CN101014608B - 抑制基因表达的方法和组合物 - Google Patents

抑制基因表达的方法和组合物 Download PDF

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Publication number
CN101014608B
CN101014608B CN200580025490XA CN200580025490A CN101014608B CN 101014608 B CN101014608 B CN 101014608B CN 200580025490X A CN200580025490X A CN 200580025490XA CN 200580025490 A CN200580025490 A CN 200580025490A CN 101014608 B CN101014608 B CN 101014608B
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oligonucleotide
cell
gene
certain embodiments
cancer
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Expired - Fee Related
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Chinese (zh)
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CN101014608A (zh
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G·谢克内亚德
M·P·索奇
N·古德温
D·奥尔森
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Sierra Oncology Inc
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ProNAi Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200580025490XA 2004-06-01 2005-06-01 抑制基因表达的方法和组合物 Expired - Fee Related CN101014608B (zh)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US10/858,013 US20060135455A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,341 2004-06-01
US10/858,145 2004-06-01
US10/858,164 US7524827B2 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,146 US20060229267A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,094 US20080152700A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,341 US20050287667A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,164 2004-06-01
US10/858,013 2004-06-01
US10/858,145 US7498315B2 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,146 2004-06-01
US10/858,094 2004-06-01
US61197404P 2004-09-22 2004-09-22
US60/611,974 2004-09-22
US63721204P 2004-12-17 2004-12-17
US60/637,212 2004-12-17
PCT/US2005/018993 WO2005118824A2 (en) 2004-06-01 2005-06-01 Methods and compositions for the inhibition of gene expression

Publications (2)

Publication Number Publication Date
CN101014608A CN101014608A (zh) 2007-08-08
CN101014608B true CN101014608B (zh) 2011-07-06

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CN200580025490XA Expired - Fee Related CN101014608B (zh) 2004-06-01 2005-06-01 抑制基因表达的方法和组合物

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US (6) US20050287667A1 (enExample)
EP (2) EP1773859A4 (enExample)
JP (3) JP4906717B2 (enExample)
CN (1) CN101014608B (enExample)
AU (1) AU2005250453B2 (enExample)
BR (1) BRPI0511770A (enExample)
CA (1) CA2569183A1 (enExample)
ES (1) ES2402532T3 (enExample)
PL (1) PL2141173T3 (enExample)
WO (1) WO2005118824A2 (enExample)

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US8815599B2 (en) * 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
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US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8734859B1 (en) 2010-11-13 2014-05-27 Sirbal Ltd. Molecular combinations for cancer or other disease treatment
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JP6077997B2 (ja) 2011-09-07 2017-02-08 中外製薬株式会社 癌幹細胞の分離
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CN104884637A (zh) 2012-11-05 2015-09-02 普隆奈治疗公司 利用生物标志物通过bcl2表达的调节治疗癌症的方法
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JP7427227B2 (ja) * 2020-01-21 2024-02-05 学校法人産業医科大学 腫瘍細胞の生存を低下させるｋｒａｓアンチセンスオリゴヌクレオチド及びその用途
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Also Published As

Publication number Publication date
AU2005250453A1 (en) 2005-12-15
JP4906717B2 (ja) 2012-03-28
US20080152700A1 (en) 2008-06-26
US20060073596A1 (en) 2006-04-06
CN101014608A (zh) 2007-08-08
PL2141173T3 (pl) 2013-08-30
JP2015133967A (ja) 2015-07-27
US20060135455A1 (en) 2006-06-22
BRPI0511770A (pt) 2008-01-08
HK1107098A1 (en) 2008-03-28
AU2005250453B2 (en) 2012-02-23
EP2141173B1 (en) 2013-01-02
WO2005118824A2 (en) 2005-12-15
WO2005118824A8 (en) 2007-01-25
ES2402532T3 (es) 2013-05-06
CA2569183A1 (en) 2005-12-15
WO2005118824A3 (en) 2006-11-09
EP1773859A4 (en) 2008-03-26
JP2012085642A (ja) 2012-05-10
WO2005118824A9 (en) 2006-06-15
US20060198828A1 (en) 2006-09-07
JP5922913B2 (ja) 2016-05-24
US20060229267A1 (en) 2006-10-12
US7498315B2 (en) 2009-03-03
US7524827B2 (en) 2009-04-28
EP1773859A2 (en) 2007-04-18
EP2141173A1 (en) 2010-01-06
JP2008500838A (ja) 2008-01-17
US20050287667A1 (en) 2005-12-29

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