JP4815053B2 - 経口投与の固形投与形態物としてのマイクロエマルション - Google Patents
経口投与の固形投与形態物としてのマイクロエマルション Download PDFInfo
- Publication number
- JP4815053B2 JP4815053B2 JP2000564596A JP2000564596A JP4815053B2 JP 4815053 B2 JP4815053 B2 JP 4815053B2 JP 2000564596 A JP2000564596 A JP 2000564596A JP 2000564596 A JP2000564596 A JP 2000564596A JP 4815053 B2 JP4815053 B2 JP 4815053B2
- Authority
- JP
- Japan
- Prior art keywords
- drug
- microemulsion
- dosage form
- solid dosage
- magnesium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9634798P | 1998-08-13 | 1998-08-13 | |
| US60/096,347 | 1998-08-13 | ||
| PCT/US1999/018552 WO2000009093A1 (en) | 1998-08-13 | 1999-08-13 | Microemulsions as solid dosage forms for oral administration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002522473A JP2002522473A (ja) | 2002-07-23 |
| JP2002522473A5 JP2002522473A5 (enExample) | 2006-09-28 |
| JP4815053B2 true JP4815053B2 (ja) | 2011-11-16 |
Family
ID=22256941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000564596A Expired - Fee Related JP4815053B2 (ja) | 1998-08-13 | 1999-08-13 | 経口投与の固形投与形態物としてのマイクロエマルション |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6280770B1 (enExample) |
| EP (2) | EP1104290B1 (enExample) |
| JP (1) | JP4815053B2 (enExample) |
| AT (1) | ATE462417T1 (enExample) |
| AU (1) | AU5486899A (enExample) |
| CA (1) | CA2339991C (enExample) |
| DE (1) | DE69942205D1 (enExample) |
| ES (1) | ES2341510T3 (enExample) |
| WO (1) | WO2000009093A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| US6350470B1 (en) * | 1998-04-29 | 2002-02-26 | Cima Labs Inc. | Effervescent drug delivery system for oral administration |
| US6793934B1 (en) | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| AUPQ573300A0 (en) * | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| EP1318790A4 (en) * | 2000-09-19 | 2006-02-01 | Cima Labs Inc | PHARMACEUTICAL COMPOSITIONS FOR RECTAL AND VAGINAL ADMINISTRATION |
| US7799342B2 (en) * | 2000-12-06 | 2010-09-21 | Wyeth Llc | Fast dissolving tablet |
| US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
| JP5684440B2 (ja) * | 2001-02-23 | 2015-03-11 | シーマ・ラブス、インコーポレイテッド | 組成物および固形製剤 |
| CA2448825C (en) * | 2001-06-22 | 2009-08-11 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drug |
| US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
| ITMI20011756A1 (it) * | 2001-08-09 | 2003-02-09 | Remedia S R L | Composizione farmaceutica comprendente una microemulsione doppia acqua/olio/acqua incorporata in un supporto solido |
| US20030124196A1 (en) * | 2001-08-22 | 2003-07-03 | Susan Weinbach | Pulsatile release compositions and methods for enhanced intestinal drug absorption |
| US20030083286A1 (en) * | 2001-08-22 | 2003-05-01 | Ching-Leou Teng | Bioadhesive compositions and methods for enhanced intestinal drug absorption |
| HUP0501186A2 (en) * | 2001-12-03 | 2006-05-29 | Novacea | Pharmaceutical compositions comprising active vitamin d compounds |
| ITMI20012694A1 (it) * | 2001-12-19 | 2003-06-19 | Remedia S R L | Composizione farmaceutica comprendente una microemulsione doppia olio/acqua/olio incorporata in un supporto solido |
| ES2305434T3 (es) | 2002-02-01 | 2008-11-01 | Pfizer Products Inc. | Composiciones framaceuticas de dispersiones amorfas de farmacos y materiales que forman microfases lipofilas. |
| ITMI20021392A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
| WO2004002443A1 (en) * | 2002-06-26 | 2004-01-08 | Tuo Jin | Solid dosage forms for rapid dissolution of poorly soluble drugs |
| US20040115226A1 (en) * | 2002-12-12 | 2004-06-17 | Wenji Li | Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same |
| FR2851918B1 (fr) * | 2003-03-06 | 2006-06-16 | Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication | |
| BRPI0413277A (pt) * | 2003-08-04 | 2006-10-10 | Pfizer Prod Inc | composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| KR20130116378A (ko) * | 2004-02-17 | 2013-10-23 | 트랜스셉트 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 |
| US20050220866A1 (en) * | 2004-04-02 | 2005-10-06 | Dr. Reddy's Laboratories Limited | Novel capsule formulations of etoposide for oral use |
| WO2005105040A2 (en) * | 2004-04-26 | 2005-11-10 | Micelle Products, Inc. | Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications |
| US20060014677A1 (en) * | 2004-07-19 | 2006-01-19 | Isotechnika International Inc. | Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds |
