JP4778053B2 - 局所的脂肪組織処置のための徐放性増強脂肪分解処方物 - Google Patents
局所的脂肪組織処置のための徐放性増強脂肪分解処方物 Download PDFInfo
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- JP4778053B2 JP4778053B2 JP2008521646A JP2008521646A JP4778053B2 JP 4778053 B2 JP4778053 B2 JP 4778053B2 JP 2008521646 A JP2008521646 A JP 2008521646A JP 2008521646 A JP2008521646 A JP 2008521646A JP 4778053 B2 JP4778053 B2 JP 4778053B2
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- fat
- formulation
- salmeterol
- adipose tissue
- formoterol
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| Application Number | Priority Date | Filing Date | Title |
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| US69915505P | 2005-07-14 | 2005-07-14 | |
| US60/699,155 | 2005-07-14 | ||
| US72953105P | 2005-10-24 | 2005-10-24 | |
| US60/729,531 | 2005-10-24 | ||
| US73298105P | 2005-11-03 | 2005-11-03 | |
| US60/732,981 | 2005-11-03 | ||
| PCT/US2006/027405 WO2007011743A2 (en) | 2005-07-14 | 2006-07-13 | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
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| JP2011083171A Division JP2011132262A (ja) | 2005-07-14 | 2011-04-04 | 局所的脂肪組織処置のための徐放性増強脂肪分解処方物 |
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| JP2009501719A JP2009501719A (ja) | 2009-01-22 |
| JP2009501719A5 JP2009501719A5 (enExample) | 2010-12-24 |
| JP4778053B2 true JP4778053B2 (ja) | 2011-09-21 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013543897A (ja) * | 2010-11-24 | 2013-12-09 | リセラ,インク. | 脂肪症及び輪郭の膨れの美容処置のための、選択的な、親油性の、及び長時間作用性のベータアゴニストの単剤療法製剤、及び方法 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2884068B1 (fr) * | 2005-03-31 | 2007-07-27 | Valeo Equip Electr Moteur | Rotor de machine electrique tournante comportant un manchon intermediaire interpose entre l'arbre et les roues polaires et procede de realisation du rotor. |
| BRPI0613034A8 (pt) | 2005-07-14 | 2018-01-02 | Lipothera Inc | formulação injetável para acúmulo de tecido adiposo, formulação injetável e método para o tratamento de acúmulo de gordura, e, método para reduzir o tecido adiposo. |
| CN101626759B (zh) * | 2006-10-17 | 2014-08-06 | 利特拉公司 | 用于治疗甲状腺眼病的组合物和制剂 |
| MX2009004198A (es) * | 2006-10-17 | 2009-10-19 | Lithera Inc | Metodos, composiciones y formulaciones para el tratamiento de enfermedad ocular tiroidea. |
| GB2436412A (en) * | 2006-11-27 | 2007-09-26 | Cvon Innovations Ltd | Authentication of network usage for use with message modifying apparatus |
| US20090264477A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc., An Indiana Corporation | Beta adrenergic receptor agonists for treatment of pain and/or inflammation |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| US8263581B2 (en) | 2009-07-03 | 2012-09-11 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
| US8513259B2 (en) | 2009-07-03 | 2013-08-20 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
| GB2477030A (en) * | 2010-01-15 | 2011-07-20 | Lithera Inc | Lyophilised forms of fluticasone, salmeterol and combinations thereof |
| JP5909070B2 (ja) * | 2010-10-28 | 2016-04-26 | 国立大学法人 東京大学 | Gs共役受容体に対する医薬品候補化合物をスクリーニングする方法 |
| GB2485886A (en) * | 2010-11-24 | 2012-05-30 | Lithera Inc | Injectable formulations comprising a lipophilic glucocorticosteroid for regional adiposity reduction |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| WO2014081941A1 (en) | 2012-11-21 | 2014-05-30 | Topokine Therapeutics, Inc. | Methods and compositions for locally increasing body fat |
