JP5008783B2 - 高分子量のポリマーを基剤とするプロドラッグ - Google Patents
高分子量のポリマーを基剤とするプロドラッグ Download PDFInfo
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- JP5008783B2 JP5008783B2 JP51094998A JP51094998A JP5008783B2 JP 5008783 B2 JP5008783 B2 JP 5008783B2 JP 51094998 A JP51094998 A JP 51094998A JP 51094998 A JP51094998 A JP 51094998A JP 5008783 B2 JP5008783 B2 JP 5008783B2
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- camptothecin
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- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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Landscapes
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- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
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| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| JP3737518B2 (ja) * | 1996-03-12 | 2006-01-18 | ピージー−ティーエックスエル カンパニー， エル．ピー． | 水溶性パクリタキセルプロドラッグ |
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| US20050158273A1 (en) * | 1997-09-25 | 2005-07-21 | Harris J. M. | Soluble, degradable polyethylene glycol) derivatives for controllable release of bound molecules into solution |
| US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| US6111107A (en) * | 1997-11-20 | 2000-08-29 | Enzon, Inc. | High yield method for stereoselective acylation of tertiary alcohols |
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| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| PT1053019E (pt) * | 1998-01-07 | 2004-04-30 | Debio Rech Pharma Sa | Acrilatos de poli(etileno-glicol) heterobifuncional degradaveis e geles e conjugados derivados dos mesmos |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
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| US7953788B2 (en) * | 2001-09-29 | 2011-05-31 | Siebel Systems, Inc. | System and method for queuing data for an application server |
| CN1762990A (zh) * | 1999-06-08 | 2006-04-26 | 拉卓拉药物公司 | 包含氨基氧基的化合价平台分子 |
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| US6541508B2 (en) | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
| US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
| US6713454B1 (en) * | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| US6376470B1 (en) * | 1999-09-23 | 2002-04-23 | Enzon, Inc. | Polymer conjugates of ara-C and ara-C derivatives |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| DE60026073T2 (de) | 1999-12-22 | 2006-09-28 | Nektar Therapeutics Al, Corp., Huntsville | Sterisch gehinderte derivate von wasserlöslichen polymeren |
| AU2001257577A1 (en) | 2000-02-28 | 2001-09-03 | Shearwater Corporation | Water-soluble polymer conjugates of artelinic acid |
| WO2001093914A2 (en) | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| MXPA03000310A (es) * | 2000-07-12 | 2004-12-13 | Gryphon Therapeutics Inc | Quimiocinas sinteticas bioactivas, modificadas con polimeros y metodos para su elaboracion y uso. |
| KR20030046411A (ko) * | 2000-09-08 | 2003-06-12 | 그리폰 테라퓨틱스, 인코포레이티드 | '위'-천연 화학적 라이게이션 |
| US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
| US6436386B1 (en) | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
| US7829074B2 (en) * | 2001-10-18 | 2010-11-09 | Nektar Therapeutics | Hydroxypatite-targeting poly(ethylene glycol) and related polymers |
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| US20040077835A1 (en) * | 2001-07-12 | 2004-04-22 | Robin Offord | Chemokine receptor modulators, production and use |
| DK1450822T3 (da) * | 2001-11-09 | 2010-04-19 | Enzon Inc | Polyalkylenoxidkonjugater af thiolholdige medicinske præparater |
| GB0202906D0 (en) * | 2002-02-07 | 2002-03-27 | Univ London | Prevention of myocardial damage |
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| AU4406793A (en) * | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
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| WO1994005282A1 (en) * | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Water soluble taxol derivatives |
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| AU6361294A (en) * | 1993-03-09 | 1994-09-26 | Enzon, Inc. | Taxol-based compositions with enhanced bioactivity |
| US5547981A (en) * | 1993-03-09 | 1996-08-20 | Enzon, Inc. | Taxol-7-carbazates |
| CA2174350A1 (en) * | 1993-10-20 | 1995-04-27 | Richard B. Greenwald | 2'- and/or 7- substituted taxoids |
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5489589A (en) * | 1994-12-07 | 1996-02-06 | Bristol-Myers Squibb Company | Amino acid derivatives of paclitaxel |
-
1996
- 1996-08-20 US US08/700,269 patent/US5840900A/en not_active Expired - Lifetime
-
1997
- 1997-08-20 JP JP51094998A patent/JP5008783B2/ja not_active Expired - Fee Related
- 1997-08-20 DK DK97938484T patent/DK0923566T3/da active
- 1997-08-20 DE DE69725862T patent/DE69725862T2/de not_active Expired - Lifetime
- 1997-08-20 AT AT97938484T patent/ATE253060T1/de not_active IP Right Cessation
- 1997-08-20 WO PCT/US1997/014692 patent/WO1998007713A1/en not_active Ceased
- 1997-08-20 ES ES97938484T patent/ES2210564T3/es not_active Expired - Lifetime
- 1997-08-20 PT PT97938484T patent/PT923566E/pt unknown
- 1997-08-20 CA CA2263409A patent/CA2263409C/en not_active Expired - Fee Related
- 1997-08-20 EP EP97938484A patent/EP0923566B1/en not_active Expired - Lifetime
- 1997-08-20 SI SI9730607T patent/SI0923566T1/xx unknown
- 1997-08-20 AU AU40794/97A patent/AU730244B2/en not_active Ceased
- 1997-08-20 NZ NZ334283A patent/NZ334283A/xx active IP Right Revival
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2009
- 2009-11-27 JP JP2009270416A patent/JP2010100628A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0923566A4 (en) | 2001-10-10 |
| US5840900A (en) | 1998-11-24 |
| PT923566E (pt) | 2004-03-31 |
| AU4079497A (en) | 1998-03-06 |
| SI0923566T1 (en) | 2004-04-30 |
| JP2010100628A (ja) | 2010-05-06 |
| ES2210564T3 (es) | 2004-07-01 |
| EP0923566B1 (en) | 2003-10-29 |
| CA2263409C (en) | 2011-02-22 |
| DE69725862T2 (de) | 2004-08-19 |
| DE69725862D1 (de) | 2003-12-04 |
| JP2000517304A (ja) | 2000-12-26 |
| EP0923566A1 (en) | 1999-06-23 |
| DK0923566T3 (da) | 2004-03-08 |
| WO1998007713A1 (en) | 1998-02-26 |
| ATE253060T1 (de) | 2003-11-15 |
| NZ334283A (en) | 2000-03-27 |
| CA2263409A1 (en) | 1998-02-26 |
| AU730244B2 (en) | 2001-03-01 |
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