JP4856294B2 - 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 - Google Patents

癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 Download PDF

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JP4856294B2
JP4856294B2 JP50081799A JP50081799A JP4856294B2 JP 4856294 B2 JP4856294 B2 JP 4856294B2 JP 50081799 A JP50081799 A JP 50081799A JP 50081799 A JP50081799 A JP 50081799A JP 4856294 B2 JP4856294 B2 JP 4856294B2
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cancer
nitroxide
prodrug
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JP2002500671A (ja
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ビー． ミッチェル、ジェイムズ
ラッソウ、アンジェロ
マリー デルーカ、アン
クリシュナ チェルクリ、ミュラリ
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アメリカ合衆国政府
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP50081799A 1997-05-27 1998-05-27 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 Expired - Fee Related JP4856294B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4772497P 1997-05-27 1997-05-27
US60/047,724 1997-05-27
PCT/US1998/010685 WO1998053835A1 (en) 1997-05-27 1998-05-27 The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009062262A Division JP5270413B2 (ja) 1997-05-27 2009-03-16 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用

Publications (2)

Publication Number Publication Date
JP2002500671A JP2002500671A (ja) 2002-01-08
JP4856294B2 true JP4856294B2 (ja) 2012-01-18

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ID=21950574

Family Applications (3)

Application Number Title Priority Date Filing Date
JP50081799A Expired - Fee Related JP4856294B2 (ja) 1997-05-27 1998-05-27 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用
JP2009062262A Expired - Fee Related JP5270413B2 (ja) 1997-05-27 2009-03-16 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用
JP2013003496A Pending JP2013121964A (ja) 1997-05-27 2013-01-11 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009062262A Expired - Fee Related JP5270413B2 (ja) 1997-05-27 2009-03-16 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用
JP2013003496A Pending JP2013121964A (ja) 1997-05-27 2013-01-11 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用

Country Status (10)

Country Link
EP (1) EP0986393B1 (https=)
JP (3) JP4856294B2 (https=)
AT (1) ATE262330T1 (https=)
AU (1) AU746505B2 (https=)
CA (1) CA2289017C (https=)
DE (1) DE69822626T8 (https=)
DK (1) DK0986393T3 (https=)
ES (1) ES2216286T3 (https=)
PT (1) PT986393E (https=)
WO (1) WO1998053835A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096759A (en) * 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
AU765110B2 (en) * 1998-06-26 2003-09-11 Georgetown University Medical Center Compositions and methods for inducing cell death
US20040219201A1 (en) * 2001-12-06 2004-11-04 Yechezkel Barenholz Tempamine compositions and methods of use
JP2007500227A (ja) * 2003-05-29 2007-01-11 ミトス・ファーマシューティカルズ・インコーポレーテッド 光増感剤及び音増感剤と関連してのニトロキシドの使用方法
WO2006084197A2 (en) * 2005-02-02 2006-08-10 Mitos Pharmaceuticals, Inc. Nitroxides for use in treating or preventing neoplastic disease
US8466130B2 (en) 2009-09-04 2013-06-18 Colby Pharmaceutical Company Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers
WO2008109740A2 (en) * 2007-03-06 2008-09-12 Colby Pharmaceutical Company Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers
US8853277B2 (en) 2009-11-30 2014-10-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nitroxide therapy for the treatment of von Hippel—Lindau disease (VHL) and renal clear cell carcinoma (RCC)
US10231959B2 (en) 2016-03-23 2019-03-19 Louis Habash Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide
JP2019509352A (ja) * 2016-03-23 2019-04-04 ルイス ハバシュ， ヒトの被験物質をニトロキシドで処理することによってａｐｏｐｔｏｓｉｓ関連遺伝子の発現レベルを増加させる
US20180078539A1 (en) 2016-03-23 2018-03-22 Louis Habash T-cell regulation in t-cell mediated diseases by reducing pathogenic function of th17 in a human subject through treatment with a nitroxide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758580A (en) * 1985-06-26 1988-07-19 Yamanouchi Pharmaceutical Co., Ltd. Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts
DK0462305T3 (da) * 1990-06-21 1995-04-24 Huland Edith Anvendelse af cytokinholdige aerosoler såvel som cytokholdige aerosoler i sig selv
US6605619B1 (en) * 1992-03-20 2003-08-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxides as protectors against oxidatives stress
AU4788396A (en) * 1995-02-16 1996-09-04 Children's Medical Center Corporation Inhibition of angiogenesis using interleukin-12

Also Published As

Publication number Publication date
AU7598798A (en) 1998-12-30
DE69822626D1 (de) 2004-04-29
JP5270413B2 (ja) 2013-08-21
ES2216286T3 (es) 2004-10-16
AU746505B2 (en) 2002-05-02
DE69822626T8 (de) 2005-02-03
JP2009185034A (ja) 2009-08-20
JP2002500671A (ja) 2002-01-08
EP0986393A1 (en) 2000-03-22
JP2013121964A (ja) 2013-06-20
EP0986393B1 (en) 2004-03-24
DE69822626T2 (de) 2004-08-12
CA2289017C (en) 2008-07-22
DK0986393T3 (da) 2004-07-05
WO1998053835A1 (en) 1998-12-03
CA2289017A1 (en) 1998-12-03
ATE262330T1 (de) 2004-04-15
PT986393E (pt) 2004-06-30

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