| EP3834840B8 (en) * | 2013-03-15 | 2025-09-17 | Endo Biologics Limited | Treatment method and product for uterine fibroids using purified collagenase |
| NO2753788T3 (enExample) | 2013-05-10 | 2018-06-16 | ||
| US9820993B2 (en) | 2013-05-15 | 2017-11-21 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| WO2015006610A1 (en) * | 2013-07-11 | 2015-01-15 | Eastern Vision, Ltd. | Direct sale and social networking platform and system |
| AU2014340351B2 (en) | 2013-10-21 | 2020-01-30 | Alevere Medical Corporation | Fused heterocyclic organic compounds, pharmaceutical compositions, and medical uses thereof |
| US10188661B2 (en) | 2014-06-27 | 2019-01-29 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| CN106999465B (zh) * | 2014-10-14 | 2020-08-14 | 斯科勒普特有限公司 | 身体塑形 |
| HRP20251142T1 (hr) | 2015-08-28 | 2025-11-21 | Caliway Biopharmaceuticals Co., Ltd. | Farmaceutski pripravak koji se koristi za smanjenje lokaliziranih masnoća i uporaba farmaceutskog pripravka |
| US20170079985A1 (en) * | 2015-09-21 | 2017-03-23 | Teva Pharmaceuticals International Gmbh | Sustained release olanzapine formulations |
| JP2020511483A (ja) | 2017-03-20 | 2020-04-16 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーTeva Pharmaceuticals International GmbH | 徐放性オランザピン製剤 |
| KR20190121699A (ko) * | 2018-04-18 | 2019-10-28 | (주)인벤티지랩 | 데옥시콜린산을 포함하는 피하 주사용 조성물 및 이의 제조 방법 |
| JP2025510868A (ja) | 2022-03-30 | 2025-04-15 | ライニッシェ フリードリッヒ ヴィルヘルムス ウニヴェルジテート ボン | ミラベグロン製剤 |
| WO2025073804A1 (en) | 2023-10-04 | 2025-04-10 | Rheinische Friedrich-Wilhelms Universität Bonn, Körperschaft Des Öffentlichen Rechts | Composition comprising beta-2-adrenergic receptor agonist for transdermal administration |
Family Cites Families (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3898330A (en) | 1973-08-01 | 1975-08-05 | Squibb & Sons Inc | Corticosteroid phosphate salts/neomycin sulfate ophthalmic |
| JPS58134404U (ja) | 1982-03-04 | 1983-09-09 | 大成道路株式会社 | コンクリ−ト舗装装置 |
| US4525359A (en) * | 1982-12-10 | 1985-06-25 | Greenway Frank L Iii | Treatment for selective weight control |
| JPS59146905A (ja) | 1983-02-07 | 1984-08-23 | Nippon Mining Co Ltd | 水素製造装置におけるスチ−ム供給量の制御方法 |
| JPS59155313U (ja) | 1983-04-02 | 1984-10-18 | 山内 真治 | 家具の組立装置 |
| NZ212204A (en) | 1984-06-04 | 1988-07-28 | Merck & Co Inc | Growth-promoting compositions containing hydroxylic compounds |
| GB8426672D0 (en) | 1984-10-22 | 1984-11-28 | Erba Farmitalia | Pharmaceutical compositions |
| JPH0696521B2 (ja) * | 1986-01-31 | 1994-11-30 | 千寿製薬株式会社 | 眼局所投与用眼圧降下剤 |
| FR2602423B1 (fr) * | 1986-08-08 | 1989-05-05 | Ethypharm Sa | Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede |
| US5270305A (en) | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
| CA2030174C (en) * | 1990-01-10 | 1996-12-24 | Anthony H. Cincotta | Process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hypoglycemia in vertebrates |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| US5919827A (en) * | 1990-07-11 | 1999-07-06 | Sepracor Inc. | Method for treating asthma using optically pure R(-) salmeterol |
| SE9302777D0 (sv) * | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
| US5658549A (en) | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
