JP2008500838A5 - - Google Patents
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- JP2008500838A5 JP2008500838A5 JP2007515472A JP2007515472A JP2008500838A5 JP 2008500838 A5 JP2008500838 A5 JP 2008500838A5 JP 2007515472 A JP2007515472 A JP 2007515472A JP 2007515472 A JP2007515472 A JP 2007515472A JP 2008500838 A5 JP2008500838 A5 JP 2008500838A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- seq
- composition
- nucleotides
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/858,013 US20060135455A1 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,341 | 2004-06-01 | ||
| US10/858,145 | 2004-06-01 | ||
| US10/858,164 US7524827B2 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,146 US20060229267A1 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,094 US20080152700A1 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,341 US20050287667A1 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,164 | 2004-06-01 | ||
| US10/858,013 | 2004-06-01 | ||
| US10/858,145 US7498315B2 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,146 | 2004-06-01 | ||
| US10/858,094 | 2004-06-01 | ||
| US61197404P | 2004-09-22 | 2004-09-22 | |
| US60/611,974 | 2004-09-22 | ||
| US63721204P | 2004-12-17 | 2004-12-17 | |
| US60/637,212 | 2004-12-17 | ||
| PCT/US2005/018993 WO2005118824A2 (en) | 2004-06-01 | 2005-06-01 | Methods and compositions for the inhibition of gene expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011250762A Division JP5922913B2 (ja) | 2004-06-01 | 2011-11-16 | 遺伝子発現の阻害に関する方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008500838A JP2008500838A (ja) | 2008-01-17 |
| JP2008500838A5 true JP2008500838A5 (enExample) | 2008-07-17 |
| JP4906717B2 JP4906717B2 (ja) | 2012-03-28 |
Family
ID=35463455
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515472A Expired - Fee Related JP4906717B2 (ja) | 2004-06-01 | 2005-06-01 | 遺伝子発現の阻害に関する方法および組成物 |
| JP2011250762A Expired - Fee Related JP5922913B2 (ja) | 2004-06-01 | 2011-11-16 | 遺伝子発現の阻害に関する方法および組成物 |
| JP2015023485A Pending JP2015133967A (ja) | 2004-06-01 | 2015-02-09 | 遺伝子発現の阻害に関する方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011250762A Expired - Fee Related JP5922913B2 (ja) | 2004-06-01 | 2011-11-16 | 遺伝子発現の阻害に関する方法および組成物 |
| JP2015023485A Pending JP2015133967A (ja) | 2004-06-01 | 2015-02-09 | 遺伝子発現の阻害に関する方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20050287667A1 (enExample) |
| EP (2) | EP1773859A4 (enExample) |
| JP (3) | JP4906717B2 (enExample) |
| CN (1) | CN101014608B (enExample) |
| AU (1) | AU2005250453B2 (enExample) |
| BR (1) | BRPI0511770A (enExample) |
| CA (1) | CA2569183A1 (enExample) |
| ES (1) | ES2402532T3 (enExample) |
| PL (1) | PL2141173T3 (enExample) |
| WO (1) | WO2005118824A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3111258B2 (ja) | 1991-03-14 | 2000-11-20 | 古野電気株式会社 | 水中探知装置 |
| US20050287667A1 (en) * | 2004-06-01 | 2005-12-29 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US8815599B2 (en) * | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| JP5122474B2 (ja) * | 2005-12-01 | 2013-01-16 | プロネイ・セラピューティクス・インコーポレイテッド | 両性リポソーム製剤 |
| US20090324587A1 (en) * | 2005-12-01 | 2009-12-31 | Neal Clifford Goodwin | Cancer Therapies and Pharmaceutical Compositions Used Therein |
| CA2659082A1 (en) * | 2006-06-07 | 2007-12-21 | Tethys Bioscience, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| EP2121925A2 (en) * | 2007-03-02 | 2009-11-25 | MDRNA, Inc. | Nucleic acid compounds for inhibiting ras gene expression and uses thereof |
| US9023819B2 (en) * | 2008-06-09 | 2015-05-05 | National Chung Cheng University | Treatment of a disease or a condition associated with aberrant gene hypomethylation by a method involving tailored epigenomic modification |
| US11536713B2 (en) | 2009-12-25 | 2022-12-27 | Chugai Seiyaku Kabushiki Kaisha | Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein |
| SG189302A1 (en) | 2010-10-06 | 2013-05-31 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8734859B1 (en) | 2010-11-13 | 2014-05-27 | Sirbal Ltd. | Molecular combinations for cancer or other disease treatment |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| US20170049687A1 (en) | 2015-07-29 | 2017-02-23 | Sirbal Ltd. | Herbal Combinations For Treating Scalp Conditions |
| JP6077997B2 (ja) | 2011-09-07 | 2017-02-08 | 中外製薬株式会社 | 癌幹細胞の分離 |
| EP3603671A3 (en) | 2011-10-28 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| ITMI20120275A1 (it) * | 2012-02-24 | 2013-08-25 | Biogenera Societa A Responsabilita Limitata | Oligonucleotidi per la modulazione dell'espressione genica e loro usi |
