CA2339991C - Microemulsions as solid dosage forms for oral administration - Google Patents
Microemulsions as solid dosage forms for oral administration Download PDFInfo
- Publication number
- CA2339991C CA2339991C CA002339991A CA2339991A CA2339991C CA 2339991 C CA2339991 C CA 2339991C CA 002339991 A CA002339991 A CA 002339991A CA 2339991 A CA2339991 A CA 2339991A CA 2339991 C CA2339991 C CA 2339991C
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- CA
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- Prior art keywords
- drug
- microemulsion
- dosage form
- solid dosage
- solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 136
- 239000007909 solid dosage form Substances 0.000 title claims description 24
- 229940079593 drug Drugs 0.000 claims abstract description 121
- 239000003814 drug Substances 0.000 claims abstract description 121
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- 239000000203 mixture Substances 0.000 claims abstract description 34
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- 239000002552 dosage form Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
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- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9634798P | 1998-08-13 | 1998-08-13 | |
| US60/096,347 | 1998-08-13 | ||
| PCT/US1999/018552 WO2000009093A1 (en) | 1998-08-13 | 1999-08-13 | Microemulsions as solid dosage forms for oral administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2339991A1 CA2339991A1 (en) | 2000-02-24 |
| CA2339991C true CA2339991C (en) | 2007-01-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002339991A Expired - Fee Related CA2339991C (en) | 1998-08-13 | 1999-08-13 | Microemulsions as solid dosage forms for oral administration |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6280770B1 (enExample) |
| EP (2) | EP2127642A3 (enExample) |
| JP (1) | JP4815053B2 (enExample) |
| AT (1) | ATE462417T1 (enExample) |
| AU (1) | AU5486899A (enExample) |
| CA (1) | CA2339991C (enExample) |
| DE (1) | DE69942205D1 (enExample) |
| ES (1) | ES2341510T3 (enExample) |
| WO (1) | WO2000009093A1 (enExample) |
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| US6793934B1 (en) | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| AUPQ573300A0 (en) * | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
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| JP5684440B2 (ja) * | 2001-02-23 | 2015-03-11 | シーマ・ラブス、インコーポレイテッド | 組成物および固形製剤 |
| BR0210519A (pt) * | 2001-06-22 | 2004-06-22 | Pfizer Prod Inc | Composições farmacêuticas de adsorvatos de fármaco amorfo |
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| US20030083286A1 (en) * | 2001-08-22 | 2003-05-01 | Ching-Leou Teng | Bioadhesive compositions and methods for enhanced intestinal drug absorption |
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| CN100515388C (zh) * | 2002-06-26 | 2009-07-22 | 金拓 | 难溶药物快速溶出固体剂型 |
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| FR2851918B1 (fr) * | 2003-03-06 | 2006-06-16 | Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication | |
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| US11197828B2 (en) * | 2014-06-19 | 2021-12-14 | Solural Pharma ApS | Solid oral dosage form of lipophilic compounds |
| EP3185872B1 (en) * | 2014-08-28 | 2021-03-31 | Board of Regents, The University of Texas System | Formulations of testosterone and methods of treatment therewith |
| MX384044B (es) | 2015-05-28 | 2025-03-14 | Dr Reddy´S Laboratories Ltd | Composicion oral de celecoxib para tratamiento de dolor. |
| ITUA20164228A1 (it) * | 2016-06-09 | 2017-12-09 | Labomar S R L | Formulazione a matrice grassa auto-emulsionante e gastro-resistente e relativo metodo di preparazione |
| EP3500349B1 (en) * | 2016-08-22 | 2021-10-06 | Remediation Products, Inc. | Bioremediation composition with time-release materials for removing energetic compounds from contaminated environments |
| CA3077645A1 (en) | 2017-10-10 | 2019-04-18 | Douglas Pharmaceuticals Ltd. | A solid extended-release pharmaceutical formulations comprising ketamine or norketamine |
