JP4885715B2 - イリノテカン製剤 - Google Patents
イリノテカン製剤 Download PDFInfo
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- JP4885715B2 JP4885715B2 JP2006514098A JP2006514098A JP4885715B2 JP 4885715 B2 JP4885715 B2 JP 4885715B2 JP 2006514098 A JP2006514098 A JP 2006514098A JP 2006514098 A JP2006514098 A JP 2006514098A JP 4885715 B2 JP4885715 B2 JP 4885715B2
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- irinotecan
- lipid
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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| JP2006514098A JP4885715B2 (ja) | 2004-06-01 | 2005-05-31 | イリノテカン製剤 |
| PCT/JP2005/009953 WO2005117878A1 (ja) | 2004-06-01 | 2005-05-31 | イリノテカン製剤 |
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| JP (1) | JP4885715B2 (de) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10172943B2 (en) | 2015-08-18 | 2019-01-08 | Industry—University Cooperation Foundation Hanyang University Erica Campus | Irinotecan-loaded dual-reverse thermosensitive hydrogel composition |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101376895B1 (ko) | 2004-05-03 | 2014-03-25 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| US20090196918A1 (en) * | 2008-02-01 | 2009-08-06 | University Of Kentucky Research Foundation | Liposomal formulations of hydrophobic lactone drugs in the presence of metal ions |
| US8389768B2 (en) * | 2008-05-19 | 2013-03-05 | The University Of North Carolina At Chapel Hill | Methods and compositions comprising novel cationic lipids |
| WO2010058840A1 (ja) * | 2008-11-20 | 2010-05-27 | テルモ株式会社 | リポソームからの薬物放出手段および放出性評価法 |
| CN102271659B (zh) * | 2009-12-03 | 2013-09-18 | 江苏恒瑞医药股份有限公司 | 伊立替康或盐酸伊立替康脂质体及其制备方法 |
| CN103120645B (zh) * | 2009-12-03 | 2015-03-11 | 江苏恒瑞医药股份有限公司 | 伊立替康或盐酸伊立替康脂质体及其制备方法 |
| TWI619496B (zh) | 2011-11-03 | 2018-04-01 | 台灣微脂體股份有限公司 | 疏水性喜樹鹼衍生物之醫藥組合物 |
| US10980798B2 (en) | 2011-11-03 | 2021-04-20 | Taiwan Liposome Company, Ltd. | Pharmaceutical compositions of hydrophobic camptothecin derivatives |
| KR101842279B1 (ko) * | 2012-03-29 | 2018-03-26 | 우석대학교 산학협력단 | 이리노테칸의 안정성증진을 위한 주사제용 조성물 |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| EA023079B1 (ru) * | 2012-12-24 | 2016-04-29 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Способ получения липосомальной формы иринотекана (варианты) |
| CN104906586A (zh) * | 2014-03-10 | 2015-09-16 | 中国科学院上海药物研究所 | 一种盐酸伊立替康复合磷脂组合物、制备方法及其应用 |
| CN105796495B (zh) * | 2014-12-29 | 2020-10-23 | 南京绿叶制药有限公司 | 一种盐酸伊立替康脂质体药物组合物及其制备方法 |
| CN105982857B (zh) * | 2015-02-09 | 2019-03-08 | 湖南科伦药物研究有限公司 | 一种盐酸伊立替康脂质体组合物及其制备方法 |
| ES2589320B2 (es) * | 2015-04-14 | 2017-06-01 | Universidad Politécnica de Madrid | Sistema de compartimentación de espacios con membranas enrollables |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| EP3337467B1 (de) | 2015-08-20 | 2020-12-09 | Ipsen Biopharm Ltd. | Kombinationstherapie unter verwendung von liposomalem irinotecan und einem parp-hemmer zur behandlung von krebs |
| IL257149B1 (en) | 2015-08-21 | 2024-07-01 | Ipsen Biopharm Ltd | Methods for treating pancreatic cancer metastases using combined treatments including liposomal irinotecan and oxaliplatin |
| CA3001467A1 (en) | 2015-10-16 | 2017-04-20 | Ipsen Biopharm Ltd. | Stabilizing camptothecin pharmaceutical compositions |
| BR112019007844A2 (pt) * | 2016-11-02 | 2019-07-16 | Ipsen Biopharm Ltd | tratamento de câncer gástrico usando terapias de combinação compreendendo irinotecano lipossômico, oxaliplatina, 5-fluoroacila (e leucovorina) |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| CN109260155B (zh) | 2018-11-05 | 2021-04-06 | 杭州高田生物医药有限公司 | 伊立替康脂质体制剂及其制备与应用 |
| KR102185475B1 (ko) * | 2019-06-20 | 2020-12-02 | 대화제약 주식회사 | 이리노테칸 자유 염기를 포함하는 경구투여용 약학 조성물 |
| CA3231432A1 (en) * | 2021-10-15 | 2023-04-20 | Tianyi Ke | Composition containing antitumor drug, and preparation method therefor and use thereof |
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|---|---|---|---|---|
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| EP0721328A4 (de) | 1993-09-27 | 1997-09-17 | Smithkline Beecham Corp | Camptothecin-formulierungen |
| US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| US6090407A (en) | 1997-09-23 | 2000-07-18 | Research Development Foundation | Small particle liposome aerosols for delivery of anti-cancer drugs |
| ATE238039T1 (de) * | 1998-09-16 | 2003-05-15 | Alza Corp | In liposomen eingeschlossene topoisomerase inhibitoren |
| JP2001064158A (ja) * | 1999-06-25 | 2001-03-13 | Terumo Corp | リポソーム |
| EP1190706B1 (de) * | 1999-06-25 | 2009-05-06 | Terumo Kabushiki Kaisha | Liposome |
| US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| ES2253398T3 (es) * | 2000-06-30 | 2006-06-01 | Inex Pharmaceuticals Corp. | Camptotecinas liposomales mejoradas y sus usos. |
| EP1432402B1 (de) | 2001-10-03 | 2006-11-22 | Celator Pharmaceuticals, Inc. | Zusammensetzungen zur verabreichung von arzneimittelkombinationen |
| DE60237162D1 (de) | 2001-10-03 | 2010-09-09 | Celator Pharmaceuticals Inc | Liposomenladung mit metallionen |
| ES2290333T3 (es) * | 2001-11-13 | 2008-02-16 | Celator Pharmaceuticals, Inc. | Composiciones de vehiculos lipidicos y metodos para la retencion mejorada de farmacos. |
| JP4555569B2 (ja) * | 2001-11-13 | 2010-10-06 | セレーター ファーマシューティカルズ， インコーポレイテッド | 増強された血中安定性を有する脂質キャリア組成物 |
| EP1608338A1 (de) | 2003-04-02 | 2005-12-28 | Celator Technologies Inc. | Pharmazeutische zusammensetzungen enthaltend wirkstoffe mit einer lactongruppe und übergangsmetallionen |
| KR101376895B1 (ko) * | 2004-05-03 | 2014-03-25 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| US8658203B2 (en) * | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10172943B2 (en) | 2015-08-18 | 2019-01-08 | Industry—University Cooperation Foundation Hanyang University Erica Campus | Irinotecan-loaded dual-reverse thermosensitive hydrogel composition |
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