| NZ246421A (en) | 1991-12-18 | 1996-05-28 | Minnesota Mining & Mfg | Aerosol formulation containing a drug and a propellant and which is substantially free of surfactant |
| WO1993011773A1 (en) | 1991-12-18 | 1993-06-24 | Aktiebolaget Astra | New combination of formoterol and budesonide |
| US5314916A (en) * | 1993-04-19 | 1994-05-24 | Alcon Laboratories, Inc. | B2 adrenegic agonists and use thereof in the treatment of glaucoma |
| US6316443B1 (en) | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
| GB9512854D0 (en) | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
| DE19780476T1 (de) * | 1996-05-13 | 1998-10-15 | Seagate Technology | Formstrahl-Lasertexturierung von magnetischen Medien |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6066675A (en) * | 1996-09-13 | 2000-05-23 | The Regents Of The University Of California | Method for treatment of retinal diseases |
| JP4335316B2 (ja) | 1996-09-19 | 2009-09-30 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー |
| SE9700135D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US5837283A (en) | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
| TW469832U (en) | 1997-03-14 | 2001-12-21 | Astra Ab | Inhalation device |
| SK122199A3 (en) | 1997-03-18 | 2000-12-11 | Basf Ag | Methods and compositions for modulating responsiveness to corticosteroids |
| US6656508B2 (en) * | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| BR9815470A (pt) * | 1997-04-30 | 2001-10-23 | Bridge Pharma Inc | Composição e processo usando um eutÈmero |
| KR100289510B1 (ko) * | 1997-05-26 | 2001-05-02 | 다니구찌 이찌로오, 기타오카 다카시 | 티에프티어레이기판및그것을이용한액정표시장치 |
| US20010044584A1 (en) | 1997-08-28 | 2001-11-22 | Kensey Kenneth R. | In vivo delivery methods and compositions |
| SE9703407D0 (sv) * | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
| JPH11106334A (ja) | 1997-09-30 | 1999-04-20 | Saitama Daiichi Seiyaku Kk | 尿失禁治療剤 |
| US20030095925A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| DK1098988T4 (da) * | 1998-07-21 | 2007-09-03 | Danisco | Födevare |
| US20040152664A1 (en) | 1998-09-02 | 2004-08-05 | Allergan, Inc. | Prednisolone compositions |
| US6384259B1 (en) | 1998-11-16 | 2002-05-07 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and dosage form |
| AU7127600A (en) | 1999-09-17 | 2001-04-17 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
| GB9924992D0 (en) * | 1999-10-21 | 1999-12-22 | Glaxo Group Ltd | Pharmaceutical aerosol formulations |
| WO2001041806A1 (en) | 1999-12-07 | 2001-06-14 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic compositions |
| US20040208910A1 (en) * | 2000-04-26 | 2004-10-21 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of adrenergic agents |
| GB0012260D0 (en) | 2000-05-19 | 2000-07-12 | Astrazeneca Ab | Novel composition |
| AUPQ797700A0 (en) | 2000-06-06 | 2000-06-29 | Austin Research Institute, The | Vaccine |
| FI20002215A0 (fi) | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit |
| US6936426B2 (en) | 2000-10-06 | 2005-08-30 | Harbor-Ucla Research And Education Institute | Detection of antibody mediated inflammatory auto-immune disorders |
| FI20002216A0 (fi) | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit astman hoitoon |
| KR20030060921A (ko) | 2000-11-03 | 2003-07-16 | 히스트오테크 에이피에스 | 조직 블록을 절단하는 장치 및 방법 |
| DE60117858T2 (de) | 2000-12-07 | 2006-11-30 | Universiteit Utrecht Holding B.V. | Zusammensetzung zur behandlung von entzündlichen erkrankungen |
