DE69822626T8 - Verwendung eines nitroxids oder seiner prodrugs zur prophylaktischen und therapeutischen behandlung von krebs - Google Patents
Verwendung eines nitroxids oder seiner prodrugs zur prophylaktischen und therapeutischen behandlung von krebs Download PDFInfo
- Publication number
- DE69822626T8 DE69822626T8 DE69822626T DE69822626T DE69822626T8 DE 69822626 T8 DE69822626 T8 DE 69822626T8 DE 69822626 T DE69822626 T DE 69822626T DE 69822626 T DE69822626 T DE 69822626T DE 69822626 T8 DE69822626 T8 DE 69822626T8
- Authority
- DE
- Germany
- Prior art keywords
- cancer
- nitroxide
- prodrug
- prophylactic
- therapeutic treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 201000011510 cancer Diseases 0.000 title abstract 6
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 title abstract 4
- 229940002612 prodrug Drugs 0.000 title abstract 4
- 239000000651 prodrug Substances 0.000 title abstract 4
- 230000000069 prophylactic effect Effects 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4772497P | 1997-05-27 | 1997-05-27 | |
| US47724P | 1997-05-27 | ||
| PCT/US1998/010685 WO1998053835A1 (en) | 1997-05-27 | 1998-05-27 | The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69822626D1 DE69822626D1 (de) | 2004-04-29 |
| DE69822626T2 DE69822626T2 (de) | 2004-08-12 |
| DE69822626T8 true DE69822626T8 (de) | 2005-02-03 |
Family
ID=21950574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69822626T Active DE69822626T8 (de) | 1997-05-27 | 1998-05-27 | Verwendung eines nitroxids oder seiner prodrugs zur prophylaktischen und therapeutischen behandlung von krebs |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0986393B1 (https=) |
| JP (3) | JP4856294B2 (https=) |
| AT (1) | ATE262330T1 (https=) |
| AU (1) | AU746505B2 (https=) |
| CA (1) | CA2289017C (https=) |
| DE (1) | DE69822626T8 (https=) |
| DK (1) | DK0986393T3 (https=) |
| ES (1) | ES2216286T3 (https=) |
| PT (1) | PT986393E (https=) |
| WO (1) | WO1998053835A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096759A (en) * | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| AU765110B2 (en) * | 1998-06-26 | 2003-09-11 | Georgetown University Medical Center | Compositions and methods for inducing cell death |
| US20040219201A1 (en) * | 2001-12-06 | 2004-11-04 | Yechezkel Barenholz | Tempamine compositions and methods of use |
| JP2007500227A (ja) * | 2003-05-29 | 2007-01-11 | ミトス・ファーマシューティカルズ・インコーポレーテッド | 光増感剤及び音増感剤と関連してのニトロキシドの使用方法 |
| WO2006084197A2 (en) * | 2005-02-02 | 2006-08-10 | Mitos Pharmaceuticals, Inc. | Nitroxides for use in treating or preventing neoplastic disease |
| US8466130B2 (en) | 2009-09-04 | 2013-06-18 | Colby Pharmaceutical Company | Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers |
| WO2008109740A2 (en) * | 2007-03-06 | 2008-09-12 | Colby Pharmaceutical Company | Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers |
| US8853277B2 (en) | 2009-11-30 | 2014-10-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nitroxide therapy for the treatment of von Hippel—Lindau disease (VHL) and renal clear cell carcinoma (RCC) |
| US10231959B2 (en) | 2016-03-23 | 2019-03-19 | Louis Habash | Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide |
| JP2019509352A (ja) * | 2016-03-23 | 2019-04-04 | ルイス ハバシュ， | ヒトの被験物質をニトロキシドで処理することによってａｐｏｐｔｏｓｉｓ関連遺伝子の発現レベルを増加させる |
| US20180078539A1 (en) | 2016-03-23 | 2018-03-22 | Louis Habash | T-cell regulation in t-cell mediated diseases by reducing pathogenic function of th17 in a human subject through treatment with a nitroxide |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758580A (en) * | 1985-06-26 | 1988-07-19 | Yamanouchi Pharmaceutical Co., Ltd. | Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts |
| DK0462305T3 (da) * | 1990-06-21 | 1995-04-24 | Huland Edith | Anvendelse af cytokinholdige aerosoler såvel som cytokholdige aerosoler i sig selv |
| US6605619B1 (en) * | 1992-03-20 | 2003-08-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxides as protectors against oxidatives stress |
| AU4788396A (en) * | 1995-02-16 | 1996-09-04 | Children's Medical Center Corporation | Inhibition of angiogenesis using interleukin-12 |
-
1998
- 1998-05-27 AT AT98923772T patent/ATE262330T1/de active
- 1998-05-27 DE DE69822626T patent/DE69822626T8/de active Active
- 1998-05-27 CA CA002289017A patent/CA2289017C/en not_active Expired - Fee Related
- 1998-05-27 JP JP50081799A patent/JP4856294B2/ja not_active Expired - Fee Related
- 1998-05-27 ES ES98923772T patent/ES2216286T3/es not_active Expired - Lifetime
- 1998-05-27 AU AU75987/98A patent/AU746505B2/en not_active Ceased
- 1998-05-27 EP EP98923772A patent/EP0986393B1/en not_active Expired - Lifetime
- 1998-05-27 WO PCT/US1998/010685 patent/WO1998053835A1/en not_active Ceased
- 1998-05-27 PT PT98923772T patent/PT986393E/pt unknown
- 1998-05-27 DK DK98923772T patent/DK0986393T3/da active
-
2009
- 2009-03-16 JP JP2009062262A patent/JP5270413B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-11 JP JP2013003496A patent/JP2013121964A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU7598798A (en) | 1998-12-30 |
| DE69822626D1 (de) | 2004-04-29 |
| JP5270413B2 (ja) | 2013-08-21 |
| ES2216286T3 (es) | 2004-10-16 |
| AU746505B2 (en) | 2002-05-02 |
| JP2009185034A (ja) | 2009-08-20 |
| JP2002500671A (ja) | 2002-01-08 |
| EP0986393A1 (en) | 2000-03-22 |
| JP4856294B2 (ja) | 2012-01-18 |
| JP2013121964A (ja) | 2013-06-20 |
| EP0986393B1 (en) | 2004-03-24 |
| DE69822626T2 (de) | 2004-08-12 |
| CA2289017C (en) | 2008-07-22 |
| DK0986393T3 (da) | 2004-07-05 |
| WO1998053835A1 (en) | 1998-12-03 |
| CA2289017A1 (en) | 1998-12-03 |
| ATE262330T1 (de) | 2004-04-15 |
| PT986393E (pt) | 2004-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS |
|
| 8364 | No opposition during term of opposition |