JP5047164B2 - ＩＫＫ酵素活性の阻害剤としての１，６−ジヒドロ−１，３，５，６−テトラアザ−ａｓ−インダセンをベースとした三環式化合物およびそれを含む医薬組成物 - Google Patents

ＩＫＫ酵素活性の阻害剤としての１，６−ジヒドロ−１，３，５，６−テトラアザ−ａｓ−インダセンをベースとした三環式化合物およびそれを含む医薬組成物 Download PDF

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JP5047164B2
JP5047164B2 JP2008511281A JP2008511281A JP5047164B2 JP 5047164 B2 JP5047164 B2 JP 5047164B2 JP 2008511281 A JP2008511281 A JP 2008511281A JP 2008511281 A JP2008511281 A JP 2008511281A JP 5047164 B2 JP5047164 B2 JP 5047164B2
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alkyl
heteroaryl
aryl
cycloalkyl
heterocyclo
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JP2008540547A5 (https=
JP2008540547A (ja
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ウィリアム・ジェイ・ピッツ
ジェイムズ・ケンプソン
ジュンキン・グオ
ジャガバンドゥ・ダス
チャールズ・エム・ラングバイン
スティーブン・エイチ・スパージェル
スコット・エイチ・ワッターソン
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2008511281A 2005-05-10 2006-05-09 ＩＫＫ酵素活性の阻害剤としての１，６−ジヒドロ−１，３，５，６−テトラアザ−ａｓ−インダセンをベースとした三環式化合物およびそれを含む医薬組成物 Expired - Fee Related JP5047164B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US67969205P 2005-05-10 2005-05-10
US60/679,692 2005-05-10
US11/430,215 US7737279B2 (en) 2005-05-10 2006-05-08 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
US11/430,215 2006-05-08
PCT/US2006/017950 WO2006122137A1 (en) 2005-05-10 2006-05-09 1, 6 -dihydro- 1,3, 5, 6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same as inhibitors of ikk enzyme activity

Publications (3)

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JP2008540547A JP2008540547A (ja) 2008-11-20
JP2008540547A5 JP2008540547A5 (https=) 2009-06-04
JP5047164B2 true JP5047164B2 (ja) 2012-10-10

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US (2) US7737279B2 (https=)
EP (1) EP1888584B1 (https=)
JP (1) JP5047164B2 (https=)
AR (1) AR053725A1 (https=)
AT (1) ATE465162T1 (https=)
CY (1) CY1110419T1 (https=)
DE (1) DE602006013816D1 (https=)
DK (1) DK1888584T3 (https=)
ES (1) ES2342976T3 (https=)
PE (1) PE20061424A1 (https=)
PL (1) PL1888584T3 (https=)
PT (1) PT1888584E (https=)
SI (1) SI1888584T1 (https=)
TW (1) TW200718422A (https=)
WO (1) WO2006122137A1 (https=)

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Also Published As

Publication number Publication date
EP1888584A1 (en) 2008-02-20
US20060270654A1 (en) 2006-11-30
ES2342976T3 (es) 2010-07-20
EP1888584B1 (en) 2010-04-21
ATE465162T1 (de) 2010-05-15
CY1110419T1 (el) 2015-04-29
PT1888584E (pt) 2010-06-22
JP2008540547A (ja) 2008-11-20
US7737279B2 (en) 2010-06-15
US20100210629A1 (en) 2010-08-19
PE20061424A1 (es) 2006-12-17
US8268855B2 (en) 2012-09-18
WO2006122137A1 (en) 2006-11-16
AR053725A1 (es) 2007-05-16
DE602006013816D1 (de) 2010-06-02
SI1888584T1 (sl) 2010-07-30
DK1888584T3 (da) 2010-08-09
PL1888584T3 (pl) 2010-09-30
TW200718422A (en) 2007-05-16

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