JP5055417B2 - 組織へ治療剤を投与するための装置 - Google Patents
組織へ治療剤を投与するための装置 Download PDFInfo
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- JP5055417B2 JP5055417B2 JP2010257252A JP2010257252A JP5055417B2 JP 5055417 B2 JP5055417 B2 JP 5055417B2 JP 2010257252 A JP2010257252 A JP 2010257252A JP 2010257252 A JP2010257252 A JP 2010257252A JP 5055417 B2 JP5055417 B2 JP 5055417B2
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3114—Filling or refilling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0216—Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1003—Spinal column
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/06—Body-piercing guide needles or the like
- A61M25/065—Guide needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Medical Informatics (AREA)
- Organic Chemistry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
i)手順が不可逆であること
ii)組織に傷跡が残ること
iii)回復に時間がかかること
iv)長期にわたり病院にいなくてはならないこと
といった欠点がある。
・臨床上および神経放射線学上の禁忌が少ないこと
・椎間板においての成功率が約70%以上であること
・回復にかかる時間がほとんどまたは全くないこと
・副作用がほとんどまたは全くないこと
・瘢痕がほとんどまたは全く形成されないこと
・侵襲的な処置が最小限でよいこと
・休息や日常の行動の制限などの保存療法では治療できない疾患に対する効果的な代替治療であること
・消毒薬
・ドレープ
・皮膚調製物質
・バイアル入れられた局部麻酔薬
・シリンジ
・短針および長針(一部側孔を有する)
・構台ドレープ
・X線透過性の針ホルダ
・椎間板造影のための非イオン性X線染料
・注入ワイヤ
・活性炭オゾン捕集器
・バイアルに入れられたステロイド
・滅菌可能であり、一回の使用毎に使い捨て可能な、気体もしくは液体としてオゾンを生成するオゾン源。オゾンを電池駆動式の携帯型使い捨て装置形態の供給システム中で生成することができる。
・注入器内に設置するオゾン発生装置は、1ccから5ccまでの供給するオゾン量の範囲に応じて、さまざまな大きさとすることができる。しかしこの発生装置は、0.1ccから1リットルまでの液体または気体オゾンを生成するように作ることも可能である。
・一般的に用いられる量は、接続チューブ/針などの死積を考慮に入れると、1ccから10ccの間にあると考えられる。
・使い捨てフィルタ付取付け具
・活栓
・ノンコンプライアント(非柔軟)・チューブ
・皮膚閉鎖に使用する手術後の包帯剤
・中心にガーゼパッドを有するガーゼ付絆創膏
映像装置によってヘルニア状態になった椎間板を特定するステップ;
疾患部位上の皮膚に準備を施すステップ;
手術部位に局部麻酔薬を施すステップ;
ヘルニア状態になった椎間板に椎間板の位置まで針を挿入するステップ;
針に非イオン性X線染料を注入するステップ;
椎間板造影を行うステップ;
患者の外部にあるオゾン発生装置を起動させるステップ;
オゾン発生器上のO3/O2ガス混合物の具体的濃度を選択するステップ;
捕集器およびシリンジをオゾン発生装置に取り付けるステップ;
シリンジにO3/O2ガス混合物を吸引するステップ;
一定濃度のオゾン/酸素ガス混合物の所定量を椎間板および椎間板の傍脊椎軟組織に注入するステップ;
使用されなかったオゾンを活性炭捕集器で捕集するステップ;
全ての針を取り外すステップ;および
手術部位の手当てをするステップ。
・消毒薬、ドレープおよび皮膚調製材料
・リドカインおよび長さ22Gの針を有する10ccのシリンジ
・オムニパーク300M等の、椎間板造影用非イオン性X線染色
・同軸導入針として作用する外側の16Gまたは18Gの針
・椎間板にオゾンを注入するための、側孔を有することのできる20Gまたは22Gの針
・ステロイド注入を行うための16〜18Gの外側の大きな針(これはオゾンを傍脊椎軟組織に注入するのにも使用することができる)
・椎間板部分にオゾンを均一に分配するための注入ワイヤ
・活性炭オゾン捕集器(活性炭および100%のO2を有する瓶)
・バイアルに入っており、注入の準備が整っているステロイドおよび局部麻酔薬
・AOS−1M医療用オゾン発生器、もしくはAOS−1MSステンレス医療用オゾン発生器などのオゾン源またはオゾンで満たされているためにオゾンを発生させることのできる使い捨ての注射器
・シリンジ用の使い捨てフィルタ付き取付け具、オゾン発生装置に取り付けられた一方向ストップコック
・画像誘導下での注入の間、手術者の手への放射を低減するための長さ20〜30cmの接続用のノンコンプライアントチューブ。
・チューブを活性炭オゾン捕集ボトルに連結する三方向ストップコック
・上述の使い捨てフィルタ付き取付け具を介してチューブをシリンジに連結する一方向のストップコック
・ポビドンゲル等の医薬ゲル
・バンドエイドなどの中心部分にガーゼがついている粘着性の絆創膏または小さな包帯。
Claims (4)
- 治療剤の発生および投与を内蔵するためのシリンジにおいて:
前記治療剤を保持するための円筒部;
前記円筒部の第一端に挿入し、前記治療剤を前記円筒部の第二端から押し出すためのプランジャ;
前記プランジャに同軸的に一体に取り付けられた電源;
前記プランジャに同軸的に一体に取り付けられ、前記円筒部とプランジャ内を通る経路を介して連通する治療剤発生器で、前記発生器が前記電源と接続されており前記プランジャに同軸的に取り付けられた発生器;
前記電源に接続されたスイッチで、前記スイッチが作動されると前記治療剤発生器が前記治療剤を発生させ前記円筒部を治療剤で満たすスイッチ;
を備えることを特徴とするシリンジ。 - 前記治療剤がオゾンである、請求項1に記載のシリンジ。
- 治療剤の発生および投与を内蔵するインプラント可能な装置において:
前記治療剤を保持するためのチャンバ;
前記チャンバを前記治療剤の投与部位に接続するためのカテーテル;
電源;
前記チャンバと連通しており、前記電源と接続されている治療剤発生器;
前記装置をインプラントされた患者によって外部から作動可能なスイッチで、前記装置が前記電源に接続されており、前記スイッチが作動されたときに前記治療剤発生器が前記治療剤を発生させ、治療剤でチャンバを満たすスイッチ;
を備えることを特徴とする装置。 - 前記治療剤がオゾンであり、前記治療剤発生器がオゾンと一体的に利用可能な酸素源を有するオゾン発生器である、請求項3に記載の装置。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50830003P | 2003-10-06 | 2003-10-06 | |
US60/508,300 | 2003-10-06 | ||
US10/867,215 US7615030B2 (en) | 2003-10-06 | 2004-06-15 | Apparatus and method for administering a therapeutic agent into tissue |
US10/867,215 | 2004-06-15 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006530769A Division JP4734248B2 (ja) | 2003-10-06 | 2004-10-01 | 組織へ治療剤を投与するための装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011067648A JP2011067648A (ja) | 2011-04-07 |
JP5055417B2 true JP5055417B2 (ja) | 2012-10-24 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP2006530769A Expired - Fee Related JP4734248B2 (ja) | 2003-10-06 | 2004-10-01 | 組織へ治療剤を投与するための装置 |
JP2010257252A Active JP5055417B2 (ja) | 2003-10-06 | 2010-11-17 | 組織へ治療剤を投与するための装置 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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JP2006530769A Expired - Fee Related JP4734248B2 (ja) | 2003-10-06 | 2004-10-01 | 組織へ治療剤を投与するための装置 |
Country Status (7)
Country | Link |
---|---|
US (5) | US7615030B2 (ja) |
EP (1) | EP1670526B1 (ja) |
JP (2) | JP4734248B2 (ja) |
AU (4) | AU2004277759B2 (ja) |
CA (1) | CA2540447C (ja) |
DE (3) | DE602004029210D1 (ja) |
WO (1) | WO2005032387A2 (ja) |
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JP4734248B2 (ja) | 2011-07-27 |
AU2010204467A1 (en) | 2010-08-19 |
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AU2010204467B2 (en) | 2012-08-23 |
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EP1670526B1 (en) | 2008-04-09 |
CA2540447C (en) | 2010-07-20 |
AU2004277759A1 (en) | 2005-04-14 |
JP2007507272A (ja) | 2007-03-29 |
US20090204062A1 (en) | 2009-08-13 |
DE602004028532D1 (de) | 2010-09-16 |
DE602004013027D1 (de) | 2008-05-21 |
AU2010204469B2 (en) | 2011-08-25 |
CA2540447A1 (en) | 2005-04-14 |
AU2010206008A1 (en) | 2010-08-26 |
AU2004277759B2 (en) | 2010-06-10 |
US20090209901A1 (en) | 2009-08-20 |
US20090254021A1 (en) | 2009-10-08 |
DE602004013027T2 (de) | 2009-05-14 |
EP1670526A2 (en) | 2006-06-21 |
US8162873B2 (en) | 2012-04-24 |
WO2005032387A3 (en) | 2005-10-13 |
US8066695B2 (en) | 2011-11-29 |
US20090209902A1 (en) | 2009-08-20 |
JP2011067648A (ja) | 2011-04-07 |
AU2010206008B2 (en) | 2011-05-19 |
DE602004029210D1 (de) | 2010-10-28 |
WO2005032387A2 (en) | 2005-04-14 |
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