JP5072604B2 - １−［３−［３−（４−クロロフェニル）プロポキシ］プロピル］−ピペリジン一塩酸塩 - Google Patents

１−［３−［３−（４−クロロフェニル）プロポキシ］プロピル］−ピペリジン一塩酸塩 Download PDF

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JP5072604B2
JP5072604B2 JP2007554541A JP2007554541A JP5072604B2 JP 5072604 B2 JP5072604 B2 JP 5072604B2 JP 2007554541 A JP2007554541 A JP 2007554541A JP 2007554541 A JP2007554541 A JP 2007554541A JP 5072604 B2 JP5072604 B2 JP 5072604B2
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chlorophenyl
propoxy
propyl
pharmaceutical composition
piperidine monohydrochloride
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Expired - Lifetime
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JP2007554541A
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Japanese (ja)
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JP2008530050A5 (enExample
JP2008530050A (ja
Inventor
エメ． ラガ，マヌエル
サラレス，ホアン
ゲレーロ，マルタ
グリエッタ，アントニオ
アラン，ジャン−ミシェル
シュワルツ，ジャン−シャルル
スタルク，ホルガー
シュナック，バルター
リグノー，グザビエ
ルコント，ジャンヌ−マリー
ロビン ガネリン，シャロン
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ビオプロジェ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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  • Immunology (AREA)
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  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
JP2007554541A 2005-02-10 2006-02-06 １−［３−［３−（４−クロロフェニル）プロポキシ］プロピル］−ピペリジン一塩酸塩 Expired - Lifetime JP5072604B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05100942A EP1690858B1 (en) 2005-02-10 2005-02-10 Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine
EP05100942.1 2005-02-10
PCT/EP2006/050703 WO2006084833A1 (en) 2005-02-10 2006-02-06 Monohydrochloride salt of 1- [3- [3- (4-chlorophenyl) propoxy] propyl] -piperidine

Publications (3)

Publication Number Publication Date
JP2008530050A JP2008530050A (ja) 2008-08-07
JP2008530050A5 JP2008530050A5 (enExample) 2009-04-02
JP5072604B2 true JP5072604B2 (ja) 2012-11-14

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JP2007554541A Expired - Lifetime JP5072604B2 (ja) 2005-02-10 2006-02-06 １−［３−［３−（４−クロロフェニル）プロポキシ］プロピル］−ピペリジン一塩酸塩

Country Status (22)

Country Link
US (2) US8207197B2 (enExample)
EP (2) EP1690858B1 (enExample)
JP (1) JP5072604B2 (enExample)
KR (1) KR101344271B1 (enExample)
CN (1) CN101155793B (enExample)
AR (1) AR054734A1 (enExample)
AT (2) ATE391716T1 (enExample)
CA (1) CA2597016C (enExample)
CY (1) CY1108428T1 (enExample)
DE (2) DE602005005941D1 (enExample)
DK (1) DK1846384T3 (enExample)
ES (1) ES2309948T3 (enExample)
HR (1) HRP20080446T3 (enExample)
ME (1) ME01103B (enExample)
MX (1) MX2007009574A (enExample)
PL (1) PL1846384T3 (enExample)
PT (1) PT1846384E (enExample)
RS (1) RS50624B (enExample)
SI (1) SI1846384T1 (enExample)
TW (1) TWI393711B (enExample)
UY (1) UY29369A1 (enExample)
WO (1) WO2006084833A1 (enExample)

Families Citing this family (21)

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EP2167096A4 (en) * 2007-06-13 2010-07-14 Cypress Bioscience Inc IMPROVING TOLERANCE TO MIRTAZAPINE AND A SECOND ACTIVE INGREDIENT BY THE COMBINED USE OF THEM
RU2011137419A (ru) 2009-02-11 2013-03-20 Суновион Фармасьютикалз Инк. Обратные агонисты и антагонисты гистамина н3 и способы их применения
KR20120035183A (ko) 2009-06-10 2012-04-13 선오비온 파마슈티컬스 인코포레이티드 히스타민 ｈ3 역 작용제 및 길항제, 및 이의 사용 방법
CA2772522A1 (en) 2009-09-11 2011-03-17 Sunovion Pharmaceuticals Inc. Histamine h3 inverse agonists and antagonists and methods of use thereof
WO2014199935A1 (ja) * 2013-06-10 2014-12-18 株式会社エム・エス・エス 小胞体ストレスシグナルを抑制することによる，薬剤の副作用としての体重増加や肥満を防止するために用いられる肥満防止剤
CN103435575A (zh) * 2013-08-06 2013-12-11 中国人民解放军军事医学科学院毒物药物研究所 1-（ 3-（ 3-（ 4-氯苯基）丙氧基）丙基）哌啶盐酸盐的制备方法
CN104447620B (zh) * 2014-11-28 2016-05-04 瑞阳制药有限公司 1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶盐酸盐的制备方法
EP3239138A1 (en) 2016-04-25 2017-11-01 Sandoz Ag Hydrogen fumarate salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine
WO2020092604A1 (en) * 2018-10-30 2020-05-07 Concert Pharmaceuticals, Inc. Deuterated pitolisant
IT201900013941A1 (it) 2019-08-05 2021-02-05 Procos Spa PROCESSO PER LA SINTESI DI PITOLISANT HCl
CN110804026B (zh) * 2019-11-18 2022-04-01 苏州永健生物医药有限公司 1- (3- (3-（4-氯苯基）丙氧基)丙基)哌啶盐酸盐的合成方法
US11623920B2 (en) 2021-06-07 2023-04-11 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
US11945788B2 (en) 2021-06-07 2024-04-02 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
EP4457219A4 (en) * 2021-12-29 2025-12-10 Biophore India Pharmaceuticals Pvt Ltd SOLID FORMS OF 1-3-[3-(4-CHLOROPHENYL)PROPOXY]PROPYL PIPERIDINE HYDROCHLORIDE AND THEIR PREPARATION PROCESS
US20250281475A1 (en) * 2022-05-04 2025-09-11 Msn Laboratories Private Limited, R & D Center A pharmaceutical composition of pitolisant hydrochloride and their process for the preparation
WO2024084379A1 (en) * 2022-10-17 2024-04-25 Biophore India Pharmaceuticals Pvt. Ltd A NOVEL PROCESS FOR THE PREPARATION OF AMORPHOUS SOLID DISPERSION OF 1-{3-[3-(4-CHLOROPHENYL) PROPOXY] PROPYL} PIPERIDINE, HYDROCHLORIDE WITH HYDROXYPROPYL BETA-CYCLODEXTRIN (HPβCD)
EP4374854A1 (en) * 2022-11-28 2024-05-29 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical mixture comprising amorphous pitolisant
CN121175294A (zh) 2023-03-31 2025-12-19 生物计划制药公司 盐酸替洛利生的多晶型形式
TW202535386A (zh) 2023-10-16 2025-09-16 法商拜爾普羅傑特醫藥有限公司 腸溶包衣必托里賽（ｐｉｔｏｌｉｓａｎｔ）調配物及使用方法
EP4681704A1 (en) 2024-07-18 2026-01-21 BIOPROJET Pharma New formulations of pitolisant
EP4732903A1 (en) 2024-10-28 2026-04-29 BIOPROJET Pharma Co-crystals of pitolisant hydrochloride

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
EP0982300A3 (en) * 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications

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ME01103B (me) 2013-03-20
US8207197B2 (en) 2012-06-26
CA2597016A1 (en) 2006-08-17
DK1846384T3 (da) 2008-11-17
ATE391716T1 (de) 2008-04-15
EP1846384A1 (en) 2007-10-24
CA2597016C (en) 2013-01-15
DE602006001938D1 (de) 2008-09-04
DE602005005941D1 (de) 2008-05-21
CY1108428T1 (el) 2014-04-09
PT1846384E (pt) 2008-10-21
US20120289546A1 (en) 2012-11-15
MX2007009574A (es) 2007-09-25
SI1846384T1 (sl) 2008-12-31
EP1846384B1 (en) 2008-07-23
EP1690858A1 (en) 2006-08-16
ATE402154T1 (de) 2008-08-15
TWI393711B (zh) 2013-04-21
WO2006084833A1 (en) 2006-08-17
KR20070101381A (ko) 2007-10-16
US8354430B2 (en) 2013-01-15
CN101155793A (zh) 2008-04-02
PL1846384T3 (pl) 2009-01-30
KR101344271B1 (ko) 2013-12-26
CN101155793B (zh) 2015-05-20
ES2309948T3 (es) 2008-12-16
HRP20080446T3 (en) 2008-10-31
UY29369A1 (es) 2006-05-31
EP1690858B1 (en) 2008-04-09
TW200639157A (en) 2006-11-16
JP2008530050A (ja) 2008-08-07
AR054734A1 (es) 2007-07-11
RS50624B (sr) 2010-06-30
US20080221162A1 (en) 2008-09-11

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