| WO2002060410A2 (en) * | 2001-01-30 | 2002-08-08 | The Regents Of The University Of Michigan | Methods for sustained release local delivery of drugs for ablation of unwanted tissue |
| UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| CA2445839A1 (en) | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
| US6726714B2 (en) * | 2001-08-09 | 2004-04-27 | Scimed Life Systems, Inc. | Stent delivery system |
| GB0124523D0 (en) | 2001-10-12 | 2001-12-05 | Glaxo Group Ltd | Pharmaceutical combination |
| EP1438019A1 (en) | 2001-10-24 | 2004-07-21 | PARI GmbH Spezialisten für effektive Inhalation | Kit for the preparation of a pharmaceutical composition |
| US6625078B2 (en) | 2002-02-11 | 2003-09-23 | United Memories, Inc. | Look-ahead refresh for an integrated circuit memory |
| ATE418347T1 (de) | 2002-02-19 | 2009-01-15 | Resolution Chemicals Ltd | Auf lösungsmitteln basierende sterilisation von steroiden |
| US20050009798A1 (en) | 2002-02-20 | 2005-01-13 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists |
| US7140371B2 (en) | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
| US6688311B2 (en) | 2002-03-14 | 2004-02-10 | Allergan, Inc. | Method for determining effect of a clostridial toxin upon a muscle |
| US6643212B1 (en) | 2002-04-18 | 2003-11-04 | United Memories, Inc. | Simultaneous function dynamic random access memory device technique |
| US20040028545A1 (en) * | 2002-08-06 | 2004-02-12 | Ta-Chin Wang | Cylinder assembly for a mini air compressor |
| AU2003263717A1 (en) * | 2002-09-25 | 2004-04-19 | Astrazeneca Ab | A COMBINATION OF A LONG-ACTING Beta2-AGONIST AND A GLUCOCORTICOSTEROID IN THE TREATMENT OF FIBROTIC DISEASES |
| CN1694689A (zh) | 2002-09-30 | 2005-11-09 | 阿库斯菲尔公司 | 供吸入的缓释多孔微粒 |
| US20040208833A1 (en) | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
| EP1613266A4 (en) | 2003-04-15 | 2009-05-06 | Theraquest Biosciences Llc | METHOD FOR TREATING PAIN AND COMPOSITIONS FOR USE THEREOF |
| US9808471B2 (en) | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| WO2004103057A2 (en) * | 2003-05-15 | 2004-12-02 | The University Of Georgia Research Foundation, Inc. | Compositions and methods for inducing adipose tissue cell death |
| EP1635844A1 (en) | 2003-05-22 | 2006-03-22 | ALTANA Pharma AG | Salmeterol and ciclesonide combination |
| SE0302029D0 (sv) | 2003-07-07 | 2003-07-07 | Astrazeneca Ab | Novel process |
| TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| GB2403655A (en) * | 2003-07-11 | 2005-01-12 | Cipla Ltd | Combined pharmaceutical product comprising a beta-2 adrenoreceptor agonist & an antihistamine for treatment of respiratory diseases such as asthma |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| WO2005009375A2 (en) | 2003-07-22 | 2005-02-03 | Baxter International Inc. | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
| CA2533887A1 (en) * | 2003-09-30 | 2005-04-14 | Acusphere, Inc. | Injectable, oral, or topical sustained release pharmaceutical formulations |
| US20050075900A1 (en) | 2003-10-02 | 2005-04-07 | Arguimbau Vincent C. | Method and apparatus for bulk food marking and tracking with supplier rating system |
| DE10347994A1 (de) | 2003-10-15 | 2005-06-16 | Pari GmbH Spezialisten für effektive Inhalation | Wässrige Aerosol-Zubereitung |
