ME01103B - Monohidrohloridna so 1-[3-[3-(4-hlorofenil)propoksi]propil]piperidina - Google Patents
Monohidrohloridna so 1-[3-[3-(4-hlorofenil)propoksi]propil]piperidinaInfo
- Publication number
- ME01103B ME01103B MEP-2008-394A MEP2008394A ME01103B ME 01103 B ME01103 B ME 01103B ME P2008394 A MEP2008394 A ME P2008394A ME 01103 B ME01103 B ME 01103B
- Authority
- ME
- Montenegro
- Prior art keywords
- chlorophenyl
- propoxy
- piperidine
- propyl
- monohydrochloride salt
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100942A EP1690858B1 (en) | 2005-02-10 | 2005-02-10 | Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine |
| PCT/EP2006/050703 WO2006084833A1 (en) | 2005-02-10 | 2006-02-06 | Monohydrochloride salt of 1- [3- [3- (4-chlorophenyl) propoxy] propyl] -piperidine |
| EP06708050A EP1846384B1 (en) | 2005-02-10 | 2006-02-06 | Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01103B true ME01103B (me) | 2013-03-20 |
Family
ID=34938687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2008-394A ME01103B (me) | 2005-02-10 | 2006-02-06 | Monohidrohloridna so 1-[3-[3-(4-hlorofenil)propoksi]propil]piperidina |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8207197B2 (me) |
| EP (2) | EP1690858B1 (me) |
| JP (1) | JP5072604B2 (me) |
| KR (1) | KR101344271B1 (me) |
| CN (1) | CN101155793B (me) |
| AR (1) | AR054734A1 (me) |
| AT (2) | ATE391716T1 (me) |
| CA (1) | CA2597016C (me) |
| CY (1) | CY1108428T1 (me) |
| DE (2) | DE602005005941D1 (me) |
| DK (1) | DK1846384T3 (me) |
| ES (1) | ES2309948T3 (me) |
| HR (1) | HRP20080446T3 (me) |
| ME (1) | ME01103B (me) |
| MX (1) | MX2007009574A (me) |
| PL (1) | PL1846384T3 (me) |
| PT (1) | PT1846384E (me) |
| RS (1) | RS50624B (me) |
| SI (1) | SI1846384T1 (me) |
| TW (1) | TWI393711B (me) |
| UY (1) | UY29369A1 (me) |
| WO (1) | WO2006084833A1 (me) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008157094A1 (en) * | 2007-06-13 | 2008-12-24 | Cypress Bioscience, Inc. | Improving the tolerability of mirtazapine and a second active by using them in combination |
| EP2396327A1 (en) | 2009-02-11 | 2011-12-21 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
| US20120077802A1 (en) | 2009-06-10 | 2012-03-29 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
| AU2010292287A1 (en) | 2009-09-11 | 2012-03-15 | Sunovion Pharmaceuticals Inc. | Histamine H3 inverse agonists and antagonists and methods of use thereof |
| WO2014199935A1 (ja) * | 2013-06-10 | 2014-12-18 | 株式会社エム・エス・エス | 小胞体ストレスシグナルを抑制することによる，薬剤の副作用としての体重増加や肥満を防止するために用いられる肥満防止剤 |
| CN103435575A (zh) * | 2013-08-06 | 2013-12-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 1-（ 3-（ 3-（ 4-氯苯基）丙氧基）丙基）哌啶盐酸盐的制备方法 |
| CN104447620B (zh) * | 2014-11-28 | 2016-05-04 | 瑞阳制药有限公司 | 1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶盐酸盐的制备方法 |
| EP3239138A1 (en) | 2016-04-25 | 2017-11-01 | Sandoz Ag | Hydrogen fumarate salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine |
| WO2020092604A1 (en) * | 2018-10-30 | 2020-05-07 | Concert Pharmaceuticals, Inc. | Deuterated pitolisant |
| IT201900013941A1 (it) | 2019-08-05 | 2021-02-05 | Procos Spa | PROCESSO PER LA SINTESI DI PITOLISANT HCl |
