JP4778550B2 - 4−(3−ベンゾイルアミノフェニル)−6,7−ジメトキシ−2−メチルアミノキナゾリン誘導体 - Google Patents
4−(3−ベンゾイルアミノフェニル)−6,7−ジメトキシ−2−メチルアミノキナゾリン誘導体 Download PDFInfo
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- JP4778550B2 JP4778550B2 JP2008501719A JP2008501719A JP4778550B2 JP 4778550 B2 JP4778550 B2 JP 4778550B2 JP 2008501719 A JP2008501719 A JP 2008501719A JP 2008501719 A JP2008501719 A JP 2008501719A JP 4778550 B2 JP4778550 B2 JP 4778550B2
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- salt
- hydrate
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- dimethoxy
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 12
- -1 methoxyethoxy group Chemical group 0.000 claims description 94
- UKFCRQFQEAFNRG-UHFFFAOYSA-N 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]-2-methylbenzoic acid Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=C(C(O)=O)C(C)=C1 UKFCRQFQEAFNRG-UHFFFAOYSA-N 0.000 claims description 26
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- ZZQXDZSMUGHTJA-UHFFFAOYSA-N 4-n-[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]-1-n-methylbenzene-1,4-dicarboxamide Chemical compound C1=CC(C(=O)NC)=CC=C1C(=O)NC1=CC=CC(C=2C3=CC(OC)=C(OC)C=C3N=C(NC)N=2)=C1 ZZQXDZSMUGHTJA-UHFFFAOYSA-N 0.000 claims description 7
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- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 4
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- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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- 229920000053 polysorbate 80 Polymers 0.000 description 1
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- 239000011698 potassium fluoride Substances 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 239000012453 solvate Substances 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
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- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
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- 235000010487 tragacanth Nutrition 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- WXAZIUYTQHYBFW-UHFFFAOYSA-N tris(4-methylphenyl)phosphane Chemical compound C1=CC(C)=CC=C1P(C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 WXAZIUYTQHYBFW-UHFFFAOYSA-N 0.000 description 1
- DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical compound C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 description 1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008501719A JP4778550B2 (ja) | 2006-02-21 | 2007-02-20 | 4−(3−ベンゾイルアミノフェニル)−6,7−ジメトキシ−2−メチルアミノキナゾリン誘導体 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006043273 | 2006-02-21 | ||
JP2006043273 | 2006-02-21 | ||
JP2008501719A JP4778550B2 (ja) | 2006-02-21 | 2007-02-20 | 4−(3−ベンゾイルアミノフェニル)−6,7−ジメトキシ−2−メチルアミノキナゾリン誘導体 |
PCT/JP2007/053066 WO2007097317A1 (ja) | 2006-02-21 | 2007-02-20 | 4-(3-ベンゾイルアミノフェニル)-6,7-ジメトキシ-2-メチルアミノキナゾリン誘導体 |
Publications (2)
Publication Number | Publication Date |
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JPWO2007097317A1 JPWO2007097317A1 (ja) | 2009-07-16 |
JP4778550B2 true JP4778550B2 (ja) | 2011-09-21 |
Family
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Application Number | Title | Priority Date | Filing Date |
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JP2008501719A Expired - Fee Related JP4778550B2 (ja) | 2006-02-21 | 2007-02-20 | 4−(3−ベンゾイルアミノフェニル)−6,7−ジメトキシ−2−メチルアミノキナゾリン誘導体 |
Country Status (18)
Country | Link |
---|---|
JP (1) | JP4778550B2 (xx) |
KR (1) | KR101278852B1 (xx) |
AT (1) | ATE517875T1 (xx) |
