JP2008508328A5 - - Google Patents
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- Publication number
- JP2008508328A5 JP2008508328A5 JP2007524145A JP2007524145A JP2008508328A5 JP 2008508328 A5 JP2008508328 A5 JP 2008508328A5 JP 2007524145 A JP2007524145 A JP 2007524145A JP 2007524145 A JP2007524145 A JP 2007524145A JP 2008508328 A5 JP2008508328 A5 JP 2008508328A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- chloro
- halo
- fluoro
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000001309 chloro group Chemical group Cl* 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000001153 fluoro group Chemical group F* 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000001246 bromo group Chemical group Br* 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 230000000798 anti-retroviral effect Effects 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940124522 antiretrovirals Drugs 0.000 claims 1
- 239000003903 antiretrovirus agent Substances 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229940124524 integrase inhibitor Drugs 0.000 claims 1
- 239000002850 integrase inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59822704P | 2004-08-02 | 2004-08-02 | |
| US60/598,227 | 2004-08-02 | ||
| PCT/CA2005/001179 WO2006012733A1 (en) | 2004-08-02 | 2005-07-28 | Benzoic acid derivatives as non-nucleoside reverse transcriptase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008508328A JP2008508328A (ja) | 2008-03-21 |
| JP2008508328A5 true JP2008508328A5 (https=) | 2008-09-11 |
| JP4847450B2 JP4847450B2 (ja) | 2011-12-28 |
Family
ID=35786846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524145A Expired - Fee Related JP4847450B2 (ja) | 2004-08-02 | 2005-07-28 | 非ヌクレオシド系逆転写酵素阻害剤である安息香酸誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20060025480A1 (https=) |
| EP (1) | EP1781600B1 (https=) |
| JP (1) | JP4847450B2 (https=) |
| AR (1) | AR050032A1 (https=) |
| AT (1) | ATE526309T1 (https=) |
| CA (1) | CA2573315C (https=) |
| PE (1) | PE20060384A1 (https=) |
| TW (1) | TW200616933A (https=) |
| UY (1) | UY29042A1 (https=) |
| WO (1) | WO2006012733A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5036543B2 (ja) * | 2004-09-30 | 2012-09-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非ヌクレオシド逆転写酵素インヒビターとしてのベンゾフェノンのアルキニル誘導体 |
| CL2008001631A1 (es) * | 2007-06-06 | 2009-01-02 | Smithkline Beecham Corp | Compuestos derivados de heterociclos sustituidos, con la presencia de un grupo fenoxi, inhibidores de transcriptasa inversa; composicion farmaceutica; y uso en el tratamiento de infecciones virales por vih. |
| US8242140B2 (en) * | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| JP2010535155A (ja) * | 2007-08-03 | 2010-11-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼ阻害剤 |
| EP2234977A4 (en) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
| CN102219717A (zh) * | 2011-04-20 | 2011-10-19 | 复旦大学 | N-苯基芳基甲酰胺衍生物及其制备方法和用途 |
| CN102212022A (zh) * | 2011-04-20 | 2011-10-12 | 复旦大学 | 二苯甲醇衍生物及其制备方法和用途 |
| CN102206177A (zh) * | 2011-04-20 | 2011-10-05 | 复旦大学 | 1-萘基苯甲酮衍生物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920872D0 (en) * | 1999-09-04 | 1999-11-10 | Glaxo Group Ltd | Benzophenones as inhibitors of reverse transcriptase |
| TWI270547B (en) | 2000-06-16 | 2007-01-11 | Boehringer Ingelheim Ca Ltd | Non-nucleoside reverse transcriptase inhibitors |
| JP2004525914A (ja) * | 2001-03-02 | 2004-08-26 | スミスクライン ビーチャム コーポレーション | 逆転写酵素阻害剤としてのベンゾフェノン類 |
| JPWO2003030937A1 (ja) | 2001-10-05 | 2005-01-20 | 小野薬品工業株式会社 | ミトコンドリアルベンゾジアゼピン受容体アンタゴニストからなるストレス疾患の治療剤 |
| JP4627987B2 (ja) | 2002-03-11 | 2011-02-09 | テイボテク・フアーマシユーチカルズ・リミテツド | 低分子侵入阻害剤 |
| AU2003254157A1 (en) | 2002-07-24 | 2004-02-09 | Ptc Therapeutics, Inc. | Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
-
2005
- 2005-07-19 US US11/184,689 patent/US20060025480A1/en not_active Abandoned
- 2005-07-27 PE PE2005000877A patent/PE20060384A1/es not_active Application Discontinuation
- 2005-07-28 EP EP05770583A patent/EP1781600B1/en not_active Expired - Lifetime
- 2005-07-28 WO PCT/CA2005/001179 patent/WO2006012733A1/en not_active Ceased
- 2005-07-28 JP JP2007524145A patent/JP4847450B2/ja not_active Expired - Fee Related
- 2005-07-28 CA CA2573315A patent/CA2573315C/en not_active Expired - Fee Related
- 2005-07-28 AT AT05770583T patent/ATE526309T1/de not_active IP Right Cessation
- 2005-07-29 AR ARP050103169A patent/AR050032A1/es unknown
- 2005-07-29 UY UY29042A patent/UY29042A1/es not_active Application Discontinuation
- 2005-08-01 TW TW094126063A patent/TW200616933A/zh unknown
-
2008
- 2008-01-15 US US12/014,185 patent/US7569723B2/en not_active Expired - Lifetime