JP4906717B2 - 遺伝子発現の阻害に関する方法および組成物 - Google Patents

遺伝子発現の阻害に関する方法および組成物 Download PDF

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Publication number
JP4906717B2
JP4906717B2 JP2007515472A JP2007515472A JP4906717B2 JP 4906717 B2 JP4906717 B2 JP 4906717B2 JP 2007515472 A JP2007515472 A JP 2007515472A JP 2007515472 A JP2007515472 A JP 2007515472A JP 4906717 B2 JP4906717 B2 JP 4906717B2
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oligonucleotide
gene
cell
cancer
composition
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Japanese (ja)
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JP2008500838A5 (enExample
JP2008500838A (ja
Inventor
ゴーラムレザ・シェイクネージャド
ミナ・ペイテル・スーク
ニール・グッドウィン
デイビッド・オルソン
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Sierra Oncology Inc
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ProNAi Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2007515472A 2004-06-01 2005-06-01 遺伝子発現の阻害に関する方法および組成物 Expired - Fee Related JP4906717B2 (ja)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US10/858,341 2004-06-01
US10/858,341 US20050287667A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,145 US7498315B2 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,146 2004-06-01
US10/858,013 US20060135455A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,164 2004-06-01
US10/858,094 2004-06-01
US10/858,094 US20080152700A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,013 2004-06-01
US10/858,164 US7524827B2 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,145 2004-06-01
US10/858,146 US20060229267A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US61197404P 2004-09-22 2004-09-22
US60/611,974 2004-09-22
US63721204P 2004-12-17 2004-12-17
US60/637,212 2004-12-17
PCT/US2005/018993 WO2005118824A2 (en) 2004-06-01 2005-06-01 Methods and compositions for the inhibition of gene expression

Related Child Applications (1)

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JP2011250762A Division JP5922913B2 (ja) 2004-06-01 2011-11-16 遺伝子発現の阻害に関する方法および組成物

Publications (3)

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JP2008500838A JP2008500838A (ja) 2008-01-17
JP2008500838A5 JP2008500838A5 (enExample) 2008-07-17
JP4906717B2 true JP4906717B2 (ja) 2012-03-28

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JP2007515472A Expired - Fee Related JP4906717B2 (ja) 2004-06-01 2005-06-01 遺伝子発現の阻害に関する方法および組成物
JP2011250762A Expired - Fee Related JP5922913B2 (ja) 2004-06-01 2011-11-16 遺伝子発現の阻害に関する方法および組成物
JP2015023485A Pending JP2015133967A (ja) 2004-06-01 2015-02-09 遺伝子発現の阻害に関する方法および組成物

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JP2011250762A Expired - Fee Related JP5922913B2 (ja) 2004-06-01 2011-11-16 遺伝子発現の阻害に関する方法および組成物
JP2015023485A Pending JP2015133967A (ja) 2004-06-01 2015-02-09 遺伝子発現の阻害に関する方法および組成物

Country Status (10)

Country Link
US (6) US20060229267A1 (enExample)
EP (2) EP1773859A4 (enExample)
JP (3) JP4906717B2 (enExample)
CN (1) CN101014608B (enExample)
AU (1) AU2005250453B2 (enExample)
BR (1) BRPI0511770A (enExample)
CA (1) CA2569183A1 (enExample)
ES (1) ES2402532T3 (enExample)
PL (1) PL2141173T3 (enExample)
WO (1) WO2005118824A2 (enExample)

Cited By (2)

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JP2009519242A (ja) * 2005-12-01 2009-05-14 プロネイ・セラピューティクス・インコーポレイテッド 癌治療法およびそれに用いる医薬組成物
JP2012085642A (ja) * 2004-06-01 2012-05-10 Pronai Therapeutics Inc 遺伝子発現の阻害に関する方法および組成物