| WO2013183964A1 (ko) * | 2012-06-07 | 2013-12-12 | 한양대학교 산학협력단 | 폐암 진단 및 치료를 위한 표적 단백질 |
| ES2795450T3 (es) | 2012-09-17 | 2020-11-23 | Madrigal Pharmaceuticals Inc | Procedimiento para sintetizar análogos de hormonas tiroideas y polimorfos de los mismos |
| CN104884637A (zh) | 2012-11-05 | 2015-09-02 | 普隆奈治疗公司 | 利用生物标志物通过bcl2表达的调节治疗癌症的方法 |
| WO2014144942A2 (en) * | 2013-03-15 | 2014-09-18 | Pronai Therapeutics, Inc. | Dnai for the modulation of genes |
| WO2015082950A1 (en) | 2013-12-02 | 2015-06-11 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| EP3083960B1 (en) | 2013-12-16 | 2021-02-03 | Syddansk Universitet | Ras exon 2 skipping for cancer treatment |
| CN105581979A (zh) * | 2016-02-24 | 2016-05-18 | 南京大学 | 一种抑制her-2表达的核酸脂质体纳米药物及其制备方法和应用 |
| MX394463B (es) | 2016-10-18 | 2025-03-19 | Madrigal Pharmaceuticals Inc | Métodos para tratar trastornos del hígado o trastornos lipídicos con un agonista de thr-beta. |
| EP3618838A1 (en) * | 2017-05-04 | 2020-03-11 | Sanofi | Methods for treatment of alport syndrome |
| JP7427227B2 (ja) * | 2020-01-21 | 2024-02-05 | 学校法人産業医科大学 | 腫瘍細胞の生存を低下させるkrasアンチセンスオリゴヌクレオチド及びその用途 |
| US12377104B1 (en) | 2024-02-06 | 2025-08-05 | Madrigal Pharmaceuticals, Inc. | Methods for treating a fatty liver disease |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5264423A (en) | 1987-03-25 | 1993-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5276019A (en) * | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US4981785A (en) | 1988-06-06 | 1991-01-01 | Ventrex Laboratories, Inc. | Apparatus and method for performing immunoassays |
| US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| WO1992020698A1 (en) * | 1991-05-17 | 1992-11-26 | Uab Research Foundation | Sequence specific dna binding drugs |
| WO1994008003A1 (en) * | 1991-06-14 | 1994-04-14 | Isis Pharmaceuticals, Inc. | ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5582986A (en) * | 1991-06-14 | 1996-12-10 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide inhibition of the ras gene |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5792608A (en) * | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5376313A (en) | 1992-03-27 | 1994-12-27 | Abbott Laboratories | Injection molding a plastic assay cuvette having low birefringence |
| WO1994017086A1 (en) | 1993-01-25 | 1994-08-04 | Apollon, Inc. | Gene regulation by targeting putative intramolecular triple helix |
| AU6044994A (en) * | 1993-02-19 | 1994-09-14 | Nippon Shinyaku Co. Ltd. | Glycerol derivative, device and pharmaceutical composition |
| US5643765A (en) | 1993-04-06 | 1997-07-01 | University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5876978A (en) | 1993-04-06 | 1999-03-02 | Medical College Of Ohio | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| EP0707653B1 (en) | 1993-06-11 | 2004-09-01 | Commonwealth Scientific And Industrial Research Organisation | Method for specific silencing of genes by dna methylation |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995017507A1 (en) * | 1993-12-23 | 1995-06-29 | Biognostik Gesellschaft für Biomolekulare Diagnostik mbH | ANTISENSE NUCLEIC ACIDS FOR THE PREVENTION AND TREATMENT OF DISORDERS IN WHICH EXPRESSION OF c-erbB PLAYS A ROLE |
| US5599677A (en) | 1993-12-29 | 1997-02-04 | Abbott Laboratories | Immunoassays for prostate specific antigen |
| US5599922A (en) | 1994-03-18 | 1997-02-04 | Lynx Therapeutics, Inc. | Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties |
| US5844107A (en) | 1994-03-23 | 1998-12-01 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
| US5518885A (en) * | 1994-04-19 | 1996-05-21 | The United States Of America As Represented By The Department Of Health & Human Services | ERBB2 promoter binding protein in neoplastic disease |
| US6221959B1 (en) * | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
| WO1996018732A2 (en) | 1994-12-15 | 1996-06-20 | Board Of Trustees Of The University Of Illinois | Sequence-specific inhibition of dna synthesis by triplex-forming oligonucleotides |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| WO1997014440A1 (en) | 1995-10-19 | 1997-04-24 | Johnson & Johnson Interventional Systems | Conjugation of c-myc antisense oligonucleotides with cholesterol to significantly enhance their inhibitory effect on neointimal hyperplasia |
| DE19542372A1 (de) | 1995-11-14 | 1997-05-15 | Bayer Ag | Acylierte 5-Aminoisothiazole |
| US6379966B2 (en) | 1999-02-26 | 2002-04-30 | Mirus Corporation | Intravascular delivery of non-viral nucleic acid |
