JP4885852B2 - 流体操作および分析のためのマイクロ流体デバイス - Google Patents
流体操作および分析のためのマイクロ流体デバイス Download PDFInfo
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Description
Claims (12)
- 液体サンプルを分析するためのマイクロ流体デバイスであって、
第一末端および第二末端を有する第一マイクロ流体チャネルと、
前記液体サンプルを受けるために、前記第一マイクロ流体チャネルの前記第一末端に流体を介して接続されるサンプル注入口と、
第一試薬を受けるために前記第一マイクロ流体チャネルの前記第一末端に流体を介して接続される第一試薬注入口と、
前記第一マイクロ流体チャネルの前記第二末端に流体を介して接続されるベローズポンプと、
前記ベローズポンプと、前記第一マイクロ流体チャネルの第二末端との間に置かれる第一液体バリアであって、ガス透過性でかつ液体不透過性である第一液体バリアと、
前記サンプル注入口に流体を介して接続される第一末端、および前記ベローズポンプに流体を介して接続される第二末端を有する第二マイクロ流体チャネルと、
第二試薬を受けるために前記第二マイクロ流体チャネルの前記第一末端に流体を介して接続される第二試薬注入口と、
前記ベローズポンプと前記第二マイクロ流体チャネルの前記第二末端との間に置かれる第二液体バリアであって、ガス透過性でかつ液体不透過性である第二液体バリアと、
前記サンプル注入口に流体を介して接続される第一末端、および前記ベローズポンプに流体を介して接続される第二末端を有する第三マイクロ流体チャネルと、
第三試薬を受けるために前記第三マイクロ流体チャネルの前記第一末端に流体を介して接続される第三試薬注入口と、
前記ベローズポンプと前記第三マイクロ流体チャネルの前記第二末端との間に置かれる第三液体バリアであって、ガス透過性でかつ液体不透過性である第三液体バリアと、
を備え、ここで、
前記第一試薬注入口は前記第一試薬を含む第一ブリスター袋を備え、前記第二試薬注入口は前記第二試薬を含む第二ブリスター袋を備え、前記第三試薬注入口は前記第三試薬を含む第三ブリスター袋を備える、液体サンプルを分析するためのマイクロ流体デバイス。 - 液体サンプルを分析するためのマイクロ流体デバイスであって、
第一末端および第二末端を有する第一マイクロ流体チャネルと、
前記液体サンプルを受けるために、前記第一マイクロ流体チャネルの前記第一末端に流体を介して接続されるサンプル注入口と、
第一乾燥試薬ゾーンであって、その上に印刷された第一試薬を含み、前記第一マイクロ流体チャネルの前記第一末端に流体を介して接続される第一乾燥試薬ゾーンと、
前記第一マイクロ流体チャネルの前記第二末端に流体を介して接続されるベローズポンプと、
前記ベローズポンプと、前記第一マイクロ流体チャネルの前記第二末端との間に置かれる第一液体バリアであって、ガス透過性でかつ液体不透過性である第一液体バリアと、
前記サンプル注入口に流体を介して接続される第一末端、および前記ベローズポンプに流体を介して接続される第二末端を有する第二マイクロ流体チャネルと、
第二乾燥試薬ゾーンであって、その上に印刷された第二試薬を含み、前記第二マイクロ流体チャネルの前記第一末端に流体を介して接続される第二乾燥試薬ゾーンと、
前記ベローズポンプと前記第二マイクロ流体チャネルの前記第二末端との間に置かれる第二液体バリアであって、ガス透過性でかつ液体不透過性である第二液体バリアと、
前記サンプル注入口に流体を介して接続される第一末端、および前記ベローズポンプに流体を介して接続される第二末端を有する第三マイクロ流体チャネルと、
第三乾燥試薬ゾーンであって、その上に印刷された第三試薬を含み、前記第三マイクロ流体チャネルの前記第一末端に流体を介して接続される第三乾燥試薬ゾーンと、
前記ベローズポンプと前記第三マイクロ流体チャネルの前記第二末端との間に置かれる第三液体バリアであって、ガス透過性でかつ液体不透過性である第三液体バリア
を備える、マイクロ流体デバイス。 - 前記ベローズポンプは通気口を備える、請求項1または2に記載のマイクロ流体デバイス。
- 請求項1または2に記載のマイクロ流体デバイスであって、前記ベローズポンプに流体を介して接続されるチェックバルブであって、流体が前記ベローズポンプから遠ざかるように流れることを可能にするチェックバルブをさらに備える、マイクロ流体デバイス。
- 前記第一マイクロ流体チャネルは一つ以上の視覚観察エリアをさらに備える、請求項1または2に記載のマイクロ流体デバイス。
- 前記第二マイクロ流体チャネルは一つ以上の視覚観察エリアをさらに備える、請求項1または2に記載のマイクロ流体デバイス。
