JP4997107B2 - リン酸塩吸着剤用組成物の調整方法、得られた組成物及びリン酸塩吸着剤としての該組成物の使用 - Google Patents
リン酸塩吸着剤用組成物の調整方法、得られた組成物及びリン酸塩吸着剤としての該組成物の使用 Download PDFInfo
- Publication number
- JP4997107B2 JP4997107B2 JP2007518586A JP2007518586A JP4997107B2 JP 4997107 B2 JP4997107 B2 JP 4997107B2 JP 2007518586 A JP2007518586 A JP 2007518586A JP 2007518586 A JP2007518586 A JP 2007518586A JP 4997107 B2 JP4997107 B2 JP 4997107B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- iron
- phosphate
- preparing
- adsorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims description 67
- 229910019142 PO4 Inorganic materials 0.000 title claims description 44
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims description 44
- 239000010452 phosphate Substances 0.000 title claims description 44
- 238000000034 method Methods 0.000 title claims description 36
- 239000003463 adsorbent Substances 0.000 title claims description 32
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 72
- 239000007900 aqueous suspension Substances 0.000 claims description 33
- 239000007864 aqueous solution Substances 0.000 claims description 28
- 235000014413 iron hydroxide Nutrition 0.000 claims description 27
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims description 27
- 229910052742 iron Inorganic materials 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 15
- 239000002585 base Substances 0.000 claims description 15
- 150000001720 carbohydrates Chemical class 0.000 claims description 15
- 235000014633 carbohydrates Nutrition 0.000 claims description 15
- 239000002244 precipitate Substances 0.000 claims description 13
- 239000004021 humic acid Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 10
- 229930006000 Sucrose Natural products 0.000 claims description 10
- 230000006866 deterioration Effects 0.000 claims description 10
- 239000005720 sucrose Substances 0.000 claims description 10
- 239000000725 suspension Substances 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 8
- 229910002651 NO3 Inorganic materials 0.000 claims description 8
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
- 159000000007 calcium salts Chemical class 0.000 claims description 6
- 230000015556 catabolic process Effects 0.000 claims description 6
- 238000006731 degradation reaction Methods 0.000 claims description 6
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 claims description 6
- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
- 238000000502 dialysis Methods 0.000 claims description 5
- 229910000360 iron(III) sulfate Inorganic materials 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 claims description 5
- 239000004375 Dextrin Substances 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 235000019425 dextrin Nutrition 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- -1 alkali metal bicarbonate Chemical class 0.000 claims description 3
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims description 3
- 150000008041 alkali metal carbonates Chemical class 0.000 claims description 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 3
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- 150000001341 alkaline earth metal compounds Chemical class 0.000 claims description 2
- 150000001719 carbohydrate derivatives Chemical class 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 201000005991 hyperphosphatemia Diseases 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 230000003449 preventive effect Effects 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000463 material Substances 0.000 description 16
- 238000001179 sorption measurement Methods 0.000 description 16
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 14
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 10
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 7
- 239000011574 phosphorus Substances 0.000 description 7
- 229910052698 phosphorus Inorganic materials 0.000 description 7
- 239000011734 sodium Substances 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 5
- 238000004255 ion exchange chromatography Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000001488 sodium phosphate Substances 0.000 description 5