BR (1) | BRPI0708098B8 (xx) |
CY (1) | CY1112554T1 (xx) |
DK (1) | DK1992622T3 (xx) |
ES (1) | ES2368089T3 (xx) |
HK (1) | HK1122025A1 (xx) |
HR (1) | HRP20110604T1 (xx) |
IL (1) | IL193322A (xx) |
JO (1) | JO2726B1 (xx) |
MY (1) | MY146275A (xx) |
NZ (1) | NZ569936A (xx) |
PT (1) | PT1992622E (xx) |
RS (1) | RS51969B (xx) |
RU (1) | RU2431632C2 (xx) |
SI (1) | SI1992622T1 (xx) |
TW (1) | TWI404709B (xx) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8492543B2 (en) | 2007-08-17 | 2013-07-23 | Eisai R&D Management Co., Ltd. | Method for producing quinazoline derivative |
US8513269B2 (en) | 2007-08-17 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Preparation for external use |
US8530654B2 (en) | 2007-02-16 | 2013-09-10 | Eisai R&D Management Co., Ltd. | Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR015966A1 (es) * | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
JPH11209350A (ja) | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
-
2007
- 2007-02-16 TW TW096105966A patent/TWI404709B/zh not_active IP Right Cessation
- 2007-02-20 MY MYPI20083110A patent/MY146275A/en unknown
- 2007-02-20 JP JP2008501719A patent/JP4778550B2/ja not_active Expired - Fee Related
- 2007-02-20 SI SI200730730T patent/SI1992622T1/sl unknown
- 2007-02-20 BR BRPI0708098A patent/BRPI0708098B8/pt not_active IP Right Cessation
- 2007-02-20 AT AT07714569T patent/ATE517875T1/de active
- 2007-02-20 JO JO200752A patent/JO2726B1/en active
- 2007-02-20 KR KR1020087021869A patent/KR101278852B1/ko active IP Right Grant
- 2007-02-20 ES ES07714569T patent/ES2368089T3/es active Active
- 2007-02-20 NZ NZ569936A patent/NZ569936A/en not_active IP Right Cessation
- 2007-02-20 DK DK07714569.6T patent/DK1992622T3/da active
- 2007-02-20 PT PT07714569T patent/PT1992622E/pt unknown
- 2007-02-20 RS RS20110421A patent/RS51969B/en unknown
- 2007-02-20 RU RU2008137654/04A patent/RU2431632C2/ru active
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2008
- 2008-08-07 IL IL193322A patent/IL193322A/en active IP Right Grant
-
2009
- 2009-03-11 HK HK09102334.2A patent/HK1122025A1/xx not_active IP Right Cessation
-
2011
- 2011-08-12 HR HR20110604T patent/HRP20110604T1/hr unknown
- 2011-10-10 CY CY20111100969T patent/CY1112554T1/el unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8530654B2 (en) | 2007-02-16 | 2013-09-10 | Eisai R&D Management Co., Ltd. | Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid |
US8492543B2 (en) | 2007-08-17 | 2013-07-23 | Eisai R&D Management Co., Ltd. | Method for producing quinazoline derivative |
US8513269B2 (en) | 2007-08-17 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Preparation for external use |
Also Published As
Publication number | Publication date |
---|---|
RU2431632C2 (ru) | 2011-10-20 |
RS51969B (en) | 2012-02-29 |
PT1992622E (pt) | 2011-09-19 |
HK1122025A1 (xx) | 2009-05-08 |
TW200812980A (en) | 2008-03-16 |
SI1992622T1 (sl) | 2011-11-30 |
KR20080094811A (ko) | 2008-10-24 |
CY1112554T1 (el) | 2016-02-10 |
TWI404709B (zh) | 2013-08-11 |
DK1992622T3 (da) | 2011-09-05 |
MY146275A (en) | 2012-07-31 |
IL193322A (en) | 2014-04-30 |
BRPI0708098B8 (pt) | 2021-05-25 |
JO2726B1 (en) | 2013-09-15 |
ES2368089T3 (es) | 2011-11-14 |
KR101278852B1 (ko) | 2013-07-01 |
BRPI0708098B1 (pt) | 2019-08-06 |
HRP20110604T1 (hr) | 2011-09-30 |
ATE517875T1 (de) | 2011-08-15 |
NZ569936A (en) | 2010-07-30 |
IL193322A0 (en) | 2009-05-04 |
BRPI0708098A2 (pt) | 2011-05-17 |
RU2008137654A (ru) | 2010-03-27 |
JPWO2007097317A1 (ja) | 2009-07-16 |
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