| US10869838B2 (en) | 2017-10-10 | 2020-12-22 | Douglas Pharmaceuticals, Ltd. | Extended release pharmaceutical formulation |
| US11471415B2 (en) | 2017-10-10 | 2022-10-18 | Douglas Pharmaceuticals, Ltd. | Extended release pharmaceutical formulation and methods of treatment |
| US12090123B2 (en) | 2017-10-10 | 2024-09-17 | Douglas Pharmaceuticals Ltd. | Extended release pharmaceutical formulation |
| US10441544B2 (en) | 2017-10-10 | 2019-10-15 | Douglas Pharmaceuticals, Ltd. | Extended release pharmaceutical formulation |
| MX2022004257A (es) | 2019-10-11 | 2022-05-26 | Pike Therapeutics Inc | Composicion farmaceutica y metodo para tratamiento de los trastornos convulsionales. |
| WO2022144590A1 (en) | 2020-12-28 | 2022-07-07 | Dr. Reddy's Laboratories Ltd. | Celecoxib for treating pain |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH586568A5 (enExample) * | 1972-04-10 | 1977-04-15 | Hoffmann La Roche | |
| US3962384A (en) * | 1972-04-10 | 1976-06-08 | Hoffmann-La Roche Inc. | Spray-drying technique for preparing agglomerated powders |
| JPS5157813A (en) * | 1974-11-14 | 1976-05-20 | Sankyo Co | Ll dooba mataha sonojudotaiseizaino seiho |
| SE421042B (sv) * | 1976-06-29 | 1981-11-23 | Kockums Chem | Sett att minska den for en viss biologisk effekt erforderliga mengden biologiskt aktiv substans |
| US4353806A (en) | 1980-04-03 | 1982-10-12 | Exxon Research And Engineering Company | Polymer-microemulsion complexes for the enhanced recovery of oil |
| US4360061A (en) | 1980-04-03 | 1982-11-23 | Exxon Research And Engineering Co. | Oil recovery process using polymer microemulsion complexes |
| DE3224619A1 (de) | 1981-07-14 | 1983-05-19 | Freund Industrial Co., Ltd., Tokyo | Orale pharmazeutische zusammensetzung |
| FR2594693B1 (fr) * | 1986-02-24 | 1990-01-05 | Farah Nabil | Nouveaux procedes de preparation a partir d'emulsions seches de formes orales solides a liberation modifiee et retardee de leur principes actifs |
| GB8822857D0 (en) * | 1988-09-29 | 1988-11-02 | Patralan Ltd | Pharmaceutical formulations |
| US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| CA2108266C (en) | 1991-04-19 | 2003-06-03 | Albert J. Owen | Convertible microemulsion formulations |
| US5688761A (en) | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| US5206219A (en) | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
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| SE9503143D0 (sv) * | 1995-09-12 | 1995-09-12 | Astra Ab | New preparation |
| US5800834A (en) | 1996-06-10 | 1998-09-01 | Spireas; Spiridon | Liquisolid systems and methods of preparing same |
-
1999
- 1999-08-13 AU AU54868/99A patent/AU5486899A/en not_active Abandoned
- 1999-08-13 EP EP09011793A patent/EP2127642A3/en not_active Withdrawn
- 1999-08-13 JP JP2000564596A patent/JP4815053B2/ja not_active Expired - Fee Related
- 1999-08-13 CA CA002339991A patent/CA2339991C/en not_active Expired - Fee Related
- 1999-08-13 ES ES99941159T patent/ES2341510T3/es not_active Expired - Lifetime
- 1999-08-13 AT AT99941159T patent/ATE462417T1/de not_active IP Right Cessation
- 1999-08-13 WO PCT/US1999/018552 patent/WO2000009093A1/en not_active Ceased
- 1999-08-13 DE DE69942205T patent/DE69942205D1/de not_active Expired - Lifetime
- 1999-08-13 EP EP99941159A patent/EP1104290B1/en not_active Expired - Lifetime
- 1999-08-13 US US09/374,393 patent/US6280770B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6280770B1 (en) | 2001-08-28 |
| EP2127642A2 (en) | 2009-12-02 |
| EP1104290A4 (en) | 2006-01-18 |
| JP4815053B2 (ja) | 2011-11-16 |
| EP1104290A1 (en) | 2001-06-06 |
| CA2339991A1 (en) | 2000-02-24 |
| ES2341510T3 (es) | 2010-06-21 |
| ATE462417T1 (de) | 2010-04-15 |
| JP2002522473A (ja) | 2002-07-23 |
| WO2000009093A1 (en) | 2000-02-24 |
| EP2127642A3 (en) | 2010-02-24 |
| EP1104290B1 (en) | 2010-03-31 |
| AU5486899A (en) | 2000-03-06 |
| DE69942205D1 (de) | 2010-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180813 |