JP5047613B2 - ヒドロゲルコンタクトレンズ及び包装システム及びそれらの製造方法 - Google Patents
ヒドロゲルコンタクトレンズ及び包装システム及びそれらの製造方法 Download PDFInfo
- Publication number
- JP5047613B2 JP5047613B2 JP2006509403A JP2006509403A JP5047613B2 JP 5047613 B2 JP5047613 B2 JP 5047613B2 JP 2006509403 A JP2006509403 A JP 2006509403A JP 2006509403 A JP2006509403 A JP 2006509403A JP 5047613 B2 JP5047613 B2 JP 5047613B2
- Authority
- JP
- Japan
- Prior art keywords
- contact lens
- water
- soluble polymer
- polymer component
- lens body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004806 packaging method and process Methods 0.000 title claims description 60
- 238000000034 method Methods 0.000 title claims description 32
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 239000000017 hydrogel Substances 0.000 title description 20
- 239000000178 monomer Substances 0.000 claims description 62
- 239000007788 liquid Substances 0.000 claims description 42
- 239000002609 medium Substances 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 35
- 229920003169 water-soluble polymer Polymers 0.000 claims description 34
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 32
- 239000002861 polymer material Substances 0.000 claims description 32
- -1 hydroxyalkyl acrylates Chemical class 0.000 claims description 26
- 238000006116 polymerization reaction Methods 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 14
- 239000003085 diluting agent Substances 0.000 claims description 13
- 238000005266 casting Methods 0.000 claims description 8
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 6
- 229920002554 vinyl polymer Polymers 0.000 claims description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical class CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 239000012736 aqueous medium Substances 0.000 claims description 4
- 238000010528 free radical solution polymerization reaction Methods 0.000 claims description 4
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical class OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 claims description 3
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 3
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 239000002243 precursor Substances 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 2
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 description 38
- 229920001223 polyethylene glycol Polymers 0.000 description 38
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 27
- 239000011780 sodium chloride Substances 0.000 description 26
- 239000004743 Polypropylene Substances 0.000 description 12
- 239000003999 initiator Substances 0.000 description 12
- 229920001155 polypropylene Polymers 0.000 description 12
- 239000000243 solution Substances 0.000 description 10
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 9
- 238000003860 storage Methods 0.000 description 9
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 6
- 238000001723 curing Methods 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 238000000016 photochemical curing Methods 0.000 description 6
- 229920001187 thermosetting polymer Polymers 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 238000005461 lubrication Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000002685 polymerization catalyst Substances 0.000 description 3
- 230000000379 polymerizing effect Effects 0.000 description 3
- GWZMWHWAWHPNHN-UHFFFAOYSA-N 2-hydroxypropyl prop-2-enoate Chemical group CC(O)COC(=O)C=C GWZMWHWAWHPNHN-UHFFFAOYSA-N 0.000 description 2
- 102100026735 Coagulation factor VIII Human genes 0.000 description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 2
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 2
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical compound CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 description 1
- NEBBLNDVSSWJLL-UHFFFAOYSA-N 2,3-bis(2-methylprop-2-enoyloxy)propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(OC(=O)C(C)=C)COC(=O)C(C)=C NEBBLNDVSSWJLL-UHFFFAOYSA-N 0.000 description 1
- FTALTLPZDVFJSS-UHFFFAOYSA-N 2-(2-ethoxyethoxy)ethyl prop-2-enoate Chemical compound CCOCCOCCOC(=O)C=C FTALTLPZDVFJSS-UHFFFAOYSA-N 0.000 description 1
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 1