- 229910000162 sodium phosphate Inorganic materials 0.000 description 5
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 239000005913 Maltodextrin Substances 0.000 description 3
- 229920002774 Maltodextrin Polymers 0.000 description 3
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 3
- 229910001626 barium chloride Inorganic materials 0.000 description 3
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 3
- 229940035034 maltodextrin Drugs 0.000 description 3
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229910000358 iron sulfate Inorganic materials 0.000 description 2
- MVFCKEFYUDZOCX-UHFFFAOYSA-N iron(2+);dinitrate Chemical compound [Fe+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O MVFCKEFYUDZOCX-UHFFFAOYSA-N 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- LCPUDZUWZDSKMX-UHFFFAOYSA-K azane;hydrogen sulfate;iron(3+);sulfate;dodecahydrate Chemical compound [NH4+].O.O.O.O.O.O.O.O.O.O.O.O.[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O LCPUDZUWZDSKMX-UHFFFAOYSA-K 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- MSNWSDPPULHLDL-UHFFFAOYSA-K ferric hydroxide Chemical compound [OH-].[OH-].[OH-].[Fe+3] MSNWSDPPULHLDL-UHFFFAOYSA-K 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052816 inorganic phosphate Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
- B01J20/0225—Compounds of Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt
- B01J20/0229—Compounds of Fe
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/06—Ferric oxide [Fe2O3]
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/28—Treatment of water, waste water, or sewage by sorption
- C02F1/288—Treatment of water, waste water, or sewage by sorption using composite sorbents, e.g. coated, impregnated, multi-layered
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
- C09C1/22—Compounds of iron
- C09C1/24—Oxides of iron
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/46—Materials comprising a mixture of inorganic and organic materials
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2101/00—Nature of the contaminant
- C02F2101/10—Inorganic compounds
- C02F2101/105—Phosphorus compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Animal Husbandry (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hydrology & Water Resources (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Compounds Of Iron (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004031181A DE102004031181A1 (de) | 2004-06-28 | 2004-06-28 | Phosphatadsorbens |
| DE102004031181.1 | 2004-06-28 | ||
| PCT/EP2005/052861 WO2006000547A2 (de) | 2004-06-28 | 2005-06-21 | Verfahren zur herstellung eines phosphatadsorbens auf eisensulfat-basis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504344A JP2008504344A (ja) | 2008-02-14 |
| JP4997107B2 true JP4997107B2 (ja) | 2012-08-08 |
Family
ID=35507997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518586A Expired - Fee Related JP4997107B2 (ja) | 2004-06-28 | 2005-06-21 | リン酸塩吸着剤用組成物の調整方法、得られた組成物及びリン酸塩吸着剤としての該組成物の使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20090169645A1 (ru) |
| EP (1) | EP1899270B1 (ru) |
| JP (1) | JP4997107B2 (ru) |
| KR (1) | KR101122752B1 (ru) |
| CN (1) | CN1997596B (ru) |
| AR (1) | AR049522A1 (ru) |
| AU (1) | AU2005256617C1 (ru) |
| BR (1) | BRPI0512636A (ru) |
| CA (1) | CA2571364C (ru) |
| DE (1) | DE102004031181A1 (ru) |
| ES (1) | ES2718458T3 (ru) |
| HK (1) | HK1108422A1 (ru) |
| MX (1) | MX2007000335A (ru) |
| NO (1) | NO20070391L (ru) |
| NZ (1) | NZ552247A (ru) |
| RU (1) | RU2344083C2 (ru) |
| TW (1) | TWI351926B (ru) |
| UA (1) | UA92894C2 (ru) |
| WO (1) | WO2006000547A2 (ru) |
| ZA (1) | ZA200700767B (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2319804T1 (sl) | 2006-12-14 | 2015-01-30 | Novartis Ag | Fosfatni adsorbent na osnovi Ĺľelezo(III)-ogljikovega hidrata |
| PL2319804T3 (pl) | 2006-12-14 | 2015-03-31 | Elanco Tiergesundheit Ag | Węglowodanowy adsorbent fosforanów oparty na żelazie (III) |
| EP1932807A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Inorganic compounds |
| TWI468167B (zh) | 2007-11-16 | 2015-01-11 | 威佛（國際）股份有限公司 | 藥學組成物 |
