JP4805564B2 - 生体試料分析装置および方法 - Google Patents
生体試料分析装置および方法 Download PDFInfo
- Publication number
- JP4805564B2 JP4805564B2 JP2004308701A JP2004308701A JP4805564B2 JP 4805564 B2 JP4805564 B2 JP 4805564B2 JP 2004308701 A JP2004308701 A JP 2004308701A JP 2004308701 A JP2004308701 A JP 2004308701A JP 4805564 B2 JP4805564 B2 JP 4805564B2
- Authority
- JP
- Japan
- Prior art keywords
- substance
- measurement
- measured
- value
- calibration curve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012472 biological sample Substances 0.000 title claims description 85
- 238000000034 method Methods 0.000 title description 174
- 238000005259 measurement Methods 0.000 claims description 339
- 239000000523 sample Substances 0.000 claims description 225
- 238000011088 calibration curve Methods 0.000 claims description 184
- 239000000126 substance Substances 0.000 claims description 162
- 239000002245 particle Substances 0.000 claims description 121
- 238000002835 absorbance Methods 0.000 claims description 92
- 238000004220 aggregation Methods 0.000 claims description 92
- 230000002776 aggregation Effects 0.000 claims description 92
- 230000008859 change Effects 0.000 claims description 63
- 238000004458 analytical method Methods 0.000 claims description 60
- 238000002360 preparation method Methods 0.000 claims description 59
- 239000003153 chemical reaction reagent Substances 0.000 claims description 40
- 238000012360 testing method Methods 0.000 claims description 25
- 239000000427 antigen Substances 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 230000007246 mechanism Effects 0.000 claims description 12
- 238000001514 detection method Methods 0.000 claims description 6
- 238000012284 sample analysis method Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 description 228
- 230000008569 process Effects 0.000 description 125
- 239000012086 standard solution Substances 0.000 description 116
- 238000006243 chemical reaction Methods 0.000 description 88
- 108010074051 C-Reactive Protein Proteins 0.000 description 47
- 102100032752 C-reactive protein Human genes 0.000 description 47
- 210000004369 blood Anatomy 0.000 description 42
- 239000008280 blood Substances 0.000 description 42
- 238000003860 storage Methods 0.000 description 31
- 210000004027 cell Anatomy 0.000 description 29
- 239000007788 liquid Substances 0.000 description 26
- 239000000725 suspension Substances 0.000 description 26
- 210000002381 plasma Anatomy 0.000 description 24
- 239000004973 liquid crystal related substance Substances 0.000 description 21
- 238000012545 processing Methods 0.000 description 19
- 239000000243 solution Substances 0.000 description 19
- 210000000601 blood cell Anatomy 0.000 description 16
- 239000011535 reaction buffer Substances 0.000 description 16
- 238000003756 stirring Methods 0.000 description 13
- 239000004816 latex Substances 0.000 description 11
- 229920000126 latex Polymers 0.000 description 11
- 230000003287 optical effect Effects 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 238000005534 hematocrit Methods 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 238000012937 correction Methods 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 238000004820 blood count Methods 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 238000003018 immunoassay Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 239000012491 analyte Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000002834 transmittance Methods 0.000 description 3
- DUHQIGLHYXLKAE-UHFFFAOYSA-N 3,3-dimethylglutaric acid Chemical compound OC(=O)CC(C)(C)CC(O)=O DUHQIGLHYXLKAE-UHFFFAOYSA-N 0.000 description 2
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
- 102000008857 Ferritin Human genes 0.000 description 2
- 108050000784 Ferritin Proteins 0.000 description 2
- 238000008416 Ferritin Methods 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 239000003219 hemolytic agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00603—Reinspection of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/075—Investigating concentration of particle suspensions by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0092—Monitoring flocculation or agglomeration
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Quality & Reliability (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004308701A JP4805564B2 (ja) | 2004-10-22 | 2004-10-22 | 生体試料分析装置および方法 |
| US11/255,576 US9568488B2 (en) | 2004-10-22 | 2005-10-21 | Biological sample analyzing apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004308701A JP4805564B2 (ja) | 2004-10-22 | 2004-10-22 | 生体試料分析装置および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006119044A JP2006119044A (ja) | 2006-05-11 |
| JP2006119044A5 JP2006119044A5 (enExample) | 2007-11-29 |
| JP4805564B2 true JP4805564B2 (ja) | 2011-11-02 |
Family
ID=36207178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004308701A Expired - Fee Related JP4805564B2 (ja) | 2004-10-22 | 2004-10-22 | 生体試料分析装置および方法 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US9568488B2 (enExample) |