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US8815599B2 (en) * 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
CA2631677C (en) * 2005-12-01 2014-08-12 Pronai Therapeutics, Inc. Amphoteric liposome formulation
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WO2011078301A1 (ja) * 2009-12-25 2011-06-30 ファーマロジカルズ・リサーチ プライベート リミテッド Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法
SG189302A1 (en) 2010-10-06 2013-05-31 Pharmalogicals Res Pte Ltd Cancer stem cell population and method for production thereof
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8734859B1 (en) 2010-11-13 2014-05-27 Sirbal Ltd. Molecular combinations for cancer or other disease treatment
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8541382B2 (en) 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
US20170049835A1 (en) 2015-07-29 2017-02-23 Sirbal Ltd. Herbal Combinations For Treating Scalp Conditions
JP6077997B2 (ja) 2011-09-07 2017-02-08 中外製薬株式会社 癌幹細胞の分離
WO2013062083A1 (ja) 2011-10-28 2013-05-02 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞特異的分子
WO2013183964A1 (ko) * 2012-06-07 2013-12-12 한양대학교 산학협력단 폐암 진단 및 치료를 위한 표적 단백질
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BR112015010220A2 (pt) 2012-11-05 2017-12-05 Pronai Therapeutics Inc métodos de utilização de biomarcadores para tratamento de câncer
WO2014144942A2 (en) * 2013-03-15 2014-09-18 Pronai Therapeutics, Inc. Dnai for the modulation of genes
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WO2015091525A1 (en) * 2013-12-16 2015-06-25 Syddansk Universitet Ras exon 2 skipping for cancer treatment
CN105581979A (zh) * 2016-02-24 2016-05-18 南京大学 一种抑制her-2表达的核酸脂质体纳米药物及其制备方法和应用
EP3528817B1 (en) 2016-10-18 2022-05-25 Madrigal Pharmaceuticals, Inc. Methods of treating liver disorders or lipid disorders with a thr-beta agonist
MA50749A (fr) * 2017-05-04 2020-03-11 Sanofi Sa Méthodes de traitement du syndrome d'alport
JP7427227B2 (ja) * 2020-01-21 2024-02-05 学校法人産業医科大学 腫瘍細胞の生存を低下させるｋｒａｓアンチセンスオリゴヌクレオチド及びその用途
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012085642A (ja) * 2004-06-01 2012-05-10 Pronai Therapeutics Inc 遺伝子発現の阻害に関する方法および組成物
JP2009519242A (ja) * 2005-12-01 2009-05-14 プロネイ・セラピューティクス・インコーポレイテッド 癌治療法およびそれに用いる医薬組成物

Also Published As

Publication number Publication date
EP2141173B1 (en) 2013-01-02
CN101014608B (zh) 2011-07-06
US20060198828A1 (en) 2006-09-07
HK1107098A1 (en) 2008-03-28
US20050287667A1 (en) 2005-12-29
JP2008500838A (ja) 2008-01-17
JP5922913B2 (ja) 2016-05-24
WO2005118824A2 (en) 2005-12-15
WO2005118824A8 (en) 2007-01-25
US20060229267A1 (en) 2006-10-12
US20080152700A1 (en) 2008-06-26
PL2141173T3 (pl) 2013-08-30
ES2402532T3 (es) 2013-05-06
AU2005250453A1 (en) 2005-12-15
EP2141173A1 (en) 2010-01-06
US7498315B2 (en) 2009-03-03
WO2005118824A9 (en) 2006-06-15
EP1773859A2 (en) 2007-04-18
EP1773859A4 (en) 2008-03-26
US7524827B2 (en) 2009-04-28
CA2569183A1 (en) 2005-12-15
US20060135455A1 (en) 2006-06-22
JP2012085642A (ja) 2012-05-10
JP2015133967A (ja) 2015-07-27
US20060073596A1 (en) 2006-04-06
AU2005250453B2 (en) 2012-02-23
BRPI0511770A (pt) 2008-01-08
WO2005118824A3 (en) 2006-11-09
CN101014608A (zh) 2007-08-08

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