| CA2578356C (en) | 2004-09-24 | 2013-05-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | A new class of surfactant-like materials |
| WO2006085217A2 (en) * | 2005-02-08 | 2006-08-17 | Pfizer Products Inc. | Solid adsorbates of hydrophobic drugs |
| RU2623206C2 (ru) | 2005-04-15 | 2017-06-22 | Кларус Терапьютикс, Инк. | Фармацевтические системы доставки для гидрофобных лекарственных средств и композиций, их содержащих |
| US8492369B2 (en) | 2010-04-12 | 2013-07-23 | Clarus Therapeutics Inc | Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same |
| US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| US20060281783A1 (en) * | 2005-05-25 | 2006-12-14 | Transoral Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| JP5050322B2 (ja) * | 2005-06-21 | 2012-10-17 | 三菱化学株式会社 | 含油固形物およびその製造方法 |
| US20080069891A1 (en) | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
| EP2079450A2 (en) * | 2006-11-08 | 2009-07-22 | Novavax, INC. | Method of preparing solid dosage forms of multi-phasic pharmaceutical compositions |
| WO2008091592A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| WO2008135855A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
| WO2008135828A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| WO2008149192A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
| WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
| US20090060993A1 (en) * | 2007-09-04 | 2009-03-05 | Joseph Schwarz | Solid pharmaceutical composition for enhanced delivery of coenzyme q-10 and ubiquinones |
| WO2009073216A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer |
| WO2009073215A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| GB0724279D0 (en) * | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
| EP2111854A1 (en) | 2008-04-22 | 2009-10-28 | Lek Pharmaceuticals D.D. | Self-microemulsifying systems incorporated into liquid core microcapsules |
| CA2735660C (en) * | 2008-09-09 | 2017-05-30 | Cima Labs Inc. | Dosage forms for weakly ionizable compounds |
| WO2010077878A1 (en) * | 2008-12-15 | 2010-07-08 | Fleming And Company, Pharmaceuticals | Rapidly dissolving vitamin formulation and methods of using the same |
| KR101004205B1 (ko) * | 2008-12-17 | 2010-12-24 | 동아제약주식회사 | 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물 |
| PE20120858A1 (es) * | 2009-06-11 | 2012-08-01 | Photocure Asa | Composiciones solidas que comprenden acido 5-aminolevulinico |
| ES2385240B1 (es) | 2010-07-26 | 2013-09-23 | Gp-Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata. |
| US20120213855A1 (en) * | 2011-02-17 | 2012-08-23 | Cima Labs Inc. | Dosage forms for weakly ionizable compounds |
| US20170325481A1 (en) * | 2011-06-28 | 2017-11-16 | Kemin Industries, Inc. | Method of forming encapsulated compositions with enhanced solubility and stability |
| US20130004619A1 (en) * | 2011-06-28 | 2013-01-03 | Kemin Industries, Inc. | Method of Forming Encapsulated Compositions with Enhanced Solubility and Stability |
| CA2886276A1 (en) | 2012-10-30 | 2014-05-08 | Nektar Therapeutics | Solid salt form of alpha-6-mpeg6-o-hydroxycodone as opioid agonists and uses thereof |
| CN113842362A (zh) | 2012-11-14 | 2021-12-28 | 格雷斯公司 | 含有生物活性材料与无序无机氧化物的组合物 |
| CA2931086C (en) | 2012-12-20 | 2020-11-03 | Solural Pharma ApS | Solid oral dosage form of testosterone derivative |
| US20160000799A1 (en) | 2013-02-21 | 2016-01-07 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| US10245273B2 (en) | 2013-12-26 | 2019-04-02 | Clarus Therapeutics, Inc. | Oral pharmaceutical products and methods of use combining testosterone esters with hypolipidemic agents |
| DK3157508T3 (da) * | 2014-06-19 | 2021-02-15 | Solural Pharma ApS | Fast oral doseringsform af lipofile forbindelser |
| EP3185872B1 (en) * | 2014-08-28 | 2021-03-31 | Board of Regents, The University of Texas System | Formulations of testosterone and methods of treatment therewith |
| WO2016191744A1 (en) | 2015-05-28 | 2016-12-01 | Dr. Reddy's Laboratories Ltd. | Oral composition of celecoxib for treatment of pain |
| ITUA20164228A1 (it) * | 2016-06-09 | 2017-12-09 | Labomar S R L | Formulazione a matrice grassa auto-emulsionante e gastro-resistente e relativo metodo di preparazione |