- XMLYCEVDHLAQEL-UHFFFAOYSA-N 2-hydroxy-2-methyl-1-phenylpropan-1-one Chemical group CC(C)(O)C(=O)C1=CC=CC=C1 XMLYCEVDHLAQEL-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- AKSCZDCJTQRRIA-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate;2-hydroxypropyl 2-methylprop-2-enoate Chemical compound OCCOC(=O)C=C.CC(O)COC(=O)C(C)=C AKSCZDCJTQRRIA-UHFFFAOYSA-N 0.000 description 1
- YXYJVFYWCLAXHO-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate Chemical compound COCCOC(=O)C(C)=C YXYJVFYWCLAXHO-UHFFFAOYSA-N 0.000 description 1
- VSSGDAWBDKMCMI-UHFFFAOYSA-N 2-methyl-2-(2-methylprop-2-enoylamino)propane-1-sulfonic acid Chemical compound CC(=C)C(=O)NC(C)(C)CS(O)(=O)=O VSSGDAWBDKMCMI-UHFFFAOYSA-N 0.000 description 1
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 description 1
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 1
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- SERIZWCPINYSDI-UHFFFAOYSA-N 5-hydroxy-2-methylidenepentanamide Chemical compound NC(=O)C(=C)CCCO SERIZWCPINYSDI-UHFFFAOYSA-N 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229920006397 acrylic thermoplastic Polymers 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229930006711 bornane-2,3-dione Natural products 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 231100000065 noncytotoxic Toxicity 0.000 description 1
- 230000002020 noncytotoxic effect Effects 0.000 description 1
- FZUGPQWGEGAKET-UHFFFAOYSA-N parbenate Chemical compound CCOC(=O)C1=CC=C(N(C)C)C=C1 FZUGPQWGEGAKET-UHFFFAOYSA-N 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- BWJUFXUULUEGMA-UHFFFAOYSA-N propan-2-yl propan-2-yloxycarbonyloxy carbonate Chemical compound CC(C)OC(=O)OOC(=O)OC(C)C BWJUFXUULUEGMA-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000001175 rotational moulding Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
- B65D2585/54—Containers, packaging elements or packages specially adapted for particular articles or materials for articles of special shape not otherwise provided for
- B65D2585/545—Contact lenses
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
- Polymerisation Methods In General (AREA)
- Graft Or Block Polymers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Containers And Plastic Fillers For Packaging (AREA)
- Colloid Chemistry (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46509003P | 2003-04-24 | 2003-04-24 | |
| US60/465,090 | 2003-04-24 | ||
| PCT/US2004/009482 WO2004097504A1 (en) | 2003-04-24 | 2004-03-29 | Hydrogel contact lenses and package systems and production methods for same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010267782A Division JP2011095758A (ja) | 2003-04-24 | 2010-11-30 | ヒドロゲルコンタクトレンズ及び包装システム及びそれらの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006526807A JP2006526807A (ja) | 2006-11-24 |
| JP2006526807A5 JP2006526807A5 (https=) | 2011-01-27 |
| JP5047613B2 true JP5047613B2 (ja) | 2012-10-10 |
Family
ID=33418180
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509403A Expired - Lifetime JP5047613B2 (ja) | 2003-04-24 | 2004-03-29 | ヒドロゲルコンタクトレンズ及び包装システム及びそれらの製造方法 |
| JP2010267782A Abandoned JP2011095758A (ja) | 2003-04-24 | 2010-11-30 | ヒドロゲルコンタクトレンズ及び包装システム及びそれらの製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010267782A Abandoned JP2011095758A (ja) | 2003-04-24 | 2010-11-30 | ヒドロゲルコンタクトレンズ及び包装システム及びそれらの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20040214914A1 (https=) |
| EP (1) | EP1623269B2 (https=) |
| JP (2) | JP5047613B2 (https=) |
| ES (1) | ES2634840T5 (https=) |
| HU (1) | HUE035379T2 (https=) |
| WO (1) | WO2004097504A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040004008A1 (en) * | 2002-06-26 | 2004-01-08 | Peck James M. | Contact lens packages |
| US20060073185A1 (en) * | 2002-12-13 | 2006-04-06 | Bausch & Lomb Incorporated | Method and composition for contact lenses |
| US20050070661A1 (en) * | 2003-09-30 | 2005-03-31 | Frank Molock | Methods of preparing ophthalmic devices |
| EP2543376A1 (en) | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| US7652051B2 (en) | 2004-08-25 | 2010-01-26 | Targegen, Inc. | Heterocyclic compounds and methods of use |
| US7857447B2 (en) * | 2004-10-05 | 2010-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Interpenetrating polymer network hydrogel contact lenses |
