AR054734A1 - Compuesto que comprende monoclorhidrato de 1-[3-[3(4-clorofenil) propoxi] propil] - piperidina cristalino, procedimiento para su fabricacion y composiciones farmaceuticas. - Google Patents
Compuesto que comprende monoclorhidrato de 1-[3-[3(4-clorofenil) propoxi] propil] - piperidina cristalino, procedimiento para su fabricacion y composiciones farmaceuticas.Info
- Publication number
- AR054734A1 AR054734A1 ARP060100448A ARP060100448A AR054734A1 AR 054734 A1 AR054734 A1 AR 054734A1 AR P060100448 A ARP060100448 A AR P060100448A AR P060100448 A ARP060100448 A AR P060100448A AR 054734 A1 AR054734 A1 AR 054734A1
- Authority
- AR
- Argentina
- Prior art keywords
- chlorophenyl
- pharmaceutical compositions
- monoclorhydrate
- propoxi
- propil
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XLFKECRRMPOAQS-UHFFFAOYSA-N 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine;hydrochloride Chemical compound Cl.C1=CC(Cl)=CC=C1CCCOCCCN1CCCCC1 XLFKECRRMPOAQS-UHFFFAOYSA-N 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100942A EP1690858B1 (en) | 2005-02-10 | 2005-02-10 | Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054734A1 true AR054734A1 (es) | 2007-07-11 |
Family
ID=34938687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100448A AR054734A1 (es) | 2005-02-10 | 2006-02-08 | Compuesto que comprende monoclorhidrato de 1-[3-[3(4-clorofenil) propoxi] propil] - piperidina cristalino, procedimiento para su fabricacion y composiciones farmaceuticas. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8207197B2 (enExample) |
| EP (2) | EP1690858B1 (enExample) |
| JP (1) | JP5072604B2 (enExample) |
| KR (1) | KR101344271B1 (enExample) |
| CN (1) | CN101155793B (enExample) |
| AR (1) | AR054734A1 (enExample) |
| AT (2) | ATE391716T1 (enExample) |
| CA (1) | CA2597016C (enExample) |
| CY (1) | CY1108428T1 (enExample) |
| DE (2) | DE602005005941D1 (enExample) |
| DK (1) | DK1846384T3 (enExample) |
| ES (1) | ES2309948T3 (enExample) |
| HR (1) | HRP20080446T3 (enExample) |
| ME (1) | ME01103B (enExample) |
| MX (1) | MX2007009574A (enExample) |
| PL (1) | PL1846384T3 (enExample) |
| PT (1) | PT1846384E (enExample) |
| RS (1) | RS50624B (enExample) |
| SI (1) | SI1846384T1 (enExample) |
| TW (1) | TWI393711B (enExample) |
| UY (1) | UY29369A1 (enExample) |
| WO (1) | WO2006084833A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008157094A1 (en) * | 2007-06-13 | 2008-12-24 | Cypress Bioscience, Inc. | Improving the tolerability of mirtazapine and a second active by using them in combination |
| AU2010214101A1 (en) | 2009-02-11 | 2011-09-01 | Sunovion Pharmaceuticals Inc. | Histamine H3 inverse agonists and antagonists and methods of use thereof |
| KR20120035183A (ko) | 2009-06-10 | 2012-04-13 | 선오비온 파마슈티컬스 인코포레이티드 | 히스타민 ｈ3 역 작용제 및 길항제, 및 이의 사용 방법 |
| JP2013504580A (ja) | 2009-09-11 | 2013-02-07 | スノヴィオン ファーマシューティカルズ インコーポレイテッド | ヒスタミンｈ３インバースアゴニストおよびアンタゴニストとその使用方法 |
| WO2014199935A1 (ja) * | 2013-06-10 | 2014-12-18 | 株式会社エム・エス・エス | 小胞体ストレスシグナルを抑制することによる，薬剤の副作用としての体重増加や肥満を防止するために用いられる肥満防止剤 |
| CN103435575A (zh) * | 2013-08-06 | 2013-12-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 1-（ 3-（ 3-（ 4-氯苯基）丙氧基）丙基）哌啶盐酸盐的制备方法 |
| CN104447620B (zh) * | 2014-11-28 | 2016-05-04 | 瑞阳制药有限公司 | 1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶盐酸盐的制备方法 |
| EP3239138A1 (en) | 2016-04-25 | 2017-11-01 | Sandoz Ag | Hydrogen fumarate salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine |
| WO2020092604A1 (en) * | 2018-10-30 | 2020-05-07 | Concert Pharmaceuticals, Inc. | Deuterated pitolisant |
| IT201900013941A1 (it) | 2019-08-05 | 2021-02-05 | Procos Spa | PROCESSO PER LA SINTESI DI PITOLISANT HCl |
| CN110804026B (zh) * | 2019-11-18 | 2022-04-01 | 苏州永健生物医药有限公司 | 1- (3- (3-（4-氯苯基）丙氧基)丙基)哌啶盐酸盐的合成方法 |
| US11945788B2 (en) | 2021-06-07 | 2024-04-02 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
| US11623920B2 (en) | 2021-06-07 | 2023-04-11 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
| US20250059145A1 (en) * | 2021-12-29 | 2025-02-20 | Biophore India Pharmaceuticals Pvt. Ltd. | Solid forms of 1-{3-[3-(4-chlorophenyl) propoxy] propyl} piperidine hydrochloride and process for the preparation thereof |
| US20250281475A1 (en) * | 2022-05-04 | 2025-09-11 | Msn Laboratories Private Limited, R & D Center | A pharmaceutical composition of pitolisant hydrochloride and their process for the preparation |
| WO2024084379A1 (en) * | 2022-10-17 | 2024-04-25 | Biophore India Pharmaceuticals Pvt. Ltd | A NOVEL PROCESS FOR THE PREPARATION OF AMORPHOUS SOLID DISPERSION OF 1-{3-[3-(4-CHLOROPHENYL) PROPOXY] PROPYL} PIPERIDINE, HYDROCHLORIDE WITH HYDROXYPROPYL BETA-CYCLODEXTRIN (HPβCD) |
| EP4374854A1 (en) * | 2022-11-28 | 2024-05-29 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical mixture comprising amorphous pitolisant |
| JP2026511788A (ja) | 2023-03-31 | 2026-04-14 | ビオプロジェ・ファルマ | ピトリサント塩酸塩の多形形態 |
| EP4681704A1 (en) | 2024-07-18 | 2026-01-21 | BIOPROJET Pharma | New formulations of pitolisant |
| CN122374013A (zh) | 2023-10-16 | 2026-07-10 | 生物计划制药公司 | 替洛利生的新制剂和使用方法 |
| EP4732903A1 (en) | 2024-10-28 | 2026-04-29 | BIOPROJET Pharma | Co-crystals of pitolisant hydrochloride |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
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2005
- 2005-02-10 DE DE602005005941T patent/DE602005005941D1/de not_active Expired - Lifetime
- 2005-02-10 AT AT05100942T patent/ATE391716T1/de not_active IP Right Cessation
- 2005-02-10 EP EP05100942A patent/EP1690858B1/en not_active Expired - Lifetime
-
2006
- 2006-02-06 CN CN200680008857.1A patent/CN101155793B/zh not_active Expired - Lifetime
- 2006-02-06 KR KR1020077020422A patent/KR101344271B1/ko not_active Expired - Lifetime
- 2006-02-06 ME MEP-2008-394A patent/ME01103B/me unknown
- 2006-02-06 HR HR20080446T patent/HRP20080446T3/xx unknown
- 2006-02-06 PL PL06708050T patent/PL1846384T3/pl unknown
- 2006-02-06 ES ES06708050T patent/ES2309948T3/es not_active Expired - Lifetime
- 2006-02-06 WO PCT/EP2006/050703 patent/WO2006084833A1/en not_active Ceased
- 2006-02-06 DK DK06708050T patent/DK1846384T3/da active
- 2006-02-06 CA CA2597016A patent/CA2597016C/en not_active Expired - Lifetime
- 2006-02-06 EP EP06708050A patent/EP1846384B1/en not_active Expired - Lifetime
- 2006-02-06 MX MX2007009574A patent/MX2007009574A/es active IP Right Grant
- 2006-02-06 DE DE602006001938T patent/DE602006001938D1/de not_active Expired - Lifetime
- 2006-02-06 JP JP2007554541A patent/JP5072604B2/ja not_active Expired - Lifetime
- 2006-02-06 AT AT06708050T patent/ATE402154T1/de active
- 2006-02-06 PT PT06708050T patent/PT1846384E/pt unknown
- 2006-02-06 RS RSP-2008/0482A patent/RS50624B/sr unknown
- 2006-02-06 SI SI200630073T patent/SI1846384T1/sl unknown
- 2006-02-06 US US11/815,736 patent/US8207197B2/en active Active
- 2006-02-08 AR ARP060100448A patent/AR054734A1/es not_active Application Discontinuation
- 2006-02-08 TW TW095104184A patent/TWI393711B/zh not_active IP Right Cessation
- 2006-02-09 UY UY29369A patent/UY29369A1/es not_active Application Discontinuation
-
2008
- 2008-10-21 CY CY20081101174T patent/CY1108428T1/el unknown
-
2012
- 2012-06-07 US US13/491,229 patent/US8354430B2/en not_active Expired - Lifetime
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