HK1045809B - 多環2-氨基噻唑體系在預防或治療肥胖的藥物製備中的用途 - Google Patents

多環2-氨基噻唑體系在預防或治療肥胖的藥物製備中的用途 Download PDF

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Publication number
HK1045809B
HK1045809B HK02107056.4A HK02107056A HK1045809B HK 1045809 B HK1045809 B HK 1045809B HK 02107056 A HK02107056 A HK 02107056A HK 1045809 B HK1045809 B HK 1045809B
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HK
Hong Kong
Prior art keywords
alkyl
phenyl
acid
compound
formula
Prior art date
Application number
HK02107056.4A
Other languages
English (en)
Chinese (zh)
Other versions
HK1045809A1 (en
Inventor
G‧杰恩
G‧傑恩
K‧盖森
H-J‧兰格
K‧蓋森
M‧毕克尔
H-J‧蘭格
M‧畢克爾
Original Assignee
阿文蒂斯药物德国有限公司
阿文蒂斯藥物德國有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 阿文蒂斯药物德国有限公司, 阿文蒂斯藥物德國有限公司 filed Critical 阿文蒂斯药物德国有限公司
Publication of HK1045809A1 publication Critical patent/HK1045809A1/xx
Publication of HK1045809B publication Critical patent/HK1045809B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
HK02107056.4A 1999-02-26 2000-02-05 多環2-氨基噻唑體系在預防或治療肥胖的藥物製備中的用途 HK1045809B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19908537A DE19908537A1 (de) 1999-02-26 1999-02-26 Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE19908537.4 1999-02-26
PCT/EP2000/000925 WO2000051602A1 (de) 1999-02-26 2000-02-05 Verwendung von polycyclischen 2-amino-thiazol systemen zur herstellung von medikamenten zur prophylaxe oder behandlung von obesitas

Publications (2)

Publication Number Publication Date
HK1045809A1 HK1045809A1 (en) 2002-12-13
HK1045809B true HK1045809B (zh) 2005-04-22

Family

ID=7899081

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107056.4A HK1045809B (zh) 1999-02-26 2000-02-05 多環2-氨基噻唑體系在預防或治療肥胖的藥物製備中的用途

Country Status (16)

Country Link
US (1) US6476059B1 (https=)
EP (1) EP1173176B1 (https=)
JP (1) JP4728483B2 (https=)
KR (1) KR20020002394A (https=)
CN (1) CN1161120C (https=)
AT (1) ATE267597T1 (https=)
AU (1) AU766295B2 (https=)
BR (1) BR0008557A (https=)
CA (1) CA2362554A1 (https=)
DE (2) DE19908537A1 (https=)
DK (1) DK1173176T3 (https=)
ES (1) ES2218122T3 (https=)
HK (1) HK1045809B (https=)
PT (1) PT1173176E (https=)
WO (1) WO2000051602A1 (https=)
ZA (1) ZA200106199B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19908538A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
EP1816127A1 (en) * 1999-04-22 2007-08-08 H. Lundbeck A/S Triazine derivatives for use as selective npy (y5) antagonists
AU2001246494A1 (en) * 2000-03-03 2001-09-12 Novartis Ag Condensed thiazolamines and their use as neuropeptide y5 antagonists
US7732484B2 (en) * 2000-08-01 2010-06-08 University Of Virginia Patent Foundation Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis
JP2005529846A (ja) * 2002-01-16 2005-10-06 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ１アデノシン受容体の２−アミノチアゾールアロステリックエンハンサ
CA2530634A1 (en) * 2003-06-12 2004-12-23 Menachem Rubinstein Methods of treating obesity and related disorders using tellurium and selenium compounds
CA2575339A1 (en) * 2004-08-05 2006-02-09 F. Hoffmann-La Roche Ag Substituted n-acyl-2-aminothiazoles
WO2006080406A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
ES2480994T3 (es) 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
ES2558742T3 (es) 2009-09-28 2016-02-08 F. Hoffmann-La Roche Ag Compuestos inhibidores de PI3K de benzoxepina y métodos de uso
ES2570569T3 (es) 2009-09-28 2016-05-19 Hoffmann La Roche Compuestos de benzoxazepina como inhibidores de la PI3K y métodos de uso
WO2012126901A1 (en) 2011-03-21 2012-09-27 F. Hoffmann-La Roche Ag Benzoxazepin compounds selective for pi3k p110 delta and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
JPS5334471A (en) * 1976-09-10 1978-03-31 Toshiba Corp Manufacture for semiconductor device
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908538A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen

Also Published As

Publication number Publication date
BR0008557A (pt) 2001-12-18
CN1161120C (zh) 2004-08-11
JP2002538117A (ja) 2002-11-12
AU766295B2 (en) 2003-10-16
DK1173176T3 (da) 2004-09-27
JP4728483B2 (ja) 2011-07-20
DE19908537A1 (de) 2000-08-31
CA2362554A1 (en) 2000-09-08
EP1173176A1 (de) 2002-01-23
EP1173176B1 (de) 2004-05-26
ES2218122T3 (es) 2004-11-16
DE50006603D1 (de) 2004-07-01
ZA200106199B (en) 2002-03-06
KR20020002394A (ko) 2002-01-09
ATE267597T1 (de) 2004-06-15
PT1173176E (pt) 2004-09-30
HK1045809A1 (en) 2002-12-13
US6476059B1 (en) 2002-11-05
WO2000051602A1 (de) 2000-09-08
CN1349404A (zh) 2002-05-15
AU2670300A (en) 2000-09-21

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090205