| JP (1) | JP4805564B2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006277424A (ja) * | 2005-03-30 | 2006-10-12 | Sysmex Corp | 分析システム、データ処理装置、測定装置、及びアプリケーションプログラム |
| EP1909207B1 (de) * | 2006-09-11 | 2015-03-04 | F.Hoffmann-La Roche Ag | Messbereichserweiterung chromatografischer Schnellteste |
| EP1909206A1 (de) | 2006-09-11 | 2008-04-09 | Roche Diagnostics GmbH | Messbereichserweiterung chromatografischer Schnellteste |
| EP2074223A4 (en) * | 2006-09-15 | 2010-03-10 | Foldrx Pharmaceuticals Inc | TEST PROCEDURE FOR THE DETECTION OF PROTEINS IN THE NATIVE CONDITION AND FOR THE IDENTIFICATION OF THE STABILITY OF PROTEINS IN THE NATIVE CONDITION MODULATING COMPOUNDS |
| WO2008038329A1 (en) * | 2006-09-25 | 2008-04-03 | Kowa Kabushiki Kaisha | Apparatus for gelation measurement and sample cell |
| GB0705495D0 (en) * | 2007-03-22 | 2007-05-02 | Quotient Diagnostics Ltd | Whole blood assay |
| JP4969292B2 (ja) * | 2007-03-30 | 2012-07-04 | シスメックス株式会社 | 試料分析装置 |
| JP5193940B2 (ja) * | 2009-05-11 | 2013-05-08 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| US9995688B2 (en) * | 2009-09-21 | 2018-06-12 | Arizona Board Of Regents | Use of superhydrophobic surfaces for liquid agglutination assays |
| JP2014122851A (ja) * | 2012-12-21 | 2014-07-03 | Sysmex Corp | 免疫測定方法および免疫測定装置 |
| JP6257418B2 (ja) * | 2014-04-01 | 2018-01-10 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| CN105116156B (zh) * | 2015-07-22 | 2017-12-12 | 江苏英诺华医疗技术有限公司 | 一种优化的适合医学检验的生化检测方法 |
| CA3075248C (en) * | 2017-09-08 | 2022-06-21 | Alfresa Pharma Corporation | Analysis device and analysis method |
| JP7357425B2 (ja) | 2020-03-19 | 2023-10-06 | シスメックス株式会社 | 細胞分類方法、分類装置及びプログラム。 |
| DK202330198A1 (da) * | 2023-09-07 | 2025-04-03 | Shaya Michael | Fremgangsmåde og apparat til automatisk detektering af forskellige celletyper, herunder kræftceller, i organisk væv |
| KR20250064295A (ko) * | 2023-11-02 | 2025-05-09 | 동우 화인켐 주식회사 | 유동 입자 측정 장치 및 유동 입자 측정 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56150333A (en) * | 1980-04-23 | 1981-11-20 | Olympus Optical Co Ltd | Sample analysis method |
| JPS56155835A (en) | 1980-05-02 | 1981-12-02 | Olympus Optical Co Ltd | Component analyzing method |
| JPH0635980B2 (ja) | 1985-06-05 | 1994-05-11 | 東亜医用電子株式会社 | 体液成分の測定方法 |
| JPH0672845B2 (ja) * | 1986-09-01 | 1994-09-14 | 富士写真フイルム株式会社 | 分析方法 |
| JP2666568B2 (ja) | 1990-12-29 | 1997-10-22 | 株式会社島津製作所 | 生化学自動分析装置 |
| JPH0599930A (ja) * | 1991-01-31 | 1993-04-23 | Shimadzu Corp | 自動化学分析装置 |
| JPH06249856A (ja) * | 1993-02-26 | 1994-09-09 | Shimadzu Corp | 生化学自動分析装置における測定方法 |
| JPH08247950A (ja) * | 1995-03-15 | 1996-09-27 | Olympus Optical Co Ltd | 濃度分析方法 |
| JP4404994B2 (ja) | 1999-07-22 | 2010-01-27 | シスメックス株式会社 | 免疫分析方法 |
| EP1460414B1 (en) * | 2001-12-27 | 2018-09-19 | ARKRAY, Inc. | Concentration measuring method |
| DE60308259T2 (de) * | 2002-05-22 | 2007-04-05 | Sysmex Corp. | Immunologische Verfahren, Vorrichtungen und Reagenzien |
-
2004
- 2004-10-22 JP JP2004308701A patent/JP4805564B2/ja not_active Expired - Fee Related
-
2005
- 2005-10-21 US US11/255,576 patent/US9568488B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9568488B2 (en) | 2017-02-14 |
| US20060089810A1 (en) | 2006-04-27 |
| JP2006119044A (ja) | 2006-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4805564B2 (ja) | 生体試料分析装置および方法 | |
| JP4796265B2 (ja) | 免疫測定方法及び免疫測定装置 | |
| CN101236194B (zh) | 标本分析仪及其控制系统 | |
| CN105891090B (zh) | 血细胞分析仪、体液分析方法及其控制系统 | |
| US8008089B2 (en) | Method and system for checking measurement result | |
| JP4490069B2 (ja) | 臨床検査システム | |
| CN102472738B (zh) | 血液分析装置及血液分析方法 | |
| JP2004125775A (ja) | 血液分析装置及び方法 | |
| US8652848B2 (en) | Sample measuring apparatus and sample measuring method | |
| JP6987540B2 (ja) | 血液分析装置を制御する方法、血液分析装置の制御装置、血液分析装置、コンピュータプログラム、および記憶媒体 | |
| US7727769B2 (en) | Measurement result correction method, urine analysis system, and urine analyzer | |
| JP2004305173A (ja) | 細菌測定方法と装置とプログラム | |
| US20030224534A1 (en) | Immunoassay methods, immunoassay apparatuses, and reagents for immunoassays | |
| EP2047232A1 (en) | Integrated apparatus and method to detect inflammatory states present in a sample of whole blood | |
| JPH08114600A (ja) | 生体試料分析システム | |
| JP4233382B2 (ja) | 免疫測定方法、免疫測定装置、及び免疫測定用試薬 | |
| JP4435581B2 (ja) | 免疫測定装置および方法 | |
| US20140212991A1 (en) | Immunoassay method and immunoassay apparatus | |
| JP7128196B2 (ja) | 検体の存在に関する生体サンプルの分類のためのシステムおよび方法 | |
| JP2005172546A (ja) | 免疫測定方法、免疫測定装置、及び免疫測定用試薬 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071016 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071016 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100831 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20101029 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110419 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110617 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110712 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110811 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140819 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |