JP4860085B2 - 表面結合リガンドから溶出された分析物を捕捉するための方法 - Google Patents

表面結合リガンドから溶出された分析物を捕捉するための方法 Download PDF

Info

Publication number
JP4860085B2
JP4860085B2 JP2001568086A JP2001568086A JP4860085B2 JP 4860085 B2 JP4860085 B2 JP 4860085B2 JP 2001568086 A JP2001568086 A JP 2001568086A JP 2001568086 A JP2001568086 A JP 2001568086A JP 4860085 B2 JP4860085 B2 JP 4860085B2
Authority
JP
Japan
Prior art keywords
analyte
liquid
bound
capture
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2001568086A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003527606A5 (https=
JP2003527606A (ja
Inventor
エステン ヤンソン，
マグヌス マルモクヴィスト，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Amersham Bioscience AB
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Bioscience AB, GE Healthcare Bio Sciences Corp filed Critical Amersham Bioscience AB
Publication of JP2003527606A publication Critical patent/JP2003527606A/ja
Publication of JP2003527606A5 publication Critical patent/JP2003527606A5/ja
Application granted granted Critical
Publication of JP4860085B2 publication Critical patent/JP4860085B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
JP2001568086A 2000-03-16 2001-03-14 表面結合リガンドから溶出された分析物を捕捉するための方法 Expired - Lifetime JP4860085B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19033600P 2000-03-16 2000-03-16
US60/190,336 2000-03-16
PCT/SE2001/000531 WO2001069258A1 (en) 2000-03-16 2001-03-14 Method for capturing analytes eluted from surface-bound ligands

Publications (3)

Publication Number Publication Date
JP2003527606A JP2003527606A (ja) 2003-09-16
JP2003527606A5 JP2003527606A5 (https=) 2011-05-12
JP4860085B2 true JP4860085B2 (ja) 2012-01-25

Family

ID=22700919

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001568086A Expired - Lifetime JP4860085B2 (ja) 2000-03-16 2001-03-14 表面結合リガンドから溶出された分析物を捕捉するための方法

Country Status (7)