- 前記液体サンプルは血液サンプルを備え、前記第一試薬は抗体Aを備え、前記第二試薬は抗体Bを備え、前記第三試薬が抗体Dを備える、請求項1または2に記載のマイクロ流体デバイス。
- 前記第三マイクロ流体チャネルは一つ以上の視覚観察エリアをさらに備える、請求項1または2に記載のマイクロ流体デバイス。
- 水和バッファを受けるために、前記第一、第二および第三乾燥試薬ゾーン、ならびに前記第一、第二および第三マイクロ流体チャネルの前記第一末端に流体を介して接続される水和バッファ注入口をさらに備える、請求項2に記載のマイクロ流体デバイス。
- 前記水和バッファ注入口は水和バッファを含む水和バッファブリスター袋を備える、請求項9に記載のマイクロ流体デバイス。
- 前記液体サンプルが前記第一、第二および第三乾燥試薬ゾーンを通り抜けることによって、前記第一、第二および第三乾燥試薬が水和されるように、前記第一、第二および第三乾燥試薬ゾーンが、前記サンプル注入口に流体を介して接続される、請求項2に記載のマイクロ流体デバイス。
- 前記水和バッファが前記第一、第二および第三乾燥試薬ゾーンを通り抜けることによって、前記第一、第二および第三乾燥試薬が水和されるように、前記第一、第二および第三乾燥試薬ゾーンが、前記水和バッファ注入口に流体を介して接続される、請求項9に記載のマイクロ流体デバイス。
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Cited By (5)
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US9599613B2 (en) | 2011-07-20 | 2017-03-21 | University Of Washington Through Its Center For Commercialization | Photonic blood typing |
US10073102B2 (en) | 2011-07-20 | 2018-09-11 | University Of Washington Through Its Center For Commercialization | Photonic blood typing |
US10794921B2 (en) | 2011-07-20 | 2020-10-06 | University Of Washington | Photonic blood typing |
US11105820B2 (en) | 2011-07-20 | 2021-08-31 | University Of Washington Through Its Center For Commercialization | Photonic pathogen detection |
US10031138B2 (en) | 2012-01-20 | 2018-07-24 | University Of Washington Through Its Center For Commercialization | Hierarchical films having ultra low fouling and high recognition element loading properties |
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US20140010736A1 (en) | 2014-01-09 |
WO2006009724A3 (en) | 2006-05-04 |
JP2008503722A (ja) | 2008-02-07 |
US8557198B2 (en) | 2013-10-15 |
DE602005022878D1 (de) | 2010-09-23 |
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ATE477049T1 (de) | 2010-08-15 |
US7419638B2 (en) | 2008-09-02 |
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EP1773481B1 (en) | 2010-08-11 |
US20050106066A1 (en) | 2005-05-19 |
US20140370581A1 (en) | 2014-12-18 |
US8697009B2 (en) | 2014-04-15 |
US20090022624A1 (en) | 2009-01-22 |
WO2006009724A2 (en) | 2006-01-26 |
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