| CA2239957A1 (en) | 1995-12-22 | 1997-07-03 | Abbott Laboratories | Fluorescence polarization immunoassay diagnostic method |
| US6126964A (en) | 1996-01-04 | 2000-10-03 | Mirus Corporation | Process of making a compound by forming a polymer from a template drug |
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| US5994316A (en) | 1996-02-21 | 1999-11-30 | The Immune Response Corporation | Method of preparing polynucleotide-carrier complexes for delivery to cells |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| US5885529A (en) | 1996-06-28 | 1999-03-23 | Dpc Cirrus, Inc. | Automated immunoassay analyzer |
| US6977244B2 (en) * | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| CA2289702C (en) * | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6291673B1 (en) | 1997-10-17 | 2001-09-18 | Purdue Research Foundation | Folic acid derivatives |
| US5874416A (en) * | 1997-11-07 | 1999-02-23 | Sheikhnejad; Gholamreza | RAS antisense inhibition |
| US6383811B2 (en) | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
| US5968748A (en) * | 1998-03-26 | 1999-10-19 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of human HER-2 expression |
| CN1333678A (zh) * | 1998-05-20 | 2002-01-30 | 表达遗传学公司 | 定向肝细胞的聚乙二醇接枝的聚-l-赖氨酸的聚合基因载体 |
| US6429200B1 (en) | 1998-07-17 | 2002-08-06 | Mirus Corporation | Reverse micelles for delivery of nucleic acids |
| US6169177B1 (en) | 1998-11-06 | 2001-01-02 | Isis Pharmaceuticals, Inc. | Processes for the synthesis of oligomeric compounds |
| US6458382B1 (en) | 1999-11-12 | 2002-10-01 | Mirus Corporation | Nucleic acid transfer complexes |
| AU2001250572A1 (en) * | 2000-04-07 | 2001-10-23 | Epigenomics Ag | Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations |
| US20040006036A1 (en) * | 2000-04-12 | 2004-01-08 | Gmr, A Delaware Corporation | Silencing transcription by methylation |
| EP1389209B1 (en) | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| US20050176025A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA) |
| ITMI20012367A1 (it) * | 2001-11-09 | 2003-05-09 | Visufarma S R L | Oligonucleotidi antisenso che regolano l'espressione del gene antiapoptotico bcl-2 |
| CA2486967A1 (en) * | 2002-05-24 | 2003-12-04 | Neopharm, Inc. | Cardiolipin compositions their methods of preparation and use |
| AU2003295561A1 (en) * | 2002-11-14 | 2004-06-15 | Genta Salus Llc | Inhibitory oliogonucleotides targeted to bcl-2 |
| CA2508052A1 (en) | 2002-12-05 | 2004-06-17 | Imperial College Innovations Limited | Control of apoptosis using a complex of an oligonucleotide and a regulatory peptide |
| WO2004056971A2 (en) * | 2002-12-19 | 2004-07-08 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| ES2344566T3 (es) * | 2003-12-23 | 2010-08-31 | Santaris Pharma A/S | Compuestos oligomericos para la modulacion de bcl-2. |
| DE102004054730A1 (de) * | 2004-03-28 | 2006-05-11 | Novosom Ag | Serumstabile amphotere Liposomen |
| US20050287667A1 (en) * | 2004-06-01 | 2005-12-29 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
-
2004
- 2004-06-01 US US10/858,341 patent/US20050287667A1/en not_active Abandoned
- 2004-06-01 US US10/858,013 patent/US20060135455A1/en not_active Abandoned
- 2004-06-01 US US10/858,164 patent/US7524827B2/en not_active Expired - Fee Related
- 2004-06-01 US US10/858,146 patent/US20060229267A1/en not_active Abandoned
- 2004-06-01 US US10/858,145 patent/US7498315B2/en not_active Expired - Fee Related
- 2004-06-01 US US10/858,094 patent/US20080152700A1/en not_active Abandoned
-
2005
- 2005-06-01 BR BRPI0511770-4A patent/BRPI0511770A/pt not_active IP Right Cessation
- 2005-06-01 ES ES09171679T patent/ES2402532T3/es not_active Expired - Lifetime
- 2005-06-01 EP EP05804859A patent/EP1773859A4/en not_active Withdrawn
- 2005-06-01 PL PL09171679T patent/PL2141173T3/pl unknown
- 2005-06-01 EP EP09171679A patent/EP2141173B1/en not_active Expired - Lifetime
- 2005-06-01 CN CN200580025490XA patent/CN101014608B/zh not_active Expired - Fee Related
- 2005-06-01 AU AU2005250453A patent/AU2005250453B2/en not_active Ceased
- 2005-06-01 JP JP2007515472A patent/JP4906717B2/ja not_active Expired - Fee Related
- 2005-06-01 WO PCT/US2005/018993 patent/WO2005118824A2/en not_active Ceased
- 2005-06-01 CA CA002569183A patent/CA2569183A1/en not_active Abandoned
-
2011
- 2011-11-16 JP JP2011250762A patent/JP5922913B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-09 JP JP2015023485A patent/JP2015133967A/ja active Pending
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