAC7.html)
JP (3) JP5086267B2 (cg-RX-API-DMAC7.html)
KR (1) KR101395881B1 (cg-RX-API-DMAC7.html)
CN (1) CN102731494A (cg-RX-API-DMAC7.html)
AT (1) ATE552256T1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0608427A2 (cg-RX-API-DMAC7.html)
CA (1) CA2627729A1 (cg-RX-API-DMAC7.html)
DK (1) DK1869035T4 (cg-RX-API-DMAC7.html)
ES (2) ES2384486T3 (cg-RX-API-DMAC7.html)
IL (1) IL187947A0 (cg-RX-API-DMAC7.html)
MX (1) MX2007009988A (cg-RX-API-DMAC7.html)
PL (2) PL2123650T3 (cg-RX-API-DMAC7.html)
PT (1) PT1869035E (cg-RX-API-DMAC7.html)
RS (1) RS52663B2 (cg-RX-API-DMAC7.html)
TW (1) TW200732340A (cg-RX-API-DMAC7.html)
WO (1) WO2007075858A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012176975A (ja) * 2005-12-19 2012-09-13 Sicor Inc 臭化チオトロピウムの新規な形態およびそれを製造する方法
PT106142A (pt) * 2012-02-10 2013-08-12 Hovione Farmaciencia S A Processo para a preparação de brometo de tiotrópio

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108962B2 (en) * 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
PT2240477E (pt) * 2008-01-10 2014-11-19 Generics Uk Ltd Um novo processo para a preparação de ésteres de escopina
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
KR101557633B1 (ko) * 2008-11-04 2015-10-06 시플라 리미티드 낮은 결정화도를 갖는 티오트로피움 브로마이드
BRPI0916047A2 (pt) * 2008-11-04 2015-11-10 Cipla Ltd composição farmacêutica em aerossol, uso de uma composição farmacêutica em aerossol, método para tratamento de sintomas crônicos ou agudos severos, moderados ou leves, ou para tratamento profilático de um distúrbio respiratório, dispensador farmacêutico em aerossol, processo para fabricação de um dispensador farmacêutico em aerossol e processo para fabricação de um complexo de um agente ativo e um adjuvante
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
US8697719B2 (en) * 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
UA115888C2 (uk) 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
KR20150135328A (ko) 2013-04-01 2015-12-02 풀매트릭스 인코퍼레이티드 티오트로피움 건조 분말
EP2789611A1 (en) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. A crystalline form of tiotropium bromide
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
EP3414243A1 (en) 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Crystalline form of tiotropium bromide anhydrate
US11365170B2 (en) 2018-07-13 2022-06-21 Kyowa Hakko Bio Co., Ltd. Non-solvate crystal of eucomic acid and method for producing same
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610163A (en) 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US6736830B2 (en) 2000-08-22 2004-05-18 Deborah M. Roust Baby pacifier
MXPA02005666A (es) * 2000-10-12 2002-11-29 Boehringer Ingelheim Pharma Nuevos polvos para anhalacion que contienen tiotropio.
IL155335A0 (en) * 2000-10-12 2003-11-23 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
HRP20031066B1 (en) * 2001-06-22 2011-10-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg. Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
PL375868A1 (en) 2002-12-16 2005-12-12 Boehringer Ingelheim Pharma Gmbh & Co.Kg Tiotropium containing hfc solution formulations
UA83813C2 (ru) 2002-12-20 2008-08-26 Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола
DE10351196B4 (de) 2003-10-28 2016-08-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung einer anodisch mit Silizium bondbaren Glas-Keramik (LTCC)
EP2336126A1 (de) 2003-11-03 2011-06-22 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend
EP1682542B1 (de) 2003-11-03 2009-12-30 Boehringer Ingelheim International GmbH Neues kristallines anhydrat mit anticholinerger wirksamkeit
EP2322522A1 (de) * 2003-11-03 2011-05-18 Boehringer Ingelheim International Gmbh Neue Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
CN1271073C (zh) * 2004-10-26 2006-08-23 江苏正大天晴药业股份有限公司 结晶性抗胆碱能药噻托溴铵晶体
PL1881980T3 (pl) * 2005-05-02 2013-01-31 Boehringer Ingelheim Int Nowe krystaliczne formy bromku tiotropium
EP1879888A2 (en) 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide
CN101331128B (zh) * 2005-12-19 2013-05-29 西科尔公司 噻托溴铵的形式及其制备方法
KR101395881B1 (ko) * 2005-12-19 2014-05-21 시코르, 인크. 브롬화 티오트로피움의 신규한 형태 및 이의 제조 방법
EP1923393A1 (en) 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP2020403A1 (en) * 2007-08-02 2009-02-04 Esteve Quimica, S.A. Process for the resolution of zopiclone and intermediate compounds
US8697719B2 (en) * 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012176975A (ja) * 2005-12-19 2012-09-13 Sicor Inc 臭化チオトロピウムの新規な形態およびそれを製造する方法
PT106142A (pt) * 2012-02-10 2013-08-12 Hovione Farmaciencia S A Processo para a preparação de brometo de tiotrópio
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio

Also Published As

Publication number Publication date
MX2007009988A (es) 2008-02-22
US8163913B2 (en) 2012-04-24
WO2007075858A2 (en) 2007-07-05
EP1869035B2 (en) 2015-08-12
RS52663B (sr) 2013-06-28
US20120165364A1 (en) 2012-06-28
EP1869035A2 (en) 2007-12-26
BRPI0608427A2 (pt) 2009-12-29
CN102731494A (zh) 2012-10-17
US20140057935A1 (en) 2014-02-27
PT1869035E (pt) 2013-01-10
DK1869035T4 (en) 2015-11-16
WO2007075858A3 (en) 2007-11-01
EP2123650A1 (en) 2009-11-25
US20120108625A1 (en) 2012-05-03
JP2009513675A (ja) 2009-04-02
ATE552256T1 (de) 2012-04-15
ES2396978T3 (es) 2013-03-01
EP2123650B1 (en) 2012-04-04
US20070225314A1 (en) 2007-09-27
PL2123650T3 (pl) 2012-09-28
JP5567610B2 (ja) 2014-08-06
ES2396978T5 (es) 2015-12-04
ES2384486T3 (es) 2012-07-05
US8846926B2 (en) 2014-09-30
KR101395881B1 (ko) 2014-05-21
PL1869035T3 (pl) 2013-04-30
JP2012176975A (ja) 2012-09-13
RS52663B2 (sr) 2018-05-31
JP2012136538A (ja) 2012-07-19
EP1869035B1 (en) 2012-10-03
CA2627729A1 (en) 2007-07-05
PL1869035T5 (pl) 2016-01-29
DK1869035T3 (da) 2013-01-14
TW200732340A (en) 2007-09-01
IL187947A0 (en) 2008-03-20
KR20080078779A (ko) 2008-08-28

Similar Documents

Publication Publication Date Title
JP5567610B2 (ja) 臭化チオトロピウムの新規な形態およびそれを製造する方法
US9181268B2 (en) Anhydrate of tiotropium bromide
CN116987069B (zh) 呋喹替尼的共晶、其制备方法、组合物和用途
CN110582497B (zh) Galunisertib的晶型及其制备方法和药物组合物
CN101331128B (zh) 噻托溴铵的形式及其制备方法
RU2453547C2 (ru) Новые формы тиотропия бромида и способы их получения
CN115772166B (zh) 一种s1p1受体激动剂的加成盐及其晶型和药物组合物
US9108962B2 (en) Forms of tiotropium bromide and processes for preparation thereof
CN110582279B (zh) 2-(6-甲基-吡啶-2-基)-3-基-[6-酰胺基-喹啉-4-基]-5,6-二氢-4H-吡咯并[1,2-b]吡唑的共晶，其制备方法和药物组合物
US7777049B2 (en) Crystalline forms of Rizatriptan benzoate

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110906

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111205

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111212

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120223

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120327

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120604

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120615

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120807

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120906

R150 Certificate of patent or registration of utility model

Ref document number: 5086267

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150914

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250