| ES2899037T3 (es) * | 2016-08-22 | 2022-03-09 | Remediation Products Inc | Composición de biorremediación con materiales de liberación en el tiempo para eliminar compuestos energéticos de entornos contaminados |
| MX2020003546A (es) | 2017-10-10 | 2020-08-03 | Douglas Pharmaceuticals Ltd | Formulacion farmaceutica de liberacion prolongada y metodos de tratamiento. |
| US10869838B2 (en) | 2017-10-10 | 2020-12-22 | Douglas Pharmaceuticals, Ltd. | Extended release pharmaceutical formulation |
| US10441544B2 (en) | 2017-10-10 | 2019-10-15 | Douglas Pharmaceuticals, Ltd. | Extended release pharmaceutical formulation |
| US12090123B2 (en) | 2017-10-10 | 2024-09-17 | Douglas Pharmaceuticals Ltd. | Extended release pharmaceutical formulation |
| US11471415B2 (en) | 2017-10-10 | 2022-10-18 | Douglas Pharmaceuticals, Ltd. | Extended release pharmaceutical formulation and methods of treatment |
| JP7670700B2 (ja) | 2019-10-11 | 2025-04-30 | パイク セラピューティクス インコーポレイテッド | 発作性障害の治療用のカンナビジオール(cbd)を含む経皮医薬組成物 |
| CN114681470A (zh) | 2020-12-28 | 2022-07-01 | 雷迪博士实验室有限公司 | 治疗疼痛的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3962384A (en) * | 1972-04-10 | 1976-06-08 | Hoffmann-La Roche Inc. | Spray-drying technique for preparing agglomerated powders |
| CH586568A5 (enExample) * | 1972-04-10 | 1977-04-15 | Hoffmann La Roche | |
| JPS5157813A (en) * | 1974-11-14 | 1976-05-20 | Sankyo Co | Ll dooba mataha sonojudotaiseizaino seiho |
| SE421042B (sv) * | 1976-06-29 | 1981-11-23 | Kockums Chem | Sett att minska den for en viss biologisk effekt erforderliga mengden biologiskt aktiv substans |
| US4360061A (en) | 1980-04-03 | 1982-11-23 | Exxon Research And Engineering Co. | Oil recovery process using polymer microemulsion complexes |
| US4353806A (en) | 1980-04-03 | 1982-10-12 | Exxon Research And Engineering Company | Polymer-microemulsion complexes for the enhanced recovery of oil |
| DE3224619A1 (de) | 1981-07-14 | 1983-05-19 | Freund Industrial Co., Ltd., Tokyo | Orale pharmazeutische zusammensetzung |
| FR2594693B1 (fr) * | 1986-02-24 | 1990-01-05 | Farah Nabil | Nouveaux procedes de preparation a partir d'emulsions seches de formes orales solides a liberation modifiee et retardee de leur principes actifs |
| GB8822857D0 (en) * | 1988-09-29 | 1988-11-02 | Patralan Ltd | Pharmaceutical formulations |
| US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| CA2108266C (en) | 1991-04-19 | 2003-06-03 | Albert J. Owen | Convertible microemulsion formulations |
| US5688761A (en) | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
| US5393527A (en) | 1993-01-04 | 1995-02-28 | Becton, Dickinson And Company | Stabilized microspheres and methods of preparation |
| US5435936A (en) | 1993-09-01 | 1995-07-25 | Colgate Palmolive Co. | Nonaqueous liquid microemulsion compositions |
| ES2094688B1 (es) * | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| SE9503143D0 (sv) * | 1995-09-12 | 1995-09-12 | Astra Ab | New preparation |
| US5800834A (en) | 1996-06-10 | 1998-09-01 | Spireas; Spiridon | Liquisolid systems and methods of preparing same |
-
1999
- 1999-08-13 US US09/374,393 patent/US6280770B1/en not_active Expired - Lifetime
- 1999-08-13 JP JP2000564596A patent/JP4815053B2/ja not_active Expired - Fee Related
- 1999-08-13 AT AT99941159T patent/ATE462417T1/de not_active IP Right Cessation
- 1999-08-13 EP EP99941159A patent/EP1104290B1/en not_active Expired - Lifetime
- 1999-08-13 AU AU54868/99A patent/AU5486899A/en not_active Abandoned
- 1999-08-13 DE DE69942205T patent/DE69942205D1/de not_active Expired - Lifetime
- 1999-08-13 WO PCT/US1999/018552 patent/WO2000009093A1/en not_active Ceased
- 1999-08-13 CA CA002339991A patent/CA2339991C/en not_active Expired - Fee Related
- 1999-08-13 ES ES99941159T patent/ES2341510T3/es not_active Expired - Lifetime
- 1999-08-13 EP EP09011793A patent/EP2127642A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US6280770B1 (en) | 2001-08-28 |
| EP1104290B1 (en) | 2010-03-31 |
| AU5486899A (en) | 2000-03-06 |
| CA2339991C (en) | 2007-01-02 |
| DE69942205D1 (de) | 2010-05-12 |
| EP2127642A2 (en) | 2009-12-02 |
| EP2127642A3 (en) | 2010-02-24 |
| ES2341510T3 (es) | 2010-06-21 |
| EP1104290A1 (en) | 2001-06-06 |
| CA2339991A1 (en) | 2000-02-24 |
| ATE462417T1 (de) | 2010-04-15 |
| JP2002522473A (ja) | 2002-07-23 |
| WO2000009093A1 (en) | 2000-02-24 |
| EP1104290A4 (en) | 2006-01-18 |
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