Country Link
US (2) US6503760B2 (https=)
EP (1) EP1264179B1 (https=)
JP (1) JP4860085B2 (https=)
AT (1) ATE335202T1 (https=)
AU (1) AU2001242928A1 (https=)
DE (1) DE60121923T2 (https=)
WO (1) WO2001069258A1 (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4860085B2 (ja) * 2000-03-16 2012-01-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 表面結合リガンドから溶出された分析物を捕捉するための方法
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6833920B2 (en) 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7023547B2 (en) * 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
CA2474469A1 (en) * 2002-01-28 2003-08-07 Mds Proteomics, Inc. Chemical proteomics
US20030166007A1 (en) * 2002-01-28 2003-09-04 Mds Proteomics Inc. Chemical proteomics
AU2003231731A1 (en) * 2002-04-15 2003-11-03 American National Red Cross Method for detecting ligands and targets in a mixture
US6821744B2 (en) * 2002-10-29 2004-11-23 Roche Diagnostics Operations, Inc. Method, assay, and kit for quantifying HIV protease inhibitors
JPWO2004051231A1 (ja) * 2002-11-29 2006-04-06 日本電気株式会社 分離装置および分離方法
US7736909B2 (en) 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
US7483140B1 (en) 2004-12-10 2009-01-27 University Of Central Florida Research Foundation, Inc. Micro integrated planar optical waveguide type SPR sensor
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
JP2006313091A (ja) * 2005-05-06 2006-11-16 Fuji Photo Film Co Ltd 結合物質回収方法及び装置
EP1943500A4 (en) 2005-09-30 2013-01-16 Fujifilm Corp DETECTION SYSTEM
JP4768417B2 (ja) * 2005-11-28 2011-09-07 富士フイルム株式会社 バイオセンサー
US7867783B2 (en) * 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US8354280B2 (en) * 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
EP2128617A1 (en) * 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Device and methods for detecting analytes in saliva
BRPI1013012A2 (pt) 2009-06-02 2016-10-18 Opko Health Inc identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas
WO2011047257A1 (en) 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
US9050595B2 (en) 2010-12-03 2015-06-09 Abbott Point Of Care Inc. Assay devices with integrated sample dilution and dilution verification and methods of using same
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
CN108780081B (zh) 2015-08-10 2021-04-09 Essenlix公司 步骤简化、小样品、快速、易使用的生物/化学分析装置和方法
WO2017048871A1 (en) 2015-09-14 2017-03-23 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same
CN111426822B (zh) 2015-09-14 2022-12-13 艾森利克斯公司 采集分析蒸汽凝析，特别是呼出气凝析的装置与系统，以及使用方法
US10628693B2 (en) 2016-12-21 2020-04-21 Essenlix Corporation Devices and methods for authenticating a sample and use of the same
WO2018148342A1 (en) 2017-02-07 2018-08-16 Essenlix Corporation Compressed open flow assay and use
CN111656155B (zh) 2017-02-08 2024-05-31 上海宜晟生物科技有限公司 用于延迟分析的样品采集和操作
US12151246B2 (en) 2017-02-08 2024-11-26 Essenlix Corporation Molecular manipulation and assay with controlled temperature
US11927560B2 (en) 2017-02-08 2024-03-12 Essenlix Corporation Bio/chemical material extraction and assay
CN110998324B (zh) 2017-02-08 2025-03-28 上海宜晟生物科技有限公司 数字测定
CA3052809A1 (en) 2017-02-08 2018-08-23 Essenlix Corporation Qmax assays and applications
EP3662259A4 (en) 2017-02-09 2021-08-25 Essenlix Corporation COLORIMETRIC TESTS
CN111433606B (zh) 2017-02-09 2024-05-24 上海宜晟生物科技有限公司 采用不同间距高度的测定
CN110998325B (zh) 2017-02-09 2024-08-16 上海宜晟生物科技有限公司 扩增测定
JP2020508043A (ja) 2017-02-15 2020-03-19 エッセンリックス コーポレーション 急速な温度変化を伴うアッセイ
US11523752B2 (en) 2017-02-16 2022-12-13 Essenlix Corporation Assay for vapor condensates
EP3638421A4 (en) 2017-06-12 2021-04-07 Essenlix Corporation HOMOGENOUS ASSAY
CN120668916A (zh) 2017-08-01 2025-09-19 上海宜晟生物科技有限公司 检查药物对微生物影响的装置和方法
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
WO2019028123A1 (en) 2017-08-01 2019-02-07 Essenlix Corporation COLLECTION, MAINTENANCE AND DETERMINATION OF SAMPLES
WO2019075244A1 (en) 2017-10-11 2019-04-18 Essenlix Corporation CONTAINING A LIQUID SAMPLE
WO2019075415A1 (en) 2017-10-13 2019-04-18 Essenlix Corporation DEVICES AND METHODS FOR AUTHENTICATING MEDICAL ANALYSIS AND USES THEREOF
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
CN107899552B (zh) * 2017-10-31 2020-06-30 苏州博进生物技术有限公司 一种以磁性聚合物微球为基质的金属螯合亲和层析介质
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
CN112534259A (zh) 2017-12-14 2021-03-19 Essenlix公司 监测毛发的装置，系统和方法
WO2019140334A1 (en) 2018-01-11 2019-07-18 Essenlix Corporation Homogeneous assay (ii)
EP3775834A4 (en) * 2018-07-09 2021-03-17 Hewlett-Packard Development Company, L.P. ANALYTIC TRAP DEVICES WITH FLUID EJECTOR DEVICES
US11885952B2 (en) 2018-07-30 2024-01-30 Essenlix Corporation Optics, device, and system for assaying and imaging
WO2020225971A1 (ja) * 2019-05-08 2020-11-12 株式会社日立ハイテク 自動分析装置の前処理方法
EP4089401B1 (de) * 2021-05-10 2024-11-06 Siemens Aktiengesellschaft Messeinrichtung und verfahren zur messung von mindestens zwei verschiedenen komponenten eines fluids mittels ramanstreuung und chemilumineszenz

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02152541A (ja) * 1988-09-21 1990-06-12 Glaverbel Sa 流体媒体から材料の生化学分離法
JPH0466871A (ja) * 1990-07-07 1992-03-03 Eiji Ishikawa 高感度な免疫測定法
JPH0682453A (ja) * 1992-05-27 1994-03-22 Ciba Corning Diagnostics Corp 免疫複合体転移技術の使用による改良免疫アッセイ
JPH08304397A (ja) * 1995-05-11 1996-11-22 Sumitomo Pharmaceut Co Ltd 病原体感染の検出方法
WO1999063333A1 (en) * 1998-05-29 1999-12-09 Biacore Ab Surface regeneration of biosensors
JP2000060554A (ja) * 1998-08-27 2000-02-29 Hitachi Ltd ポリヌクレオチドプローブチップ及びポリヌクレオチド検出法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236826A (en) * 1985-12-10 1993-08-17 Murex Corporation Immunoassay for the detection or quantitation of an analyte
US5750338A (en) * 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
US5236849A (en) * 1987-08-11 1993-08-17 Eiji Ishikawa Method of high sensitivity immunoassay
SE9201976D0 (sv) * 1992-06-26 1992-06-26 Tektolit Ab Haakan Eriksson En metod foer att adsorbera proteiner och peptider till hydrofoba zeoliter
JPH08503698A (ja) * 1992-10-02 1996-04-23 ザ ゼネラル ホスピタル コーポレーション アミノ酸模倣物を溶出試薬として用いる親和精製方法
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
US5445936A (en) * 1993-09-15 1995-08-29 Ciba Corning Diagnostics Corp. Method for non-competitive binding assays
DE69422604T2 (de) * 1994-03-08 2000-06-08 Zeptosens Ag, Witterwil Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
JPH08178926A (ja) * 1994-10-25 1996-07-12 Sumitomo Pharmaceut Co Ltd イムノアッセイプレートおよびその用途
AU4117696A (en) * 1994-11-24 1996-06-17 Unipath Limited Recovery of and uses of specific binding agents
US5756717A (en) * 1995-05-24 1998-05-26 Perseptive Biosystems, Inc Protein imaging
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
CA2245714A1 (en) * 1996-02-09 1997-08-14 Martin Thomas French Assay apparatus
WO1997044664A1 (en) * 1996-05-23 1997-11-27 Unilever Plc Improvements in or relating to specific binding assays
ATE317979T1 (de) * 1996-12-19 2006-03-15 Dade Behring Marburg Gmbh Immundissoziation zur verbesserung der immunchemischen bestimmung eines analyten
US6025197A (en) * 1997-03-19 2000-02-15 Zymogenetics, Inc. Secreted salivary zsig32 polypeptides
US6127129A (en) * 1999-05-04 2000-10-03 Wisconsin Alumni Research Foundation Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby
JP4860085B2 (ja) * 2000-03-16 2012-01-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 表面結合リガンドから溶出された分析物を捕捉するための方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02152541A (ja) * 1988-09-21 1990-06-12 Glaverbel Sa 流体媒体から材料の生化学分離法
JPH0466871A (ja) * 1990-07-07 1992-03-03 Eiji Ishikawa 高感度な免疫測定法
JPH0682453A (ja) * 1992-05-27 1994-03-22 Ciba Corning Diagnostics Corp 免疫複合体転移技術の使用による改良免疫アッセイ
JPH08304397A (ja) * 1995-05-11 1996-11-22 Sumitomo Pharmaceut Co Ltd 病原体感染の検出方法
WO1999063333A1 (en) * 1998-05-29 1999-12-09 Biacore Ab Surface regeneration of biosensors
JP2000060554A (ja) * 1998-08-27 2000-02-29 Hitachi Ltd ポリヌクレオチドプローブチップ及びポリヌクレオチド検出法

