AU2005250453B2 - Methods and compositions for the inhibition of gene expression - Google Patents
Methods and compositions for the inhibition of gene expression Download PDFInfo
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- AU2005250453B2 AU2005250453B2 AU2005250453A AU2005250453A AU2005250453B2 AU 2005250453 B2 AU2005250453 B2 AU 2005250453B2 AU 2005250453 A AU2005250453 A AU 2005250453A AU 2005250453 A AU2005250453 A AU 2005250453A AU 2005250453 B2 AU2005250453 B2 AU 2005250453B2
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61P35/00—Antineoplastic agents
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
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- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| US8815599B2 (en) * | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| CA2631677C (en) * | 2005-12-01 | 2014-08-12 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| EP1971371B1 (en) * | 2005-12-01 | 2015-08-05 | Pronai Therapeutics, Inc. | Cancer therapies and pharmaceutical compositions used therein |
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| US20100055783A1 (en) * | 2007-03-02 | 2010-03-04 | Mdrna, Inc. | Nucleic acid compounds for inhibiting ras gene expression and uses thereof |
| US9023819B2 (en) * | 2008-06-09 | 2015-05-05 | National Chung Cheng University | Treatment of a disease or a condition associated with aberrant gene hypomethylation by a method involving tailored epigenomic modification |
| CN102821600B (zh) * | 2009-12-25 | 2016-01-20 | 中外制药株式会社 | 使用移植了nog确立癌细胞株的非人动物模型进行的抗癌药靶探索以及筛选方法 |
| US11124773B2 (en) | 2010-10-06 | 2021-09-21 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell population and method for production thereof |
| US8597695B1 (en) | 2010-11-13 | 2013-12-03 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| EP3603671A3 (en) | 2011-10-28 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| WO2013183964A1 (ko) * | 2012-06-07 | 2013-12-12 | 한양대학교 산학협력단 | 폐암 진단 및 치료를 위한 표적 단백질 |
| KR20200023528A (ko) * | 2012-09-17 | 2020-03-04 | 마드리갈 파마슈티칼스, 인크. | 갑상선 호르몬 유사체 및 이의 다형의 합성 방법 |
| CN104884637A (zh) | 2012-11-05 | 2015-09-02 | 普隆奈治疗公司 | 利用生物标志物通过bcl2表达的调节治疗癌症的方法 |
| EP2970965A2 (en) * | 2013-03-15 | 2016-01-20 | Pronai Therapeutics, Inc. | Dnai for the modulation of genes |
| CN105939721A (zh) | 2013-12-02 | 2016-09-14 | 塞尔巴有限公司 | 用于治疗皮肤疾病的草药组合 |
| US10266828B2 (en) | 2013-12-16 | 2019-04-23 | Syddansk Universitet | RAS exon 2 skipping for cancer treatment |
| US20170049688A1 (en) | 2015-07-29 | 2017-02-23 | Sirbal Ltd. | Herbal Combinations For Treating Psoriasis |
| CN105581979A (zh) * | 2016-02-24 | 2016-05-18 | 南京大学 | 一种抑制her-2表达的核酸脂质体纳米药物及其制备方法和应用 |
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| CN110740737A (zh) * | 2017-05-04 | 2020-01-31 | 赛诺菲 | 用于治疗奥尔波特综合征的方法 |
| JP7427227B2 (ja) * | 2020-01-21 | 2024-02-05 | 学校法人産業医科大学 | 腫瘍細胞の生存を低下させるｋｒａｓアンチセンスオリゴヌクレオチド及びその用途 |
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| WO2004056971A2 (en) * | 2002-12-19 | 2004-07-08 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
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| DE102004054730A1 (de) * | 2004-03-28 | 2006-05-11 | Novosom Ag | Serumstabile amphotere Liposomen |
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2004
- 2004-06-01 US US10/858,094 patent/US20080152700A1/en not_active Abandoned
- 2004-06-01 US US10/858,341 patent/US20050287667A1/en not_active Abandoned
- 2004-06-01 US US10/858,145 patent/US7498315B2/en not_active Expired - Fee Related
- 2004-06-01 US US10/858,146 patent/US20060229267A1/en not_active Abandoned
- 2004-06-01 US US10/858,013 patent/US20060135455A1/en not_active Abandoned
- 2004-06-01 US US10/858,164 patent/US7524827B2/en not_active Expired - Fee Related
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2005
- 2005-06-01 CN CN200580025490XA patent/CN101014608B/zh not_active Expired - Fee Related
- 2005-06-01 BR BRPI0511770-4A patent/BRPI0511770A/pt not_active IP Right Cessation
- 2005-06-01 ES ES09171679T patent/ES2402532T3/es not_active Expired - Lifetime
- 2005-06-01 WO PCT/US2005/018993 patent/WO2005118824A2/en not_active Ceased
- 2005-06-01 EP EP05804859A patent/EP1773859A4/en not_active Withdrawn
- 2005-06-01 JP JP2007515472A patent/JP4906717B2/ja not_active Expired - Fee Related
- 2005-06-01 EP EP09171679A patent/EP2141173B1/en not_active Expired - Lifetime
- 2005-06-01 PL PL09171679T patent/PL2141173T3/pl unknown
- 2005-06-01 AU AU2005250453A patent/AU2005250453B2/en not_active Ceased
- 2005-06-01 CA CA002569183A patent/CA2569183A1/en not_active Abandoned
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2011
- 2011-11-16 JP JP2011250762A patent/JP5922913B2/ja not_active Expired - Fee Related
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2015
- 2015-02-09 JP JP2015023485A patent/JP2015133967A/ja active Pending
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| Title |
|---|
| SHEN, C. et al. Cancer Biotherapy & Radiopharmaceuticals 2003, vol. 18, pages 17-26 * |
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| US20060135455A1 (en) | 2006-06-22 |
| US7524827B2 (en) | 2009-04-28 |
| EP1773859A4 (en) | 2008-03-26 |
| US7498315B2 (en) | 2009-03-03 |
| US20060198828A1 (en) | 2006-09-07 |
| EP1773859A2 (en) | 2007-04-18 |
| EP2141173B1 (en) | 2013-01-02 |
| HK1107098A1 (en) | 2008-03-28 |
| BRPI0511770A (pt) | 2008-01-08 |
| PL2141173T3 (pl) | 2013-08-30 |
| CN101014608B (zh) | 2011-07-06 |
| CN101014608A (zh) | 2007-08-08 |
| WO2005118824A9 (en) | 2006-06-15 |
| ES2402532T3 (es) | 2013-05-06 |
| WO2005118824A2 (en) | 2005-12-15 |
| WO2005118824A8 (en) | 2007-01-25 |
| JP5922913B2 (ja) | 2016-05-24 |
| US20060073596A1 (en) | 2006-04-06 |
| JP4906717B2 (ja) | 2012-03-28 |
| JP2012085642A (ja) | 2012-05-10 |
| AU2005250453A1 (en) | 2005-12-15 |
| JP2008500838A (ja) | 2008-01-17 |
| JP2015133967A (ja) | 2015-07-27 |
| US20080152700A1 (en) | 2008-06-26 |
| CA2569183A1 (en) | 2005-12-15 |
| US20050287667A1 (en) | 2005-12-29 |
| EP2141173A1 (en) | 2010-01-06 |
| WO2005118824A3 (en) | 2006-11-09 |
| US20060229267A1 (en) | 2006-10-12 |
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