| US20050089555A1 (en) | 2003-10-24 | 2005-04-28 | Aventis Pharma Deutschland Gmbh | Medicinal targeted local lipolysis |
| ATE551339T1 (de) | 2003-11-05 | 2012-04-15 | Sarcode Bioscience Inc | Modulatoren der zellulären adhäsion |
| ES2381672T3 (es) * | 2003-11-14 | 2012-05-30 | Senju Pharmaceutical Co., Ltd. | Preparación en solución acuosa que comprende un antibiótico aminoglicósido y bromfenaco |
| NZ547178A (en) * | 2003-11-20 | 2008-06-30 | Alteragon Pty Ltd | Method of decreasing fat deposits and body weight in mammals and birdsusing the R-isomer of Salbutamol |
| KR100573828B1 (ko) | 2003-12-29 | 2006-04-26 | 주식회사 하이닉스반도체 | 셀데이터의 손실을 방지하기 위한 반도체 메모리 소자 |
| US20080270175A1 (en) | 2003-12-31 | 2008-10-30 | Klinger Advanced Aesthetics, Inc. | Systems and methods using a dynamic expert system to provide patients with aesthetic improvement procedures |
| CN1640390A (zh) | 2004-01-17 | 2005-07-20 | 北京博尔达生物技术开发有限公司 | 注射用新鱼腥草素钠冻干粉针剂及制备方法 |
| US20050212152A1 (en) | 2004-03-23 | 2005-09-29 | Reens Daniel J | System and method for humidifying homes and commercial sites |
| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| WO2006086001A2 (en) | 2004-07-20 | 2006-08-17 | Allergan, Inc. | Thermographic assessment of clostridial toxin applications |
| EP1778638A1 (en) | 2004-07-21 | 2007-05-02 | Theravance, Inc. | Diaryl ether beta2 adrenergic receptor agonists |
| CN101065110A (zh) | 2004-11-24 | 2007-10-31 | 柳署弘 | 水溶胆汁酸制剂的干燥形式:制备及其用途 |
| KR20070104645A (ko) | 2005-02-18 | 2007-10-26 | 산텐 세이야꾸 가부시키가이샤 | 스테로이드 화합물의 부작용 경감 또는 회피 방법 |
| WO2006108176A2 (en) | 2005-04-08 | 2006-10-12 | The Regents Of The University Of California | Wound healing composition |
| US7931909B2 (en) | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
| CN1706501A (zh) | 2005-05-27 | 2005-12-14 | 沈阳药科大学 | 亲脂性药物环糊精包合物的制备方法 |
| BRPI0613034A8 (pt) | 2005-07-14 | 2018-01-02 | Lipothera Inc | formulação injetável para acúmulo de tecido adiposo, formulação injetável e método para o tratamento de acúmulo de gordura, e, método para reduzir o tecido adiposo. |
| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| FR2893845B1 (fr) | 2005-11-30 | 2010-10-29 | Galderma Sa | Composition sous forme de spray comprenant un corticoide et une phase huileuse |
| CA2631493A1 (en) | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
| US20070178051A1 (en) | 2006-01-27 | 2007-08-02 | Elan Pharma International, Ltd. | Sterilized nanoparticulate glucocorticosteroid formulations |
| US7666912B2 (en) | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
| MX2008012794A (es) | 2006-04-03 | 2008-10-15 | Teva Pharma | Microparticulas de farmacos. |
| DE102007026979A1 (de) | 2006-10-06 | 2008-04-10 | Friedrich Siller | Inhalationsvorrichtung |
| MX2009004198A (es) | 2006-10-17 | 2009-10-19 | Lithera Inc | Metodos, composiciones y formulaciones para el tratamiento de enfermedad ocular tiroidea. |
| US20100063006A1 (en) | 2006-11-22 | 2010-03-11 | American Network Of Lipolysis, Llc | Compositions and methods to reduce fat and retract skin |
| CA2680329A1 (en) | 2007-04-04 | 2008-10-16 | Theratechnologies Inc. | Pharmaceutical formulations of ghrh molecules |
| EP2155180B1 (en) | 2007-04-24 | 2016-07-13 | Acacia Pharma Limited | Drug combination and its use in the treatment of muscle loss |
| US20090208492A1 (en) | 2007-06-14 | 2009-08-20 | Elan Pharmaceuticals, Inc. | Lyophilized Immunoglobulin Formulations and Methods of Preparation |
