JP4847450B2 - 非ヌクレオシド系逆転写酵素阻害剤である安息香酸誘導体 - Google Patents
非ヌクレオシド系逆転写酵素阻害剤である安息香酸誘導体 Download PDFInfo
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- JP4847450B2 JP4847450B2 JP2007524145A JP2007524145A JP4847450B2 JP 4847450 B2 JP4847450 B2 JP 4847450B2 JP 2007524145 A JP2007524145 A JP 2007524145A JP 2007524145 A JP2007524145 A JP 2007524145A JP 4847450 B2 JP4847450 B2 JP 4847450B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59822704P | 2004-08-02 | 2004-08-02 | |
| US60/598,227 | 2004-08-02 | ||
| PCT/CA2005/001179 WO2006012733A1 (en) | 2004-08-02 | 2005-07-28 | Benzoic acid derivatives as non-nucleoside reverse transcriptase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008508328A JP2008508328A (ja) | 2008-03-21 |
| JP2008508328A5 JP2008508328A5 (https=) | 2008-09-11 |
| JP4847450B2 true JP4847450B2 (ja) | 2011-12-28 |
Family
ID=35786846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524145A Expired - Fee Related JP4847450B2 (ja) | 2004-08-02 | 2005-07-28 | 非ヌクレオシド系逆転写酵素阻害剤である安息香酸誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20060025480A1 (https=) |
| EP (1) | EP1781600B1 (https=) |
| JP (1) | JP4847450B2 (https=) |
| AR (1) | AR050032A1 (https=) |
| AT (1) | ATE526309T1 (https=) |
| CA (1) | CA2573315C (https=) |
| PE (1) | PE20060384A1 (https=) |
| TW (1) | TW200616933A (https=) |
| UY (1) | UY29042A1 (https=) |
| WO (1) | WO2006012733A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5036543B2 (ja) * | 2004-09-30 | 2012-09-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非ヌクレオシド逆転写酵素インヒビターとしてのベンゾフェノンのアルキニル誘導体 |
| CL2008001631A1 (es) * | 2007-06-06 | 2009-01-02 | Smithkline Beecham Corp | Compuestos derivados de heterociclos sustituidos, con la presencia de un grupo fenoxi, inhibidores de transcriptasa inversa; composicion farmaceutica; y uso en el tratamiento de infecciones virales por vih. |
| US8242140B2 (en) * | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| JP2010535155A (ja) * | 2007-08-03 | 2010-11-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼ阻害剤 |
| EP2234977A4 (en) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
| CN102219717A (zh) * | 2011-04-20 | 2011-10-19 | 复旦大学 | N-苯基芳基甲酰胺衍生物及其制备方法和用途 |
| CN102212022A (zh) * | 2011-04-20 | 2011-10-12 | 复旦大学 | 二苯甲醇衍生物及其制备方法和用途 |
| CN102206177A (zh) * | 2011-04-20 | 2011-10-05 | 复旦大学 | 1-萘基苯甲酮衍生物及其制备方法和用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003510252A (ja) * | 1999-09-04 | 2003-03-18 | グラクソ グループ リミテッド | 逆転写酵素のインヒビターとしてのベンゾフェノン類 |
| JP2004525914A (ja) * | 2001-03-02 | 2004-08-26 | スミスクライン ビーチャム コーポレーション | 逆転写酵素阻害剤としてのベンゾフェノン類 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI270547B (en) | 2000-06-16 | 2007-01-11 | Boehringer Ingelheim Ca Ltd | Non-nucleoside reverse transcriptase inhibitors |
| JPWO2003030937A1 (ja) | 2001-10-05 | 2005-01-20 | 小野薬品工業株式会社 | ミトコンドリアルベンゾジアゼピン受容体アンタゴニストからなるストレス疾患の治療剤 |
| JP4627987B2 (ja) | 2002-03-11 | 2011-02-09 | テイボテク・フアーマシユーチカルズ・リミテツド | 低分子侵入阻害剤 |
| AU2003254157A1 (en) | 2002-07-24 | 2004-02-09 | Ptc Therapeutics, Inc. | Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
-
2005
- 2005-07-19 US US11/184,689 patent/US20060025480A1/en not_active Abandoned
- 2005-07-27 PE PE2005000877A patent/PE20060384A1/es not_active Application Discontinuation
- 2005-07-28 EP EP05770583A patent/EP1781600B1/en not_active Expired - Lifetime
- 2005-07-28 WO PCT/CA2005/001179 patent/WO2006012733A1/en not_active Ceased
- 2005-07-28 JP JP2007524145A patent/JP4847450B2/ja not_active Expired - Fee Related
- 2005-07-28 CA CA2573315A patent/CA2573315C/en not_active Expired - Fee Related
- 2005-07-28 AT AT05770583T patent/ATE526309T1/de not_active IP Right Cessation
- 2005-07-29 AR ARP050103169A patent/AR050032A1/es unknown
- 2005-07-29 UY UY29042A patent/UY29042A1/es not_active Application Discontinuation
- 2005-08-01 TW TW094126063A patent/TW200616933A/zh unknown
-
2008
- 2008-01-15 US US12/014,185 patent/US7569723B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003510252A (ja) * | 1999-09-04 | 2003-03-18 | グラクソ グループ リミテッド | 逆転写酵素のインヒビターとしてのベンゾフェノン類 |
| JP2004525914A (ja) * | 2001-03-02 | 2004-08-26 | スミスクライン ビーチャム コーポレーション | 逆転写酵素阻害剤としてのベンゾフェノン類 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2573315C (en) | 2011-03-29 |
| EP1781600A1 (en) | 2007-05-09 |
| US20080114068A1 (en) | 2008-05-15 |
| CA2573315A1 (en) | 2006-02-09 |
| EP1781600B1 (en) | 2011-09-28 |
| TW200616933A (en) | 2006-06-01 |
| ATE526309T1 (de) | 2011-10-15 |
| US20060025480A1 (en) | 2006-02-02 |
| AR050032A1 (es) | 2006-09-20 |
| UY29042A1 (es) | 2006-03-31 |
| PE20060384A1 (es) | 2006-06-05 |
| JP2008508328A (ja) | 2008-03-21 |
| WO2006012733A1 (en) | 2006-02-09 |
| US7569723B2 (en) | 2009-08-04 |
| EP1781600A4 (en) | 2008-12-10 |
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