JP4985763B2 - 育毛・発毛用経口組成物 - Google Patents
育毛・発毛用経口組成物 Download PDFInfo
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- JP4985763B2 JP4985763B2 JP2009503893A JP2009503893A JP4985763B2 JP 4985763 B2 JP4985763 B2 JP 4985763B2 JP 2009503893 A JP2009503893 A JP 2009503893A JP 2009503893 A JP2009503893 A JP 2009503893A JP 4985763 B2 JP4985763 B2 JP 4985763B2
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- hair growth
- hair
- oral composition
- kombu
- temporary root
- Prior art date
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Description
また、本発明経口組成物は、粉末剤、錠剤、顆粒剤、カプセル剤、ドリンク剤またはゼリーの形態であるのが好ましい。
上記表に示す通り、養殖コンブ仮根は食物繊維に富んでいることが明らかである。なお、養殖コンブ仮根はアルギン酸ナトリウム約7g/100 g、フコイダン分画約4g/100 gを含む。これらは水溶性食物繊維として有用で、アルギン酸ナトリウムにはコレステロール排泄促進、血圧降下作用、整腸作用、有害物排泄促進作用などがあり、フコイダンには抗血液凝固作用、抗腫瘍作用が知られている。
この結果から、養殖コンブ仮根には旨み成分であるグルタミン酸が通常のコンブの1/10程度しか含まれていないことが分かる。なお、メチオニンとシスチンはいずれの試料からも検出できなかった。
(参考例1)
養殖コンブ仮根粉末の調製
乾燥した養殖コンブ仮根100 kgを粗砕機(カッターミル)で粗く粉砕した後、微砕機(サンプルミル)で微粉末にした。微砕機のスクリーンを1mmφにした場合は200 メッシュ以下が30%、100 〜200 メッシュが20%、48〜100 メッシュが30%、48メッシュ以上が20%であった。この粉砕物をさらに0.5 mmφのスクリーンを用いて粉砕すると、200 メッシュ以下が50%、100 〜200 メッシュが30%、48〜100 メッシュが18%、48メッシュ以上が2%の粉体が得られた(収量は92kg)。
(参考例2)
養殖コンブ仮根エキスの調製
粗く裁断した養殖コンブ仮根を、5%酢酸溶液(1kg当たり10L)で下記の条件(室温で14日間および110 ℃で1時間)で抽出して、それぞれ下記表1に示す量および無機質組成のエキスを得た。(単位は試料1kg当たりのg量)
(1カプセル中)
養殖コンブ仮根粉末 250mg
養殖コンブ仮根エキス粉末 50mg
ビール酵母 60mg
ショ糖脂肪酸エステル 10mg
(1カプセル中)
養殖コンブ仮根粉末 250.00mg
松樹皮エキス 2.50mg
ケラチンSHパウダー 30.00mg
ビタミンB1 塩酸塩 2.00mg
ビタミンB2 1.00mg
ビタミンB6 塩酸塩 0.84mg
ニコチン酸アミド 1.25mg
パントテン酸カルシウム 2.50mg
食添ビオチン1% 0.05mg
ヒハツエキスパウダーMF 47.50mg
乾燥ビール酵母A 8.87mg
ステアリン酸カルシウム 3.50mg
(試験例1)
参考例1のようにして製造した養殖コンブ仮根粉末を用いて育毛・発毛効果を試験した。薄毛、抜け毛、白髪などが気になる年齢30〜70歳の男性、女性合わせて40人のボランティアに、朝と夕方の2回、養殖コンブ仮根粉末を3ヶ月間摂取させた (そのうち2人は養殖コンブ仮根粉末無摂取の対照) 。1000mg摂取群には1日合計1000mgを、1500mg摂取群には1日合計1500mgを摂取させた。1ヶ月おきに以下の判定方法により効果を評価し、さらに頭皮の写真撮影およびマイクロスコープによる毛根撮影を行った。
育毛効果
a:服用前に比べ抜け毛が減った
b:髪の毛が増えた、または生えてきた
c:髪の太さが太くなった
d:髪にハリやコシが出てきた
e:白髪が減ってきた
効果判定スコア基準(各項目に対する)
3:著効
2:有効
1:やや有効
0:無効
上記育毛効果に関するa〜eの5項目の点数を合計し、下記の基準により総合的な効果を判定した。
0 :無効
1〜2:やや有効
3〜5:有効
6以上:著効
結果は以下の表7に示す通りである。
実施例2で製造したカプセル剤を用いて試験例1と同様にして育毛・発毛効果を試験した。ただし、ボランティアは107 人であり、摂取量は養殖コンブ仮根粉末として1日1000mgであった。結果を表9に示す。
Claims (7)
- 養殖コンブ仮根部を原料とする素材を含む育毛・発毛のための経口組成物。
- さらに、ケラチン蛋白質もしくはその加水分解物、ビタミン類、血行促進物質、酵母およびアミノ酸類から選ばれる1種または2種以上を含有する、請求項1記載の経口組成物。
- 血行促進物質がヒハツエキス、松樹皮エキスおよびカプサイシンから選ばれる1種または2種以上である、請求項3記載の経口組成物。
- 養殖コンブ仮根部を原料とする素材が粉末形態である請求項1、3、4のいずれかの項記載の経口組成物。
- 養殖コンブ仮根部を原料とする素材が養殖コンブ仮根部の抽出物の形態である請求項1、3、4のいずれかの項記載の経口組成物。
- 粉末剤、錠剤、顆粒剤、カプセル剤、ドリンク剤またはゼリーの形態である請求項1、3、4、5、6のいずれかの項記載の経口組成物。
- 経口用育毛・発毛剤の製造のための、養殖コンブ仮根部を原料とする素材の使用。
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JP2003081862A (ja) * | 2001-09-14 | 2003-03-19 | Kyosei Seiyaku Kk | コンブ仮根を用いる抗腫瘍剤および食品 |
JP2004141140A (ja) * | 2001-12-27 | 2004-05-20 | Jigyo Sozo Kenkyusho:Kk | 海藻類の防腐処理方法、防腐処理した海藻類の加工食品、梅塩の製造方法、並びに海藻類及び梅を利用した飲み物 |
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JP3407064B2 (ja) * | 1993-11-13 | 2003-05-19 | サンスター株式会社 | 育毛養毛用食品 |
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