JP4728483B2 - 肥満の予防または治療のための医薬の製造のための多環２−アミノチアゾール系の使用 - Google Patents

肥満の予防または治療のための医薬の製造のための多環２−アミノチアゾール系の使用 Download PDF

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JP4728483B2
JP4728483B2 JP2000602070A JP2000602070A JP4728483B2 JP 4728483 B2 JP4728483 B2 JP 4728483B2 JP 2000602070 A JP2000602070 A JP 2000602070A JP 2000602070 A JP2000602070 A JP 2000602070A JP 4728483 B2 JP4728483 B2 JP 4728483B2
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alkyl
phenyl
substituted
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conh
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JP2002538117A (ja
JP2002538117A5 (https=
Inventor
ゲーアハルト・イェーネ
カール・ガイゼン
ハンス−ヨッヘン・ラング
マルティン・ビッケル
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サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2000602070A 1999-02-26 2000-02-05 肥満の予防または治療のための医薬の製造のための多環２−アミノチアゾール系の使用 Expired - Fee Related JP4728483B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19908537A DE19908537A1 (de) 1999-02-26 1999-02-26 Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE19908537.4 1999-02-26
PCT/EP2000/000925 WO2000051602A1 (de) 1999-02-26 2000-02-05 Verwendung von polycyclischen 2-amino-thiazol systemen zur herstellung von medikamenten zur prophylaxe oder behandlung von obesitas

Publications (3)

Publication Number Publication Date
JP2002538117A JP2002538117A (ja) 2002-11-12
JP2002538117A5 JP2002538117A5 (https=) 2007-03-29
JP4728483B2 true JP4728483B2 (ja) 2011-07-20

Family

ID=7899081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000602070A Expired - Fee Related JP4728483B2 (ja) 1999-02-26 2000-02-05 肥満の予防または治療のための医薬の製造のための多環２−アミノチアゾール系の使用

Country Status (16)

Country Link
US (1) US6476059B1 (https=)
EP (1) EP1173176B1 (https=)
JP (1) JP4728483B2 (https=)
KR (1) KR20020002394A (https=)
CN (1) CN1161120C (https=)
AT (1) ATE267597T1 (https=)
AU (1) AU766295B2 (https=)
BR (1) BR0008557A (https=)
CA (1) CA2362554A1 (https=)
DE (2) DE19908537A1 (https=)
DK (1) DK1173176T3 (https=)
ES (1) ES2218122T3 (https=)
HK (1) HK1045809B (https=)
PT (1) PT1173176E (https=)
WO (1) WO2000051602A1 (https=)
ZA (1) ZA200106199B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19908538A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
EP1816127A1 (en) * 1999-04-22 2007-08-08 H. Lundbeck A/S Triazine derivatives for use as selective npy (y5) antagonists
AU2001246494A1 (en) * 2000-03-03 2001-09-12 Novartis Ag Condensed thiazolamines and their use as neuropeptide y5 antagonists
US7732484B2 (en) * 2000-08-01 2010-06-08 University Of Virginia Patent Foundation Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis
JP2005529846A (ja) * 2002-01-16 2005-10-06 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ１アデノシン受容体の２−アミノチアゾールアロステリックエンハンサ
CA2530634A1 (en) * 2003-06-12 2004-12-23 Menachem Rubinstein Methods of treating obesity and related disorders using tellurium and selenium compounds
CA2575339A1 (en) * 2004-08-05 2006-02-09 F. Hoffmann-La Roche Ag Substituted n-acyl-2-aminothiazoles
WO2006080406A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
ES2480994T3 (es) 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
ES2558742T3 (es) 2009-09-28 2016-02-08 F. Hoffmann-La Roche Ag Compuestos inhibidores de PI3K de benzoxepina y métodos de uso
ES2570569T3 (es) 2009-09-28 2016-05-19 Hoffmann La Roche Compuestos de benzoxazepina como inhibidores de la PI3K y métodos de uso
WO2012126901A1 (en) 2011-03-21 2012-09-27 F. Hoffmann-La Roche Ag Benzoxazepin compounds selective for pi3k p110 delta and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
JPS5334471A (en) * 1976-09-10 1978-03-31 Toshiba Corp Manufacture for semiconductor device
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908538A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen

Also Published As

Publication number Publication date
BR0008557A (pt) 2001-12-18
CN1161120C (zh) 2004-08-11
JP2002538117A (ja) 2002-11-12
AU766295B2 (en) 2003-10-16
DK1173176T3 (da) 2004-09-27
DE19908537A1 (de) 2000-08-31
CA2362554A1 (en) 2000-09-08
EP1173176A1 (de) 2002-01-23
EP1173176B1 (de) 2004-05-26
ES2218122T3 (es) 2004-11-16
DE50006603D1 (de) 2004-07-01
ZA200106199B (en) 2002-03-06
KR20020002394A (ko) 2002-01-09
ATE267597T1 (de) 2004-06-15
PT1173176E (pt) 2004-09-30
HK1045809A1 (en) 2002-12-13
HK1045809B (zh) 2005-04-22
US6476059B1 (en) 2002-11-05
WO2000051602A1 (de) 2000-09-08
CN1349404A (zh) 2002-05-15
AU2670300A (en) 2000-09-21

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