| PT2170348T (pt) | 2007-06-22 | 2016-11-02 | Dompé Farm S P A | Comprimidos efervescentes para utilização por via inalatória |
| US20090143343A1 (en) | 2007-11-13 | 2009-06-04 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| AU2008331928B2 (en) | 2007-12-03 | 2012-08-16 | Bridge Pharma, Inc. | Use of RR/SR-ractopamine |
| US20120169732A1 (en) | 2008-01-09 | 2012-07-05 | Allergan, Inc. | Method for analysis of facial appearance to assist medical procedure |
| US20130060123A1 (en) | 2008-01-09 | 2013-03-07 | Allergan, Inc. | Method for determining breast volume to assist medical procedure |
| KR101184869B1 (ko) | 2008-04-24 | 2012-09-20 | 이매틱스 바이오테크놀로지스 게엠베하 | 백신을 위한 인간 조직 적합성 항원(hla) 종류 i 또는 ii 분자에 결합하는 종양 관련 펩티드의 신규한 제형 |
| US20110230964A1 (en) | 2008-10-17 | 2011-09-22 | Allergan, Inc. | Prosthetic implant shell |
| AU2009305625A1 (en) | 2008-10-17 | 2010-04-22 | Allergan, Inc. | Prosthetic implant shell |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| GB2477030A (en) | 2010-01-15 | 2011-07-20 | Lithera Inc | Lyophilised forms of fluticasone, salmeterol and combinations thereof |
| GEP201606551B (en) | 2010-11-24 | 2016-10-10 | Novamedica Llc | Selective, lipophilic, and long-acting beta agonists monotherapeutic formulations tions and methods for cosmetic treatment of adiposity and contour bulging |
| CA2866067C (en) | 2011-01-19 | 2015-04-21 | Topokine Therapeutics, Inc. | Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| US20140094662A1 (en) | 2012-10-03 | 2014-04-03 | Allergan, Inc. | Method of assessing capsular formation and/or contracture |
| WO2014055895A1 (en) | 2012-10-05 | 2014-04-10 | Allergan, Inc. | Injectable device and method for sculpting, augmenting or correcting facial features such as the chin |
| WO2014081941A1 (en) | 2012-11-21 | 2014-05-30 | Topokine Therapeutics, Inc. | Methods and compositions for locally increasing body fat |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013543897A (ja) * | 2010-11-24 | 2013-12-09 | リセラ,インク. | 脂肪症及び輪郭の膨れの美容処置のための、選択的な、親油性の、及び長時間作用性のベータアゴニストの単剤療法製剤、及び方法 |
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| EP1921919A4 (en) | 2010-04-14 |
| EP2397034A1 (en) | 2011-12-21 |
| WO2007011743A2 (en) | 2007-01-25 |
| US20120015918A1 (en) | 2012-01-19 |
| US9707192B2 (en) | 2017-07-18 |
| US20170266137A1 (en) | 2017-09-21 |
| BRPI0613034A8 (pt) | 2018-01-02 |
| CA2615173A1 (en) | 2007-01-25 |
| US9198885B2 (en) | 2015-12-01 |
| ES2384641T3 (es) | 2012-07-10 |
| US9370498B2 (en) | 2016-06-21 |
| US20110105446A1 (en) | 2011-05-05 |
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| EP1921919A2 (en) | 2008-05-21 |
| US20070014843A1 (en) | 2007-01-18 |
| JP2009501719A (ja) | 2009-01-22 |
| JP2011132262A (ja) | 2011-07-07 |
| US7829554B2 (en) | 2010-11-09 |
| WO2007011743A3 (en) | 2007-11-01 |
| AU2006270165B2 (en) | 2010-03-11 |
| US8420625B2 (en) | 2013-04-16 |
| BRPI0613034A2 (pt) | 2013-01-08 |
| CA2615173C (en) | 2012-01-03 |
| ATE552032T1 (de) | 2012-04-15 |
| US20120046256A1 (en) | 2012-02-23 |
| US20150359760A1 (en) | 2015-12-17 |
| JP2014098041A (ja) | 2014-05-29 |
| EP1921919B1 (en) | 2012-04-04 |
| CN106075449A (zh) | 2016-11-09 |
| US9452147B2 (en) | 2016-09-27 |
| AU2006270165A1 (en) | 2007-01-25 |
| US20140322305A1 (en) | 2014-10-30 |
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