Also Published As

Publication number Publication date
US20020012929A1 (en) 2002-01-31
AU2001242928A1 (en) 2001-09-24
US20030077842A1 (en) 2003-04-24
DE60121923D1 (de) 2006-09-14
EP1264179B1 (en) 2006-08-02
ATE335202T1 (de) 2006-08-15
US6503760B2 (en) 2003-01-07
EP1264179A1 (en) 2002-12-11
JP2003527606A (ja) 2003-09-16
US6844201B2 (en) 2005-01-18
DE60121923T2 (de) 2006-11-30
WO2001069258A1 (en) 2001-09-20

Similar Documents

Publication Publication Date Title
JP4860085B2 (ja) 表面結合リガンドから溶出された分析物を捕捉するための方法
JP2003527606A5 (https=)
Pattnaik Surface plasmon resonance: applications in understanding receptor-ligand interaction
JP5595382B2 (ja) 唾液内の検体を検出する装置及び方法
US7221457B2 (en) Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
US7989213B2 (en) Surface enhanced resonance raman scattering spectroscopy (SERRS) nanoparticle probes and methods of use
CN102597774B (zh) 利用多种磁性标记示踪结合试剂的结合测定
JP2018511805A (ja) サンプル分析のためのデバイスおよび方法
WO2008053822A1 (en) Method of detecting specific bond reaction of molecule by single molecule fluorometry
JP5401724B2 (ja) 被覆磁性微粒子を用いたバイオセンシング方法及び該方法に用いるバイオセンシング装置
Peoples et al. Microfluidic immunoaffinity separations for bioanalysis
Grote et al. Surface plasmon resonance/mass spectrometry interface
JP2021036245A (ja) センサー表面でアナライト−リガンド結合を測定するための方法
Ke et al. Detection of morphine in urine based on a surface plasmon resonance imaging immunoassay
JP2005535874A (ja) 分析装置
EP2031393A1 (en) Sensor element for spr measurement
WO2015178729A1 (ko) 신규한 시료 내 검출대상물의 검출방법 및 그를 이용한 검출키트
KR100952891B1 (ko) 광분해성 올리고머를 이용한, 복수의 생체분자에 대한신호의 동시 검출 방법
JP2006030155A (ja) 分光法を用いたプレートアッセイ
JP5205293B2 (ja) 抗体固定基板、並びに該抗体固定基板の製造方法及び利用
JP2012010664A (ja) 細胞分析装置
JP2006329631A (ja) 分子間相互作用検出装置およびそれを用いた分子回収装置
JP2007225348A (ja) 近接した複数の微粒子の検出方法及びそれを用いる被検物質の検出方法
US20250224395A1 (en) Methods of solution-phase kinetic analysis on a digital microfluidic (dmf) device
CN100491976C (zh) 基于固相表面增强光散射的生物分子相互作用分析方法

Legal Events

Date Code Title Description
RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20070823

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20070906

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080312

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080312

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20080618

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20100806

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100831

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101130

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20101130

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20101130

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101224

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101207

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20110228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110324

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110830

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110907

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20111004

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20111102

R150 Certificate of patent or registration of utility model

Ref document number: 4860085

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20141111

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

EXPY Cancellation because of completion of term