| US20090088846A1 (en) | 2007-04-17 | 2009-04-02 | David Myung | Hydrogel arthroplasty device |
| WO2012050591A1 (en) * | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
| EP1861069B2 (en) † | 2005-02-09 | 2013-07-03 | Safilens S.R.L. | Contact lens, method for producing same, and pack for storage and maintenance of a contact lens |
| KR20070114130A (ko) | 2005-02-14 | 2007-11-29 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 착용감이 편안한 안용 장치 및 이의 제조방법 |
| US8684729B2 (en) * | 2005-03-07 | 2014-04-01 | Align Technology, Inc. | Disposable dental aligner |
| US9804295B2 (en) * | 2005-05-05 | 2017-10-31 | Novartis Ag | Ophthalmic devices for sustained delivery of active compounds |
| US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| JP5191391B2 (ja) | 2005-11-01 | 2013-05-08 | ターゲジェン インコーポレーティッド | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| US20070149428A1 (en) * | 2005-12-14 | 2007-06-28 | Bausch & Lomb Incorporated | Method of Packaging a Lens |
| US9052529B2 (en) | 2006-02-10 | 2015-06-09 | Johnson & Johnson Vision Care, Inc. | Comfortable ophthalmic device and methods of its production |
| JP5194218B2 (ja) * | 2006-06-05 | 2013-05-08 | 株式会社メニコンネクト | 含水性コンタクトレンズの保存方法ならびに該保存方法により保存された含水性コンタクトレンズ |
| JP2009545662A (ja) * | 2006-08-04 | 2009-12-24 | フジフィルム マニュファクチャリング ユーロプ ビー.ブイ. | 多孔性膜およびこれを含む記録媒体 |
| ATE502691T1 (de) * | 2006-08-04 | 2011-04-15 | Fujifilm Mfg Europe Bv | Poröse membran und verfahren zur herstellung |
| EP2052039B1 (en) * | 2006-08-04 | 2010-07-14 | FUJIFILM Manufacturing Europe B.V. | Compositions for porous membranes and recording media |
| US7477366B2 (en) * | 2006-12-07 | 2009-01-13 | Coopervision International Holding Company, Lp | Contact lens blister packages and methods for automated inspection of hydrated contact lenses |
| USD559706S1 (en) | 2007-03-15 | 2008-01-15 | Coopervision International Holding Company, Lp | Contact lens blister package array |
| USD556603S1 (en) | 2006-12-08 | 2007-12-04 | Coopervision International Holding Company, Lp | Contact lens blister package |
| USD556602S1 (en) | 2006-12-08 | 2007-12-04 | Coopervision International Holding Company, Lp | Contact lens blister package |
| EP2115499B1 (en) * | 2007-02-26 | 2015-11-11 | Novartis AG | Method for imparting hydrogel contact lenses with desired properties |
| JP2011500898A (ja) * | 2007-10-10 | 2011-01-06 | ベンズ リサーチ アンド ディベロップメント コーポレーション | 高い含水率および安定性を有するヒドロゲル |
| WO2009091733A2 (en) * | 2008-01-14 | 2009-07-23 | Coopervision International Holding Company, Lp | Polymerizable contact lens formulations and contact lenses obtained therefrom |
| US20120209396A1 (en) | 2008-07-07 | 2012-08-16 | David Myung | Orthopedic implants having gradient polymer alloys |
| KR20110040969A (ko) | 2008-08-05 | 2011-04-20 | 바이오미메디카, 인코포레이티드 | 폴리우레탄-그라프트된 하이드로겔 |
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-
2004
- 2004-03-29 JP JP2006509403A patent/JP5047613B2/ja not_active Expired - Lifetime
- 2004-03-29 US US10/811,690 patent/US20040214914A1/en not_active Abandoned
- 2004-03-29 HU HUE04760220A patent/HUE035379T2/en unknown
- 2004-03-29 WO PCT/US2004/009482 patent/WO2004097504A1/en not_active Ceased
- 2004-03-29 EP EP04760220.6A patent/EP1623269B2/en not_active Expired - Lifetime
- 2004-03-29 ES ES04760220T patent/ES2634840T5/es not_active Expired - Lifetime
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2007
- 2007-01-31 US US11/669,395 patent/US7431152B2/en not_active Expired - Lifetime
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2010
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- 2010-11-30 JP JP2010267782A patent/JP2011095758A/ja not_active Abandoned
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| JP2006526807A (ja) | 2006-11-24 |
| EP1623269A4 (en) | 2006-08-30 |
| US20100300902A1 (en) | 2010-12-02 |
| EP1623269B2 (en) | 2022-08-31 |
| US20070119721A1 (en) | 2007-05-31 |
| EP1623269A1 (en) | 2006-02-08 |
| HUE035379T2 (en) | 2018-05-02 |
| WO2004097504A1 (en) | 2004-11-11 |
| EP1623269B1 (en) | 2017-05-10 |
| US20040214914A1 (en) | 2004-10-28 |
| ES2634840T5 (es) | 2022-12-22 |
| US7816455B2 (en) | 2010-10-19 |
| JP2011095758A (ja) | 2011-05-12 |
| ES2634840T3 (es) | 2017-09-29 |
| US7431152B2 (en) | 2008-10-07 |
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