JP5072848B2 - 低血糖イベントを低減するためのｄｐｐ−ｉｖ阻害剤の使用 - Google Patents

低血糖イベントを低減するためのｄｐｐ−ｉｖ阻害剤の使用 Download PDF

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JP5072848B2
JP5072848B2 JP2008532308A JP2008532308A JP5072848B2 JP 5072848 B2 JP5072848 B2 JP 5072848B2 JP 2008532308 A JP2008532308 A JP 2008532308A JP 2008532308 A JP2008532308 A JP 2008532308A JP 5072848 B2 JP5072848 B2 JP 5072848B2
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insulin
dpp
treatment
diabetes
metformin
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JP2009508955A5 (OSRAM
JP2009508955A (ja
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ベルク・バルカン
ダビト・グレンビル・ホルメス
トーマス・エドワード・ヒューズ
エドウィン・バーナード・ビルハウアー
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ノバルティス アーゲー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008532308A 2005-09-20 2006-09-18 低血糖イベントを低減するためのｄｐｐ−ｉｖ阻害剤の使用 Active JP5072848B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US71885605P 2005-09-20 2005-09-20
US60/718,856 2005-09-20
US78675506P 2006-03-28 2006-03-28
US60/786,755 2006-03-28
PCT/US2006/036338 WO2007035665A1 (en) 2005-09-20 2006-09-18 Use of a dpp-iv inhibitor to reduce hypoglycemic events

Publications (3)

Publication Number Publication Date
JP2009508955A JP2009508955A (ja) 2009-03-05
JP2009508955A5 JP2009508955A5 (OSRAM) 2009-10-01
JP5072848B2 true JP5072848B2 (ja) 2012-11-14

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JP2008532308A Active JP5072848B2 (ja) 2005-09-20 2006-09-18 低血糖イベントを低減するためのｄｐｐ−ｉｖ阻害剤の使用

Country Status (12)

Country Link
US (2) US8143217B2 (OSRAM)
EP (1) EP1928499B1 (OSRAM)
JP (1) JP5072848B2 (OSRAM)
KR (1) KR101368525B1 (OSRAM)
AT (1) ATE514435T1 (OSRAM)
AU (1) AU2006292377B2 (OSRAM)
BR (1) BRPI0616195A2 (OSRAM)
CA (1) CA2622579C (OSRAM)
PL (1) PL1928499T3 (OSRAM)
PT (1) PT1928499E (OSRAM)
RU (1) RU2440143C2 (OSRAM)
WO (1) WO2007035665A1 (OSRAM)

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AU2006292377A1 (en) 2007-03-29
CA2622579A1 (en) 2007-03-29
ATE514435T1 (de) 2011-07-15
RU2440143C2 (ru) 2012-01-20
AU2006292377B2 (en) 2011-03-03
EP1928499B1 (en) 2011-06-29
KR20080046198A (ko) 2008-05-26
RU2008115114A (ru) 2009-11-27
EP1928499A1 (en) 2008-06-11
PT1928499E (pt) 2011-09-09
BRPI0616195A2 (pt) 2011-06-14
JP2009508955A (ja) 2009-03-05
WO2007035665A1 (en) 2007-03-29
KR101368525B1 (ko) 2014-03-06
PL1928499T3 (pl) 2011-11-30
CA2622579C (en) 2013-12-31
US20120149639A1 (en) 2012-06-14
US8143217B2 (en) 2012-03-27

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