JP4782675B2 - ワクチン接種用スフィンゴイドポリアルキルアミン抱合体 - Google Patents

ワクチン接種用スフィンゴイドポリアルキルアミン抱合体 Download PDF

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Publication number
JP4782675B2
JP4782675B2 JP2006516807A JP2006516807A JP4782675B2 JP 4782675 B2 JP4782675 B2 JP 4782675B2 JP 2006516807 A JP2006516807 A JP 2006516807A JP 2006516807 A JP2006516807 A JP 2006516807A JP 4782675 B2 JP4782675 B2 JP 4782675B2
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Prior art keywords
lipid
ccs
sphingoid
polyalkylamine
conjugate
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Expired - Fee Related
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JP2006516807A
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Japanese (ja)
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JP2006527762A (ja
JP2006527762A5 (enExample
Inventor
バレンホルツ、イェチェズケル
ジョセフ、アビバ
ケダー、エリーザー
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Yissum Research Development Co of Hebrew University of Jerusalem
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Yissum Research Development Co of Hebrew University of Jerusalem
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2006516807A 2003-06-18 2004-06-17 ワクチン接種用スフィンゴイドポリアルキルアミン抱合体 Expired - Fee Related JP4782675B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US47918503P 2003-06-18 2003-06-18
US60/479,185 2003-06-18
US50563803P 2003-09-25 2003-09-25
US60/505,638 2003-09-25
US53755304P 2004-01-21 2004-01-21
US60/537,553 2004-01-21
US54550504P 2004-02-19 2004-02-19
US60/545,505 2004-02-19
PCT/IL2004/000534 WO2004110496A1 (en) 2003-06-18 2004-06-17 Sphingoid polyalkylamine conjugates for vaccination

Publications (3)

Publication Number Publication Date
JP2006527762A JP2006527762A (ja) 2006-12-07
JP2006527762A5 JP2006527762A5 (enExample) 2007-08-02
JP4782675B2 true JP4782675B2 (ja) 2011-09-28

Family

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Family Applications (3)

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JP2006516809A Pending JP2006527763A (ja) 2003-06-18 2004-06-17 スフィンゴ脂質のポリアルキルアミン抱合体
JP2006516807A Expired - Fee Related JP4782675B2 (ja) 2003-06-18 2004-06-17 ワクチン接種用スフィンゴイドポリアルキルアミン抱合体
JP2006516806A Expired - Fee Related JP4695075B2 (ja) 2003-06-18 2004-06-17 トランスフェクションで使用するためのスフィンゴ脂質ポリアルキルアミン抱合体

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JP2006516809A Pending JP2006527763A (ja) 2003-06-18 2004-06-17 スフィンゴ脂質のポリアルキルアミン抱合体

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JP2006516806A Expired - Fee Related JP4695075B2 (ja) 2003-06-18 2004-06-17 トランスフェクションで使用するためのスフィンゴ脂質ポリアルキルアミン抱合体

Country Status (8)

Country Link
US (4) US7771711B2 (enExample)
EP (3) EP1638610B1 (enExample)
JP (3) JP2006527763A (enExample)
AU (3) AU2004246904B2 (enExample)
BR (1) BRPI0411505A (enExample)
CA (1) CA2528402A1 (enExample)
MX (1) MXPA05013746A (enExample)
WO (3) WO2004110980A1 (enExample)

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Also Published As

Publication number Publication date
EP1638610B1 (en) 2015-03-18
EP1638919B1 (en) 2012-09-26
US20060252718A1 (en) 2006-11-09
AU2004247505B2 (en) 2010-01-21
US8673285B2 (en) 2014-03-18
US20060252717A1 (en) 2006-11-09
CA2528402A1 (en) 2004-12-23
JP4695075B2 (ja) 2011-06-08
WO2004110499A1 (en) 2004-12-23
EP1638611B1 (en) 2012-10-03
JP2006527762A (ja) 2006-12-07
JP2006527763A (ja) 2006-12-07
WO2004110496A1 (en) 2004-12-23
US20080112917A1 (en) 2008-05-15
US8242089B2 (en) 2012-08-14
AU2004246905B2 (en) 2010-01-21
EP1638611A1 (en) 2006-03-29
EP1638919A1 (en) 2006-03-29
AU2004246905A1 (en) 2004-12-23
WO2004110980A1 (en) 2004-12-23
US7771711B2 (en) 2010-08-10
JP2006527761A (ja) 2006-12-07
US20070264273A1 (en) 2007-11-15
AU2004246904A1 (en) 2004-12-23
EP1638610A1 (en) 2006-03-29
BRPI0411505A (pt) 2006-07-25
AU2004247505A1 (en) 2004-12-23
AU2004246904B2 (en) 2010-02-04
MXPA05013746A (es) 2006-06-27

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