JP4928079B2 - 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 - Google Patents

慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 Download PDF

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JP4928079B2
JP4928079B2 JP2004555563A JP2004555563A JP4928079B2 JP 4928079 B2 JP4928079 B2 JP 4928079B2 JP 2004555563 A JP2004555563 A JP 2004555563A JP 2004555563 A JP2004555563 A JP 2004555563A JP 4928079 B2 JP4928079 B2 JP 4928079B2
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JP2006514013A (ja
JP2006514013A5 (https=
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ジョン エム． ウィリアムズ，
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Genzyme Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2004555563A 2002-11-21 2003-11-21 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 Expired - Fee Related JP4928079B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42833202P 2002-11-21 2002-11-21
US60/428,332 2002-11-21
PCT/US2003/037318 WO2004047825A1 (en) 2002-11-21 2003-11-21 Use of diamide derivatives for inhibiting chronic tissue transplant rejection

Related Child Applications (1)

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JP2010210237A Division JP2010280725A (ja) 2002-11-21 2010-09-17 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用

Publications (3)

Publication Number Publication Date
JP2006514013A JP2006514013A (ja) 2006-04-27
JP2006514013A5 JP2006514013A5 (https=) 2007-01-11
JP4928079B2 true JP4928079B2 (ja) 2012-05-09

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JP2004555563A Expired - Fee Related JP4928079B2 (ja) 2002-11-21 2003-11-21 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用
JP2010210237A Withdrawn JP2010280725A (ja) 2002-11-21 2010-09-17 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用

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JP2010210237A Withdrawn JP2010280725A (ja) 2002-11-21 2010-09-17 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用

Country Status (9)

Country Link
US (2) US7687530B2 (https=)
EP (1) EP1567138B1 (https=)
JP (2) JP4928079B2 (https=)
AT (1) ATE493980T1 (https=)
AU (1) AU2003291134A1 (https=)
DE (1) DE60335652D1 (https=)
ES (1) ES2363914T3 (https=)
PT (1) PT1567138E (https=)
WO (1) WO2004047825A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100494182C (zh) 2000-05-12 2009-06-03 基酶有限公司 肿瘤坏死α因子信号的调节因子
ATE493980T1 (de) * 2002-11-21 2011-01-15 Genzyme Corp Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung
AU2003291143A1 (en) * 2002-11-21 2004-06-18 Genzyme Corporation Combination of diamide derivatives and immunosuppressive agents for induction of immune tolerance
CA2553551C (en) 2004-01-21 2020-12-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
EP2604703B1 (en) * 2005-03-14 2017-02-01 The Board of Trustees of the Leland Stanford Junior University Methods for evaluating graft survival in a solid organ transplant recipient
USRE46843E1 (en) 2005-03-14 2018-05-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for evaluating graft survival in a solid organ transplant recipient
WO2010021696A1 (en) * 2008-08-18 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
EP2387618B1 (en) 2009-01-15 2014-05-21 The Board of Trustees of The Leland Stanford Junior University Biomarker panel for diagnosis and prediction of graft rejection
US9290813B2 (en) 2009-12-02 2016-03-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
WO2011119980A1 (en) 2010-03-25 2011-09-29 The Board Of Trustees Of The Leland Stanford Junior University Protein and gene biomarkers for rejection of organ transplants
WO2012139051A2 (en) 2011-04-06 2012-10-11 The Board Of Trustees Of The Leland Stanford Junior University Autoantibody biomarkers for iga nephropathy
WO2013142376A1 (en) * 2012-03-19 2013-09-26 Aposignal Bioscience Llc Composition and methods for cell modulation
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2001087849A2 (en) * 2000-05-12 2001-11-22 Genzyme Corporation Modulators of tnf- alpha signaling

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US4997950A (en) * 1989-04-20 1991-03-05 Richard Finbar Murphy Novel C-terminal gastrin antagonists
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
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Also Published As

Publication number Publication date
EP1567138A1 (en) 2005-08-31
JP2006514013A (ja) 2006-04-27
WO2004047825A1 (en) 2004-06-10
ES2363914T3 (es) 2011-08-19
ATE493980T1 (de) 2011-01-15
US20100256211A1 (en) 2010-10-07
AU2003291134A1 (en) 2004-06-18
EP1567138B1 (en) 2011-01-05
DE60335652D1 (de) 2011-02-17
US20040163654A1 (en) 2004-08-26
US7687530B2 (en) 2010-03-30
JP2010280725A (ja) 2010-12-16
PT1567138E (pt) 2011-04-11

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