| CN110804026B (zh) * | 2019-11-18 | 2022-04-01 | 苏州永健生物医药有限公司 | 1- (3- (3-（4-氯苯基）丙氧基)丙基)哌啶盐酸盐的合成方法 |
| US11945788B2 (en) | 2021-06-07 | 2024-04-02 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
| US11623920B2 (en) | 2021-06-07 | 2023-04-11 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
| WO2023126865A1 (en) * | 2021-12-29 | 2023-07-06 | Biophore India Pharmaceuticals Pvt Ltd | Solid forms of 1-{3-[3-(4-chlorophenyl) propoxy] propyl} piperidine hydrochloride and process for the preparation thereof |
| WO2023214431A1 (en) * | 2022-05-04 | 2023-11-09 | Msn Laboratories Private Limited, R&D Center | A pharmaceutical composition of pitolisant hydrochloride and their process for the preparation |
| WO2024084379A1 (en) * | 2022-10-17 | 2024-04-25 | Biophore India Pharmaceuticals Pvt. Ltd | A NOVEL PROCESS FOR THE PREPARATION OF AMORPHOUS SOLID DISPERSION OF 1-{3-[3-(4-CHLOROPHENYL) PROPOXY] PROPYL} PIPERIDINE, HYDROCHLORIDE WITH HYDROXYPROPYL BETA-CYCLODEXTRIN (HPβCD) |
| EP4374854A1 (en) | 2022-11-28 | 2024-05-29 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical mixture comprising amorphous pitolisant |
| WO2024201139A1 (en) | 2023-03-31 | 2024-10-03 | Bioprojet Pharma | Polymorph form of pitolisant hydrochloride |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
-
2005
- 2005-02-10 DE DE602005005941T patent/DE602005005941D1/de active Active
- 2005-02-10 AT AT05100942T patent/ATE391716T1/de not_active IP Right Cessation
- 2005-02-10 EP EP05100942A patent/EP1690858B1/en active Active
-
2006
- 2006-02-06 CN CN200680008857.1A patent/CN101155793B/zh active Active
- 2006-02-06 SI SI200630073T patent/SI1846384T1/sl unknown
- 2006-02-06 ES ES06708050T patent/ES2309948T3/es active Active
- 2006-02-06 PT PT06708050T patent/PT1846384E/pt unknown
- 2006-02-06 WO PCT/EP2006/050703 patent/WO2006084833A1/en active Application Filing
- 2006-02-06 ME MEP-2008-394A patent/ME01103B/me unknown
- 2006-02-06 MX MX2007009574A patent/MX2007009574A/es active IP Right Grant
- 2006-02-06 PL PL06708050T patent/PL1846384T3/pl unknown
- 2006-02-06 CA CA2597016A patent/CA2597016C/en active Active
- 2006-02-06 US US11/815,736 patent/US8207197B2/en active Active
- 2006-02-06 RS RSP-2008/0482A patent/RS50624B/sr unknown
- 2006-02-06 JP JP2007554541A patent/JP5072604B2/ja active Active
- 2006-02-06 DE DE602006001938T patent/DE602006001938D1/de active Active
- 2006-02-06 EP EP06708050A patent/EP1846384B1/en active Active
- 2006-02-06 DK DK06708050T patent/DK1846384T3/da active
- 2006-02-06 AT AT06708050T patent/ATE402154T1/de active
- 2006-02-08 AR ARP060100448A patent/AR054734A1/es not_active Application Discontinuation
- 2006-02-08 TW TW095104184A patent/TWI393711B/zh active
- 2006-02-09 UY UY29369A patent/UY29369A1/es not_active Application Discontinuation
-
2007
- 2007-09-06 KR KR1020077020422A patent/KR101344271B1/ko active Protection Beyond IP Right Term
-
2008
- 2008-09-15 HR HR20080446T patent/HRP20080446T3/xx unknown
- 2008-10-21 CY CY20081101174T patent/CY1108428T1/el unknown
-
2012
- 2012-06-07 US US13/491,229 patent/US8354430B2/en active Active
Also Published As
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