CA2622579C - Use of a dpp-iv inhibitor to reduce hypoglycemic events - Google Patents
Use of a dpp-iv inhibitor to reduce hypoglycemic events Download PDFInfo
- Publication number
- CA2622579C CA2622579C CA2622579A CA2622579A CA2622579C CA 2622579 C CA2622579 C CA 2622579C CA 2622579 A CA2622579 A CA 2622579A CA 2622579 A CA2622579 A CA 2622579A CA 2622579 C CA2622579 C CA 2622579C
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- Prior art keywords
- insulin
- dpp
- diabetes
- treatment
- inhibitor
- Prior art date
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/13—Amines
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Zoology (AREA)
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- Hematology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71885605P | 2005-09-20 | 2005-09-20 | |
| US60/718,856 | 2005-09-20 | ||
| US78675506P | 2006-03-28 | 2006-03-28 | |
| US60/786,755 | 2006-03-28 | ||
| PCT/US2006/036338 WO2007035665A1 (en) | 2005-09-20 | 2006-09-18 | Use of a dpp-iv inhibitor to reduce hypoglycemic events |
Publications (2)
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| CA2622579A1 CA2622579A1 (en) | 2007-03-29 |
| CA2622579C true CA2622579C (en) | 2013-12-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2622579A Expired - Fee Related CA2622579C (en) | 2005-09-20 | 2006-09-18 | Use of a dpp-iv inhibitor to reduce hypoglycemic events |
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| Country | Link |
|---|---|
| US (2) | US8143217B2 (OSRAM) |
| EP (1) | EP1928499B1 (OSRAM) |
| JP (1) | JP5072848B2 (OSRAM) |
| KR (1) | KR101368525B1 (OSRAM) |
| AT (1) | ATE514435T1 (OSRAM) |
| AU (1) | AU2006292377B2 (OSRAM) |
| BR (1) | BRPI0616195A2 (OSRAM) |
| CA (1) | CA2622579C (OSRAM) |
| PL (1) | PL1928499T3 (OSRAM) |
| PT (1) | PT1928499E (OSRAM) |
| RU (1) | RU2440143C2 (OSRAM) |
| WO (1) | WO2007035665A1 (OSRAM) |
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| JP3124632B2 (ja) * | 1992-07-28 | 2001-01-15 | 株式会社ユニシアジェックス | 車両懸架装置 |
| CN101273987A (zh) * | 2002-06-03 | 2008-10-01 | 诺瓦提斯公司 | 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途 |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| WO2005117861A1 (en) * | 2004-06-04 | 2005-12-15 | Novartis Ag | Use of organic compounds |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| GB0425248D0 (en) | 2004-11-16 | 2004-12-15 | Gw Pharma Ltd | New use for cannabinoid |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| AU2007247190A1 (en) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Polymorphs |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| JP2010508348A (ja) * | 2006-11-01 | 2010-03-18 | ノバルティス アーゲー | 浮腫の予防、遅延または軽減のためのジペプチジルペプチダーゼｉｖ阻害剤の使用 |
| CL2008002427A1 (es) | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
| WO2009121804A1 (en) * | 2008-03-31 | 2009-10-08 | Glaxo Group Limited | Drug fusions and conjugates |
| PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| CA2729696A1 (en) * | 2008-07-03 | 2010-01-07 | Ratiopharm Gmbh | Crystalline salts of sitagliptin |
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| HUP0600522A2 (en) * | 1999-12-23 | 2006-11-28 | Novartis Ag | Use of hypoglycemic agent for treating impaired glucose metabolism |
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| ATE409466T1 (de) | 2002-01-11 | 2008-10-15 | Novo Nordisk As | Verfahren und zusammensetzung zur behandlung von diabetes, hypertonie, chronischer herzinsuffizienz und mit flüssigkeitsretention einhergehenden zuständen |
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| WO2005117861A1 (en) * | 2004-06-04 | 2005-12-15 | Novartis Ag | Use of organic compounds |
| US20070259927A1 (en) * | 2004-08-26 | 2007-11-08 | Takeda Pharmaceutical Company Limited | Remedy for Diabetes |
| AU2005299808B2 (en) * | 2004-10-25 | 2009-08-20 | Novartis Ag | Combination of DPP-IV inhibitor, PPAR antidiabetic and metformin |
| JP2008115080A (ja) * | 2005-04-22 | 2008-05-22 | Taisho Pharmaceutical Co Ltd | 併用医薬 |
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| CA2622579A1 (en) | 2007-03-29 |
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| RU2440143C2 (ru) | 2012-01-20 |
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| KR20080046198A (ko) | 2008-05-26 |
| RU2008115114A (ru) | 2009-11-27 |
| EP1928499A1 (en) | 2008-06-11 |
| PT1928499E (pt) | 2011-09-09 |
| BRPI0616195A2 (pt) | 2011-06-14 |
| JP2009508955A (ja) | 2009-03-05 |
| WO2007035665A1 (en) | 2007-03-29 |
| KR101368525B1 (ko) | 2014-03-06 |
| PL1928499T3 (pl) | 2011-11-30 |
| JP5072848B2 (ja) | 2012-11-14 |
| US20120149639A1 (en) | 2012-06-14 |
| US8143217B2 (en) | 2012-03-27 |
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