| WO2009150232A2 (en) * | 2008-06-13 | 2009-12-17 | Novartis Ag | Manufacture process for the preparation of an iron containing phosphate adsorbent |
| CN101318122B (zh) * | 2008-07-21 | 2013-03-20 | 郜洪文 | 阴离子表面活性剂-硫酸钡复合吸附材料及其制备方法 |
| JP2012519201A (ja) * | 2009-03-02 | 2012-08-23 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフト | リン酸塩吸着剤 |
| JP2012192326A (ja) * | 2011-03-15 | 2012-10-11 | Kyoto Univ | 硫黄含有ガス除去材、その製造方法および硫黄含有ガス除去方法 |
| DE102011112898A1 (de) * | 2011-09-08 | 2013-03-14 | Charité - Universitätsmedizin Berlin | Nanopartikuläres Phosphatadsorbens basierend auf Maghämit oder Maghämit/Magnetit, dessen Herstellung und Verwendungen |
| RU2496722C1 (ru) * | 2012-04-10 | 2013-10-27 | Леонид Асхатович Мазитов | Способ очистки сточной воды от фосфатов |
| CA2931173C (en) * | 2013-11-27 | 2018-10-09 | Vifor (International) Ag | Pharmaceutical composition, comprising phosphate binder particles |
| US10343154B2 (en) | 2014-11-25 | 2019-07-09 | Graver Technologies Llc | High capacity adsorbent for fluoride ion and oxyanions of phosphorous and arsenic and method for making the same |
| US11583846B2 (en) | 2014-11-25 | 2023-02-21 | Graver Technologies Llc | High capacity adsorbent for oxyanions and cations and method for making the same |
| CN107397759A (zh) * | 2016-05-19 | 2017-11-28 | 欣凯医药化工中间体（上海）有限公司 | 基于铁的氢氧化物－降解的碳水化合物的磷结合剂、其制备方法及其应用 |
| CN107397758A (zh) * | 2016-05-19 | 2017-11-28 | 欣凯医药化工中间体（上海）有限公司 | 一种磷结合剂及其制备方法 |
| CN107397810B (zh) * | 2016-05-19 | 2021-08-24 | 欣凯医药化工中间体（上海）有限公司 | 基于铁的氢氧化物－桃胶的磷结合剂、其制备方法及其应用 |
| CN107397760B (zh) * | 2016-05-19 | 2021-07-30 | 欣凯医药化工中间体（上海）有限公司 | 基于铁的氢氧化物－低分子量糖的磷结合剂、其制备方法及其应用 |
| CN108773889A (zh) * | 2018-09-10 | 2018-11-09 | 芜湖新达园林绿化集团有限公司 | 一种去污絮凝剂用复合微球及去污絮凝剂的制备、应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1206874B (de) * | 1956-01-31 | 1965-12-16 | Siemens Ag | Verfahren zur Herstellung von weitgehend sulfat-freiem Eisenoxydhydrat als Ausgangsprodukt fuer die Ferritherstellung |
| US2885393A (en) * | 1956-02-24 | 1959-05-05 | R K Laros Company | Dextran-iron complex and process for making same |
| JPS56136648A (en) * | 1980-03-27 | 1981-10-26 | Taki Chem Co Ltd | Chemical agent for water treatment |
| US4597958A (en) * | 1984-09-17 | 1986-07-01 | Mitsui Mining & Smelting Co., Ltd. | Method of producing hydrated iron oxide |
| US4970079A (en) * | 1989-06-05 | 1990-11-13 | Purdue Research Foundation | Method and composition of oxy-iron compounds for treatment of hyperphosphatemia |
| US5411569A (en) * | 1991-08-28 | 1995-05-02 | Kemiron, Inc. | Iron humate product |
| JPH05155776A (ja) * | 1991-12-02 | 1993-06-22 | Otsuka Pharmaceut Factory Inc | 高リン血症治療剤 |
| DE19547356A1 (de) * | 1995-12-19 | 1997-06-26 | Vifor Int Ag | Adsorbens für Phosphat aus wäßrigem Medium, dessen Herstellung und Verwendung |
| GB9720061D0 (en) * | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| DE10115415A1 (de) * | 2001-03-29 | 2002-10-02 | Bayer Ag | Kontakt- und Adsorber-Granulate |
| JP5150033B2 (ja) * | 2000-09-26 | 2013-02-20 | ランクセス ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 接触体および吸着体粒状物 |
| DE10232069A1 (de) * | 2002-07-16 | 2004-02-05 | Sachtleben Chemie Gmbh | Verfahren zur Herstellung von Eisenhydroxid, Eisenoxidhydrat oder Eisenoxid aus Filtersalzen der Dünnsäurerückgewinnung |
| DE10249552A1 (de) * | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
-
2004
- 2004-06-28 DE DE102004031181A patent/DE102004031181A1/de not_active Withdrawn
-
2005
- 2005-06-17 AR ARP050102500A patent/AR049522A1/es not_active Application Discontinuation
- 2005-06-21 KR KR1020077002294A patent/KR101122752B1/ko not_active IP Right Cessation
- 2005-06-21 WO PCT/EP2005/052861 patent/WO2006000547A2/de active Application Filing
- 2005-06-21 CN CN2005800214599A patent/CN1997596B/zh not_active Expired - Fee Related
- 2005-06-21 RU RU2007103154/15A patent/RU2344083C2/ru not_active IP Right Cessation
- 2005-06-21 UA UAA200614017A patent/UA92894C2/ru unknown
- 2005-06-21 AU AU2005256617A patent/AU2005256617C1/en not_active Ceased
- 2005-06-21 MX MX2007000335A patent/MX2007000335A/es active IP Right Grant
- 2005-06-21 CA CA2571364A patent/CA2571364C/en not_active Expired - Fee Related
- 2005-06-21 ES ES05753905T patent/ES2718458T3/es active Active
- 2005-06-21 NZ NZ552247A patent/NZ552247A/en not_active IP Right Cessation
- 2005-06-21 BR BRPI0512636-3A patent/BRPI0512636A/pt not_active IP Right Cessation
- 2005-06-21 EP EP05753905.8A patent/EP1899270B1/de active Active
- 2005-06-21 JP JP2007518586A patent/JP4997107B2/ja not_active Expired - Fee Related
- 2005-06-21 US US11/571,305 patent/US20090169645A1/en not_active Abandoned
- 2005-06-24 TW TW094121167A patent/TWI351926B/zh not_active IP Right Cessation
-
2007
- 2007-01-22 NO NO20070391A patent/NO20070391L/no not_active Application Discontinuation
- 2007-01-26 ZA ZA200700767A patent/ZA200700767B/xx unknown
- 2007-12-14 HK HK07113656.1A patent/HK1108422A1/xx not_active IP Right Cessation
-
2014
- 2014-07-23 US US14/338,776 patent/US20140335202A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008504344A (ja) | 2008-02-14 |
| CA2571364A1 (en) | 2006-01-05 |
| HK1108422A1 (en) | 2008-05-09 |
| KR101122752B1 (ko) | 2012-03-23 |
| UA92894C2 (ru) | 2010-12-27 |
| NO20070391L (no) | 2007-03-20 |
| US20140335202A1 (en) | 2014-11-13 |
| AU2005256617C1 (en) | 2011-03-10 |
| KR20070031420A (ko) | 2007-03-19 |
| DE102004031181A1 (de) | 2006-01-19 |
| TW200603746A (en) | 2006-02-01 |
| ZA200700767B (en) | 2008-09-25 |
| CN1997596B (zh) | 2011-03-30 |
| RU2007103154A (ru) | 2008-08-10 |
| CN1997596A (zh) | 2007-07-11 |
| US20090169645A1 (en) | 2009-07-02 |
| CA2571364C (en) | 2013-05-14 |
| ES2718458T3 (es) | 2019-07-02 |
| BRPI0512636A (pt) | 2008-03-25 |
| AU2005256617B2 (en) | 2010-08-26 |
| TWI351926B (en) | 2011-11-11 |
| EP1899270B1 (de) | 2019-02-27 |
| EP1899270A2 (de) | 2008-03-19 |
| AR049522A1 (es) | 2006-08-09 |
| RU2344083C2 (ru) | 2009-01-20 |
| WO2006000547A2 (de) | 2006-01-05 |
| MX2007000335A (es) | 2007-03-12 |
| NZ552247A (en) | 2010-06-25 |
| WO2006000547A3 (de) | 2006-06-22 |
| AU2005256617A1 (en) | 2006-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4997107B2 (ja) | リン酸塩吸着剤用組成物の調整方法、得られた組成物及びリン酸塩吸着剤としての該組成物の使用 | |
| JP3665345B2 (ja) | 水性媒質からのリン酸塩に対する吸着剤、その製造および使用 | |
| EP2319804A1 (en) | Iron(III)-Carbohydrate based phosphate adsorbent | |
| JPH05329361A (ja) | リン酸イオン吸着剤 | |
| KR100966977B1 (ko) | 항생 활성을 갖는 약제 조성물 | |
| JPS63280100A (ja) | 結晶性ヒトプロインシュリンおよびその製造方法 | |
| EP0040521B1 (en) | Antacid material based on magnesium aluminium hydroxide and the preparation thereof | |
| WO1996038058A1 (fr) | Composition contenant du calcium facilement absorbable et son procede de fabrication | |
| US4443433A (en) | Antacid material based on magnesium aluminum hydroxide and preparation thereof | |
| JP2007296464A5 (ru) | ||
| WO2005067975A1 (en) | Title: a sustained release captopril formulation having a supermolecular intercalation structure and the preparation process thereof | |
| JPH062580B2 (ja) | ベーマイト状水酸化アルミニウム、その製造法及びそれを有効成分とする経口用リン酸イオン吸着剤 | |
| JPH0513092B2 (ru) | ||
| JPS5879927A (ja) | 制酸剤 | |
| JPS6226811B2 (ru) | ||
| JPH04178330A (ja) | 抗腫瘍性物質 | |
| HU196436B (en) | Process for producing calcium-containing mixed salts of polyuronic acids and pharmaceutical compositions comprising such active ingredient | |
| WO2006132321A1 (ja) | リン障害予防改善治療剤、飲食品又は薬品中のリン酸イオンを吸着するための経口剤及びそれらの製造方法 | |
| JP2005143327A (ja) | にがり粒 | |
| JPH08245679A (ja) | 酸化鉄グルコサミン複合体、その製法および用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080404 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110621 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110728 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20111004 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120127 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20120127 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20120217 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120327 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120328 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120424 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120514 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150518 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |